79 results about "Osteoconduction" patented technology

A motion sickness reduction device is disclosed. More specifically, the present invention relates to a device for reducing a motion sickness phenomenon caused by a mismatch between visual information perceived by the eyes and sensing information by the vestibular system. According to an embodiment of the present invention, a difference between visual information received by a user and motion information perceived by the vestibular system is checked, a moving direction based on a rigid body motion of the vestibular system is calculated, and a mechanical stimulus corresponding to the visual information is applied to the vestibular system through a bone conduction unit worn by the user, thereby having the effect of minimizing a motion sickness phenomenon caused by a difference between visual information and motion information of a user riding in a vehicle or watching VR content.

The application provides a wearable portable hairband for mental fatigue detection and intervention, a flexible conductive polymer dry electrode is embedded in the inner side of the hairband, the dry electrode is attached to the scalp through mechanical pressure, and thus inductive collection is realized without conductive paste; the output end of the dry electrode collection signal is directly connected to a collection front end located at the side edge of the hairband through FPC, the front end is integrated with an amplifier and an analog-to-digital converter, weak electrical signals on the cerebral cortex are amplified and converted into a data format; a SoC chip is selected as a processor to build a full-integrated edge computing platform inside the flexible fabric hairband, and the calculation task of mental fatigue detection is sunk to the hairband end; an ultrathin bone conduction unit is used as an acoustic output component, which is connected through a flexible circuit and embedded in the inner side of the hairband corresponding to the anatomical site of the user's temple, when the mental fatigue detection result triggers the fatigue warning threshold, a binaural rhythm intervention module is activated to perform binaural rhythm intervention. The application can perform mental fatigue detection and intervention.

The present application relates to the field of medical informatics, and provides a tooth abnormal vibration signal detection system, comprising: an arc-shaped base body; a plurality of arc-shaped base body vibration sensors embedded in the arc-shaped base body, each arc-shaped base body vibration sensor corresponding to one of two sides of a predetermined implant implantation position of a user and being adjacent to a tooth, for real-time sensing of an external mechanical vibration signal acting on the arc-shaped base body and the two sides of the tooth; a bone conduction vibration sensor for sensing a bone conduction vibration signal conducted to the predetermined implant screw base through the jaw bone of the user; and a signal processing module for receiving the external mechanical vibration signal and the bone conduction vibration signal respectively, performing frequency domain conversion, calculating the similarity of first and second frequency spectrum characteristics, and outputting a same frequency judgment result. The present application improves the real-time detection accuracy of implant nail and tooth root collision, and improves the implant success rate and safety.

The application belongs to the technical field of bone organ preparation, and relates to a bone organ for promoting nerve growth and a construction method and application thereof. The construction method comprises the following steps: S1, immersing a hydrogel mineralization scaffold with conductive polymer induction in an EDC / NHS crosslinking agent, and sterilizing and crosslinking; S2, immersing the crosslinked product in a culture medium and culturing, inoculating bone organ seed cells, and replacing the culture medium with a complete culture medium for adaptive culture; and S3, transferring to an osteogenic induction culture medium for osteogenic induction, so as to obtain the bone organ for promoting nerve growth. Compared with the prior art, the bone organ constructed by the application has good biological activity, osteogenic activity and bone conduction, can effectively promote the growth of peripheral nerves, provides a reliable in-vitro model for bone-nerve interaction research, and provides a new technical path and theoretical basis for bone-nerve integrated regeneration and repair.

The present disclosure relates to a device that can guide perpendicular drilling and simultaneously measure flatness of an insertion surface through a locking protrusion by rotating the device in bone conduction implantation. According to the present disclosure, it is possible to measure flatness and guide perpendicular boring with a constant force even without using a separate flatness measurer in surgery. Further, it is also possible to guide drilling using a spacer having a smaller diameter by using an assistant guide member.

Provided in the present utility model is a bone conduction packaging structure, comprising: a base board, a housing covering the base board to form an accommodating space, and a bone conduction MEMS chip and an ASIC chip which are disposed in the accommodating space. The bone conduction MEMS chip comprises a substrate having a cavity, a vibration diaphragm supported on the substrate, and a back plate spaced apart from the side of the vibration diaphragm away from the substrate; a first cavity is formed between the vibration diaphragm and the back plate; a second cavity is formed between the vibration diaphragm and the substrate and the base board; a third cavity is formed between the back plate, and the housing, the substrate and the base board; and the first cavity is configured as a low-pressure region the pressure of which is lower than atmospheric pressure. The bone conduction packaging structure of the present utility model configures the region between the vibration diaphragm and the back plate as the low-pressure region, so as to reduce damping between the vibration diaphragm and the back plate, thereby improving the performance of the bone conduction packaging structure.

The application discloses a kind of biomimetic silk fibroin cartilage scaffolds for cranium defect repair, belong to biomedical engineering technical field.To solve the problem of single structure, low bone formation efficiency and mismatching of mechanical properties and degradation rate of existing cranium repair scaffold, the application provides a kind of scaffold, which includes in order from outside to inside: biomimetic periosteum layer, bone conduction and vascularization layer and cartilage induction layer.Biomimetic periosteum layer is dense nanofiber membrane structure, and plays the role of physical barrier and osteoinduction;Bone conduction and vascularization layer is gradient porous structure with gradually decreasing aperture from outside to inside, aiming to guide the ordered growth of blood vessels and cells, and promote rapid vascularization;Cartilage induction layer is sponge-like microporous structure, used for forming stable cartilage template and starting endochondral ossification.The application simulates the natural bone healing process through structural biomimicry and functional zoning, synergistically promotes vascularization and osteogenesis, and realizes efficient biological repair of cranium defect.

The invention relates to a device for bone formation, bone reshaping or healing of bone in dental, oral and maxillofacial applications, specifically in connection with installation of dental implants. The device comprises a sheet structure made of an inert material, wherein the sheet structure has an inner surface intended to be directed towards the bone and an outer surface intended to be directed away from the bone. The geometrical features of the cavity formed between the inner surface of the device and the initial bone surface when the device is installed at the intended location is further used to improve and plan the treatment. The device is customized by means of digital planning based on the initial and the optimal bone volume for the intended treatment. Modifications of the device can be introduced to facilitate a combined installation of dental implants with the device.

The invention discloses a design method of a vibration transmission sheet of thin kidney-shaped connecting ribs, which comprises the following conditions: 1, a vibration transmission sheet body is arranged, and the vibration transmission sheet body comprises one or more groups of thin kidney-shaped connecting ribs; and 2, the value of the ratio of the width wend of the two ends of the thin kidney-shaped connecting rib to the width wmiddle of the middle section of the connecting rib is as follows: by adopting the design of the vibration transmission sheet of the thin kidney-shaped connecting rib, the problems in two aspects can be solved at the same time: 1, the problem that the service life of the vibration transmission sheet is influenced due to non-uniform distribution of internal stress in the connecting rib is solved; and secondly, the equivalent average width of the connecting rib is reduced, so that the stiffness coefficient of the vibration transmission sheet is reduced, the resonant frequency of the vibrator is reduced, and the low-frequency performance of the bone conduction earphone and the tactile feedback actuator is improved.

The utility model discloses a sound diagnosis instrument, relates to medical equipment technical field, the sound diagnosis instrument comprises a housing, a lift drive assembly and a bone conduction acquisition head, the housing is provided with an accommodation space, the housing is provided with a guide via hole communicated with the accommodation space; the lifting driving assembly comprises a lifting transmission part and a lifting driving mechanism which are in transmission connection, the lifting driving mechanism is arranged in the containing space, and the lifting transmission part is arranged in the guide through hole in a penetrating mode; the bone conduction collecting head is arranged outside the shell and corresponds to a collecting position used for placing the wrist of a patient, the upper end of the bone conduction collecting head is connected with the lifting transmission part, and the lower end of the bone conduction collecting head is used for abutting against the wrist of the patient so as to collect pulse data of the wrist of the patient; according to the technical scheme, the accuracy of pulse measurement can be improved.

Disclosed is an energy transmitting device for use in a system to monitor and treat tinnitus, comprising: a first unit that produces energy for treating said tinnitus; and a second unit that is arranged to secure and fasten said first unit against a skin of said patient, wherein, when in operation, said first unit produces said energy based on a suggested treatment for transmission to said patient through bone conductivity for treating said tinnitus.

The present invention relates to a bone graft composition in which a lappaconitine derivative is surface-adsorbed on a scaffold comprising tricalcium phosphate (TCP) and hydroxyapatite (HA). In the composition of the present invention, the osteogenesis-promoting properties of the lappaconitine derivative are combined with the osteoconductivity of the TCP / HA scaffold, thereby improving problems such as high-concentration adverse effects, unstable adsorption patterns, and localized excessive formation, which occur in existing protein-based osteogenic factors.

This invention belongs to the field of foot and ankle joint replacement implant technology, and discloses an ankle joint talus prosthesis with an antibacterial porous interface and its preparation method. It includes a prosthesis substrate with an overall anatomically contoured structure, including a superior articular surface, a inferior articular surface, and an anterior articular surface; the area of ​​the prosthesis substrate in contact with residual bone tissue is designed as a three-dimensional porous structure; an antibacterial bioactive composite coating is grown in situ on the surface of the prosthesis substrate; it includes calcium and phosphorus bioactive components and antibacterial ions. This invention, by constructing an antibacterial bioactive composite coating at a porous bone integration interface, utilizes biocompatibility and osteoconductivity to induce bone tissue growth. Furthermore, the antibacterial ions can be slowly and continuously released in the interstitial spaces, achieving a dual function of promoting bone integration and preventing infection. Moreover, the antibacterial bioactive composite coating is formed through in-situ growth, resulting in a strong bond with the substrate and preventing detachment.

The utility model provides a bone conduction earphone. The bone conduction earphone comprises an FPC module, a detection module and a control module, the detection module is connected with the FPC module, and the detection module is used for obtaining the wearing state and generating a corresponding detection signal; the control module is connected with the detection module and the FPC module, and the control module is used for receiving the detection signal from the detection module and adjusting the working state of the bone conduction earphone based on the detection signal. The detection module in the bone conduction earphone can accurately detect the wearing state and automatically control and switch the working state of the bone conduction earphone based on the detection signal, the response speed is high, a user does not need to manually press a corresponding key to realize a playing or pausing function, the operation steps are simplified, and the user experience is improved.

The invention relates to a paper fiber-based bone repair scaffold which is made of hydroxyapatite, polyvinyl alcohol and paper fibers, and the paper fibers are wide in source and low in cost; hydroxyapatite has good biocompatibility and osteoconductivity, polyvinyl alcohol serving as an adhesive has good biocompatibility and degradability, and the mechanical supporting capacity of the bone repair scaffold can be improved; the invention relates to a preparation method of a paper fiber-based bone repair scaffold. The preparation method is convenient to operate. The invention also relates to application of the paper fiber-based bone repair scaffold in preparation of a bone repair material, and tests prove that the paper fiber-based bone repair scaffold prepared by the preparation method disclosed by the invention is good in swelling property and free of structural collapse and damage, and the mechanical property meets the requirements; the paper fiber-based bone repair scaffold has no cytotoxicity and good biocompatibility, and can promote proliferation, adhesion and migration of BMSC cells; animal experiments prove that the paper fiber based bone repair scaffold has a better bone repair effect and a wide application prospect.

A wearable device includes a frame element, an extension element, a plurality of capacitive sensors, a plurality of bone conduction transducers, an antenna element, and an adjustment circuit. The extension element is connected to the frame element. The plurality of capacitive sensors are disposed on the extension element and arranged along a first direction. The plurality of capacitive sensors can generate a first sensing signal about a human body part. The plurality of bone conduction transducers are arranged on the extension element and are arranged along a second direction. The plurality of bone conduction transducers can generate a second sensing signal about the body part. The antenna element is arranged on the frame element or the extension element. The adjusting circuit is coupled to the antenna element. The adjusting circuit can provide a variable impedance value according to the first sensing signal and the second sensing signal.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.

The invention provides a preparation method and application of a digital plasma matrix bone block, and belongs to the technical field of medical materials. By combining a digital technology and a plasma matrix technology, the personalized plasma matrix bone block with regeneration activity and mechanical strength is immediately prepared in an operation according to the defect condition of a patient. Compared with a traditional bone regeneration scheme, the digital plasma matrix bone block can be shaped immediately in an operation and is matched with a defect area; in addition, the digital plasma matrix bone block has good mechanical strength, and the collapse problem after traditional bone meal transplantation or the exposure problem after a titanium mesh is applied can be avoided; more importantly, the digital plasma matrix bone block has good bone regeneration effects including bone conduction, bone induction, bone regeneration and the like. The digital plasma matrix bone block is more economical for a patient, is convenient for an operator to operate, has good biological safety, and provides a personalized solution for regeneration and repair of bone tissue defects.

The present invention provides a bone conduction MEMS chip and a manufacturing method therefor, and a bone conduction packaging structure having the bone conduction MEMS chip. The bone conduction MEMS chip comprises: a substrate provided with a cavity, a diaphragm supported on the substrate, and a back plate spaced apart from the side of the diaphragm distant from the substrate, wherein a mass block is arranged on the side of the diaphragm distant from the back plate. The mass block in the bone conduction MEMS chip of the present invention is directly formed on the diaphragm, and the bone conduction packaging structure avoids additionally providing a vibration sheet and a mass block, thereby reducing costs, achieving simple packaging, and allowing the structure to be smaller.

The utility model discloses a bone conduction vibrator device which comprises an outer shell, a fixing column and a fixing ring. An iron core is arranged on the inner bottom surface of the outer shell, a coil is wound on the outer cambered surface of the iron core, a fixing column is arranged on the upper surface of the iron core, an oscillator sheet is arranged at the top end of the fixing column, a step groove is formed in the middle of the inner side wall of the outer shell, the fixing ring is fixedly connected to the upper surface of the step groove, and elastic sheets are uniformly arranged on the inner cambered surface of the fixing ring. The elastic sheets are respectively matched with the iron core and the oscillator sheets, contacts are arranged at the ends of the inner sides of the elastic sheets, and the contacts are respectively matched with the iron core and the oscillator sheets; wherein the bone conduction vibrator device further comprises a vibrating diaphragm, the lower end of the outer edge of the vibrating diaphragm is connected to the interior of a buckling groove formed in the outer cambered surface of the outer shell in a buckled mode, the inner top wall of the vibrating diaphragm is attached to the upper surface of the vibrator piece, and according to the bone conduction vibrator device, the frequency and the amplitude of the vibrator piece are increased, and the tone quality is improved.

This invention discloses a composite scaffold for promoting bone regeneration in diabetic patients, its preparation method, and its applications, relating to the field of medical biomaterials technology. The composite scaffold for promoting bone regeneration in diabetic patients comprises: a three-dimensional porous framework; and a bioactive hydrogel layer loaded with naringin. The bioactive hydrogel layer loaded with naringin is coated on the surface and pore walls of the three-dimensional porous framework. The technical solution provided by this invention uses a 3D-printed PLGA / HA porous framework to provide mechanical support and osteoconductivity, and a supramolecular hydrogel coating loaded with naringin to endow it with immunomodulatory and drug sustained-release functions. This scaffold has good hydrophilicity and biocompatibility, and can effectively induce macrophage polarization towards the M2 anti-inflammatory phenotype by activating the JAK-STAT signaling pathway, improving the local inflammatory microenvironment of diabetic bone defects. Simultaneously, it indirectly promotes vascular endothelial cell migration, lumen formation, and osteogenic differentiation of bone marrow mesenchymal stem cells by regulating macrophages.

The invention discloses a collagen and hydroxyapatite composite bone scaffold as well as a preparation method and application thereof, and relates to the technical field of bone scaffolds. The preparation method of the collagen and hydroxyapatite composite bone scaffold comprises the following steps: dissolving collagen in an acid solution to obtain a collagen solution with the concentration of 10-80 mg / L, mixing the collagen solution with hydroxyapatite, and stirring to obtain a compound; freeze-drying the compound, and cross-linking to obtain a primary product; washing the primary product with water to remove acid residues, and then freeze-drying to obtain the collagen and hydroxyapatite composite bone scaffold. The composite bone scaffold is spongy, has relatively high porosity, is beneficial to bone conduction and bone induction, is not easy to disintegrate and slag when being wetted, and is relatively good in supporting property.

The present invention provides a bone conduction package structure including a base board, a housing covered with the base board to form a receiving room, a bone conduction MEMS chip and an ASIC chip located in the receiving room. The bone conduction MEMS chip includes a substrate, a diaphragm, and a backplate. A first cavity is formed between the diaphragm and the backplate. A second cavity is formed by the diaphragm, the substrate, and the base board. And a third cavity is formed by the backplate, the housing, the substrate, and the base board. The first cavity is set as a low-pressure area below atmospheric pressure. The bone conduction package structure of the present invention sets the area between the diaphragm and the backplate as a low-pressure area to reduce damping between the diaphragm and backplate, thereby improving the performance of the bone conduction package structure.

The application relates to the technical field of neuromodulation devices, and provides a bone conduction neuromodulation device and a control method. The bone conduction neuromodulation device comprises an electroencephalogram acquisition device, a bone conduction vibration device and a control device. The control device is configured to extract electroencephalogram features in an electroencephalogram signal, determine vibration control parameters according to the electroencephalogram features, control the bone conduction vibration device to generate vibration according to the vibration control parameters, and adaptively adjust the vibration control parameters based on changes in the extracted electroencephalogram features during the process of generating vibration by the bone conduction vibration device, so as to form a closed-loop control. The closed-loop control mechanism based on real-time electroencephalogram feedback makes the vibration stimulation always adapt to the instant neural state of a target user, helps to reduce the influence of individual differences on the treatment effect, improves the stability and repeatability of the treatment effect, and further enhances the overall reliability of the bone conduction neuromodulation in clinical application.

The present invention is applied to the technical field of composite medical materials. Disclosed is an organic-inorganic composite medical material, the material consisting of organic components and inorganic components, the organic components comprising collagen, hyaluronic acid and chitosan, and the inorganic components being nano-hydroxyapatite and silica nanoparticles. Among the inorganic components of the organic-inorganic composite medical material, the nano-hydroxyapatite has the characteristics of good biocompatibility and osteoconductivity and thus enables the composite material to integrate with human bones; and the silica nanoparticles which have the characteristics of enhancing the strength and stability of materials improve the stability of the composite material. Among the organic components, proteins which are natively present in the human body and mainly comprise collagen can improve the biological activity and flexibility of the composite material, and promote cell growth and tissue regeneration; the collagen provides an attachment and growth environment for cells; and the hyaluronic acid is used for moisturizing and has an effect of promoting cell growth.

The invention relates to the field of medical informatics, and provides a tooth abnormal vibration signal detection system, which comprises an arc-shaped base body; the plurality of arc-shaped base body vibration sensors are embedded in the arc-shaped base body, and each arc-shaped base body vibration sensor is in one-to-one correspondence with adjacent teeth on two sides of a preset implant implanting position of the user and is used for sensing external mechanical vibration signals acting on the arc-shaped base body and the adjacent teeth on the two sides in real time; the bone conduction vibration sensor is used for sensing a bone conduction vibration signal which is transmitted to the preset implant screw base through the jaw bone of the user; and the signal processing module is used for respectively receiving the external mechanical vibration signal and the bone conduction vibration signal, carrying out frequency domain conversion, calculating the similarity of the first frequency spectrum characteristic and the second frequency spectrum characteristic, and outputting a same-frequency judgment result. The real-time detection accuracy of collision between the implanting nail and the tooth root is improved, and the implanting success rate and safety are improved.

A haptic feedback method includes: providing a wearable haptic feedback device comprising one or more bone-conduction haptic feedback units, and driving the one or more bone conduction haptic feedback units with at least a first signal processed using a bone conduction head related transfer function, ‘bHRTF’.

The invention discloses a novel medical polymer collagen polypeptide patch and a preparation method thereof, and relates to the technical field of medical materials, the polypeptide patch comprises the following raw materials by weight: 50-70 parts of collagen; 30 to 50 parts of polypropylene; 2 to 5 parts of nano hydroxyapatite; 5-8 parts of silk fibroin; 0.1 to 0.5 part of an immunomodulatory factor; according to the invention, through the collaborative design of multiple components, the double breakthrough of biocompatibility and mechanical property of the material is realized, the type I collagen and the medical grade polypropylene are compounded, the nano-hydroxyapatite is introduced as a bioactive filler, and the acicular structure of the nano-hydroxyapatite significantly improves the osteoconductivity of the material, so that the bioactivity of the material is improved, and the bioactivity of the material is improved. The medical grade molecular weight design of polypropylene ensures the stability after long-term implantation, and through a biocompatibility interface modification technology, polypropylene particles are placed in an ethanol solution containing 5-8% of collagen hydrolytic peptide for ultrasonic treatment, so that the immunogenicity of the material surface is effectively reduced.

The present invention relates to a 3D-printed orthopaedic implant (201, 301, 401) comprising a non-porous support portion (205, 305, 405) and a porous osteoconductive scaffold (203, 303, 403), wherein the porous osteoconductive scaffold forms at least 60% of the volume of the 3D-printed orthopaedic implant, and the 3D-printed orthopaedic implant comprises at least one discrete hollow tunnel (207a-e, 307a-c, 407a-c) extending into the osteoconductive scaffold, each discrete hollow tunnel being independently configured to allow insertion of a solid osteoinductive filament (101a, b) therein, and wherein each discrete hollow tunnel independently has: a volume of 7% or less of the 3D-printed orthopaedic implant; a substantially uniform cross-section; and a length that is at least three times greater than its width. A solid osteoinductive filament operable to be introduced into the 3D-printed orthopaedic implant, and a kit formed therefrom, are also encompassed.

The application provides an intervertebral fusion prosthesis and an intervertebral fusion prosthesis assembly, the intervertebral fusion prosthesis comprising: an outer shell, the outer shell being provided with a first conduction nail hole; a first bone conduction nail, the first bone conduction nail being arranged in the first conduction nail hole and extending out of the outer shell, the first bone conduction nail comprising a first connecting head, a first nail barrel and a first bone conduction body arranged in the first nail barrel, the outer side wall of the first nail barrel being provided with a first threaded structure, the first connecting head being provided with a first butt joint groove and the first butt joint groove being communicated with the accommodating cavity; a first adjusting body being provided with a first bone conduction block; a second bone conduction body being arranged in the first connecting barrel, the first connecting barrel extending into the first bone conduction block, and the end of the first connecting barrel being inserted into the first butt joint groove. The technical scheme of the application effectively solves the problem that the effect of the intervertebral fusion prosthesis in promoting bone ingrowth is poor in the related art, and the long-term stability of the intervertebral fusion prosthesis after implantation is poor.