11 results about "Aseptic loosening" patented technology

The application discloses a preparation method of a 3D printing hip joint stress relief heat treatment double-gradient bone support, and the method comprises the following steps: acquiring image data by performing three-dimensional scanning on a bone defect by means of a CT scanning device, designing the size and shape of a transplantable bone, designing a concave hexagonal support structure with gradient porosity by means of UG three-dimensional drawing software, and gradually transitioning from a Ti-35Nb-5Ta-7Zr alloy with good biocompatibility and a low elastic modulus to a Co-Cr-Mo alloy with good wear resistance and corrosion resistance, improving metallurgical incompatibility, obtaining better interface combination, minimizing bone resorption and aseptic loosening caused by wear, prolonging the service life of an implant, and performing annealing heat treatment on the functional support after printing to eliminate residual stress and depositing a HA coating to enhance cell activity.

The present invention relates to a metal composite material comprising: a base layer, an intermediate layer, and a surface oxide layer sequentially laminated on at least one side of the base layer; the base layer is titanium-based or titanium alloy-based; the intermediate layer is zirconium-based or zirconium alloy-based; and the surface oxide layer contains zirconium oxide. This metal composite material exhibits excellent wear resistance and can be used as a femoral condyle prosthesis, reducing aseptic loosening and lowering the revision rate of joint prostheses. Furthermore, a femoral condyle prosthesis, a method for preparing the metal composite material or the femoral condyle prosthesis, and the use of the metal composite material in the preparation of artificial joint prostheses are also provided.

The invention discloses a preparation method and application of a surface active coating, and belongs to the technical field of artificial joint coatings. A magnesium-doped porous titanium dioxide nanotube array layer and a zinc-strontium co-doped mesoporous bioactive glass release layer are formed on the surface of a substrate; the single performance such as the bonding strength, the osteogenic activity and the antibacterial ability of the coating is exceeded, and more importantly, the unification and the continuous high efficiency of the performance are realized through the gradient and synergistic system design of the coating; a new solution is provided for solving the two major problems of artificial joint replacement, namely sterile looseness and antibacterial ability, and the method has extremely high clinical transformation value and market prospect.

The present application relates to a kind of distal anchoring bone cement type prosthesis stem, including stem body, several anchoring blades and piston.The bottom end of the stem body is fixed on prosthesis, top end is inserted into medullary cavity, bone cement channel is provided in the stem body along the axial direction, injection hole is formed on the side wall of the stem body, and the injection hole is communicated with the bone cement channel;The anchoring blade is arranged at the top of the stem body, the bottom of the anchoring blade is rotatably connected with the top end of the stem body, the piston is sleeved in the bone cement channel, and under the driving of bone cement, it slides upward, when the piston slides to the top of the stem body, several anchoring blades are opened, and the anchoring blade is converted from the first state to the second state.The distal anchoring bone cement type prosthesis stem can improve the long-term stability of tumor type prosthesis, reduce the aseptic loosening of prosthesis, and improve the long-term function of limb of patients with malignant bone tumor.

The present application relates to the application of circPDE5A inhibitor in the preparation of drugs for treating aseptic loosening of artificial joints. The present application confirms that circPDE5A has a positive correlation with the occurrence of aseptic loosening. And through RNA Pull-Down experiment and mass spectrometry (MS) analysis, it is confirmed that circPDE5A can affect the regulation of LACC1 signal pathway by interacting with LACC1, and then affect the inflammatory response of macrophages. In addition, through in vivo animal experiments, the results of mouse skull osteolysis model show that the injection of lentivirus for knocking down circPDE5A can reduce the osteolysis induced by Ti particles. In general, the present application provides a new idea and theoretical basis for the research and development of drugs for treating aseptic loosening of artificial joints, and has important clinical value and social significance.

The application discloses a locking device for a tibial base in knee replacement surgery, which comprises a tibial body and a tibial base, a locking screw one is arranged on the outer upper end of the tibial body, the tibial base is arranged on the inner upper end of the tibial body, and a bottom hole one is arranged on the inner middle end of the tibial base. The locking device for the tibial base in knee replacement surgery can make the tibial base be pulled down perpendicularly to the contact surface and not be loosened upward to generate a gap, reduce aseptic loosening, reduce the incidence of complications caused by aseptic loosening, greatly relieve the mental pressure and economic burden of patients, greatly save social public medical resources, make the tibial base keep fastening with the tibial body for a long time, facilitate the operation of an operator and ensure the accuracy of punching, prolong the fastening time between the tibial base and the tibial body, and reduce the frequency of later revision.

The invention provides a medicine for preventing and / or treating sterile looseness. The medicine is a proteasome inhibitor, and the proteasome inhibitor comprises a broad-spectrum inhibitor (such as bortezomib, carfilzomib and ixazomib) and an immune proteasome selective inhibitor (such as ONX-0914, KZR-616 and analogues thereof). The drug can be in a dosage form suitable for modes of articular cavity injection, bone cement slow release, prosthesis surface coating or systemic drug delivery and the like. The invention not only can be used for preparing the medicine for treating or preventing the sterile looseness, but also can be expanded to the development of a medicine carrying delivery system and an anti-rejection prosthesis material, and provides a new thought and a feasible way for preventing and treating the sterile looseness.

The present invention relates to a femoral implant for animals, and more particularly, to a femoral implant for animals, which can perform hip arthroplasty for animals, firmly fix the implant to the femur of the animal by means of spontaneous bone growth of the animal to prevent complications such as aseptic loosening that can occur when using bone cement, bone resorption around the cement, etc., and which is formed with a plurality of voids in a porous portion and is relatively weak in strength, is protected by a support portion formed with a solid surface and is relatively strong in strength to secure prevention of damage problems such as chipping or bending due to friction between the edge of the porous portion and the bone or external force during insertion of the femoral implant into the femur of the animal, and block various inflammatory reactions and the like problems caused by the penetration of porous particles into blood vessels due to damage to the porous portion.

A femoral stem prosthesis comprises a head and neck part, a near-end part and a far-end part which are sequentially connected, the two sides of the near-end part are solid bodies, the middle of the near-end part is a near-end porous body, and the far-end part comprises a hollow far-end shell and a far-end porous body arranged in the far-end shell. The near-end porous body and the far-end porous body are internally provided with pores which are communicated with each other and extend to the surface, so that a porous structure is formed, the elastic modulus of the femoral stem prosthesis is reduced, the problem of uneven stress conduction caused by a stress shielding effect formed by overlarge elastic modulus is avoided, the fracture risk around the prosthesis is reduced, and the fracture resistance of the femoral stem prosthesis is improved. The human health is better protected; meanwhile, the human body structure tissue can grow into the pores, so that the adhesiveness and combination stability between the prosthesis and the human body tissue are met, the manufacturing and using requirements of a coating are omitted, the problem that the integration degree between the prosthesis and the femur is poor due to the fact that the coating is not uniform is solved, and the risk of sterile looseness is greatly reduced.

This application relates to the field of medical device technology, and in particular to a method for manufacturing a unicompartmental prosthesis system and the unicompartmental prosthesis system itself. The method for manufacturing the unicompartmental prosthesis system includes using zirconium-niobium alloy powder as raw material to sequentially print a first body and a first trabecular bone structure layer to form a first intermediate product of the femoral condyle prosthesis, and sequentially printing a second body and a second trabecular bone structure layer to form a first intermediate product of the tibial plateau prosthesis; when printing to the first trabecular bone structure layer of the femoral condyle prosthesis and when printing to the second trabecular bone structure layer of the tibial plateau prosthesis, magnesium metal particles are added to the zirconium-niobium alloy powder; heat treatment; machining and shaping; and surface oxidation treatment. According to the manufacturing method and unicompartmental prosthesis system provided in this application, the bone formation rate of elderly patients is effectively improved, and the incidence of aseptic loosening is reduced.

The invention discloses a preparation method of a zirconium-based alloy in-situ oxidation coating for a joint prosthesis, the medical joint prosthesis and application, the method is suitable for zirconium-based alloys (containing Zr-2. 5Nb, Zr-Nb-Ti, Zr-Mo-Nb and other systems) prepared or forged through electron beam melting (EBM) and selective laser melting (SLM), oxygen atoms are promoted to diffuse into the material by repeatedly creating oxygen concentration gradients, and the oxygen concentration gradient of the zirconium-based alloys (containing Zr-2. 5Nb, Zr-Nb-Ti, Zr-Mo-Nb and other systems) is increased. And a high-oxygen diffusion transition layer and the ZrO-based in-situ oxidation ceramic coating are accurately formed, and meanwhile, a coupling mathematical model of oxidation temperature (T)-ceramic coating thickness (d)-wear resistance (WR) is established, so that double accurate regulation and control of the coating performance and the product size are realized. The prepared coating is tightly combined with the matrix through the high-oxygen diffusion transition layer, the depth of the transition layer exceeds that of a traditional process by 40% or above, and the size variation of the prosthesis after oxidation is smaller than or equal to + / -0.01 mm; the surface hardness of the coating is larger than or equal to 1053 Hv, the wear rate is smaller than or equal to 0.8 * 10 mm / (Nm), the wear resistance and size stability of the zirconium-based alloy are remarkably improved, the problems of sterile looseness and out-of-control size precision caused by wear chippings in long-term service of joint prostheses are solved, and the method is suitable for large-scale production of medical joint prostheses such as hip joints and knee joints.