4 results about "Aseptic loosening" patented technology

The application discloses a preparation method of a 3D printing hip joint stress relief heat treatment double-gradient bone support, and the method comprises the following steps: acquiring image data by performing three-dimensional scanning on a bone defect by means of a CT scanning device, designing the size and shape of a transplantable bone, designing a concave hexagonal support structure with gradient porosity by means of UG three-dimensional drawing software, and gradually transitioning from a Ti-35Nb-5Ta-7Zr alloy with good biocompatibility and a low elastic modulus to a Co-Cr-Mo alloy with good wear resistance and corrosion resistance, improving metallurgical incompatibility, obtaining better interface combination, minimizing bone resorption and aseptic loosening caused by wear, prolonging the service life of an implant, and performing annealing heat treatment on the functional support after printing to eliminate residual stress and depositing a HA coating to enhance cell activity.

The present application relates to the application of circPDE5A inhibitor in the preparation of drugs for treating aseptic loosening of artificial joints. The present application confirms that circPDE5A has a positive correlation with the occurrence of aseptic loosening. And through RNA Pull-Down experiment and mass spectrometry (MS) analysis, it is confirmed that circPDE5A can affect the regulation of LACC1 signal pathway by interacting with LACC1, and then affect the inflammatory response of macrophages. In addition, through in vivo animal experiments, the results of mouse skull osteolysis model show that the injection of lentivirus for knocking down circPDE5A can reduce the osteolysis induced by Ti particles. In general, the present application provides a new idea and theoretical basis for the research and development of drugs for treating aseptic loosening of artificial joints, and has important clinical value and social significance.

This application relates to the field of medical device technology, and in particular to a method for manufacturing a unicompartmental prosthesis system and the unicompartmental prosthesis system itself. The method for manufacturing the unicompartmental prosthesis system includes using zirconium-niobium alloy powder as raw material to sequentially print a first body and a first trabecular bone structure layer to form a first intermediate product of the femoral condyle prosthesis, and sequentially printing a second body and a second trabecular bone structure layer to form a first intermediate product of the tibial plateau prosthesis; when printing to the first trabecular bone structure layer of the femoral condyle prosthesis and when printing to the second trabecular bone structure layer of the tibial plateau prosthesis, magnesium metal particles are added to the zirconium-niobium alloy powder; heat treatment; machining and shaping; and surface oxidation treatment. According to the manufacturing method and unicompartmental prosthesis system provided in this application, the bone formation rate of elderly patients is effectively improved, and the incidence of aseptic loosening is reduced.

The invention discloses a preparation method of a zirconium-based alloy in-situ oxidation coating for a joint prosthesis, the medical joint prosthesis and application, the method is suitable for zirconium-based alloys (containing Zr-2. 5Nb, Zr-Nb-Ti, Zr-Mo-Nb and other systems) prepared or forged through electron beam melting (EBM) and selective laser melting (SLM), oxygen atoms are promoted to diffuse into the material by repeatedly creating oxygen concentration gradients, and the oxygen concentration gradient of the zirconium-based alloys (containing Zr-2. 5Nb, Zr-Nb-Ti, Zr-Mo-Nb and other systems) is increased. And a high-oxygen diffusion transition layer and the ZrO-based in-situ oxidation ceramic coating are accurately formed, and meanwhile, a coupling mathematical model of oxidation temperature (T)-ceramic coating thickness (d)-wear resistance (WR) is established, so that double accurate regulation and control of the coating performance and the product size are realized. The prepared coating is tightly combined with the matrix through the high-oxygen diffusion transition layer, the depth of the transition layer exceeds that of a traditional process by 40% or above, and the size variation of the prosthesis after oxidation is smaller than or equal to + / -0.01 mm; the surface hardness of the coating is larger than or equal to 1053 Hv, the wear rate is smaller than or equal to 0.8 * 10 mm / (Nm), the wear resistance and size stability of the zirconium-based alloy are remarkably improved, the problems of sterile looseness and out-of-control size precision caused by wear chippings in long-term service of joint prostheses are solved, and the method is suitable for large-scale production of medical joint prostheses such as hip joints and knee joints.