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Bone restoration body with composite porous structure and preparation method thereof

A porous structure and bone prosthetic technology, applied in the field of biomedical engineering, can solve the problems of poor biological properties, insufficient mechanical properties of degradable biomaterials, mismatching elastic modulus, etc., to improve osseointegration rate and good bone conduction and osteoinductive effects

Inactive Publication Date: 2012-06-27
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to address the deficiencies of the prior art, to provide a composite porous structure bone prosthesis, which can overcome the defects of the existing metal bone prostheses such as the mismatch of elastic modulus and poor biological performance, and degradable biomaterials Insufficient mechanical properties; achieve good mechanical compatibility between bone restorations and human bone tissue, promote new bone ingrowth, and improve its integration with host bone

Method used

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  • Bone restoration body with composite porous structure and preparation method thereof
  • Bone restoration body with composite porous structure and preparation method thereof

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preparation example Construction

[0025] The preparation method of the composite porous structure bone prosthesis of the present invention comprises the following steps:

[0026] The first step is to use the direct metal rapid prototyping technology, and the rapid prototyping equipment uses metal materials for direct metal rapid prototyping under the control of the computer to form a porous metal support 1. The porous metal support 1 has a three-dimensional network structure. A plurality of pores, the size of the pores is 300-1500 μm, and the porosity is 60%-85%.

[0027] In the second step, the polymer is mixed with 0.2Mol / L acetic acid solution to prepare a polymer solution with a concentration of 1wt%-5wt%, and vacuumized at room temperature to remove residual bubbles in the solution;

[0028] In the second step, the polymer solution can also be prepared by mixing polymer, bioceramic and 0.2Mol / L acetic acid solution, the bioceramic is hydroxyapatite, tricalcium phosphate or calcium silicate, and the polyme...

Embodiment 1

[0033]First, the computer-aided design (CAD) software Unigraphics is used to design the three-dimensional structure of the porous metal support 1. The designed three-dimensional porous structure is a honeycomb structure, the size of the pores is 300 μm, and the porosity is 60%. Then the designed CAD The data is layered and sliced, and converted into the default data format of the rapid prototyping equipment, and then the rapid prototyping equipment processes the data, and uses titanium as the material under computer control for direct metal rapid prototyping to form a porous titanium metal bracket 1 . A certain amount of chitosan was mixed with 0.2Mol / L acetic acid solution to prepare a polymer solution with a concentration of 1 wt%, and vacuumized at room temperature to remove residual bubbles in the solution. Put the prepared porous titanium metal stent 1 into a container corresponding to its shape, and then pour the polymer solution into the porous titanium metal stent 1, s...

Embodiment 2

[0035] First, use the computer-aided design (CAD) software Unigraphics to design the three-dimensional structure of the porous metal support 1. The designed three-dimensional porous structure is a diamond molecular structure, the size of the pores is 700 μm, and the porosity is 70%. Then the designed CAD data Perform layered slicing processing and convert it into the default data format of the rapid prototyping equipment, and then the rapid prototyping equipment uses the titanium alloy for direct metal rapid prototyping manufacturing under computer control according to the processed data to form a porous titanium alloy bracket 1. A certain amount of chitosan, hydroxyapatite and the acetic acid solution of 0.2Mol / L are mixed, and the mass ratio of chitosan and hydroxyapatite is 4: 1, is prepared into the polymer solution that concentration is 5wt%, and Vacuumize at room temperature to remove residual air bubbles in the solution. Put the prepared porous titanium alloy stent 1 in...

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Abstract

A bone restoration body with a composite porous structure and a preparation method of the bone restoration body. The bone restoration body comprises a porous metal bracket and an infill body with a porous structure, wherein the porous metal bracket is of a three-dimensional net structure, a plurality of pores are arranged in the inner part of the porous metal bracket, and the infill body with the porous structure is fully filled in all the pores. The preparation method combines the direct metal rapid prototyping technology and the freeze drying technology and comprises the steps of preparing the porous metal bracket by a structural design and the direct metal rapid prototyping technology, pouring uniformly-mixed polymer solution or polymer / biological ceramics mixing solution into the porous metal bracket, carrying out freezing treatment, and then forming the infill body with the porous structure through freeze drying so as to obtain the bone restoration body with the composite porous structure, wherein the infill body with the porous structure has micropore characteristics. The bone restoration body has good mechanics compatibility, can obtain good bone conduction performance and bone induction performance, improves bone integration efficiency and can be used for clinical treatment of segmental bone defect of a bearing part.

Description

technical field [0001] The invention relates to a surgical implant and a preparation method thereof, in particular to a composite porous structure bone restoration and a preparation method thereof, belonging to the technical field of biomedical engineering. Background technique [0002] Bone defect caused by disease and trauma is a common clinical disease and one of the worldwide problems in orthopedic treatment, seriously affecting the quality of life of patients. At present, the methods for treating bone defects include autologous bone and allogeneic bone transplantation, biodegradable biomaterials and medical metal material transplantation, and tissue engineering techniques. Although autologous bone is good, its source is limited, and it will bring unnecessary secondary trauma to patients; allogeneic bone also has disadvantages such as immunogenicity and pathogenicity; degradable biomaterials have good biocompatibility in clinical practice. It has been widely used in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/56
Inventor 李祥罗云王成焘
Owner SHANGHAI JIAO TONG UNIV
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