22 results about "Carfilzomib" patented technology

The invention relates to application of SMARCC1 in preparation of a medicine for treating carfilzomib-resistant multiple myeloma, and belongs to the technical field of biological medicine. According to the invention, direct association between SMARCC1 and the drug resistance of multiple myeloma to carfilzomib is determined for the first time, and the sensitivity of drug-resistant cells to carfilzomib can be significantly enhanced by down-regulating the expression of the gene. Specifically, through systematic analysis on clinical data, SMARCC1 is found to be remarkably and highly expressed in relapse / refractory MM patients and is closely related to poor survival. The SMARCC1 knock-down obviously inhibits the multiplication capacity of multiple myeloma drug-resistant cells, so that the SMARCC1 not only promotes the multiplication capacity of the drug-resistant cells, but also is closely related to the drug resistance of the multiple myeloma cells to carfilzomib, which prompts that the SMARCC1 can be used as a potential therapeutic target and is used for reversing the carfilzomib drug resistance of multiple myeloma.

The present invention provides room temperature stable, i.e., dilution injectable formulations comprising carfilzomib or a pharmaceutically acceptable derivative thereof. The invention also provides a method of treating a patient suffering from multiple myeloma by administering a room temperature stable, i.e., dilution injectable formulation comprising carfilzomib or a pharmaceutically acceptable derivative thereof.

The invention discloses application of carfilzomib in preparation of a medicine for preventing and treating Nipah virus, and belongs to the technical field of medicine. The method mainly aims at ubiquitination modification of nipah virus M protein, the carfilzomib is used for inhibiting a host proteasome path, free ubiquitination factors in cells are depleted to achieve the effect of inhibiting ubiquitination of the M protein, then nucleoplasm shuttle of the M protein is inhibited, replication of the nipah virus is inhibited, and the effect is good. At present, most of research and development of virus medicines and vaccines are designed or modified aiming at viruses, a new thought is provided for research and development of medicines and vaccines in the future, and a new application is also provided for Carfilzomib.

The application discloses application of an HTRA1 inhibitor in preparation of a drug for treating pancreatitis-cancer transformation, and belongs to the technical field of medicines.The HTRA1 inhibitor is screened through a drug database, the HTRA1 inhibitor is used to treat a pancreatic cancer cell line and a mouse pancreatitis-cancer transformation in-vivo model, it is proved that the HTRA1 inhibitor Carfilzomib can inhibit the malignant phenotype of Panc1 cells in vitro, and can inhibit the transformation of a KC mouse stimulated by cerulean into a pancreatic ductal adenocarcinoma in vivo, and the application provides a basis for using the HTRA1 inhibitor as the drug for treating pancreatitis-cancer transformation.

The present disclosure provides methods for treating multiple myeloma. In certain embodiments, the present methods comprise administering to a subject in need thereof a BCMA inhibitor in combination with a proteasome inhibitor. In certain embodiments, the subject has been previously treated with one or more anti-cancer therapies. In certain embodiments, the proteasome inhibitor is carfilzomib.

This disclosure provides a stable cyclodextrin free carfilzomib formulation in aqueous solution which is suitable for injection, a kit comprising said cyclodextrin free carfilzomib formulation, and methods for preparation of said cyclodextrin free carfilzomib. Such formulation, kit and methods substantially increase the solubility and stability of the carfilzomib in aqueous solution and facilitate both their manufacture and administration.

Disclosed herein are compositions and kits which comprise anti-CD38 antibodies and carfilzomib compounds. Also disclosed are methods for treating cancers, such as multiple myeloma, in subjects with the compositions and kits.

The invention belongs to the technical field of cerebral apoplexy treatment medicine research, and particularly relates to a nano delivery system and application thereof. The nano delivery system is prepared according to the following steps: modifying cationic starch spheres with mitochondrial targeting peptide, loading PDK4-IN-1, and carrying out self-assembly to obtain an inner core; the preparation method comprises the following steps: modifying aminated anionic starch with homing peptide, and loading carfilzomib to form a starch spiral shell; and mixing the inner core with the starch spiral shell, and self-assembling to form the nano drug delivery system. According to the invention, a three-targeting, double-controlled-release and double-drug nano drug delivery system is constructed and is accurately delivered to a matrix action site in cytoplasm or mitochondria, so that double-channel synergistic enhancement of IS mitochondrial autophagy and toxicity attenuation and synergistic treatment of IS are realized.

Provided herein are methods and compositions for treating multiple myeloma, such as relapsed and / or refractory multiple myeloma and newly-diagnosed multiple myeloma, including transplant-ineligible newly-diagnosed multiple myeloma (TI-NDMM). The methods involve administering to human patients diagnosed with multiple myeloma an anti-BCMA antigen binding protein (e.g., an anti-BCMA antibody or anti-BCMA antibody drug conjugate) in combination with lenalidomide, pomalidomide, bortezomib, carfilzomib and / or dexamethasone.

The invention is directed to room temperature stable injectable formulations of carfilzomib or its pharmaceutically acceptable derivatives thereof in the form of ready to dilute solution and concentrates with no hemolytic potential. Further the invention is directed to a method for treating patients with relapsed or refractory multiple myeloma by administering such composition.

Disclosed herein are compositions and kits which comprise anti-CD38 antibodies and carfilzomib compounds. Also disclosed are methods for treating cancers, such as multiple myeloma, in subjects with the compositions and kits.

The present invention provides stable pharmaceutical compositions of a pegylated carfilzomib compound, methods for preparing the compositions, and uses of the compositions for the treatment of cancer, including hematological malignancies such as multiple myeloma. The composition can be stored in frozen form or lyophilized into dry solid form.

This disclosure provides a stable cyclodextrin free chlorobutanol carfilzomib formulation in aqueous solution which is suitable for injection, a kit comprising said cyclodextrin free carfilzomib formulation, and methods for preparation of said cyclodextrin free carfilzomib. Such formulation, kit and methods substantially increase the solubility and stability of the carfilzomib in aqueous solution and facilitate both their manufacture and administration.

The present disclosure provides methods for treating multiple myeloma. In certain embodiments, the present methods comprise administering to a subject in need thereof a BCMA inhibitor in combination with a proteasome inhibitor. In certain embodiments, the subject has been previously treated with one or more anti-cancer therapies. In certain embodiments, the proteasome inhibitor is carfilzomib.

The invention relates to a composition comprising an anti-CD38 antibody and carfilzomib. Compositions and kits comprising an anti-CD38 antibody and a carfilzomib compound are disclosed. Methods and uses for treating cancer, such as multiple myeloma, in a subject using the compositions and kits are also disclosed.

To provide a stable modified carfilzomib formulation. [Solution] The present invention provides a stable pharmaceutical composition of a PEGylated carfilzomib compound, a method for preparing the composition, and the use of the composition for treating cancer, including vascular malignancies such as multiple myeloma. The composition can be stored in a frozen form or lyophilized in a dry solid form.

The invention discloses a method for detecting N-methyl pyrrolidone in a carfilzomib intermediate, which comprises the following steps: adopting a high performance liquid chromatography, using a ZORBAX Eclipse C18 ball porous filler chromatographic column to realize reverse phase separation, and using a diode array detector to perform quantitative analysis. Chromatographic conditions are as follows: a mobile phase A is water; a mobile phase B is methanol, and carrying out gradient elution on the phase A and the phase B; the flow velocity is 0.8 to 1.0 ml / min; the column temperature is 25-40 DEG C; the detection wavelength is 205 to 220 nm; the sample size is 10-20 [mu] l; and the diluent is a 50-70% methanol aqueous solution. The N-methyl pyrrolidone disclosed by the invention is relatively high in response, high in detection sensitivity, good in peak pattern and accurate and reliable in detection result; the high performance liquid chromatography is adopted, instruments, solvents and chromatographic columns used for detection are conventional and easy to obtain, samples and reference substances are easy to prepare and operate, and the method can be widely applied to detection of N-methyl pyrrolidone.

Provided herein are improved methods for measuring the concentration of carfilzomib in a sample. The method comprises the steps of diluting the sample with a diluent comprising water and less than 50% by volume of acetonitrile to form an analysis sample; and subjecting the analysis sample to high performance liquid chromatography (HPLC) to determine the carfilzomib concentration in the sample.

The invention relates to application of retinol compounds and carfilzomib in preparation of drugs for treating multiple myeloma, and belongs to the technical field of antitumor drugs. Aiming at the problem of drug resistance in treatment of multiple myeloma, the invention provides a technical scheme of drug combination. The retinol compound is preferably synthetic retinol WYC-209, the retinol compound can enhance the sensitivity of carfilzomib for treating multiple myeloma, and the action mechanism is that WYC-209 aggravates endoplasmic reticulum stress of multiple myeloma cells and destroys an endoplasmic reticulum structure. The combined treatment scheme can inhibit proliferation of multiple myeloma cells, induce cell apoptosis, reduce tumor load, inhibit bone marrow infiltration of tumor cells and improve the long-term survival rate of mice. The invention further provides a pharmaceutical composition containing WYC-209 and carfilzomib, the mass ratio of WYC-209 to carfilzomib is (0.01-3000): 1, and the pharmaceutical composition can be prepared into a solution or suspension and is suitable for treating first-diagnosis high-risk multiple myeloma or recurrent / refractory multiple myeloma.

This invention provides a room-temperature stable, dilution-free injectable formulation comprising carfilzomib or a pharmaceutically acceptable derivative thereof. This invention also provides a method for treating patients with multiple myeloma by administering a room-temperature stable, dilution-free injectable formulation comprising carfilzomib or a pharmaceutically acceptable derivative thereof.

The invention is directed to room temperature stable injectable formulations of carfilzomib or its pharmaceutically acceptable derivatives thereof in the form of ready to dilute solution and concentrates with no hemolytic potential. Further the invention is directed to a method for treating patients with relapsed or refractory multiple myeloma by administering such composition.

Provided herein are methods of treating a subject suffering from multiple myeloma by administering a triplet therapy of carfilzomib, dexamethasone, and an antibody that specifically recognizes CD38.