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Calcium phosphate/collagen composite biologic ceramic material and preparation method thereof

A technology of composite bioceramics and calcium phosphate ceramics, applied in the field of biomedical materials, to achieve the effect of enhancing bone connection and healing function, excellent bone formation ability, and material stability

Inactive Publication Date: 2013-04-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But it is only suitable for bone tissue trauma repair in non-bearing parts

Method used

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  • Calcium phosphate/collagen composite biologic ceramic material and preparation method thereof
  • Calcium phosphate/collagen composite biologic ceramic material and preparation method thereof
  • Calcium phosphate/collagen composite biologic ceramic material and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0035] Using hydroxyapatite powder as raw material, a 5×5×20 mm cuboid porous calcium phosphate ceramic product was prepared. Product pore structure requirements: the overall porosity is 85%±5%, the macropore diameter is 400±50μm, and the interpenetrating micropore diameter is 80±20μm. Specific steps are as follows:

[0036] 1) The hydroxyapatite powder prepared by the wet reaction is screened with a standard type sieve to screen out the dry hydroxyapatite powder with a diameter of 80-160 μm, and then the porous ceramic embryo is prepared by the hydrogen peroxide foaming method, and the low temperature is <100 ℃ drying;

[0037] 2) Put the ceramic body into a muffle furnace for sintering, raise the temperature from room temperature to 1100 °C at a rate of 5 °C / min for 2 hours for sintering, and then cool with the furnace. Then the obtained porous hydroxyapatite ceramics were cut into cuboids of 5×5×20 mm;

[0038] 3) Dilute the sterilized, purified and deimmunized type I ca...

Embodiment 2

[0043] A tricalcium phosphate / collagen (TCP / Collagen) composite ceramic material was prepared using porous β-tricalcium phosphate ceramics as a matrix. The overall porosity of the ceramic is 85%±5%, the macropore diameter is 400±50 μm, and the interpenetrating micropore diameter is 80±20 μm. The rest of the product preparation process and steps are the same as in Example 1. The scanning electron microscope picture of the obtained tricalcium phosphate / collagen composite bioceramic material is as follows: image 3 As shown, its maximum compressive strength measured by a universal material testing machine is 5.4 MPa, which is about 2.9 times higher than the mechanical properties of the porous β-tricalcium phosphate ceramic material before compounding collagen, and is higher than that of hydroxyapatite in Example 1. The compressive strength of HA / Collagen composite ceramics is 3.8 MPa lower, because the mechanical properties of pure tricalcium phosphate ceramics are worse than pur...

Embodiment 3

[0045] A biphasic calcium phosphate / collagen (BCP / Collagen) composite ceramic material was prepared with porous biphasic calcium phosphate ceramics as the matrix. The overall porosity of the ceramic is 85%±5%, the macropore diameter is 400±50 μm, and the interpenetrating micropore diameter is 80±20 μm. The rest of the product preparation process and steps are the same as in Example 1. The scanning electron microscope picture of the resulting biphasic calcium phosphate / collagen composite bioceramic material is as follows: image 3 As shown, its maximum compressive strength measured by a universal material testing machine is 6.7 MPa, which is about 3.0 times higher than the mechanical properties of the porous biphasic calcium phosphate ceramic material before the composite collagen, and compared with the hydroxyapatite / calcium phosphate ceramic material in Example 1. The compressive strength of collagen (HA / Collagen) composite ceramics is low, but the compressive strength height...

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Abstract

The invention relates to a CaP (Calcium Phosphate) / collagen composite biologic ceramic material and a preparation method thereof. The composite biologic ceramic is prepared by adopting a porous calcium phosphate ceramic as the substrate and I-type collage as the toughening reinforcing phase in a vacuum negative pressure pouring and crosslinking mode. The process is as follows: firstly, preparing the first type through porous calcium phosphate ceramic, wherein the porosity is 60-95%; dipping the porous calcium phosphate ceramic into a collagen solution of which the concentration is 5-20mg / ml; and vacuuming to 0-10Pa at normal temperature and pouring, keeping the pressure for 1-3 hours and carrying out ultrasonic oscillation. The vacuum negative pressure pouring process can be repeated according to demands. The calcium phosphate ceramic poured with the collagen is frozen and dried to prepare the composite biologic ceramic after being subjected to crosslinking. The prepared biologic ceramic has good biocompatibility and biological activity, and at the same time has a mechanical strength better than that of a pure calcium phosphate ceramic material, so that the biologic ceramic can be used as artificial bones and bone tissue engineering bracket materials, and has wide clinical application prospects in orthopedics.

Description

technical field [0001] The invention relates to a bioceramic material composited with porous calcium phosphate ceramics and collagen and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Calcium Phosphate Bioceramics (CaP) is widely used as a bone repair material because of its inorganic composition similar to human bone tissue and a variety of excellent biological properties. Common calcium phosphate-based bioceramic materials include hydroxyapatite (Hydroxyapatite, HA), β-phase tricalcium phosphate (beta-Tricalcium phosphate, β-TCP) and their composite biphasic calcium phosphate ceramics (Biphasic calcium phosphate, BCP )wait. Studies have confirmed that porous calcium phosphate bioceramics have the biological characteristics required by many bone repair materials, such as biocompatibility, osteoconduction and osteoinductivity, and biodegradable absorption. They are widely used clinically in the form of particles ...

Claims

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Application Information

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IPC IPC(8): A61L27/42
Inventor 周长春樊渝江叶兴江朱向东张兴栋
Owner SICHUAN UNIV
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