241 results about "Osteoconduction" patented technology

An implant composed substantially of cortical bone is provided for use in cervical Smith-Robinson vertebral fusion procedures. The implant is derived from allograft or autograft cortical bone sources, is machined to form a symmetrically or asymmetrically shaped (e.g. a substantially "D"-shaped) implant having a canal running therethrough according to methods of this invention, and inserted into the space between adjacent cervical vertebrae to provide support and induce fusion of the adjacent vertebrae. Osteogenic, osteoinductive or osteoconductive materials may be packed into the canal of the implant to expedite vertebral fusion and to allow autologous bony ingrowth.

An apatite-coated solid composition which contains a biodegradable polymer and an apatite-coated solid composition which contains a biodegradable polymer and a medicinal substance have properties of sustained release and of osteoconductive activity.

A bone restoration body with a composite porous structure and a preparation method of the bone restoration body. The bone restoration body comprises a porous metal bracket and an infill body with a porous structure, wherein the porous metal bracket is of a three-dimensional net structure, a plurality of pores are arranged in the inner part of the porous metal bracket, and the infill body with the porous structure is fully filled in all the pores. The preparation method combines the direct metal rapid prototyping technology and the freeze drying technology and comprises the steps of preparing the porous metal bracket by a structural design and the direct metal rapid prototyping technology, pouring uniformly-mixed polymer solution or polymer / biological ceramics mixing solution into the porous metal bracket, carrying out freezing treatment, and then forming the infill body with the porous structure through freeze drying so as to obtain the bone restoration body with the composite porous structure, wherein the infill body with the porous structure has micropore characteristics. The bone restoration body has good mechanics compatibility, can obtain good bone conduction performance and bone induction performance, improves bone integration efficiency and can be used for clinical treatment of segmental bone defect of a bearing part.

The invention discloses an absorbable metal intramedullary nail and a preparation method thereof, which belong to the technical field of medical appliance. The intramedullary nail is a straight nail or a radian nail and is characterized in that the intramedullary nail comprises the follow components in percentage by mass: 0.01 to 10 percent of Zn, 0.01 to 5 percent of Ca, 0.001 to 5 percent of Fe, 0.01 to 5 percent of Mn and the balance of Mg; and the outer surface of the intramedullary nail is provided with a compound coating. The elastic modulus and the density of the intramedullary nail are close to those of a human body, which avoids or reduces stress shielding effect and promotes fracture union; and simultaneously, the intramedullary nail has higher intensity so as to make up the shortage of a degradable polymeric material. The intramedullary nail can be absorbed continuously in the human body and can generate a phosphate layer of Ca and Mg during the absorption and degradation, which contributes to bone conduction. The degradation rate can be regulated effectively by changing components and a structure of alloy, and components and a structure of a coated coating.

Structural inorganic cellular materials with controlled open porosity are produced by foaming fine particulate-laden aqueous solutions into stable, uniform, dodecahedral froth structures which are dried and sintered by microwave energy or high voltage instant electrical discharge. Porous open cell biomedical implants such as niobium or tantalum acetabular caps with engineered osteoconductive porosity are among the products achievable.

The invention includes biostructures which may be characterized as having substantially all of the organic-solvent-soluble material in the form of a network of irregularly shaped perforated films. The biostructure may further include particles of a substantially-insoluble material, which may be a member of the calcium phosphate family. The biostructure may be osteoconductive. The biostructure may further contain an Active Pharmaceutical Ingredient or other bioactive substance. The API may be a substance which stimulates the production of bone morphogenetic protein, such as Lovastatin or related substances, thereby making the biostructure effectively osteoinductive. One or more of the polymers may have a resorption rate in the human body such as to control the release of the API. Methods of manufacture are also disclosed.

Osteoconductive bone graft materials are provided. These compositions contain injectable cements and demineralized bone matrix fibers. The combination of these materials enables the filling of a bone void while balancing strength and resorption.

The present invention provides a porous bioceramics for bone scaffold. The porous bioceramics according to the present invention comprises a biocompatible porous ceramic substrate having the property to thermal-decompose hydroxyapatite in contact with it; a fluorapatite (FA) inner layer formed on said porous ceramic substrate; and a hydroxyapatite (HA) outer layer formed on said fluorapatite inner layer. The insertion of FA intermediate layer can prevent the thermal reaction between ZrO2 and HA. Therefore, the present invention can provide the implant material into human body having excellent mechanical properties of zirconia as well as the biocompatibility, bioaffinity and bioactivity of HA. The present invention can also provide the implant material to promote osteoconduction and osteointegration in human body.

The invention relates to a metal bone graft material with a porous structure, and preparation and application thereof. The metal bone graft material is used as a filling material for transplantation after orthopaedic and oral damage and defects. The metal bone graft material contains the following trace elements in the human body by weight: 70.0 to 98.0 of Mg, 0.1 to 10.0% of Si, 0.1 to 10% of Sr and 0.1 to 10.0% of Ca, wherein the trace elements are uniformly distributed in a substrate and a coating. According to the invention, good ossification capability and matching in-vivo absorption capability are obtained by adjusting the contents of components in an alloy, controlling the shape, quantity and distribution of mesophase in metal, changing processing technology and surface coating protection of the alloy and preparing the porous structure; and the metal bone graft material has good biocompatibility and bone conduction capability, is a medical absorbent metal bone graft material with excellent mechanical properties, and is applicable to bone defects caused by wounds, malformation, bone tumors, osteomyelitis and joint displacement in clinical practice to promote bone restoration and applicable as a drug sustained release system.

The invention discloses a preparation method of an artificial bone material. Provided raw materials comprise hydroxyapatite, polylactic acid and nano-crystalline cellulose. The preparation method comprises: dissolving polylactic acid in a solvent to prepare a polylactic acid solution with a mass percent concentration of 1-5%; adding nano-crystalline cellulose and hydroxyapatite into the polylactic acid solution, stirring and blending, drying for 10-24 h at a temperature of 105 DEG C, grinding to obtain the artificial bone material. The preparation method also can comprise: adding polylactic acid, nano-crystalline cellulose and hydroxyapatite into an extruder and carrying out melt blending for 5-20 min, extruding at a temperature of 175-185 DEG C, smashing to obtain the artificial bone material. The material has excellent bioactivity, biocompatibility, bone conductivity, high porosity, good pore connectivity, high intensity and good mechanical property, and can be taken as a substituted material of an artificial bone or other hard tissues, and is also applicable to 3D printing.

The invention relates to a preparation method of an artificial bone scaffold material. In application of bone tissue engineering, a cross-linking agent is usually used to improve anti-pressure ability, degradation property and the like, of an artificial bone, but chemical cross-linking agents such as glutaraldehyde and carbodiimide are usually used at present, the chemical cross-linking agents usually have a toxicity problem and have potential safety hazard for hosts. According to the preparation method, enzyme- transglutaminase is used as a cross-linking agent to improve water solubility and mechanical strength of the prepared collagen / nano hydroxyapatite artificial bone, and inactivation treatment is carried out onto the enzyme after the reaction. In the whole preparation process, no substances or reagents which are toxic and harmful or have potential hazard are introduced, so that biocompatibility of the artificial bone material is greatly improved, the related reactants are free of biological toxicity, and possible potential safety hazards of products on body are reduced; meanwhile, osteoconduction of the hydroxyapatite is also kept, and cell production promotion performance of the collagen is not affected.

The invention discloses a calcium phosphate-based compound self-setting bone repair material and a preparation method thereof. A novel calcium phosphate-based compound self-setting bone repair material is prepared by combining brushite bone cement which is quick to set and degrade and has bioactivity and osteoconduction with hydroxyapatite cement which is good in mechanical property and biocompatibility supplemented by a structure enhancing and a doping and modifying technology, wherein the initial setting time of the bone repair material is 3-10 minutes, the final setting time is 12-20 minutes, the compressive strength after solidification is 21.2-40.0MPa, and the degradation rate within 14 days can reach 18.2%, so that the bone repair material is suitable for repairing bone defects in non-loading parts of human bodies. Compared with the prior art, the material and the preparation method provided by the invention have the advantages that the cost is low, the product quality is stable, the mechanics combination property is excellent, the biodegradability, osteoconduction and X ray resistance are good, the material of the invention can slowly release strontium ions, thus prolonging pharmacologic treating efficacy of the strontium ions to the implanting position, and being applicable to the industrialized mass production.

The invention discloses a preparation method of a micron or nanometer calcium phosphate / catechol-based polymer bone repair scaffold. The preparation method comprises the following steps: A, mixing 100 parts by weight of calcium phosphate, 1-40 parts by weight of pore-forming agent and 0.1-45 parts by weight of catechol-based polymer, and adding a trihydroxymethyl aminomethane-hydrochloric acid buffer solution to obtain a slurry mixture, wherein calcium phosphate is micron calcium phosphate and / or nanometer calcium phosphate, and the catechol-based polymer is a polydopamine or dopamine graft copolymer; B, forming the slurry mixture obtained in the step A by virtue of mold pressing, pouring or 3D (Three-Dimensional) printing, and then curing the mixture for 20-30 hours in a water bath kettle at 35-40 DEG C. The bone repair material scaffold prepared by the method has good bioactivity, osteoconduction, degrading capacity and biocompatibility, and has good mechanical properties at the same time. The bone repair material scaffold can be formed by virtue of a mold pressing, pouring or 3D printing method, and can be prepared into any shape and structure.

A three component system for repairing critically sized bone defects having a first shape memory polymer (SMP) component formed as a scaffold that fills the defects, a second SMP component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third SMP component formed as a two-dimensional cell culture substate for engineering periosteal grafts.

The invention relates to a magnetic hydroxyl apatite / polymer tridimensional porous stent material with an oriented magnetic field and a preparation method thereof. The stent material has an inter-communicated tridimensional porous structure, the diameter is 60 to 400 [mu]m, the porosity is 30% to 90%, and the stent material has an oriented magnetic field with an adjustable magnetic strength. The preparation method comprises the following steps: first, dissolving a bioactive polymer material into a solvent to prepare a polymer solution; then adding permanent magnetic ferrite powder and hydroxyl apatite powder into the polymer solution, evenly stirring, loading the mixed solution into a mould, freeze-drying under an externally-applied magnetic field so as to mould the solution; finally, soaking the mould into a solution, cutting, and magnetizing the cut moulds so as to obtain the tridimensional porous stent. The method is simple, the operation is convenient, the repeatability is high, and the synthesized tridimensional porous stent has the advantages of good permeability, high porosity, good biological compatibility, good osteoconduction, and good osteoconduction, and has a wide application prospect in the field of bone repairing materials.

Methods and systems are provided for generating quality indications of bone conduction, in which bone conduction element(s) may be used to input and / or output signals when in contact with a user. A bone conduction sensor may be used to obtain bone conduction related measurement(s), relating to the bone conduction element(s) and / or operations thereof. The bone conduction measurement(s) may be processed, such as to determine or estimate quality of attachment and / or performance of the bone conduction elements. Quality indication(s) may then be generated based on the assessed quality of bone conduction, and may be configured for presentation to a user.

The invention provides a bone repair material. a molecular structure and a ratio of contents of calcium and phosphorus of the bone repair material are very similar to that of natural bone, and the bone repair material is provided with excellent biocompatibility. When the bone repair material is implanted into a bone defect, a fibrous tissue boundary surface does not exist between bone tissue and hydroxyapatite in the repair material, a bone-like apatite mineral material can be formed on a rear surface inside an implant body, and the bone repair material dynamically participates in bone tissueabsorption and reconstruction and a metabolic process of calcium ions and phosphonium ions. At the same time, the bone repair material of the has excellent osteoconductivity and osteoinductivity, a three-dimensional structure allows functions such as blood vessel ingrowth, cell penetration and adhesion, new bone formation, tissue deposition and calcification, and a bionic microstructure is beneficial to aggregation of bone morphogenetic protein (BMP), thereby generating the osteoinductivity.

Provided herein are bone grafts and methods of making and using the same, as well as products and kits that include such bone grafts. In particular, bone grafts are provided that include osteogenic stem cells in a mix of osteoinductive demineralized bone matrix and osteoconductive cortico-cancellous chips.

It is intended to provide a dental material formed by using a hydroxy apatite, which is suitable for performing the guided bone regeneration (GBR) method in the implant therapy of dentistry. Also, it is intended to provide a composite dental material which is a bioabsorbable film provided integrally with hydroxy apatite, which is capable of rapidly attracting the osteoblast and blocking the fibroblast. The dental material is a membrane to be used for a guided bone regeneration method of guiding a bone formation by preventing invasion by anaplastic fibroblast by covering a bone developing site with a blocking membrane and filling the bone developing site with osteoblast, wherein a membrane main body of the blocking membrane is formed by using hydroxy apatite having osteoconductive capability of rapidly attracting osteoblast for the purpose of disposing the hydroxy apatite at a bone developing site side of the membrane main body. The composite dental material is a membrane to be used for a guided bone regeneration method of guiding a bone formation by preventing invasion by anaplastic fibroblast by covering a bone developing site with a blocking membrane and filling the bone developing site with osteoblast, wherein a membrane main body of the blocking membrane is formed by using a bioabsorbable membrane, and the bioabsorbable membrane is integrally provided with hydroxy apatite having osteoconductive capability of rapidly attracting osteoblast and a structure of being disposed at a bone developing site side of the membrane main body.

The invention relates to the technology of biological material in the field of biomedical engineering, specifically a preparation technology for bioactive bone-repairing cement material, which is suitable for medical application in the fields of orthopaedics department, thoracic surgery department and reconstructive surgery, such as artificial joint fixation, bone defect filling and implant restoration. The invention relates to a new material which is a combination of powder and liquid with bioactivity for bone repairing and is characterized in that the combination comprises a powder component including homopolymerization powder of methyl methacrylate or copolymerization powder of methyl methacrylate, and a sosoloid powder doped with strontium hydroxyapatite capable of being hardened and solidified to form solid substance with a certain mechanical intensity and synostosis activity when mixed with the liquid component. The main component of the liquid includes methyl methacrylate monomer, which can form bioactive bone-repairing cement when mixed with the powder component. Compared with the prior art, the material can further increase osteoconduction and osteoconduction activity of the combination, and accelerate healing of bone defect part; thus, the material is suitable for orthopaedics department and craniomaxillofacial plastic repair.

The invention discloses a preparation method of a piezoelectric ceramic / bone cement biological piezoelectric composite material. The method includes the steps of: 1, preparation of a piezoelectric porous scaffold; 2, preparation of a calcium phosphate bone cement precursor; 3, preparation of a biological piezoelectric composite material preform; and 4, self-curing and polarization, thus finally obtaining the piezoelectric ceramic / bone cement biological piezoelectric composite material. The method provided by the invention solves the problems that: existing biological piezoelectric materials have a high piezoelectric phase content, osteoconduction is poor in the cell growth process; by employing the traditional physical blending to reduce the piezoelectric content, the piezoelectric coefficient is low and cannot reach a bone induction effect; and common sintering of hydroxyapatite and biological piezoelectric ceramic cannot achieve optimal material performance.

The invention is a modular composite shoulder prosthesis 64, whose construct incorporates a solid autogenous bone graft 50 to be used to replace the upper humerus in certain fracture types. The prosthesis comprises a stem 22 to be inserted in the canal of the humerus, an intermediary part reduced to a medial pillar 24 and a head which is a generally spherical cap 20 that is hollow. The head of the prosthesis being hollow and coated with an osteoconductive material, the lateral aspect of the medial pillar as well as the upper part of the stem being also coated with the same material, an epiphyso-metaphyseal space is delineated in which a solid autogenous bone graft is fitted. Union can be achieved between the coated parts of the prosthesis, the bone graft 50 and the tuberosities reattached to the humerus shaft, secured to holes 62 of the medial pillar and between themselves.

The present invention relates to a method for preparing a bone graft substitute using bovine bone, and more particularly to a method for preparing a safe bone graft substitute which does not have the risk of infection with bovine spongiform encephalopathy, the method comprising treating bovine bone with sodium hypochlorite and treating the treated bone at a high temperature of more than 600° C. The bone graft substitute does not cause an immune response, because it is prepared by effectively removing lipids and organic substances from bovine bone having a structure very similar to that of the human bone. Also, it has excellent osteoconductivity, and is free of prion, and thus it does not have the risk of infection with bovine spongiform encephalopathy. According to the disclosed invention, the bone graft substitute having such advantages can be prepared in a simple manner.

The invention discloses a preparation method of a calcium-strontium / gelatin biomimetic coating modified artificial ligament. The preparation method comprises the following steps: adding strontium salt and calcium salt into a gelatin solution, stirring so as to be fully dissolved, to obtain an evenly mixed solution; immersing a plasma-treated surface modified artificial ligament into the solution, adding phosphate, and stirring to form a mixed solution, irradiating under sunlight or simulated sunlight for 20-60 minutes, and sucking dry with filter paper; repeating the third step until the preset mineralizing circulation times are achieved, thus obtaining the calcium-strontium / gelatin biomimetic coating modified artificial ligament. According to the method, the biological mineralization mechanism of natural bone is simulated, an inorganic salt layer of apatite is deposited by taking natural high polymer or gelatin as a matrix or a template, a coating is compounded on the surface of the material, so that the artificial ligament carries nanoscale strontium substituted hydroxyapatite, so that the biocompatibility and osteoconduction of the material can be improved, and the material can meet the clinically medical requirements on the aspects of bioactivity and mechanical performance.

The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material. The present invention is also directed to a method for the manufacturing of such augmentation devices, a method for fixation of the thus fabricated tissue interface augmentation devices onto ligament or tendon grafts, a method for applying such devices for ligament and / or tendon reconstruction to tendon grafts, as well as their application in ligament and tendon reconstruction.

The invention discloses a method for preparing an artificial bone from chitosan and shell powder serving as raw materials. The chitosan is the medical class chitosan in the markets abroad and at home, and has the deacetylated degree not less than 85 percent; and the shell powder is the residue after stratum corneum of anodonta woodiana is removed, and contains a shell prismatic layer and a pearl layer. The prepared artificial bone has the flexural modulus between 250 and 900Mpa, the compression modulus between 500 and 1,300MPa and the Young modulus between 160 and 280MPa. Meanwhile, the cellular structure in the artificial bone can meet the requirement of cell growth. The porosity, pore size, bioviscoelastic mechanics parameter and the like can be adjusted according to the ratio of the chitosan to the shell powder. The artificial bone is suitable for filling a bone defect part, and the mechanism of the artificial bone is osteoconduction, namely the artificial bone induces bone formation by promoting the combination of host bone and artificial bone surfaces.