Porous gradient scaffold with mixed structure units, and preparation method

A hybrid structure and structural unit technology, applied in the field of biomedical implant materials, can solve the problems of single structure and large performance gap of bionic scaffolds, and achieve the effect of improving flexibility, increasing strength and simple structure

Active Publication Date: 2020-12-01
UNIV OF SCI & TECH BEIJING
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The main purpose of the present invention is to provide a porous gradient scaffold with mixed structural units and a preparation method. The porous gradient scaffold with mixed structural units is formed by combining multiple scaffold structures, has good mechanical and biocompatibility, and the structural units The structure is simple, the design cycle is greatly shortened, and the accuracy of the structure can be improved to solve the technical problems that the bionic scaffold structure in the prior art is single and the performance is far from that of human bone tissue.

Method used

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  • Porous gradient scaffold with mixed structure units, and preparation method
  • Porous gradient scaffold with mixed structure units, and preparation method
  • Porous gradient scaffold with mixed structure units, and preparation method

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preparation example Construction

[0072] The invention also discloses a preparation method of a porous gradient scaffold with mixed structural units, the preparation method specifically includes the following steps:

[0073] S1, build the basic unit: use SOLIDWORKS software to build the first structural unit, the second structural unit, the third structural unit and the fourth structural unit; the specific steps are not limited, according to the number of brackets included in the gradient bracket of the mixed structural unit and structure.

[0074] S2, construct the gradient structure: use SOLIDWORKS software to construct the inner layer support structure, the first support structure, the second support structure and the third support structure, and then obtain the model of the cylindrical porous gradient support through Boolean operations; specifically,

[0075] The construction steps of the gradient scaffold structure with mixed structural units including two scaffolds are as follows:

[0076] S2-1, first b...

Embodiment 1

[0093] A porous gradient scaffold with mixed structural units, the scaffold includes an inner scaffold structure 3 and a first scaffold structure 4, wherein: the inner scaffold structure 3 forms an inner low-density region, and the first scaffold structure 4 forms an outer high-density region area; the first support structure 4 is a 10*10*10mm cube formed by arranging and connecting multiple second structural units, and then the layer thickness D obtained through Boolean operations is 3mm, the hollow cylinder diameter is R4mm, and a hollow cylinder with a height of 10mm, the second The structural unit is a centered cubic structure composed of a cube frame 1 and a supporting cylinder 2 with a radius of 0.25 mm; the cube frame 1 is composed of edges with a length of 2 mm, and the edges are formed by a quarter cylinder, and the cylinder The radius is 0.25mm; the inner support structure 3 is a 6*6*10mm cube composed of multiple first structural units arranged and connected, and the...

Embodiment 5

[0106]A porous gradient scaffold with mixed structural units, the scaffold includes an inner scaffold structure 3, a second scaffold structure 6 and a third scaffold structure 7, wherein: the inner scaffold structure 3 forms an inner low-density region, and the second scaffold structure 6 forms the sub-outer medium-density area, and the third support structure 7 forms the outermost high-density area; the third support structure 7 is a 10*10*10mm cube formed by a plurality of fourth structural unit arrays, and then obtained through Boolean operations Layer thickness D 2mm, hollow cylinder diameter R 6mm, hollow cylinder with a height of 10mm, the fourth structural unit is a support cylinder composed of a cube frame 1 and a support cylinder 2 with a radius of 0.25mm. The two ends of the support cylinder are located at the edge of the cube frame 1 The structure at the / 4 position (x=a / 4); the cube frame 1 is made up of edges with a length of 2mm, and the edges are formed by a quar...

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Abstract

The invention provides a porous gradient scaffold with mixed structure units, and a preparation method. The porous gradient scaffold with mixed structure units comprises a plurality of scaffold structures, each scaffold structure comprises a plurality of structure units, each scaffold structure is formed by arraying the plurality of corresponding structure units along three dimensions of length, width and height, the relative density of each scaffold structure is in gradient change, each structure unit comprises a cubic frame, and a plurality of supporting cylinders arranged inside the cubic frame, and structures of the structure units forming the scaffold structures are different. The porous gradient scaffold with mixed structure units is formed by combining the plurality of scaffold structures, has good mechanical property and biological compatibility, is simple in structure, greatly shortens a design period, and can improve the forming accuracy of the scaffold structures.

Description

technical field [0001] The invention relates to the technical field of biomedical implant materials, in particular to a porous gradient scaffold with mixed structural units and a preparation method. Background technique [0002] Titanium and titanium alloys have low elastic modulus, excellent corrosion resistance and good biocompatibility, so they are widely used in the field of orthopedics. However, long-term studies have shown that the elastic modulus (~110GPa) of dense titanium-based implants currently used in clinical practice is significantly higher than that of human bone tissue (0.01-3GPa for cancellous bone and 3-30GPa for compact bone), which is not conducive to stress from implantation. The body is transmitted to the surrounding natural bone tissue, resulting in a "stress shielding" phenomenon, resulting in bone resorption and functional degradation around the implant, and eventually leads to aseptic loosening of the implant. [0003] Through the design of the por...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28
CPCA61F2/28A61F2002/2835A61F2002/30011
Inventor 路新徐伟于爱华刘博文潘宇张策张嘉振曲选辉
Owner UNIV OF SCI & TECH BEIJING
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