736results about "Carbonyl compound separation/purification" patented technology

The invention belongs to the technical field of chemical production, and particularly relates to an efficient energy-saving refining system for producing cyclohexanone through dehydrogenation, which comprises an alcohol tower, a dehydrogenation heat exchanger, a dehydrogenation reactor, an alcohol tower feeding heat exchanger, a dehydrating tower, a light tower I, a light tower II, a ketone tower and an alcohol recovery tower which are connected in sequence, a middle feeding port of the alcohol tower is communicated with a tube pass discharging port of the alcohol tower feeding heat exchanger, a top discharging port of the alcohol tower is communicated with a tube pass feeding port of the dehydrogenation heat exchanger, a bottom discharging port of the alcohol tower is communicated with a middle feeding port of the alcohol recovery tower, and an alcohol ketone drying tower is additionally arranged between the alcohol tower feeding heat exchanger and the dehydration tower. A feed port of the alcohol ketone drying tower is communicated with a shell pass discharge port of the alcohol tower feed heat exchanger, and a liquid phase discharge port of the alcohol ketone drying tower is communicated with an upper feed port of the dehydrating tower. The alcohol tower adopts a process that raw materials directly enter the tower top, tower top reflux is cancelled, steam consumption is reduced, and the purpose of saving energy is achieved.

The invention provides a device and a method for removing MIBK (methyl isobutyl ketone) in raffinate for extracting and separating zirconium and hafnium, the device comprises a tank body, a liquid distribution ring is fixedly connected in the tank body, one side of the liquid distribution ring penetrates through the tank body and is outwards communicated with a feeding pipe, a plurality of spray heads are arranged below the liquid distribution ring in a penetrating manner, the outer end of the tank body is fixedly connected with a bracket, and the bracket is fixedly connected with a rotating shaft. According to the device, raffinate can be quickly conveyed into the tank body by arranging a liquid distribution ring and a spray head, rotation of a rotating shaft and a rotating plate can be completed in cooperation with a gear assembly, the fallen raffinate is scattered, it is ensured that the raffinate can uniformly fall on a steam heating pipe, and the raffinate is uniformly heated; meanwhile, the contact area of the gas phase and the liquid phase can be increased in cooperation with the condensation assembly, the phase splitting barrel and the grid plate, the MIBK separation efficiency is improved, and the purpose of rapidly removing oil is achieved through the principle that the volatility is affected by factors such as liquid diffusion and temperature.

The invention relates to a lignin-based polymer pervaporation membrane, a preparation method thereof and a method for separating and purifying cyclohexane-KA oil. The invention aims to provide a pervaporation membrane which is high in permselectivity, high in stability and good in mechanical property. The pervaporation membrane is used for cyclohexane-KA oil separation and has the advantages of high separation efficiency, low energy consumption and simple process. The preparation method comprises the following steps: adding the surfactant, the polymer and the solvent into a reactor, and stirring at 50-70 DEG C for 4-6 hours to obtain a mixed solution; the method comprises the following steps: adding lignin and a solvent into a reactor, and stirring at room temperature for 4-6 hours to obtain a lignin solution; dropwise adding the lignin solution into the mixed solution, and continuously stirring at constant temperature for 12-24 hours to obtain a membrane casting solution; transferring the membrane casting solution to a centrifugal tube, performing centrifugal separation, and uniformly coating the membrane casting solution on an ultrafiltration membrane material with the membrane thickness of 100-200mm to form a uniform liquid membrane; and drying the liquid membrane to obtain the lignin-based polymer pervaporation membrane. Belongs to the technical field of membrane separation.

The invention belongs to the field of plant endophytic fungus secondary metabolites, particularly relates to a secondary metabolite of fennel endophytic fungus fusarium oxysporum as well as a preparation method and application thereof, and provides a fennel endophytic fungus secondary metabolite with structures as shown in compounds 1-8. Wherein the compound 2 and the compound 7 have inhibitory activity on staphylococcus aureus, escherichia coli, bacillus cereus, bacillus subtilis, candida albicans and shigella, and have a certain inhibitory effect on cervical cancer Hela cell strains.

A technology for preparing glutaraldehyde through cyclopentene oxidation belongs to the technical field of organic synthesis, glutaraldehyde is prepared through cyclopentene oxidation by adopting a photocatalysis-electrocatalysis synergistic catalyst g-C3N4 / TiO2 (at) Au-Co / N-G. The catalyst is of a unique core-shell structure, is stable in property, promotes an oxygen reduction reaction in a catalysis technology, and has good catalytic activity. The conversion rate of cyclopentene and the selectivity of glutaraldehyde are remarkably improved, and the effect is remarkable.

The invention relates to the technical field of synthesis of organic compounds, and discloses a dibenzoylmethane preparation method, which comprises the following steps: preparation of a functionalized ionic liquid, preparation of a deep eutectic solvent, construction of a composite system, implementation of a condensation reaction, regeneration of catalytic active sites, pH adjustment, crystal separation and the like. According to the method, a temperature-responsive two-phase system formed by the functionalized ionic liquid and the deep eutectic solvent is combined with a catalyst regeneration process and a pH regulation crystallization separation technology, so that the greenization, high efficiency and integration of the dibenzoylmethane synthesis process are realized, the product purity and yield are remarkably improved, and the environmental pollution and the production cost are reduced.

The invention relates to a process for extracting alcohols from an initial mixture (1) comprising alcohols in aqueous phase, with:a distillative separation by an isopropanol-butanol distillation column (III) equipped at the top with a condenser (c3), intended for separating said mixture into a water-isopropanol azeotrope stream (6) at the top and into a water-butanol azeotrope stream (7) at the bottom,a distillative separation intended for separating the water-butanol azeotrope stream into water and butanol, by a hetero-azeotropic distillation system comprising at least one water-recovering water column (IV) and at least one butanol (9)-recovering butanol column (V) equipped with a reboiler (r5),such that a heat transfer is performed from the top water-isopropanol azeotrope stream (6) entering the condenser of the isopropanol-butanol distillation column (III), to the stream entering the reboiler of the butanol column (V).

The invention discloses a system device and a method for producing aldehyde compounds through supergravity two-phase hydroformylation. The system device comprises a supergravity reactor, a buffer tank, a first circulating pump, a tower kettle heat exchanger, a circulating heat exchanger, a split-phase tank, a second circulating pump, a crude aldehyde transfer pump, a supergravity rectification unit, a tower kettle reboiler, a product extraction pump and a cold and hot all-in-one machine. According to the system device, under the condition that a polar solvent and a surfactant are not added, the two-phase hydroformylation reaction process can be greatly enhanced through the supergravity reactor, the technological process is shortened, and then a product is separated and purified through the supergravity rectification unit to obtain an aldehyde compound; the problems of low two-phase hydroformylation reaction efficiency, serious self-polymerization in a hydroformylation product purification process and the like in the prior art are solved; by utilizing the method, the olefin conversion rate is more than 90%, the aldehyde selectivity of the product is more than 99%, the purity of the purified product is more than 99%, and the loss amount of the catalyst is less than or equal to 0.5 mg / kg.

The invention discloses a 1, 4-bis (4-fluorobenzoyl) benzene production waste utilization process, which belongs to the technical field of 1, 4-bis (4-fluorobenzoyl) benzene production, and comprises the following steps: dissolving waste leftovers in a solvent, and adsorbing and removing pigments and solid particles in the leftovers by activated carbon; carrying out dehalogenation and hydrogenation on the pretreated leftovers in the presence of a hydrogenation catalyst and an alkaline substance to produce 1, 4-biphenyl acyl benzene; and carrying out separation and purification on the hydrogenation product in a solution crystallization manner to obtain 1, 4-biphenyl acyl benzene with the purity of more than or equal to 99.75%. The waste leftovers are used for producing the 1, 4-biphenyl acyl benzene, so that the utilization rate of the raw materials is increased, the discharge of hazardous wastes is reduced, and the method is green and environment-friendly.

The invention relates to the technical field of eutectic crystals, in particular to a phloretin and nicotinamide eutectic crystal as well as a preparation method and application thereof, an XRD (X-Ray Diffraction) pattern of the eutectic crystal has characteristic diffraction peaks at least at positions where 2 theta angles are 14.54 degrees, 14.95 degrees, 15.28 degrees, 16.11 degrees, 16.71 degrees, 19.50 degrees, 23.14 degrees, 23.48 degrees, 26.00 degrees, 27.39 degrees and 32.66 degrees, and error tolerance of + / -0.2 degrees exists; in a DSC spectrum, characteristic endothermic peaks exist at 124.3 DEG C, 178.4 DEG C and 283.4 DEG C, and error tolerance of + / -0.2 DEG C exists. The preparation method comprises the following steps: dissolving nicotinamide and phloretin in water, and carrying out ultrasonic treatment, standing, crystallization, filtration, vacuum drying and grinding to obtain the eutectic crystal which can be applied to cosmetics, health care products, food and medicines. The eutectic crystal provided by the invention has the advantages of no irritation, high safety, easy absorption and good stability.

Provided is a method for industrially mass-producing β-ionone, which is useful as a perfume compound, by an inexpensive and safe method. Using 3-methylcyclohexanone as a starting material for synthesis, 6-methylaminomethylene-2,2,3-trimethylcyclohexanone is produced by introducing two methyl groups in one step into 6-methylaminomethylene-3-methylcyclohexanone. 6-Hydroxymethylene-2,2,3-trimethylcyclohexanone obtained by hydrolyzing 6-methylaminomethylene-2,2,3-trimethylcyclohexanone is used as an intermediate. After isomerizing γ-methylcyclocitral derived therefrom to β-methylcyclocitral, β-ionone is industrially mass-produced by subjecting this to an aldol condensation reaction with acetone.

The utility model discloses rectification equipment for removing light components from MIBK (methyl isobutyl ketone), and belongs to the technical field of chemical rectification. A rectifying tower of the rectifying equipment comprises a tower body with a cylindrical barrel structure, and a vertical partition plate is arranged in the tower body and divides the rectifying tower into a first pre-fractionation section, an azeotrope rectifying section, a stripping section, a second pre-fractionation section and an acetone rectifying section. By adopting the rectification equipment, an organic matter mixed solution containing light components such as 2-MPA and acetone from an MIBK synthesis system can be rectified, extracted and separated. A target product 2-MPA debounded region is obtained in the extraction section; a target product diacetone obtained in an acetone rectifying section of the rectifying tower is directly returned to an MIBK synthesis system as a raw material for use; a target product tri-MIBK solution obtained in the stripping section of the rectifying tower is subjected to boundary region rectification, and MIBK is separated. By utilizing the rectification equipment, the quantity of equipment can be reduced, the process flow is simplified, the device investment is reduced, the consumption of raw materials and energy in production is reduced, the production cost is reduced, and the carbon emission of a production device is reduced.

The invention discloses a production system and method for preparing high-carbon aldehyde through carbonyl synthesis of high-carbon olefin. The system comprises a reaction device, a separation device, an aldehyde condensing device, a product tank, a polymer supplementing unit and a recycling unit, the polymer supplementing unit is connected with the separating device; the cyclic utilization unit comprises an extraction separation device connected with a liquid phase outlet of the separation device, a polymer recovery device connected with a water phase outlet of the extraction separation device, and a catalyst regeneration device connected with an organic phase outlet of the extraction separation device. According to the method, a carbonyl metal catalytic system is adopted to catalyze reaction of high-carbon olefin and synthesis gas, and heating separation of reaction liquid is performed by introducing an organic polymer protection catalyst; the separated catalyst liquid phase is subjected to water extraction separation and post-treatment, and the organic polymer and the catalyst are recycled. Recycling of the catalyst and efficient separation of the product are realized, and the stability of the catalyst separation section is enhanced.

The invention discloses a cadinane type sesquiterpene as well as a preparation method and application thereof. The cadinane type sesquiterpene is separated from cinnamon bark, and has at least one of structural formulas shown as a formula (I), a formula (II), a formula (III) and a formula (IV). Liver protection activity evaluation is carried out by applying an alcohol-induced hepatocyte injury model, and it is found that the cadinane type sesquiterpene can effectively relieve alcohol-induced AML-12 hepatocyte injury; the dumarane sesquiterpenes can inhibit the alcoholic liver disease and relieve fat accumulation, so that the dumarane sesquiterpenes have the anti-alcoholic liver disease activity, can be applied to preparation of the anti-alcoholic liver disease drugs, and have good research and development prospects; belongs to the field of natural medicinal chemistry.

The invention provides an application of two polycyclic polyisopentenyl acyl phloroglucinol compounds (PPAP) with different skeleton types in preparation of drugs for relieving / treating neurodegenerative diseases. Belongs to the technical field of medicines. Hypheronone A provided by the invention is a 1, 9-split-ring polycyclic polyisopentenyl phloroglucinol compound, and hypheronone L is a polycyclic polyisopentenyl phloroglucinol compound which is formed by carrying out intramolecular [4 + 2] cyclization on a monocyclic polyisopentenyl phloroglucinol compound and has a complex ring system. The compound hypherone A and the compound hypherone L both have the activity of enhancing the current of a voltage-gated T-type calcium channel, can be used for preparing medicines for treating neurodegenerative diseases, particularly can be used for preparing medicines for relieving and / or treating diseases such as spinal cerebellar ataxia, Alzheimer's disease and intellectual syndrome, and have clinical application value.

The invention relates to the technical field of natural medicines, in particular to a preparation method of active ingredients in fructus psoraleae and application of the active ingredients in anti-inflammatory products, firstly, a fructus psoraleae reflux extract is properly enriched by using an extraction method, then selective separation is performed by using different separation modes of HSCCC, and the active ingredients in the fructus psoraleae are obtained. And 10 monomeric compounds are separated by combining a prepared liquid phase. Through cell experiments, four compounds of psoralen, neopsoralen isoflavone, psoralen flavanone and psoralen flavanone methyl ether, which can well inhibit NO release, are screened out; the four monomeric compounds can reduce secretion of proinflammatory factors by weakening mRNA transcriptional ability and weaken over-phosphorylation expression of pathway protein, so that an anti-inflammatory effect is achieved; through verification, the fructus psoraleae flavanone and the fructus psoraleae flavanone methyl ether can play an anti-inflammatory role through MAPK and NF-kappa B signal channels.

Disclosed is the use of a dividing-wall column in a process for co-producing propylene oxide and styrene monomer. Feed streams to a dividing-wall column comprise a bottoms product produced in recovering crude propylene oxide from an epoxidation reaction product, a hydrogenated byproduct styrene monomer production, and a light fraction of a bottoms product withdrawn from the dividing-wall column. Products from the dividing-wall column comprise an overhead product comprising ethylbenzene for recycle to an oxidation zone, an intermediate product comprising methylbenzyl alcohol and acetophenone as feed to a dehydration zone to produce styrene monomer, and a bottoms product comprising methylbenzyl alcohol and heavy materials.

The invention discloses a rapid distillation device for 2-chloro-1-(1-chlorocyclopropyl) ethanone and a processing technology, and relates to the technical field of distillation devices. The distillation kettle comprises a distillation kettle main body, a steam inlet pipe is fixedly connected to the lower part of the outside of the distillation kettle main body, a spraying device for circularly distilling 2-chloro-1-(1-chlorocyclopropyl) ethanone is arranged at the top of the distillation kettle main body, and a steam outlet pipe is fixedly connected to the top of the distillation kettle main body. Through cooperation of the motor, the rotating shaft, the flowering-shaped baffle, the vertical Z-shaped rod, the first layering frame, the connecting plate, the second layering frame, the first notch and the second notch, 2-chloro-1-(1-chlorocyclopropyl) ethanone in the first layering frame can enter the second layering frame through the first notch; one part of the second layering frame flows to the bottom of the distillation kettle main body through the second notch, so that a dispersed flowing state is formed, and the rapid distillation of 2-chloro-1-(1-chlorocyclopropyl) ethanone is ensured.

The invention discloses a treatment device for recovering 1, 3-cyclohexanedione from crystallization centrifugal mother liquor, which comprises a dissolving kettle, a discharge port of the dissolving kettle is communicated with a bleaching kettle, a discharge port of the bleaching kettle is communicated with a washing kettle, a discharge port of the washing kettle is communicated with a crystallization kettle, a discharge port of the crystallization kettle is communicated with a centrifugal machine, and a discharge port of the centrifugal machine is communicated with a drying machine. Solid-phase residues are discharged into a dissolving kettle, deionized water is added, stirring is started, then a proper amount of bromine and hydrogen peroxide are added, and materials in the kettle are heated; and transferring the materials in the dissolving kettle into a bleaching kettle. And after the bleaching agent is treated, the feed liquid in the bleaching kettle body is transferred into a washing kettle. The water-washed feed liquid is layered, a water phase layer enters a sewage treatment system through a sewage pipeline, and an organic phase layer enters a crystallization kettle through a delivery pump. And the cooled and crystallized feed liquid enters a centrifugal machine through a delivery pump. And after separation by a centrifugal machine, drying a solid-phase part by a drying machine, and packaging. In order to overcome the defects in the prior art, 1, 3-cyclohexanedione is recycled through the recycling device, pollution to the environment is reduced, and resource waste is avoided.

The invention provides a method for separating 2-methyl-6-propionyl naphthalene through melt crystallization, which comprises the following steps: reacting 2-methylnaphthalene with propionic anhydride under the action of a catalyst to obtain a 2-methyl-propionyl naphthalene mixture; the 2-methyl-propionyl naphthalene mixture is distilled, and a 2-methyl-propionyl naphthalene crude product is obtained; and carrying out melt crystallization on the 2-methyl-acyl naphthalene crude product to obtain the 2-methyl-6-propionyl naphthalene. According to the method for separating the 2-methyl-6-propionyl naphthalene through melt crystallization, after the crude product of the 2-methyl-6-propionyl naphthalene is obtained through distillation and purification, the high-purity 2-methyl-6-propionyl naphthalene can be obtained through a melt crystallization one-step method. The method has the advantages of simple process operation, high separation efficiency, low energy consumption, high product purity and the like.

This application discloses an acetaldehyde recovery device and method in the production of 1,3-butanediol, belonging to the field of fine chemicals. The device includes: a feed pump, a preheater, a distillation column, a falling film reboiler, a bottom circulating pump, a bottom cooler, a top primary condenser, a reflux ratio distributor, a top secondary condenser, a top product tank, a top transfer tank, a bottom product tank, a bottom transfer tank, a vacuum condenser, a vacuum pump inlet separator, a high vacuum unit, and a vacuum pump outlet separator. The horizontal condenser is directly installed at the top of the distillation column, giving it advantages such as simple structure, convenient operation, low pipeline loss, and high vacuum. A method for acetaldehyde recovery in the production of 1,3-butanediol using this device is also disclosed. Compared to existing technologies, this invention uses falling film evaporation combined with vacuum deep cooling, which avoids the thermal decomposition of 3-hydroxybutyraldehyde and achieves low-temperature, high-efficiency acetaldehyde recovery. It is suitable for continuous production.

A process of controlling heavies in a recycle catalyst stream, particularly, for use in a continuous hydroformylation process of converting an olefin with synthesis gas in the presence of a hydroformylation catalyst to form an aldehyde product stream with subsequent separation of the catalyst for recycle to the hydroformylation step. The process involves removing a crude product stream from a hydroformylation reaction zone comprising one or more aldehyde products, one or more heavies by-products, a transition metal-organophosphorous ligand complex catalyst, one or more unconverted reactants, and one or more inert lights; providing a water stream; combining the water stream with the crude product stream into an azeotropic vaporizer; removing from the vaporizer an overhead gas stream comprising one or more aldehyde products, one or more unconverted reactants, one or more inert lights, a portion of the water, and a portion of the heavies by-products, and feeding said overhead gas stream into a condenser; removing from the condenser an overhead gas stream comprising one or more unconverted reactants, a portion of the added water, and one or more inert lights; removing as a tails stream from the azeotropic vaporizer, a liquid recycle catalyst stream comprising the transition metal-organophosphorous ligand complex catalyst, the balance of the aldehyde product and the balance of the heavies by-products to be sent to the reaction zone wherein at least 25% of the aldehyde product recovered in overhead gas stream from the condenser is removed as a water azeotrope.

The reaction method comprises the following steps: mixing a raw material aldehyde and a liquid alkali catalyst, feeding the mixture into a condensation reaction coupling device to carry out an aldehyde condensation reaction, and under the action of negative pressure of a steam ejector and tower bottom heating, steaming out a gas-phase component generated by the aldehyde condensation reaction to an extraction separation condenser, after condensation, entering an extraction separator; one part of a mixture of a product and a liquid alkali catalyst after the aldehyde condensation reaction is heated and then returns to a condensation reaction tower coupling device, one part of the mixture is cooled by an oil-alkali separation cooler and then enters an oil-alkali separator, the separated liquid alkali catalyst is led out, one part of the product is led into an extraction separator, and the other part of the product is led out; the raw material aldehyde is extracted in the extraction separator, the extracted oil phase is conveyed back to the distillation section of the condensation reaction tower coupling device, and the water phase is discharged. The condensation reactor and the condensation circulating tower are coupled and transformed, reaction heat and product reflux are fully utilized, the technological process can be simplified, the operation flexibility can be improved, and energy consumption can be reduced.

The present invention discloses a method for highly selectively extracting vanillin using an ionic liquid / salt / sulfonylated calix[4]arene aqueous two-phase system. n The extract containing vanillin is added to the aqueous two-phase system of mim]Br / Na3C6H5O7 / SC[4], mixed, centrifuged to separate the two phases completely, and the upper phase is collected to obtain the extracted vanillin. n mim]Br / Na3C6H5O7 aqueous two-phase system increases the polarity difference between the two phases, promotes the formation of the two-phase system, improves the distribution coefficient of vanillin in the two-phase system, and can highly selectively extract vanillin from a variety of structural analogs. The method is simple and easy.

The utility model provides a feeding mechanism of an evaporator for formaldehyde preparation, which belongs to the technical field of industrial preparation, and comprises a methanol separation assembly, an adsorption structure and a feeding assembly, the tail end of the feeding assembly is provided with an evaporator, the methanol separation assembly comprises an evaporation barrel, and the lower surface of the evaporation barrel is fixedly connected with a No.1 strut. The methanol separation assembly and the adsorption structure are arranged, the evaporation barrel is heated through the heating pipe, the temperature of methanol liquid in the evaporation barrel can be increased, then methanol and water are separated, the stirring structure is controlled by the motor to rotate, the methanol separation speed can be increased, and the separation efficiency is improved. The evaporated and purified methanol gas contains part of water vapor, and the mixed gas passes through a methanol filter, so that the water vapor is filtered out, and the methanol gas can be continuously transmitted.

The present invention provides a method for preparing the active pharmaceutical ingredient of fenfluramine. Aspects of the present invention include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to prepare a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reducing and aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with a borohydride reducing agent and ethylamine to produce a fenfluramine composition. The present invention also provides a composition and a pharmaceutical ingredient comprising a pharmaceutically acceptable salt of fenfluramine prepared according to the method and having less than a total of 0.2% by weight of trifluoromethyl regioisomers.

The application discloses a kind of miraculin compounds and its extraction method and application, belong to the field of traditional Chinese medicine extraction, specifically related to a kind of miraculin compounds as shown in general formula (I) and (II) isolated from Rhododendron dauricum and the extraction method of the compound, and the compound or the isomer of the compound, or the inhibitory effect of the compound on inflammation in pharmaceutically acceptable salt or pharmaceutical composition comprising the compound can be used for preparing anti-inflammatory drugs.The application further enriches the structural diversity of active substances of Rhododendron dauricum, which lays a foundation for subsequent related biological activity tests of monomeric compounds, provides active lead compounds for new drug development, and also provides a theoretical basis for in-depth research and development of Rhododendron dauricum medicinal materials.

The invention relates to the technical field of plant extraction, and provides a plurality of phenolic compounds in senecio scandens, and a preparation method and application thereof. The method comprises the following steps: crushing senecio scandens, adding ethyl acetate, and performing ultrasonic heating, stirring and extracting to obtain an extracting solution; carrying out rotary evaporation and vacuum concentration on the extracting solution to obtain a crude extract; dissolving the crude extract by using absolute ethyl alcohol through ultrasonic heating, carrying out gradient elution through a macroporous adsorption resin chromatographic column, and collecting an ethanol water eluent; and concentrating the ethanol water eluent under reduced pressure, stirring with a reverse-phase filler, loading with a dry method, packing with a wet method, and sequentially performing isocratic elution with a reverse-phase chromatographic column and purification with a gel column. The dissolution efficiency of phenolic compounds in senecio scandens is improved through ultrasonic and mild heating, the problems that components are degraded due to high temperature in traditional reflux extraction and time and solvent are consumed in dipping extraction are solved, and target component residues are reduced; and then through gradient elution of a chromatographic separation column, isocratic elution of a reversed-phase chromatographic column and purification of a gel column, the problem that phenols are similar in structure and easy to co-elute is accurately solved.

The curcumin extraction device comprises a container body and a first shaft rod, the first shaft rod is inserted into the container body and can rotate along the axis of the first shaft rod, a plurality of stirring rods are installed on the circumferential outer wall of the first shaft rod, a connecting plate is installed on the side, away from the first shaft rod, of each stirring rod, a wheel body is installed on the connecting plate, and the axis of the wheel body is parallel to the axis of the first shaft rod. A bottom plate is mounted on the inner bottom surface of the container body, a second shaft rod is mounted at the upper end of the bottom plate, the axis of the second shaft rod is parallel to the axis of the wheel body, a rotating plate is mounted on the second shaft rod, the second shaft rod penetrates through the rotating plate, the rotating plate is provided with a wall surface, the wall surface is an arc surface, and when the wheel body rotates along the axis of the first shaft rod, the wheel body can roll on the wall surface. The utility model provides a curcumin extraction device which can improve the curcumin extraction efficiency.

The invention discloses a preparation method of curcumin, and belongs to the technical field of natural product extraction. The method comprises the following steps: firstly, adopting a modified deep-eutectic solvent into which propyl gallate is introduced as an extraction medium, and realizing high-selectivity extraction of curcumin through a special molecular structure of the modified deep-eutectic solvent; then the ultrasonic-microwave coupling technology is combined, so that the extraction efficiency is remarkably improved; finally, the modified molecularly imprinted polymer with magnetism is used for precise purification, the material has the specific recognition capacity and the rapid magnetic separation characteristic, polyethylene glycol is introduced to serve as a pore-foaming agent, and more active sites are provided for adsorption of curcumin molecules. According to the method disclosed by the invention, through collaborative innovation of all links, the whole process optimization from extraction to purification is realized, the product purity and the extraction efficiency are remarkably improved, the energy consumption and the solvent pollution are greatly reduced, and a reliable solution is provided for industrial production of the high-quality curcumin.