Calcium phosphate/collagen composite biologic ceramic material and preparation method thereof

A technology of composite bioceramics and calcium phosphate ceramics, applied in the field of biomedical materials, to achieve the effect of enhancing bone connection and healing function, excellent bone formation ability, and material stability
CN103055352AInactive Publication Date: 2013-04-24SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2013-04-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a CaP (Calcium Phosphate) / collagen composite biologic ceramic material and a preparation method thereof. The composite biologic ceramic is prepared by adopting a porous calcium phosphate ceramic as the substrate and I-type collage as the toughening reinforcing phase in a vacuum negative pressure pouring and crosslinking mode. The process is as follows: firstly, preparing the first type through porous calcium phosphate ceramic, wherein the porosity is 60-95%; dipping the porous calcium phosphate ceramic into a collagen solution of which the concentration is 5-20mg / ml; and vacuuming to 0-10Pa at normal temperature and pouring, keeping the pressure for 1-3 hours and carrying out ultrasonic oscillation. The vacuum negative pressure pouring process can be repeated according to demands. The calcium phosphate ceramic poured with the collagen is frozen and dried to prepare the composite biologic ceramic after being subjected to crosslinking. The prepared biologic ceramic has good biocompatibility and biological activity, and at the same time has a mechanical strength better than that of a pure calcium phosphate ceramic material, so that the biologic ceramic can be used as artificial bones and bone tissue engineering bracket materials, and has wide clinical application prospects in orthopedics.
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Description

technical field

[0001] The invention relates to a bioceramic material composited with porous calcium phosphate ceramics and collagen and a preparation method thereof, belonging to the field of biomedical materials. Background technique

[0002] Calcium Phosphate Bioceramics (CaP) is widely used as a bone repair material because of its inorganic composition similar to human bone tissue and a variety of excellent biological properties. Common calcium phosphate-based bioceramic materials include hydroxyapatite (Hydroxyapatite, HA), β-phase tricalcium phosphate (beta-Tricalcium phosphate, β-TCP) and their composite biphasic calcium phosphate ceramics (Biphasic calcium phosphate, BCP )wait. Studies have confirmed that porous calcium phosphate bioceramics have the biological characteristics required by many bone repair materials, such as biocompatibility, osteoconduction and osteoinductivity, and biodegradable absorption. They are widely used clinically in the form of particles ...

Claims

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