The invention discloses a compound feed for megalobrama amblycephala. The compound feed comprises the following raw materials by weight percent: 18-20% of flour, 9-26% of soybean meal, 6-15% of cottonseed meal, 10-28% of rapeseed meal, 2 -4% of corn gluten meal, 2-8% of fish meal, 2-6% of shrimp meal, 2-7% of prickly ash seed, 5-15% of rice bran, 2-3% of soybean oil, 1-3% of bentonite, 1.5-2% of calcium dihydrogenphosphate, 0.05-0.2% of mildew preventive, 0.05-0.3% of lysine, 0.05-0.3% of choline, 0.05-0.3% of honeysuckle powder, 0.2-0.5% of vitamin premix and 0.5-1.0% of mineral premix. The above raw materials are mixed, are subjected to the concoction, extrusion expansion granulation, drying and other steps, and then are cooled to the room temperature so as to obtain the compound feed. According to the compound feed, a plurality of protein raw materials and amino acids are selected to realize the nutritional coordination, the expansion process is used for increasing the curing degree of the feed, eliminating anti-nutritional factors, and greatly improving the feed utilization efficiency and water resistance; the honeysuckle powder is added to improve the immunity of megalobrama amblycephala and effectively reduce the mortality.