113 results about "Osteoconduction" patented technology

The invention belongs to the field of medical materials. The invention provides a porous artificial bone and a preparation method thereof, the components of the porous artificial bone comprise absorbable macromolecules and an orthopedic inorganic implant material, the mass ratio of the absorbable macromolecules to the orthopedic inorganic implant material is 1: 0.1-2, the porous artificial bone has a through porous structure, the porosity is greater than 70%, and the pore size distribution range is less than 500 [mu] m. The porous artificial bone has a pore structure and mechanical properties beneficial to bone regeneration, the pore diameter is stable, the mechanical properties are appropriate, after the porous artificial bone is implanted into a defect part, the bone volume is always increased, the increase rate of regenerated bone tissue is remarkably improved, the effect of bone conduction is effectively achieved, bone regeneration is very beneficial, and animal experiments prove that the porous artificial bone has a good application prospect. The material can be used for filling and repairing various bone defects in orthopedic surgery. The preparation method is simple, stable and effective, can be absorbed, is low in cost, has great market potential, and is simple, stable and effective compared with a conventional artificial bone preparation method at present.

An osteoinductive and osteoconductive composition including DBM fibers having multiple geometries, as well as a method of producing the same are disclose. For example, such a method may include: obtaining bone tissue; cleaning the bone tissue obtained with a plurality of washes; milling the cleaned bone tissue into a plurality of fibers of two or more geometries including a long wide fiber, a long narrow fiber, a short wide fiber, and a short narrow fiber; demineralizing the plurality of fibers of two or more geometries to expose one or more biologically active components; and neutralizing the plurality of demineralized fibers of two or more geometries resulting in demineralized bone matrix.

The invention provides an extramedullary 3D printing composite intramedullary fixing bone end broach system, and relates to the technical field of medical instruments. Comprising a bone prosthesis and a fixing system, and the fixing system comprises a broach which is arranged at one end of the bone prosthesis and is fixed in a medullary cavity through bone cement; the fixing piece is arranged at the end, close to the broach, of the bone prosthesis and makes contact with the host bone, and the contact face is a 3D printing interface; the preset part is used for replacing the fixing part to make contact with the host bone in the prosthesis mounting operation. According to the fixing system, the broach, the fixing part and the preset part are used in cooperation, bone cement in a medullary cavity is fixed through the broach, and 3D interface fixing is adopted through the fixing part, so that the bone prosthesis has good bone conductivity and mechanical stability in a long term and a short term; and the influence on bone ingrowth caused by the fact that bone cement falls into a 3D contact interface of the fixing piece in a prosthesis installation operation is avoided.

A motion sickness reduction device is disclosed. More specifically, the present invention relates to a device for reducing a motion sickness phenomenon caused by a mismatch between visual information perceived by the eyes and sensing information by the vestibular system. According to an embodiment of the present invention, a difference between visual information received by a user and motion information perceived by the vestibular system is checked, a moving direction based on a rigid body motion of the vestibular system is calculated, and a mechanical stimulus corresponding to the visual information is applied to the vestibular system through a bone conduction unit worn by the user, thereby having the effect of minimizing a motion sickness phenomenon caused by a difference between visual information and motion information of a user riding in a vehicle or watching VR content.

The application provides a wearable portable hairband for mental fatigue detection and intervention, a flexible conductive polymer dry electrode is embedded in the inner side of the hairband, the dry electrode is attached to the scalp through mechanical pressure, and thus inductive collection is realized without conductive paste; the output end of the dry electrode collection signal is directly connected to a collection front end located at the side edge of the hairband through FPC, the front end is integrated with an amplifier and an analog-to-digital converter, weak electrical signals on the cerebral cortex are amplified and converted into a data format; a SoC chip is selected as a processor to build a full-integrated edge computing platform inside the flexible fabric hairband, and the calculation task of mental fatigue detection is sunk to the hairband end; an ultrathin bone conduction unit is used as an acoustic output component, which is connected through a flexible circuit and embedded in the inner side of the hairband corresponding to the anatomical site of the user's temple, when the mental fatigue detection result triggers the fatigue warning threshold, a binaural rhythm intervention module is activated to perform binaural rhythm intervention. The application can perform mental fatigue detection and intervention.

A haptic feedback method comprising the steps of providing a wearable haptic feedback device comprising one or more bone‐conduction haptic feedback units and driving the one or more bone conduction ha

The present application relates to the field of medical informatics, and provides a tooth abnormal vibration signal detection system, comprising: an arc-shaped base body; a plurality of arc-shaped base body vibration sensors embedded in the arc-shaped base body, each arc-shaped base body vibration sensor corresponding to one of two sides of a predetermined implant implantation position of a user and being adjacent to a tooth, for real-time sensing of an external mechanical vibration signal acting on the arc-shaped base body and the two sides of the tooth; a bone conduction vibration sensor for sensing a bone conduction vibration signal conducted to the predetermined implant screw base through the jaw bone of the user; and a signal processing module for receiving the external mechanical vibration signal and the bone conduction vibration signal respectively, performing frequency domain conversion, calculating the similarity of first and second frequency spectrum characteristics, and outputting a same frequency judgment result. The present application improves the real-time detection accuracy of implant nail and tooth root collision, and improves the implant success rate and safety.

The application belongs to the technical field of bone organ preparation, and relates to a bone organ for promoting nerve growth and a construction method and application thereof. The construction method comprises the following steps: S1, immersing a hydrogel mineralization scaffold with conductive polymer induction in an EDC / NHS crosslinking agent, and sterilizing and crosslinking; S2, immersing the crosslinked product in a culture medium and culturing, inoculating bone organ seed cells, and replacing the culture medium with a complete culture medium for adaptive culture; and S3, transferring to an osteogenic induction culture medium for osteogenic induction, so as to obtain the bone organ for promoting nerve growth. Compared with the prior art, the bone organ constructed by the application has good biological activity, osteogenic activity and bone conduction, can effectively promote the growth of peripheral nerves, provides a reliable in-vitro model for bone-nerve interaction research, and provides a new technical path and theoretical basis for bone-nerve integrated regeneration and repair.

The invention discloses a silicon nitride ceramic composite material for an interbody fusion device and a preparation method thereof, the composite material is composed of silicon nitride, liquid metal gallium and an osseointegration induction element, and the method comprises the following steps: preparation of basic components, sintering of the basic components, preparation of final components, and sintering of the final components. The ceramic composite material prepared by the preparation method disclosed by the invention has excellent biological activity, can promote inward growth of bone tissues, has good osteoconductivity and osteoinductivity, and also has good biomechanical properties. In addition, the preparation process provided by the invention is simple and convenient, is high in controllability and has a wide application prospect.

The present disclosure relates to a device that can guide perpendicular drilling and simultaneously measure flatness of an insertion surface through a locking protrusion by rotating the device in bone conduction implantation. According to the present disclosure, it is possible to measure flatness and guide perpendicular boring with a constant force even without using a separate flatness measurer in surgery. Further, it is also possible to guide drilling using a spacer having a smaller diameter by using an assistant guide member.

Provided in the present utility model is a bone conduction packaging structure, comprising: a base board, a housing covering the base board to form an accommodating space, and a bone conduction MEMS chip and an ASIC chip which are disposed in the accommodating space. The bone conduction MEMS chip comprises a substrate having a cavity, a vibration diaphragm supported on the substrate, and a back plate spaced apart from the side of the vibration diaphragm away from the substrate; a first cavity is formed between the vibration diaphragm and the back plate; a second cavity is formed between the vibration diaphragm and the substrate and the base board; a third cavity is formed between the back plate, and the housing, the substrate and the base board; and the first cavity is configured as a low-pressure region the pressure of which is lower than atmospheric pressure. The bone conduction packaging structure of the present utility model configures the region between the vibration diaphragm and the back plate as the low-pressure region, so as to reduce damping between the vibration diaphragm and the back plate, thereby improving the performance of the bone conduction packaging structure.

The application discloses a kind of biomimetic silk fibroin cartilage scaffolds for cranium defect repair, belong to biomedical engineering technical field.To solve the problem of single structure, low bone formation efficiency and mismatching of mechanical properties and degradation rate of existing cranium repair scaffold, the application provides a kind of scaffold, which includes in order from outside to inside: biomimetic periosteum layer, bone conduction and vascularization layer and cartilage induction layer.Biomimetic periosteum layer is dense nanofiber membrane structure, and plays the role of physical barrier and osteoinduction;Bone conduction and vascularization layer is gradient porous structure with gradually decreasing aperture from outside to inside, aiming to guide the ordered growth of blood vessels and cells, and promote rapid vascularization;Cartilage induction layer is sponge-like microporous structure, used for forming stable cartilage template and starting endochondral ossification.The application simulates the natural bone healing process through structural biomimicry and functional zoning, synergistically promotes vascularization and osteogenesis, and realizes efficient biological repair of cranium defect.

The present invention provides a skin impedance measurement method, system and bone conduction headset, including the following steps: Step S1. Generate an excitation signal U1 for exciting an external complex impedance, and transmit the excitation signal U1 to an electrode sheet in contact with the user's skin; Step S2. Collect the response signal U2 returned by the electrode sheet, perform gain amplification on the response signal U2 and then perform discrete Fourier transform processing to obtain the skin impedance Z of the response signal U2; Step S3. Calibrate the skin impedance Z with a gain coefficient G, where the gain coefficient G is obtained by looking up a mapping table, and this mapping is the correspondence between the measurement frequency corresponding to the collected response signal U2 and the set frequency, so as to obtain the calibrated skin impedance Z of the user. The present invention can quickly and accurately measure the skin permeability of the current user.

The invention relates to a device for bone formation, bone reshaping or healing of bone in dental, oral and maxillofacial applications, specifically in connection with installation of dental implants. The device comprises a sheet structure made of an inert material, wherein the sheet structure has an inner surface intended to be directed towards the bone and an outer surface intended to be directed away from the bone. The geometrical features of the cavity formed between the inner surface of the device and the initial bone surface when the device is installed at the intended location is further used to improve and plan the treatment. The device is customized by means of digital planning based on the initial and the optimal bone volume for the intended treatment. Modifications of the device can be introduced to facilitate a combined installation of dental implants with the device.

The invention discloses a design method of a vibration transmission sheet of thin kidney-shaped connecting ribs, which comprises the following conditions: 1, a vibration transmission sheet body is arranged, and the vibration transmission sheet body comprises one or more groups of thin kidney-shaped connecting ribs; and 2, the value of the ratio of the width wend of the two ends of the thin kidney-shaped connecting rib to the width wmiddle of the middle section of the connecting rib is as follows: by adopting the design of the vibration transmission sheet of the thin kidney-shaped connecting rib, the problems in two aspects can be solved at the same time: 1, the problem that the service life of the vibration transmission sheet is influenced due to non-uniform distribution of internal stress in the connecting rib is solved; and secondly, the equivalent average width of the connecting rib is reduced, so that the stiffness coefficient of the vibration transmission sheet is reduced, the resonant frequency of the vibrator is reduced, and the low-frequency performance of the bone conduction earphone and the tactile feedback actuator is improved.

The utility model discloses a sound diagnosis instrument, relates to medical equipment technical field, the sound diagnosis instrument comprises a housing, a lift drive assembly and a bone conduction acquisition head, the housing is provided with an accommodation space, the housing is provided with a guide via hole communicated with the accommodation space; the lifting driving assembly comprises a lifting transmission part and a lifting driving mechanism which are in transmission connection, the lifting driving mechanism is arranged in the containing space, and the lifting transmission part is arranged in the guide through hole in a penetrating mode; the bone conduction collecting head is arranged outside the shell and corresponds to a collecting position used for placing the wrist of a patient, the upper end of the bone conduction collecting head is connected with the lifting transmission part, and the lower end of the bone conduction collecting head is used for abutting against the wrist of the patient so as to collect pulse data of the wrist of the patient; according to the technical scheme, the accuracy of pulse measurement can be improved.

Disclosed is an energy transmitting device for use in a system to monitor and treat tinnitus, comprising: a first unit that produces energy for treating said tinnitus; and a second unit that is arranged to secure and fasten said first unit against a skin of said patient, wherein, when in operation, said first unit produces said energy based on a suggested treatment for transmission to said patient through bone conductivity for treating said tinnitus.

The present invention relates to a bone graft composition in which a lappaconitine derivative is surface-adsorbed on a scaffold comprising tricalcium phosphate (TCP) and hydroxyapatite (HA). In the composition of the present invention, the osteogenesis-promoting properties of the lappaconitine derivative are combined with the osteoconductivity of the TCP / HA scaffold, thereby improving problems such as high-concentration adverse effects, unstable adsorption patterns, and localized excessive formation, which occur in existing protein-based osteogenic factors.

The invention discloses a motor voiceprint detection device based on bone conduction, and relates to the technical field of voiceprint detection. The device comprises an outer shell and a voiceprint collection assembly, an upper cover is arranged on the upper side of the outer shell, a plurality of fixing columns are fixedly connected to the lower surface of the outer shell, and magnets are fixedly connected to the lower ends of the fixing columns; the voiceprint collection assembly is located in the outer shell and comprises a collection box body, a bone conduction sensor is arranged in the collection box body, a plurality of compression springs are connected between the collection box body and the upper cover, and a conduction rod penetrating through the bottom wall of the outer shell is fixedly connected to the lower surface of the collection box body and used for being attracted and fixed to the surface of the motor through a magnet. The collection box body is squeezed and pushed through the compression spring, so that the conduction rod is tightly attached to the surface of the motor, and vibration information is obtained through the bone conduction sensor. The voiceprint detection device is adsorbed and fixed to the surface of the motor through the magnet, vibration information is obtained through the bone conduction sensor, the detection position can be flexibly adjusted, and the problem that an existing voiceprint detection device is poor in practicability and adaptability is solved.

This invention belongs to the field of foot and ankle joint replacement implant technology, and discloses an ankle joint talus prosthesis with an antibacterial porous interface and its preparation method. It includes a prosthesis substrate with an overall anatomically contoured structure, including a superior articular surface, a inferior articular surface, and an anterior articular surface; the area of ​​the prosthesis substrate in contact with residual bone tissue is designed as a three-dimensional porous structure; an antibacterial bioactive composite coating is grown in situ on the surface of the prosthesis substrate; it includes calcium and phosphorus bioactive components and antibacterial ions. This invention, by constructing an antibacterial bioactive composite coating at a porous bone integration interface, utilizes biocompatibility and osteoconductivity to induce bone tissue growth. Furthermore, the antibacterial ions can be slowly and continuously released in the interstitial spaces, achieving a dual function of promoting bone integration and preventing infection. Moreover, the antibacterial bioactive composite coating is formed through in-situ growth, resulting in a strong bond with the substrate and preventing detachment.

The utility model provides a bone conduction earphone. The bone conduction earphone comprises an FPC module, a detection module and a control module, the detection module is connected with the FPC module, and the detection module is used for obtaining the wearing state and generating a corresponding detection signal; the control module is connected with the detection module and the FPC module, and the control module is used for receiving the detection signal from the detection module and adjusting the working state of the bone conduction earphone based on the detection signal. The detection module in the bone conduction earphone can accurately detect the wearing state and automatically control and switch the working state of the bone conduction earphone based on the detection signal, the response speed is high, a user does not need to manually press a corresponding key to realize a playing or pausing function, the operation steps are simplified, and the user experience is improved.

A non-fixed implant is proposed, which is made of raw materials including a biomaterial, a ceramic matrix composite with excellent osteoconductivity, and a polymer. The non-fixed implant can be precisely fixed to the gap between the skull and the bone flap and can be conveniently used. A method for manufacturing the non-fixed implant is also proposed. The non-fixed implant includes a flexible wedge that can be deformed to conform to the outer contour of the bone flap, and a plurality of wings connected to the upper or lower part of the flexible wedge and extending to both sides of the flexible wedge. The wings have a porous structure. The wings on one side will be located on the bone flap, while the wings on the other side will be located on the skull. The non-fixed implant has the following advantages: it can precisely fill the defect formed by craniotomy, has improved biocompatibility and osteointegration ability, and allows tissue invasion.

The invention relates to a paper fiber-based bone repair scaffold which is made of hydroxyapatite, polyvinyl alcohol and paper fibers, and the paper fibers are wide in source and low in cost; hydroxyapatite has good biocompatibility and osteoconductivity, polyvinyl alcohol serving as an adhesive has good biocompatibility and degradability, and the mechanical supporting capacity of the bone repair scaffold can be improved; the invention relates to a preparation method of a paper fiber-based bone repair scaffold. The preparation method is convenient to operate. The invention also relates to application of the paper fiber-based bone repair scaffold in preparation of a bone repair material, and tests prove that the paper fiber-based bone repair scaffold prepared by the preparation method disclosed by the invention is good in swelling property and free of structural collapse and damage, and the mechanical property meets the requirements; the paper fiber-based bone repair scaffold has no cytotoxicity and good biocompatibility, and can promote proliferation, adhesion and migration of BMSC cells; animal experiments prove that the paper fiber based bone repair scaffold has a better bone repair effect and a wide application prospect.

A wearable device includes a frame element, an extension element, a plurality of capacitive sensors, a plurality of bone conduction transducers, an antenna element, and an adjustment circuit. The extension element is connected to the frame element. The plurality of capacitive sensors are disposed on the extension element and arranged along a first direction. The plurality of capacitive sensors can generate a first sensing signal about a human body part. The plurality of bone conduction transducers are arranged on the extension element and are arranged along a second direction. The plurality of bone conduction transducers can generate a second sensing signal about the body part. The antenna element is arranged on the frame element or the extension element. The adjusting circuit is coupled to the antenna element. The adjusting circuit can provide a variable impedance value according to the first sensing signal and the second sensing signal.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.

The invention provides a preparation method and application of a digital plasma matrix bone block, and belongs to the technical field of medical materials. By combining a digital technology and a plasma matrix technology, the personalized plasma matrix bone block with regeneration activity and mechanical strength is immediately prepared in an operation according to the defect condition of a patient. Compared with a traditional bone regeneration scheme, the digital plasma matrix bone block can be shaped immediately in an operation and is matched with a defect area; in addition, the digital plasma matrix bone block has good mechanical strength, and the collapse problem after traditional bone meal transplantation or the exposure problem after a titanium mesh is applied can be avoided; more importantly, the digital plasma matrix bone block has good bone regeneration effects including bone conduction, bone induction, bone regeneration and the like. The digital plasma matrix bone block is more economical for a patient, is convenient for an operator to operate, has good biological safety, and provides a personalized solution for regeneration and repair of bone tissue defects.

The present invention provides a bone conduction MEMS chip and a manufacturing method therefor, and a bone conduction packaging structure having the bone conduction MEMS chip. The bone conduction MEMS chip comprises: a substrate provided with a cavity, a diaphragm supported on the substrate, and a back plate spaced apart from the side of the diaphragm distant from the substrate, wherein a mass block is arranged on the side of the diaphragm distant from the back plate. The mass block in the bone conduction MEMS chip of the present invention is directly formed on the diaphragm, and the bone conduction packaging structure avoids additionally providing a vibration sheet and a mass block, thereby reducing costs, achieving simple packaging, and allowing the structure to be smaller.

The utility model discloses a bone conduction vibrator device which comprises an outer shell, a fixing column and a fixing ring. An iron core is arranged on the inner bottom surface of the outer shell, a coil is wound on the outer cambered surface of the iron core, a fixing column is arranged on the upper surface of the iron core, an oscillator sheet is arranged at the top end of the fixing column, a step groove is formed in the middle of the inner side wall of the outer shell, the fixing ring is fixedly connected to the upper surface of the step groove, and elastic sheets are uniformly arranged on the inner cambered surface of the fixing ring. The elastic sheets are respectively matched with the iron core and the oscillator sheets, contacts are arranged at the ends of the inner sides of the elastic sheets, and the contacts are respectively matched with the iron core and the oscillator sheets; wherein the bone conduction vibrator device further comprises a vibrating diaphragm, the lower end of the outer edge of the vibrating diaphragm is connected to the interior of a buckling groove formed in the outer cambered surface of the outer shell in a buckled mode, the inner top wall of the vibrating diaphragm is attached to the upper surface of the vibrator piece, and according to the bone conduction vibrator device, the frequency and the amplitude of the vibrator piece are increased, and the tone quality is improved.

This invention discloses a composite scaffold for promoting bone regeneration in diabetic patients, its preparation method, and its applications, relating to the field of medical biomaterials technology. The composite scaffold for promoting bone regeneration in diabetic patients comprises: a three-dimensional porous framework; and a bioactive hydrogel layer loaded with naringin. The bioactive hydrogel layer loaded with naringin is coated on the surface and pore walls of the three-dimensional porous framework. The technical solution provided by this invention uses a 3D-printed PLGA / HA porous framework to provide mechanical support and osteoconductivity, and a supramolecular hydrogel coating loaded with naringin to endow it with immunomodulatory and drug sustained-release functions. This scaffold has good hydrophilicity and biocompatibility, and can effectively induce macrophage polarization towards the M2 anti-inflammatory phenotype by activating the JAK-STAT signaling pathway, improving the local inflammatory microenvironment of diabetic bone defects. Simultaneously, it indirectly promotes vascular endothelial cell migration, lumen formation, and osteogenic differentiation of bone marrow mesenchymal stem cells by regulating macrophages.

The invention discloses a collagen and hydroxyapatite composite bone scaffold as well as a preparation method and application thereof, and relates to the technical field of bone scaffolds. The preparation method of the collagen and hydroxyapatite composite bone scaffold comprises the following steps: dissolving collagen in an acid solution to obtain a collagen solution with the concentration of 10-80 mg / L, mixing the collagen solution with hydroxyapatite, and stirring to obtain a compound; freeze-drying the compound, and cross-linking to obtain a primary product; washing the primary product with water to remove acid residues, and then freeze-drying to obtain the collagen and hydroxyapatite composite bone scaffold. The composite bone scaffold is spongy, has relatively high porosity, is beneficial to bone conduction and bone induction, is not easy to disintegrate and slag when being wetted, and is relatively good in supporting property.