229 results about "Osteoconduction" patented technology

An implant composed substantially of cortical bone is provided for use in cervical Smith-Robinson vertebral fusion procedures. The implant is derived from allograft or autograft cortical bone sources, is machined to form a symmetrically or asymmetrically shaped (e.g. a substantially "D"-shaped) implant having a canal running therethrough according to methods of this invention, and inserted into the space between adjacent cervical vertebrae to provide support and induce fusion of the adjacent vertebrae. Osteogenic, osteoinductive or osteoconductive materials may be packed into the canal of the implant to expedite vertebral fusion and to allow autologous bony ingrowth.

The invention includes biostructures which may be characterized as having substantially all of the organic-solvent-soluble material in the form of a network of irregularly shaped perforated films. The biostructure may further include particles of a substantially-insoluble material, which may be a member of the calcium phosphate family. The biostructure may be osteoconductive. The biostructure may further contain an Active Pharmaceutical Ingredient or other bioactive substance. The API may be a substance which stimulates the production of bone morphogenetic protein, such as Lovastatin or related substances, thereby making the biostructure effectively osteoinductive. One or more of the polymers may have a resorption rate in the human body such as to control the release of the API. Methods of manufacture are also disclosed.

The invention relates to a metal bone graft material with a porous structure, and preparation and application thereof. The metal bone graft material is used as a filling material for transplantation after orthopaedic and oral damage and defects. The metal bone graft material contains the following trace elements in the human body by weight: 70.0 to 98.0 of Mg, 0.1 to 10.0% of Si, 0.1 to 10% of Sr and 0.1 to 10.0% of Ca, wherein the trace elements are uniformly distributed in a substrate and a coating. According to the invention, good ossification capability and matching in-vivo absorption capability are obtained by adjusting the contents of components in an alloy, controlling the shape, quantity and distribution of mesophase in metal, changing processing technology and surface coating protection of the alloy and preparing the porous structure; and the metal bone graft material has good biocompatibility and bone conduction capability, is a medical absorbent metal bone graft material with excellent mechanical properties, and is applicable to bone defects caused by wounds, malformation, bone tumors, osteomyelitis and joint displacement in clinical practice to promote bone restoration and applicable as a drug sustained release system.

The invention discloses a preparation method of an artificial bone material. Provided raw materials comprise hydroxyapatite, polylactic acid and nano-crystalline cellulose. The preparation method comprises: dissolving polylactic acid in a solvent to prepare a polylactic acid solution with a mass percent concentration of 1-5%; adding nano-crystalline cellulose and hydroxyapatite into the polylactic acid solution, stirring and blending, drying for 10-24 h at a temperature of 105 DEG C, grinding to obtain the artificial bone material. The preparation method also can comprise: adding polylactic acid, nano-crystalline cellulose and hydroxyapatite into an extruder and carrying out melt blending for 5-20 min, extruding at a temperature of 175-185 DEG C, smashing to obtain the artificial bone material. The material has excellent bioactivity, biocompatibility, bone conductivity, high porosity, good pore connectivity, high intensity and good mechanical property, and can be taken as a substituted material of an artificial bone or other hard tissues, and is also applicable to 3D printing.

The invention relates to a preparation method of an artificial bone scaffold material. In application of bone tissue engineering, a cross-linking agent is usually used to improve anti-pressure ability, degradation property and the like, of an artificial bone, but chemical cross-linking agents such as glutaraldehyde and carbodiimide are usually used at present, the chemical cross-linking agents usually have a toxicity problem and have potential safety hazard for hosts. According to the preparation method, enzyme- transglutaminase is used as a cross-linking agent to improve water solubility and mechanical strength of the prepared collagen/nano hydroxyapatite artificial bone, and inactivation treatment is carried out onto the enzyme after the reaction. In the whole preparation process, no substances or reagents which are toxic and harmful or have potential hazard are introduced, so that biocompatibility of the artificial bone material is greatly improved, the related reactants are free of biological toxicity, and possible potential safety hazards of products on body are reduced; meanwhile, osteoconduction of the hydroxyapatite is also kept, and cell production promotion performance of the collagen is not affected.

A three component system for repairing critically sized bone defects having a first shape memory polymer (SMP) component formed as a scaffold that fills the defects, a second SMP component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third SMP component formed as a two-dimensional cell culture substate for engineering periosteal grafts.

Methods and systems are provided for generating quality indications of bone conduction, in which bone conduction element(s) may be used to input and/or output signals when in contact with a user. A bone conduction sensor may be used to obtain bone conduction related measurement(s), relating to the bone conduction element(s) and/or operations thereof. The bone conduction measurement(s) may be processed, such as to determine or estimate quality of attachment and/or performance of the bone conduction elements. Quality indication(s) may then be generated based on the assessed quality of bone conduction, and may be configured for presentation to a user.

By irradiating ⁶⁰Co γ ray to chitin/chitosan, chitin/chitosan having high molecular weight is separated or decomposed into low molecular weight chitin/chitosan. A method of producing an osteoconduction substance comprises the steps of irradiating ⁶⁰Co γ ray to chitin/chitosan to produce low molecular weight chitin/chitosan; preparing chitosan sol by dissolving low molecular weight chitin/chitosan in an acidic aqueous solution to obtain a chitosan acidic aqueous solution and kneading the chitosan acidic aqueous solution and apatite powder; and neutralizing the chitosan sol by the use of a neutralizing agent.

The invention relates to the technology of biological material in the field of biomedical engineering, specifically a preparation technology for bioactive bone-repairing cement material, which is suitable for medical application in the fields of orthopaedics department, thoracic surgery department and reconstructive surgery, such as artificial joint fixation, bone defect filling and implant restoration. The invention relates to a new material which is a combination of powder and liquid with bioactivity for bone repairing and is characterized in that the combination comprises a powder component including homopolymerization powder of methyl methacrylate or copolymerization powder of methyl methacrylate, and a sosoloid powder doped with strontium hydroxyapatite capable of being hardened and solidified to form solid substance with a certain mechanical intensity and synostosis activity when mixed with the liquid component. The main component of the liquid includes methyl methacrylate monomer, which can form bioactive bone-repairing cement when mixed with the powder component. Compared with the prior art, the material can further increase osteoconduction and osteoconduction activity of the combination, and accelerate healing of bone defect part; thus, the material is suitable for orthopaedics department and craniomaxillofacial plastic repair.

The invention discloses a preparation method of a piezoelectric ceramic/bone cement biological piezoelectric composite material. The method includes the steps of: 1, preparation of a piezoelectric porous scaffold; 2, preparation of a calcium phosphate bone cement precursor; 3, preparation of a biological piezoelectric composite material preform; and 4, self-curing and polarization, thus finally obtaining the piezoelectric ceramic/bone cement biological piezoelectric composite material. The method provided by the invention solves the problems that: existing biological piezoelectric materials have a high piezoelectric phase content, osteoconduction is poor in the cell growth process; by employing the traditional physical blending to reduce the piezoelectric content, the piezoelectric coefficient is low and cannot reach a bone induction effect; and common sintering of hydroxyapatite and biological piezoelectric ceramic cannot achieve optimal material performance.

The invention is a modular composite shoulder prosthesis 64, whose construct incorporates a solid autogenous bone graft 50 to be used to replace the upper humerus in certain fracture types. The prosthesis comprises a stem 22 to be inserted in the canal of the humerus, an intermediary part reduced to a medial pillar 24 and a head which is a generally spherical cap 20 that is hollow. The head of the prosthesis being hollow and coated with an osteoconductive material, the lateral aspect of the medial pillar as well as the upper part of the stem being also coated with the same material, an epiphyso-metaphyseal space is delineated in which a solid autogenous bone graft is fitted. Union can be achieved between the coated parts of the prosthesis, the bone graft 50 and the tuberosities reattached to the humerus shaft, secured to holes 62 of the medial pillar and between themselves.

The invention discloses a preparation method of a calcium-strontium/gelatin biomimetic coating modified artificial ligament. The preparation method comprises the following steps: adding strontium salt and calcium salt into a gelatin solution, stirring so as to be fully dissolved, to obtain an evenly mixed solution; immersing a plasma-treated surface modified artificial ligament into the solution, adding phosphate, and stirring to form a mixed solution, irradiating under sunlight or simulated sunlight for 20-60 minutes, and sucking dry with filter paper; repeating the third step until the preset mineralizing circulation times are achieved, thus obtaining the calcium-strontium/gelatin biomimetic coating modified artificial ligament. According to the method, the biological mineralization mechanism of natural bone is simulated, an inorganic salt layer of apatite is deposited by taking natural high polymer or gelatin as a matrix or a template, a coating is compounded on the surface of the material, so that the artificial ligament carries nanoscale strontium substituted hydroxyapatite, so that the biocompatibility and osteoconduction of the material can be improved, and the material can meet the clinically medical requirements on the aspects of bioactivity and mechanical performance.

The invention discloses a method for preparing an artificial bone from chitosan and shell powder serving as raw materials. The chitosan is the medical class chitosan in the markets abroad and at home, and has the deacetylated degree not less than 85 percent; and the shell powder is the residue after stratum corneum of anodonta woodiana is removed, and contains a shell prismatic layer and a pearl layer. The prepared artificial bone has the flexural modulus between 250 and 900Mpa, the compression modulus between 500 and 1,300MPa and the Young modulus between 160 and 280MPa. Meanwhile, the cellular structure in the artificial bone can meet the requirement of cell growth. The porosity, pore size, bioviscoelastic mechanics parameter and the like can be adjusted according to the ratio of the chitosan to the shell powder. The artificial bone is suitable for filling a bone defect part, and the mechanism of the artificial bone is osteoconduction, namely the artificial bone induces bone formation by promoting the combination of host bone and artificial bone surfaces.

The invention discloses a preparation method of a composite material for joint prosthesis. The method comprises the following steps: firstly, weighing various components in parts by weight and mixing evenly in an even mixer to obtain a main material; secondly, adding a coupling agent and a dispersing agent to the main material and evenly mixing in the even mixer to obtain a mixture; thirdly, adding the mixture to a twin-screw extruder, evenly mixing and performing melting extrusion; and fourthly, performing grain-sized dicing, sieving and packaging after cooling. The preparation method is relatively short in flow, simple to operate, low in cost, environment-friendly, and high in economic benefit; and the composite material for the joint prosthesis has excellent bioactivity, biocompatibility and osteoconduction and is superior to medical titanium and silicone rubber, and also is high in strength and good in mechanical properties.

The invention discloses a novel bamboo fiber/hydroxyapatite/chitosan composite membrane and a preparation method thereof. The composite membrane is prepared by the following steps: firstly, preparinga uniform composite liquid from nano-hydroxyapatite and chitosan, then adding surface-carboxylated natural bamboo fibers into the composite liquid, performing ultrasonic dispersing and uniform stirring, and then directly performing tape casting on a glass flat plate to form the novel composite membrane. The chitosan is subjected to ionic crosslinking by carboxyl on the surface of bamboo fibers, sothat the mechanical property and degradation property of the composite membrane are greatly improved compared with that of nano-hydroxyapatite/chitosan composite membranes. The novel composite membrane is rich in raw material source and simple in preparation method, the mechanical property, the degradation property, the bone conductivity and the antibacterial property of the composite membrane can be regulated and controlled through the component content of the composite membrane, and the composite membrane with excellent performance is expected to be obtained to be used for guiding bone tissue regeneration membranes.

An artificial bone is prepared from polylactic acid (1.5-2 wt. portions), hydroxy apatite (1-1.5) and decalicified bone matrix (0.5-1) through emulsion mixing method where ethyl acetate and absolute alcohol are used as solvent. Its advantages include no damage to human body and good bone transfer and induction actions. It can be used for treating dysostosis and nonunion.

The invention discloses a diagnosis and treatment integrated gradient osteochondral bionic scaffold and a preparation method thereof, which adopts a DLP photocuring 3D printing technology, and the preparation method comprises the following steps: respectively preparing sol of a cartilage layer, a cartilage calcification layer and a subchondral bone layer, and preparing cartilage layer sol by utilizing quercetin, methacrylate esterified gelatin and an LAP solution; preparing cartilage calcification layer sol by utilizing quercetin, methacrylate esterified gelatin, iron-doped hydroxyapatite andan LAP solution; preparing subchondral bone layer sol by utilizing quercetin, methacrylate esterified gelatin, iron-doped hydroxyapatite and an LAP solution. The scaffold prepared by the method has structural gradient and material gradient, has good mechanical properties and biocompatibility, and has good bone induction capability and bone conduction capability, which can induce regeneration of bone tissue defect parts. The gradient scaffold provided by the invention has an MRI diagnosis function, which can be used to accurately evaluate the real-time condition of osteochondral defect repair in vivo.

The invention discloses a reinforced reactive injectable bone cement and a preparation method thereof. The bone cement comprises the following components: tricalcium phosphate, polylactic acid, calcium sulphate, coral powder, ferulic acid, silk fibroin, talcum powder, barium sulfate, cervus and cucumis polypeptide, gastrodin, vitamin C, zinc oxide, tantalum oxalate, PEEK(polyether-ether-ketone), polyvinylpyrrolidone, methyl-beta-cyclodextrin, maleyl chitosan and normal saline. The injectable bone cement provided by the invention is excellent in syringeability, the compressive strength and the bending strength are high, and the mechanical property requirements of a bone repair material are met. In addition, the bone cement provided by the invention is good in cell compatibility, is relatively good in osteoconduction, is convenient for promoting the self-healing repair of bone tissue, and improves the firmness in the combination of the bone cement and bone, thereby well meeting clinic application requirements.

The invention discloses a preparation method of a polyethylene material for an artificial joint. The method comprises the following steps of a step 1: weighing all components in parts by weight, and uniformly mixing all the components in a uniform mixer, so as to obtain a main ingredient; a step 2: adding a coupling agent and a dispersing agent into the main ingredient, and uniformly mixing an obtained mixture in the uniform mixer, so as to obtain a blend material; a step 3: adding the blend material into a twin-screw extruder, uniformly mixing the blend material, and then melting to extrude the uniformly mixed blend material; a step 4: cooling the extruded blend material, then carrying out grain cutting on the cooled blend material, screening grains, and packing the screened grains, so as to obtain the polyethylene material for the artificial joint. The preparation method provided by the invention is shorter in flow, simple to operate, low in cost, environment-friendly, and high in economic benefit, and the polyethylene material for the artificial joint has excellent biological activity, biological compatibility and osteoconductivity, all of which are superior to those of biomedical titanium and silicon rubber, and moreover, is high in strength and good in mechanical property.