50 results about "Osteoconduction" patented technology

The application provides a wearable portable hairband for mental fatigue detection and intervention, a flexible conductive polymer dry electrode is embedded in the inner side of the hairband, the dry electrode is attached to the scalp through mechanical pressure, and thus inductive collection is realized without conductive paste; the output end of the dry electrode collection signal is directly connected to a collection front end located at the side edge of the hairband through FPC, the front end is integrated with an amplifier and an analog-to-digital converter, weak electrical signals on the cerebral cortex are amplified and converted into a data format; a SoC chip is selected as a processor to build a full-integrated edge computing platform inside the flexible fabric hairband, and the calculation task of mental fatigue detection is sunk to the hairband end; an ultrathin bone conduction unit is used as an acoustic output component, which is connected through a flexible circuit and embedded in the inner side of the hairband corresponding to the anatomical site of the user's temple, when the mental fatigue detection result triggers the fatigue warning threshold, a binaural rhythm intervention module is activated to perform binaural rhythm intervention. The application can perform mental fatigue detection and intervention.

The present application relates to the field of medical informatics, and provides a tooth abnormal vibration signal detection system, comprising: an arc-shaped base body; a plurality of arc-shaped base body vibration sensors embedded in the arc-shaped base body, each arc-shaped base body vibration sensor corresponding to one of two sides of a predetermined implant implantation position of a user and being adjacent to a tooth, for real-time sensing of an external mechanical vibration signal acting on the arc-shaped base body and the two sides of the tooth; a bone conduction vibration sensor for sensing a bone conduction vibration signal conducted to the predetermined implant screw base through the jaw bone of the user; and a signal processing module for receiving the external mechanical vibration signal and the bone conduction vibration signal respectively, performing frequency domain conversion, calculating the similarity of first and second frequency spectrum characteristics, and outputting a same frequency judgment result. The present application improves the real-time detection accuracy of implant nail and tooth root collision, and improves the implant success rate and safety.

The application belongs to the technical field of bone organ preparation, and relates to a bone organ for promoting nerve growth and a construction method and application thereof. The construction method comprises the following steps: S1, immersing a hydrogel mineralization scaffold with conductive polymer induction in an EDC / NHS crosslinking agent, and sterilizing and crosslinking; S2, immersing the crosslinked product in a culture medium and culturing, inoculating bone organ seed cells, and replacing the culture medium with a complete culture medium for adaptive culture; and S3, transferring to an osteogenic induction culture medium for osteogenic induction, so as to obtain the bone organ for promoting nerve growth. Compared with the prior art, the bone organ constructed by the application has good biological activity, osteogenic activity and bone conduction, can effectively promote the growth of peripheral nerves, provides a reliable in-vitro model for bone-nerve interaction research, and provides a new technical path and theoretical basis for bone-nerve integrated regeneration and repair.

The present disclosure relates to a device that can guide perpendicular drilling and simultaneously measure flatness of an insertion surface through a locking protrusion by rotating the device in bone conduction implantation. According to the present disclosure, it is possible to measure flatness and guide perpendicular boring with a constant force even without using a separate flatness measurer in surgery. Further, it is also possible to guide drilling using a spacer having a smaller diameter by using an assistant guide member.

The application discloses a kind of biomimetic silk fibroin cartilage scaffolds for cranium defect repair, belong to biomedical engineering technical field.To solve the problem of single structure, low bone formation efficiency and mismatching of mechanical properties and degradation rate of existing cranium repair scaffold, the application provides a kind of scaffold, which includes in order from outside to inside: biomimetic periosteum layer, bone conduction and vascularization layer and cartilage induction layer.Biomimetic periosteum layer is dense nanofiber membrane structure, and plays the role of physical barrier and osteoinduction;Bone conduction and vascularization layer is gradient porous structure with gradually decreasing aperture from outside to inside, aiming to guide the ordered growth of blood vessels and cells, and promote rapid vascularization;Cartilage induction layer is sponge-like microporous structure, used for forming stable cartilage template and starting endochondral ossification.The application simulates the natural bone healing process through structural biomimicry and functional zoning, synergistically promotes vascularization and osteogenesis, and realizes efficient biological repair of cranium defect.

The invention discloses a design method of a vibration transmission sheet of thin kidney-shaped connecting ribs, which comprises the following conditions: 1, a vibration transmission sheet body is arranged, and the vibration transmission sheet body comprises one or more groups of thin kidney-shaped connecting ribs; and 2, the value of the ratio of the width wend of the two ends of the thin kidney-shaped connecting rib to the width wmiddle of the middle section of the connecting rib is as follows: by adopting the design of the vibration transmission sheet of the thin kidney-shaped connecting rib, the problems in two aspects can be solved at the same time: 1, the problem that the service life of the vibration transmission sheet is influenced due to non-uniform distribution of internal stress in the connecting rib is solved; and secondly, the equivalent average width of the connecting rib is reduced, so that the stiffness coefficient of the vibration transmission sheet is reduced, the resonant frequency of the vibrator is reduced, and the low-frequency performance of the bone conduction earphone and the tactile feedback actuator is improved.

The utility model discloses a sound diagnosis instrument, relates to medical equipment technical field, the sound diagnosis instrument comprises a housing, a lift drive assembly and a bone conduction acquisition head, the housing is provided with an accommodation space, the housing is provided with a guide via hole communicated with the accommodation space; the lifting driving assembly comprises a lifting transmission part and a lifting driving mechanism which are in transmission connection, the lifting driving mechanism is arranged in the containing space, and the lifting transmission part is arranged in the guide through hole in a penetrating mode; the bone conduction collecting head is arranged outside the shell and corresponds to a collecting position used for placing the wrist of a patient, the upper end of the bone conduction collecting head is connected with the lifting transmission part, and the lower end of the bone conduction collecting head is used for abutting against the wrist of the patient so as to collect pulse data of the wrist of the patient; according to the technical scheme, the accuracy of pulse measurement can be improved.

Disclosed is an energy transmitting device for use in a system to monitor and treat tinnitus, comprising: a first unit that produces energy for treating said tinnitus; and a second unit that is arranged to secure and fasten said first unit against a skin of said patient, wherein, when in operation, said first unit produces said energy based on a suggested treatment for transmission to said patient through bone conductivity for treating said tinnitus.

The present invention relates to a bone graft composition in which a lappaconitine derivative is surface-adsorbed on a scaffold comprising tricalcium phosphate (TCP) and hydroxyapatite (HA). In the composition of the present invention, the osteogenesis-promoting properties of the lappaconitine derivative are combined with the osteoconductivity of the TCP / HA scaffold, thereby improving problems such as high-concentration adverse effects, unstable adsorption patterns, and localized excessive formation, which occur in existing protein-based osteogenic factors.

This invention belongs to the field of foot and ankle joint replacement implant technology, and discloses an ankle joint talus prosthesis with an antibacterial porous interface and its preparation method. It includes a prosthesis substrate with an overall anatomically contoured structure, including a superior articular surface, a inferior articular surface, and an anterior articular surface; the area of ​​the prosthesis substrate in contact with residual bone tissue is designed as a three-dimensional porous structure; an antibacterial bioactive composite coating is grown in situ on the surface of the prosthesis substrate; it includes calcium and phosphorus bioactive components and antibacterial ions. This invention, by constructing an antibacterial bioactive composite coating at a porous bone integration interface, utilizes biocompatibility and osteoconductivity to induce bone tissue growth. Furthermore, the antibacterial ions can be slowly and continuously released in the interstitial spaces, achieving a dual function of promoting bone integration and preventing infection. Moreover, the antibacterial bioactive composite coating is formed through in-situ growth, resulting in a strong bond with the substrate and preventing detachment.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.

The invention provides a preparation method and application of a digital plasma matrix bone block, and belongs to the technical field of medical materials. By combining a digital technology and a plasma matrix technology, the personalized plasma matrix bone block with regeneration activity and mechanical strength is immediately prepared in an operation according to the defect condition of a patient. Compared with a traditional bone regeneration scheme, the digital plasma matrix bone block can be shaped immediately in an operation and is matched with a defect area; in addition, the digital plasma matrix bone block has good mechanical strength, and the collapse problem after traditional bone meal transplantation or the exposure problem after a titanium mesh is applied can be avoided; more importantly, the digital plasma matrix bone block has good bone regeneration effects including bone conduction, bone induction, bone regeneration and the like. The digital plasma matrix bone block is more economical for a patient, is convenient for an operator to operate, has good biological safety, and provides a personalized solution for regeneration and repair of bone tissue defects.

This invention discloses a composite scaffold for promoting bone regeneration in diabetic patients, its preparation method, and its applications, relating to the field of medical biomaterials technology. The composite scaffold for promoting bone regeneration in diabetic patients comprises: a three-dimensional porous framework; and a bioactive hydrogel layer loaded with naringin. The bioactive hydrogel layer loaded with naringin is coated on the surface and pore walls of the three-dimensional porous framework. The technical solution provided by this invention uses a 3D-printed PLGA / HA porous framework to provide mechanical support and osteoconductivity, and a supramolecular hydrogel coating loaded with naringin to endow it with immunomodulatory and drug sustained-release functions. This scaffold has good hydrophilicity and biocompatibility, and can effectively induce macrophage polarization towards the M2 anti-inflammatory phenotype by activating the JAK-STAT signaling pathway, improving the local inflammatory microenvironment of diabetic bone defects. Simultaneously, it indirectly promotes vascular endothelial cell migration, lumen formation, and osteogenic differentiation of bone marrow mesenchymal stem cells by regulating macrophages.

The invention discloses a collagen and hydroxyapatite composite bone scaffold as well as a preparation method and application thereof, and relates to the technical field of bone scaffolds. The preparation method of the collagen and hydroxyapatite composite bone scaffold comprises the following steps: dissolving collagen in an acid solution to obtain a collagen solution with the concentration of 10-80 mg / L, mixing the collagen solution with hydroxyapatite, and stirring to obtain a compound; freeze-drying the compound, and cross-linking to obtain a primary product; washing the primary product with water to remove acid residues, and then freeze-drying to obtain the collagen and hydroxyapatite composite bone scaffold. The composite bone scaffold is spongy, has relatively high porosity, is beneficial to bone conduction and bone induction, is not easy to disintegrate and slag when being wetted, and is relatively good in supporting property.

The application relates to the technical field of neuromodulation devices, and provides a bone conduction neuromodulation device and a control method. The bone conduction neuromodulation device comprises an electroencephalogram acquisition device, a bone conduction vibration device and a control device. The control device is configured to extract electroencephalogram features in an electroencephalogram signal, determine vibration control parameters according to the electroencephalogram features, control the bone conduction vibration device to generate vibration according to the vibration control parameters, and adaptively adjust the vibration control parameters based on changes in the extracted electroencephalogram features during the process of generating vibration by the bone conduction vibration device, so as to form a closed-loop control. The closed-loop control mechanism based on real-time electroencephalogram feedback makes the vibration stimulation always adapt to the instant neural state of a target user, helps to reduce the influence of individual differences on the treatment effect, improves the stability and repeatability of the treatment effect, and further enhances the overall reliability of the bone conduction neuromodulation in clinical application.

The present invention is applied to the technical field of composite medical materials. Disclosed is an organic-inorganic composite medical material, the material consisting of organic components and inorganic components, the organic components comprising collagen, hyaluronic acid and chitosan, and the inorganic components being nano-hydroxyapatite and silica nanoparticles. Among the inorganic components of the organic-inorganic composite medical material, the nano-hydroxyapatite has the characteristics of good biocompatibility and osteoconductivity and thus enables the composite material to integrate with human bones; and the silica nanoparticles which have the characteristics of enhancing the strength and stability of materials improve the stability of the composite material. Among the organic components, proteins which are natively present in the human body and mainly comprise collagen can improve the biological activity and flexibility of the composite material, and promote cell growth and tissue regeneration; the collagen provides an attachment and growth environment for cells; and the hyaluronic acid is used for moisturizing and has an effect of promoting cell growth.

A haptic feedback method includes: providing a wearable haptic feedback device comprising one or more bone-conduction haptic feedback units, and driving the one or more bone conduction haptic feedback units with at least a first signal processed using a bone conduction head related transfer function, ‘bHRTF’.

The application provides an intervertebral fusion prosthesis and an intervertebral fusion prosthesis assembly, the intervertebral fusion prosthesis comprising: an outer shell, the outer shell being provided with a first conduction nail hole; a first bone conduction nail, the first bone conduction nail being arranged in the first conduction nail hole and extending out of the outer shell, the first bone conduction nail comprising a first connecting head, a first nail barrel and a first bone conduction body arranged in the first nail barrel, the outer side wall of the first nail barrel being provided with a first threaded structure, the first connecting head being provided with a first butt joint groove and the first butt joint groove being communicated with the accommodating cavity; a first adjusting body being provided with a first bone conduction block; a second bone conduction body being arranged in the first connecting barrel, the first connecting barrel extending into the first bone conduction block, and the end of the first connecting barrel being inserted into the first butt joint groove. The technical scheme of the application effectively solves the problem that the effect of the intervertebral fusion prosthesis in promoting bone ingrowth is poor in the related art, and the long-term stability of the intervertebral fusion prosthesis after implantation is poor.

[Problem] To provide a wet apatite porous body and a wet apatite curable composition exhibiting excellent bone conduction and bone replacement properties, and wet apatite and related materials for regenerating cartilage. Another problem is to provide an apatite-based curable composition, a calcium phosphate composition, a calcium carbonate composition, supporting bodies, and the like necessary to provide the abovementioned, and related manufacturing methods. [Solution] This problem has been solved by discovering a wet apatite porous body, a wet apatite curable composition, a wet apatite composition and related materials for regenerating cartilage, and manufacturing methods for these.

The present application belongs to the technical field of hydrogel materials, and particularly relates to a composite hydrogel for regulating energy metabolism and a preparation method and application thereof. The preparation raw material of the composite hydrogel for regulating energy metabolism comprises creatine modified double bond hydroxybutyl chitosan, hydroxyapatite, curcumin, an initiator and a solvent. CHBC provides energy metabolism support at the cell level, is conducive to the proliferation and differentiation of osteogenesis-related cells; HA provides an inorganic environment similar to bone mineralization, and plays a bone conduction and bone induction role; Cur regulates inflammatory response and improves oxidative stress state, and optimizes the repair microenvironment. Through synergy in different aspects such as energy metabolism support, structure mineralization and microenvironment regulation, the regulation of the energy metabolism state of cells in the bone repair area is realized, which is conducive to meeting the high energy requirement of osteoblasts in the repair process, and can promote new bone formation and improve the inflammatory and oxidative stress microenvironment of the injury area, and provides more favorable repair conditions for bone tissue regeneration.

This invention provides an embedded periscope-type mining safety helmet and health monitoring system, comprising: a helmet shell body with a reinforcing rib groove inside the brim; an eye-tracking module, at least partly located within the reinforcing rib groove, for collecting eye movement characteristic parameters of the helmet wearer; an environmental monitoring module located on the side of the helmet shell body for monitoring environmental parameters; a physiological monitoring module located in the lining of the helmet shell body for collecting the wearer's physiological parameters; a counterweight module located at the rear of the helmet shell body for balancing the center of gravity of the mining safety helmet; an alarm module located on the side facing the counterweight module for generating alarm information; a bone conduction vibration module located in the lining corresponding to the wearer's temporal bone for converting electrical signals into mechanical vibrations and transmitting them to the wearer's skull; and a controller located at the rear of the helmet shell body for monitoring the wearer's health status, activating the alarm module and bone conduction vibration module to provide a warning when an abnormal state is detected.

This invention discloses a method for expanding the volume of a composite matrix, an osteogenic composition, and its applications. The components of this invention are entirely autologous, posing no risk of immune rejection or disease transmission. The composite matrix in the osteogenic composition provides a bone conduction scaffold, while the volume-expanding agent provides bone-inducing signals while simultaneously expanding the composite matrix, thus providing a dual osteogenic mechanism. This invention requires only a conventional centrifuge and sterile containers, making it suitable for outpatient surgery. It also eliminates the need to purchase expensive bone powder, offering advantages such as ease of operation and low cost. Furthermore, the materials of this invention exhibit good stability; the composite matrix, after being encapsulated by the volume-expanding agent, does not easily dissipate and conforms well to the defect morphology.

This invention discloses a marine-derived composite hydrogel with bone defect repair function, its preparation method, and its applications, belonging to the field of biomedical materials technology. The invention provides a composite hydrogel with bone defect repair function, which is prepared by combining marine-derived collagen with hydroxyapatite to form a biomimetic matrix, and innovatively doping it with fucoidan, which has multiple biological functions. The composite hydrogel achieves a synergistic effect between material structure and function, breaking through the limitations of organic phase biomimetic microenvironment construction capabilities, inorganic phase osteoconductive properties, and fucoidan anti-inflammatory functions to form a three-dimensional network composite material. This invention also provides a simple and easy-to-implement method for preparing the composite hydrogel, with low preparation cost and significant potential for widespread application. The composite hydrogel provided by this invention not only possesses excellent biocompatibility but also significantly improves the coordination of cellular response, matrix remodeling, and functional reconstruction during bone defect repair, bringing a breakthrough solution to the regeneration and repair of complex bone defects, with broad application prospects.

This specification provides a fixation component for a bone conduction oscillator, comprising: an elastic fixation portion having a strip-like structure, the elastic fixation portion including a first position and a second position, the first position and the second position being spaced apart along the length direction of the elastic fixation portion; and a fixation member configured to surround and fix the elastic fixation portion around a wearer, such that the bone conduction oscillator is located between the elastic fixation portion and the wearer; wherein, when the elastic fixation portion surrounds the wearer and is in a natural state, the fixation member engages with the first position of the elastic fixation portion; when the fixation member engages with the second position, the elastic fixation portion provides pressure to the bone conduction oscillator acting on the wearer, the pressure being within a preset pressure range.

The present application relates to a kind of porous hydroxyapatite microsphere modified PMMA bone cement preparation method and its product and application, contain gelatin, alpha-TCP, the mixed aqueous solution of hydroxyapatite as water phase solution, into vegetable oil to obtain O / W type emulsion;Add demulsifier, further crosslinking gelatin is added simultaneously with glutaraldehyde solution, centrifugal extraction microsphere, washing freeze-drying calcination obtains porous hydroxyapatite microsphere;Microsphere is added in PMMA powder to prepare and obtain porous hydroxyapatite microsphere modified PMMA bone cement.The porous hydroxyapatite microsphere prepared in the present application has good biological activity, biocompatibility and bone conduction, and its micropore is conducive to bone cell growth, nutrient transport and metabolic product discharge.Modified PMMA bone cement can regulate the mechanical properties of PMMA bone cement.

An adaptive porous femoral head necrosis support rod comprises a head, a body, a temperature-sensitive bone conduction layer and a tail; the head, the body and the tail are coaxially connected in sequence, and the temperature-sensitive bone conduction layer covers the surface of the body; the shape of the head matches the cavity surface left after the removal of dead bone, and the head and the body are both porous structures; the tail is provided with a thread, and the thread groove is provided with a porous structure. The porous personalized adaptive femoral head necrosis support rod has strong personalized adaptation. The shape of the head matches the cavity surface left after the removal of dead bone in the patient's marrow core, can maximize the contact area of the head and the patient's subchondral bone, improve the ability of the support rod to resist pressure and support the subchondral bone, and effectively prevent collapse.

The invention discloses an antibacterial and anti-inflammatory bone repair composite material and a preparation method thereof. The composite material is formed by compounding (S)-lactic acid hydrazone-based polyamide, 2, 5-dihydroxy phenyl acetic acid gamma-lactone polyester particles and modified hydroxyapatite according to the mass ratio of 0.5: 0.2: 1-2: 2: 1, and a porous structure with the porosity of 40%-60% is obtained through ultrasonic dispersion and vacuum freeze drying forming. Wherein the modified hydroxyapatite provides biocompatibility and osteogenesis promoting performance, the polyester microparticles reserve 2, 5-dihydroxyphenyl active groups to achieve the anti-inflammatory function, and the surface of the modified hydroxyapatite is grafted with pyrimidine derivatives containing phenolic hydroxyl groups and (S)-lactic acid hydrazone-based polyamide to enhance the antibacterial activity and osteoconductivity. The antibacterial rate of the composite material to staphylococcus aureus and escherichia coli is larger than or equal to 90%, the compression strength is 5-20 MPa, the in-vitro osteoblast proliferation rate is increased by 43% or above compared with pure hydroxyapatite, and the composite material is suitable for infectious bone defect repair scaffolds, antibacterial orthopedic implants and periodontitis adjuvant therapy filling materials and has the advantages of being simple and convenient in process, synergistic in function and high in biological safety.

A bone conduction implant, including a bone fixture including a male screw section configured to screw into a skull and an abutment configured to be rigidly attached to the bone fixture, wherein the abutment includes an exterior surface diameter lying on a first plane normal to a longitudinal axis of the bone conduction implant that is less than or substantially equal to the maximum thread diameter of the male screw section of the bone fixture.

This invention discloses a bio-barrier membrane with guided bone regeneration (GBR) function and its construction method, belonging to the technical field of bone tissue regeneration and repair materials. The bio-barrier membrane is a composite structure formed by a decellularized periosteum and an extracellular matrix (ECM) cross-linked layer. Specifically, it is prepared by in-situ cross-linking of the decellularized periosteum with an acidic ECM solution. This bio-barrier membrane is a bilayer composite membrane that mimics the natural periosteum, synergistically exerting barrier, osteoconduction, and osteoinduction effects, significantly improving bone repair and regeneration.