1429 results about "Calcium pidolate" patented technology

The invention describes a new calcium phosphate cement powder, whose composition can best be described over the Ca/P molar ratio range of 1.35 to 1.40, most preferably 1.39, and whose two components were prepared by wet chemical synthesis procedures. One component is chemically-synthesized, bi-phasic alpha-TCP (Ca₃(PO₄)₂, 95 wt %)+HA (Ca₁₀(PO₄)₆(OH)₂, 5 wt %) powder, while the second component is again a chemically-synthesized, single-phase DCPD (CaHPO₄·2H₂O) powder. A setting solution (Na₂HPO₄·2H₂O) is used to form a self-setting calcium phosphate cement from the powder mixture. This cement can be used as bone filler or bone substitute in applications, which require higher rates of resorption.

Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo. Methods for using these implant materials to repair damaged bone and a method of assaying the content of DBM particles, by weight, in a bone implant material are also provided.

The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable. A method for treating a bone defect also is provided by identifying a bone site suitable for receiving an implant, and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporotic bone, an intervertebral space, an alveolar ridge or a bone fracture.

The present invention relates generally to an oral drug delivery system which incorporates a therapeutic bioactive agent with biodegradable calcium phosphate particles, the particles then encapsulated by casein. The resulting particles provide a carrier designed to protect the therapeutic agent in the harsh, acidic environment of the stomach before releasing the agent into the small intestine. The therapeutic agent may be any therapeutically effective agent, such as a natural isolate or synthetic chemical or biological agent, such as a therapeutic agent, and in particular, may be a protein or a peptide such as insulin. Also incorporated with the particles may be additional surface modifying agents to assist binding, controlled release, or to otherwise modify the particles. The particles generally support the therapeutic agent to form controlled- or sustained-release particles for the oral or mucosal delivery of the therapeutic agent over time, wherein the therapeutic agent is incorporated into the structure of the particle core, disposed on the surface of the particle, or both.

The invention relates to rice fertilizer capable of improving the resistance, quality and yield of rice. The rice fertilizer consists of the following raw materials in percentage by weight: 20.0 to 27.0 percent of urea, 7.0 to 20.0 percent of ammonium sulfate, 5.0 to 13.0 percent of monoammonium phosphate, 9.8 to 17.5 percent of potassium chloride, 10.0 to 18.5 percent of calcium superphosphate, 3.0 to 6.0 percent of calcium-magnesium phosphate, 2.0 to 8.0 percent of soluble silicon, 0.1 to 0.9 percent of amino acid, 5.0 to 30.0 percent of humic acid, 0.5 to 6.0 percent of other trace elements (zinc, manganese, boron, ferrum, copper, molybdenum, selenium and the like), 0.2 to 0.5 percent of activating agent and less than or equal to 2.5 percent of water. The rice fertilizer has the advantages of comprehensively providing the nutrient required by growth of rice, improving the yield and the quality of rice, activating the nutrient of soil, enhancing the capacity of absorbing nutrient by crops, improving a soil structure, enhancing soil fertility, promoting development, and improving the resistance of the crops (disease resistance, pest resistance, drought resistance, flooding resistance, cold resistance, saline-alkaline resistance, lodging resistance and the like).

The present invention relates to mucosal immune protection, mucosal vaccine delivery, and mucosal drug delivery. Novel calcium phosphate core particles, particularly nanoparticles are used as vaccine adjuvants and compositions for inducing protective mucosal immunity. Methods of inducing an immune response to an antigen by delivering the antigen to a mucosal surface using the particles of this invention, and to methods of making such particles are also provided. The particles of this invention are also useful for delivering compositions, such as a pharmacologically active agent, to the mucosal surfaces of a patient in need thereof, to methods of delivering such compositions, and to methods of making such particles.

The invention relates to a CaP (Calcium Phosphate)/collagen composite biologic ceramic material and a preparation method thereof. The composite biologic ceramic is prepared by adopting a porous calcium phosphate ceramic as the substrate and I-type collage as the toughening reinforcing phase in a vacuum negative pressure pouring and crosslinking mode. The process is as follows: firstly, preparing the first type through porous calcium phosphate ceramic, wherein the porosity is 60-95%; dipping the porous calcium phosphate ceramic into a collagen solution of which the concentration is 5-20mg/ml; and vacuuming to 0-10Pa at normal temperature and pouring, keeping the pressure for 1-3 hours and carrying out ultrasonic oscillation. The vacuum negative pressure pouring process can be repeated according to demands. The calcium phosphate ceramic poured with the collagen is frozen and dried to prepare the composite biologic ceramic after being subjected to crosslinking. The prepared biologic ceramic has good biocompatibility and biological activity, and at the same time has a mechanical strength better than that of a pure calcium phosphate ceramic material, so that the biologic ceramic can be used as artificial bones and bone tissue engineering bracket materials, and has wide clinical application prospects in orthopedics.

The invention discloses a polysaccharide/autosolidification calcium phosphate composite bone cement composition, which comprises the following components in percentage by weight: 10 to 95 weight percent of autosolidification calcium phosphate bone cement and 5 to 90 weight percent of polysaccharide. The bone cement composition can obtain bone cement with high strength, good toughness, strong plasticity, quick solidification, and good biocompatibility and degradability, thereby overcoming the defects of inadequate toughness and slow degradation in human bodies existing in the prior calcium phosphate bone cement materials and the defects existing in a plurality of enhancement methods in the prior art, and better meeting the requirement of operation use.

The invention includes biostructures which may be characterized as having substantially all of the organic-solvent-soluble material in the form of a network of irregularly shaped perforated films. The biostructure may further include particles of a substantially-insoluble material, which may be a member of the calcium phosphate family. The biostructure may be osteoconductive. The biostructure may further contain an Active Pharmaceutical Ingredient or other bioactive substance. The API may be a substance which stimulates the production of bone morphogenetic protein, such as Lovastatin or related substances, thereby making the biostructure effectively osteoinductive. One or more of the polymers may have a resorption rate in the human body such as to control the release of the API. Methods of manufacture are also disclosed.

The invention discloses a composite frame of multi-aldehyde sodium alginate cross-linked polyethylene / chitosan for bone or cartilage repair and treatment, as well as preparation and application of the material of the framework. The framework is made from Calcium polyphosphate, chitosan and multi-aldehyde sodium alginate. As organic matrix multi-aldehyde sodium alginate cross-linked chitosan derived from nature which is the main component of the composite frameworks of the invention, therefore the composite framework is safe and non-toxic, has good biocompatibility and biodegradability, and cell identificaton signal existed on the surface provides physical support and the best chemical environment for bone or cartilage regeneration and reconstruction, the network structure makes the mechanical properties improved greatly. In addition, the components of the inorganic strengthened calcium polyphosphate are consistent with those of human bone tissue, has the property of activity which promotes bone or cartilage growth and the controllable degradation. The composite of the invention can be used as defect repair of bone or cartilage and tissue engineering, drug delivery carrier.

Aiming at the problems of low strength and low toughness of bioactive ceramics, the invention provides a method for strengthening and toughening a bioactive ceramic material by use of graphene and preparing graphene/biological ceramic artificial bone by a selective laser sintering (SLS) technology. The method has the advantages that graphene is added into the bioactive ceramic (hydroxylapatite, calcium phosphate, bioglass, calcium silicate and the like) as a nano enhanced phase, and the strength and toughness of the ceramic can be remarkably improved by use of the excellent mechanical property of graphene; the SLS technology is applied to the preparation process of graphene/biological ceramic artificial bone, and the sintering time can be shortened to the second level and even millisecond level by use of the characteristic of quick heating and cooling of laser so as to avoid structural injury of graphene caused by long-time high-temperature effect. The method for strengthening and toughening the ceramic material by use of graphene provided by the invention is of great significance to the application of bioactive ceramic to the load bearing parts of the human body.

The invention concerns microgranules produced from calcium phosphate materials. The invention also concerns a method for producing said microgranules. The inventive microgranules are characterized by a very narrow particle size distribution.

The invention relates to a porous bioceramic with calcium phosphate nanorods on the surface layer and a formation method for the same, belonging to the field of biomaterial. In the method, the porous bioceramic with calcium phosphate nanorods on the surface layer is formed by hydrothermal process, and the calcium phosphate nanorods on the surface layer of the porous bioceramic are formed by extensional growth on the substrate surfaces with same or similar chemical compositions of calcium phosphate porous ceramic. Therefore, the calcium phosphate nanorods obtained on the surface of the porous bioceramic are closely and integrally connected with the substrates of the calcium phosphate porous ceramic. Compared with traditional calcium phosphate porous ceramic, the porous bioceramic formed by the method disclosed by the invention is high in bioactivity and mechanical strength; moreover, the formation method is simple, high in repeatability and capable of realizing large-scale production.

The invention discloses a method for wet production of phosphoric acid and a byproduct, namely white gypsum, relating to the technical field of phosphorus chemical industry. The method is mainly used for solving the problems in the traditional wet production of phosphoric acid that the byproduct, namely phosphogypsum is high in impurity content, poor in quality and yellow grey, dark grey and black in appearance, can be stacked only as waste and pollutes the environment. The method comprises the steps of firstly, reacting phosphorite powder (slurry) (the content of phosphorus pentoxide in phosphorite is 18-35%) and phosphoric acid of a volume, which is 16-32w% of the weight of phosphorus pentoxide, for 15-60 minutes at the temperature of 45-70 DEG C while stirring, so as to produce mixed slurry containing phosphoric acid, a calcium phosphate solution, phosphorite carrying acid insoluble matters and a small amount of produced calcium fluoride, ferric phosphate and aluminum phosphate solid impurities; continuously or intermittently precipitating the mixed slurry for 1.0-3.5 hours, and carrying out layered separation, so as to obtain a phosphoric acid and calcium phosphate mixed solution and thick slurry containing solid impurities; adding 40-98w% sulfuric acid while stirring, reacting sulfuric acid and the phosphoric acid and calcium phosphate mixed solution for 10-40 minutes, precipitating for layering, and separating, thereby obtaining phosphoric acid and white gypsum. The method has the advantage that the pollution to atmosphere, soil and groundwater due to phosphogypsum stacking is reduced.

The invention discloses a mulberry compound fertilizer, which is prepared from the following raw materials in parts by weight: 20-23 parts of urea, 24-28 parts of calcium superphosphate, 12-15 parts of humic acid, 13-16 parts of kieselguhr, 8-10 parts of tea shell powder, 3-4 parts of azedarach powder, 2-3 parts of garlic powder, 4-5 parts of carboxymethyl starch, 4-5 parts of calcium bicarbonate, 3-4 parts of ammonium molybdate, 5-6 parts of ferrous sulfate, 2-3 parts of copper sulfate, 1-2 parts of guar gum, 1-2 parts of zirconium oxide, 1-2 parts of methylcellulose, 3-4 parts of EM (effective microorganism) fungicide, 4-6 parts of film coating agent, and proper water. The fertilizer disclosed by the invention has the effects of inorganic and organic fertilizers; the nutrient elements required in the growth and development processes of mulberry can be reasonably configured, the growth requirements of the mulberry are met; the yield and the quality of the mulberry are improved, and the prepared fertilizer is not only quick to take effect, but also can slowly release the elements in the fertilizer; the property of the soil can be effectively improved by the added fungicide, and the utilization rate of the fertilizer is increased.

An LED lamp includes a light source configured to emit radiation with a peak intensity at a wavelength between about 250 nm and about 550 nm; and a phosphor composition configured to be radiationally coupled to the light source. The phosphor composition includes particles of a phosphor of formula I, said particles having a coating composition disposed on surfaces thereof;

((Sr_1−zM_z)_1−(x+w)A_wCe_x)₃(Al_1−ySi_y)O_4+y+3(x−w)F_{1−y−3(x−w)}  I

wherein the coating composition comprises a material selected from aluminum oxide, magnesium oxide, calcium oxide, barium oxide, strontium oxide, zinc oxide, aluminum hydroxide, magnesium hydroxide, calcium hydroxide, barium hydroxide, strontium hydroxide, zinc hydroxide, aluminum phosphate, magnesium phosphate, calcium phosphate, barium phosphate, strontium phosphate, and combinations thereof; and

• • A is Li, Na, K, or Rb, or a combination thereof;
  • M is Ca, Ba, Mg, Zn, or a combination thereof; and
  • 0<x≦0.10, 0≦y≦0.5, 0≦z≦0.5, 0≦x≦x.

The present invention relates to surgical material. The material includes biologically absorbable polymer 10-90 wt%, un-sintered calcium phosphate salt 5-80 wt%, and bone growth factor less than 10 wt%. The biologically absorbable polymer includes polyester, chitosan, chondroitin sulfate, collagen, alginate, etc.; and the calcium phosphate salt is un-sintered hydroxyapatite or tricalcium phosphate of granularity less than 100 microns. The hard tissue repairing material is prepared through mixing biologically absorbably polymer, un-sintered calcium phosphate salt and bone growth factor dispersed in solvent, molding, freeze drying to eliminate solvent and obtain the composition. The composition has the function of promoting bond healing and excellent biocompatibility.

The invention belongs to the technical field of medical bone injury restoration materials, in particular discloses anti-collapsibility calcium phosphate cement, as well as a preparation method and the application thereof. The anti-collapsibility calcium phosphate cement is prepared by uniformly mixing 2-10 percent of beta-cyclodextrin or derivates thereof by mass percentage with 90-98 percent of common calcium phosphate cement by mass percentage. The invention successfully applies the beta-cyclodextrin or the derivates thereof to the common calcium phosphate cement for the first time, not only remarkably improves the anti-collapsibility performance of original calcium phosphate cement, but also keeps the original curing characteristics of the original calcium phosphate cement and improves the mechanical performance requirements thereof, effectively improves the success rate of operations, widens the application fields of the beta-cyclodextrin or the derivates thereof and enables the calcium phosphate cement to have wider application prospects.