2 results about "Aseptic loosening" patented technology

The present application relates to the application of circPDE5A inhibitor in the preparation of drugs for treating aseptic loosening of artificial joints. The present application confirms that circPDE5A has a positive correlation with the occurrence of aseptic loosening. And through RNA Pull-Down experiment and mass spectrometry (MS) analysis, it is confirmed that circPDE5A can affect the regulation of LACC1 signal pathway by interacting with LACC1, and then affect the inflammatory response of macrophages. In addition, through in vivo animal experiments, the results of mouse skull osteolysis model show that the injection of lentivirus for knocking down circPDE5A can reduce the osteolysis induced by Ti particles. In general, the present application provides a new idea and theoretical basis for the research and development of drugs for treating aseptic loosening of artificial joints, and has important clinical value and social significance.

This application relates to the field of medical device technology, and in particular to a method for manufacturing a unicompartmental prosthesis system and the unicompartmental prosthesis system itself. The method for manufacturing the unicompartmental prosthesis system includes using zirconium-niobium alloy powder as raw material to sequentially print a first body and a first trabecular bone structure layer to form a first intermediate product of the femoral condyle prosthesis, and sequentially printing a second body and a second trabecular bone structure layer to form a first intermediate product of the tibial plateau prosthesis; when printing to the first trabecular bone structure layer of the femoral condyle prosthesis and when printing to the second trabecular bone structure layer of the tibial plateau prosthesis, magnesium metal particles are added to the zirconium-niobium alloy powder; heat treatment; machining and shaping; and surface oxidation treatment. According to the manufacturing method and unicompartmental prosthesis system provided in this application, the bone formation rate of elderly patients is effectively improved, and the incidence of aseptic loosening is reduced.