49 results about "Farnesol" patented technology

Described herein is the farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts, solvates, and formulations thereof.

The present invention relates to the field of pesticide technology, and more specifically to a fungicide composition that improves the effectiveness of preventing and treating jackfruit fruit rot. The fungicide composition, comprising a compound of farnesol and cyproconazole as active ingredients; the mass ratio of farnesol to cyproconazole is 1-9:5-1. Based on existing pesticides, the present invention compounds different active ingredients of pesticides to screen for synergistic combinations. This combination can improve the effectiveness of preventing and treating jackfruit fruit rot, reduce pesticide application dosage, and delay the development of drug resistance in pathogens.

The invention provides a mild whitening composition and application thereof, and relates to the technical field of cosmetics. The nicotinamide, the tranexamic acid, the Grass rose extract, the bisabolol and the plant zymolyte are matched, the optimal compatibility dosage is given, all the components take effect in a synergistic mode, irritation of a traditional whitening component can be obviously reduced, and the whitening effect is improved. The invention also finds that the Grass rose extract, the bisabolol and the plant zymolyte are added into the whitening component, so that the whitening effect of the whitening component can be obviously improved.

This article describes pharmaceutical formulations of the farnesol X receptor agonist 3-hydroxyazacyclobutane-trans-1-carboxylic acid 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octane-1-yl)methyl)carbamoyl)cyclohexyl ester, and methods of using such pharmaceutical formulations to treat conditions, diseases, or symptoms associated with farnesol X receptor activity.

The present invention relates to the technical field of pesticides, and in particular to an active foliar fertilizer with insecticidal efficacy. An insecticidal composition, characterized in that its active ingredient is a binary compound of cyclohexaprid and farnesol. The insecticidal mechanisms of farnesol and other active ingredients in the insecticidal composition of the present invention are different. When used in combination, they can effectively delay the development of insecticide resistance and extend the service life of the insecticidal composition. Secondly, the pest control effect can be improved, the amount of active ingredients used can be reduced, and the cost of pest control can be reduced. In addition, the active foliar fertilizer of the present invention contains both insecticidal ingredients and water-soluble fertilizer ingredients. When used, it can not only prevent and control crop pests, but also provide nutrients for crops. The two cooperate with each other to improve the yield and quality of crops.

The invention relates to the technical field of cigarette perfuming, in particular to a cellulose core wire for cigarette perfuming and a preparation method of the cellulose core wire. The preparation method comprises the following steps: dipping a core wire in an essence solution, taking out the core wire after dipping, and drying to obtain the cellulose core wire for cigarette perfuming, the core yarn is made of pure viscose yarn with the linear density of 110-120 tex, the S twist and the twist degree of 60-110 twists per meter. In the essence solution, essence components comprise isoamyl isovalerate, ethyl butyrate and farnesol, and a solvent is ethanol. According to the preparation method, the stability and uniformity of the incense line in subsequent use are remarkably improved, and the consistency of essence loading and releasing is guaranteed; in addition, the prepared cellulose core wire has excellent performance and good on-machine applicability, and the situation that the cellulose core wire is seriously deformed or broken or the like is not prone to occurring in the process of being implanted into cigarette components.

The invention discloses a bile acid derivative and application of the bile acid derivative as an FXR antagonist. The invention discloses a bile acid derivative with a novel structure. The bile acid derivative is a chiral isomer of taurochenodeoxycholic acid (salt). Technicians in the field know that generally, the biological activity of chiral isomers is close, however, the antagonistic activity of the bile acid derivative provided by the invention to farnesoid X receptors is 3-4 times that of the chiral isomers, and the technical effect is unexpected. Therefore, the compound provided by the invention can be used for preparing the farnesoid X receptor antagonist, and has the application prospect of being developed into drugs for preventing, treating or relieving diseases by antagonizing the farnesoid X receptor.

Described herein is a biochemically produced sandalwood oil including at least 85% santalol and bergamotol and 1% or less cis-lanceol, where the oil has one or more of the following features: i) 5% or less alpha-santalal; ii) 5% or less farnesol; and iii) 0.5% or less spirosantalol. Also described herein are a perfuming composition including the sandalwood oil and a perfuming consumer product including the sandalwood oil. Also described herein are a method of using the biochemically produced sandalwood oil as an anti-microbial and anti-inflammatory agent, and an arthropod control composition including the sandalwood oil.

The invention discloses a preparation method of all-trans-farnesol through a three-enzyme cascade reaction. The invention firstly provides a mutant of farnesyl pyrophosphate synthase, and the amino acid sequence of the mutant is shown as SEQ ID No.3. Compared with a wild type, the mutant is applied to enzyme catalytic synthesis of farnesol, so that the conversion rate of a gold product is remarkably improved. The invention also provides a three-enzyme cascade reaction preparation method of farnesol, which comprises the following steps: in the same reaction system, dimethyl allyl diphosphate is used as a substrate; according to the method, isopentenyl diphosphate isomerase, farnesyl pyrophosphate synthase or a mutant thereof and farnesyl pyrophosphatase are used as catalytic enzymes for enzymatic reaction to prepare all-trans-farnesyl alcohol. According to the invention, in a single reaction system, three key enzymes are combined for application, so that continuous catalysis, high-efficiency and high-selectivity preparation of all-trans-farnesol is realized, process steps are simplified, and a new way is provided for green and efficient preparation of farnesol.

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of teprenone. The invention aims to solve the technical problems that the existing teprenone synthesis route is complicated, the stereo configuration of a synthesis precursor is difficult to control and the like. According to the method, alpha-farnesene, beta-farnesene, farnesol and nerolidol which are sourced from microbial fermentation are used for preparing a farnesyl acetone crude product, and then high-purity all-trans (5E, 9E)-farnesyl acetone is obtained through rectification, or all-trans (5E, 9E)-farnesyl acetone is directly synthesized from beta-farnesene and farnesol. Therefore, commercial teprenone with qualified quality can be obtained through subsequent reaction.

The application relates to the technical field of pharmaceutical preparations, and provides an ivermectin external pharmaceutical composition, a preparation method and application.The ivermectin external pharmaceutical composition is mainly composed of ivermectin, a permeation enhancer combination, oil ingredients, an emulsifier, a viscosity regulator and a carrier; the ivermectin content is 0.60%-1.00% w / w; the permeation enhancer combination is a combination of diethylene glycol monoethyl ether, decyl umbelliferrone polyoxyethylene ether 8 and farnesol, and the content is 10%-15% w / w.The application overcomes the defects of the prior art, the composition not only has improved skin permeability and retention, but also is stable and non-greasy, and meanwhile, the production process has scalability, and can ensure uniform dispersion of active ingredients and auxiliary materials.

The present invention discloses the use of Farnesol in regulating STING expression in vulvovaginal candidiasis. The present invention also provides the use of Farnesol in screening agents that promote the binding of Farnesol and STING, and in preparing STING expression regulators. The present invention provides various methods, including methods for screening drugs for treating vulvovaginal candidiasis, methods for screening compounds that affect the binding of Farnesol and STING, methods for regulating STING expression in in vitro cells, computer-assisted drug screening methods based on Farnesol and STING, and computer-assisted drug screening methods that promote the binding activity of Farnesol and STING. The present invention also provides a computer-assisted drug screening system based on Farnesol and STING, as well as a computer-assisted drug screening system that promotes the binding activity of Farnesol and STING. The present invention also provides computer-assisted drug screening equipment and computer-readable storage media.

The invention discloses a plant extract-containing composition applied to eczema and application of the plant extract-containing composition, and belongs to the technical field of cosmetics. The composition is prepared from the following components in parts by mass: 2 to 20 parts of folium mori extract, 2 to 20 parts of aloe barbadensis leaf polysaccharide, 2 to 20 parts of colloidal oat powder, 0.5 to 12 parts of bisabolol, 2 to 20 parts of ceramide, 15 to 40 parts of herba portulacae extract, 15 to 40 parts of radix gentianae extract and 15 to 40 parts of radix arnebiae seu lithospermi extract. The composition provided by the invention breaks through the limitation of a traditional single target spot, realizes four-dimensional regulation and control of inflammation control, targeted soothing, micro-ecological regulation and barrier reconstruction, and has a better treatment effect on eczema.

The present invention belongs to the technical field of pesticide compounding and relates to a composition containing polyoxin and difenoconazole. The present invention provides a composition containing polyoxin and difenoconazole, the active ingredients of which include a fungicide and a synergist; the fungicide is polyoxin and difenoconazole, and the synergist is farnesol. Within a certain ratio range, the composition performs excellently in preventing and treating plant fungal diseases, and is superior to the single dosage of each component. Further experiments of the present invention have found that the introduction of a synergist further improves the control effect of the composition on plant fungal diseases.

The invention discloses a composition for rapidly removing acnes and acne marks and a preparation method thereof, relates to the field of material science, and aims to solve the problem that the existing product has side effects on skin due to strong stripping agents, drying agents, hormones and the like, preparation raw materials and a reaction device of the composition for rapidly removing acnes and acne marks are firstly prepared; the preparation method comprises the following steps: preparing glycerol, carbomer and deionized water, preparing bisabolol from farnesol with the purity of 99.99% and a palladium-carbon catalyst with the purity of 5%, preparing microcapsules from the preparation raw materials by adopting an emulsification-crosslinking method, optimizing the microcapsules by adjusting parameters, finally mixing the prepared microcapsules with the remaining glycerol, carbomer and deionized water, and uniformly stirring to obtain the bisabolol microcapsule. According to the composition for rapidly removing acnes and acne marks, the performance of the prepared product can be improved, and meanwhile pollution in the production process is reduced.

This invention discloses a composition for improving chicken feed conversion efficiency and its application. The composition comprises *Romebutzella roximatei* post-biotic, farnesol, and paeonol in a mass ratio of 2:1:1. The composition is directly added to the feed at a dosage of 1% of the total weight of the chicken feed. This invention finds that the composition formed by the mixture of *Romebutzella roximatei* post-biotic, farnesol, and paeonol, when used as a feed additive, exhibits high safety, no toxic side effects, and can significantly improve broiler feed conversion efficiency, broiler growth performance and meat quality, and laying hen egg production performance and egg quality.

The present application relates to farnesol X receptor agonists for the treatment of disease. Described herein are the use of farnesoid X receptor (FXR) agonists, alone or in combination with additional therapy, in the treatment or prevention of diseases, conditions, or conditions that would benefit from therapy with FXR agonists.

The present disclosure relates in some aspects to compositions, such as pharmaceutical compositions for topical administration, which are useful for treating or preventing hair loss, hair graying, and dermatological conditions in a subject, such as comprising a terpene, for example farnesol. Also provided are kits comprising the compositions, and methods of using the compositions for treating or preventing hair loss, hair graying, and dermatological conditions.

The invention provides an application of inhibiting farnesol dehydrogenase in enhancing the toxicity of trifloxacin, and belongs to the technical field of pest control. The invention provides an application of inhibiting farnesol dehydrogenase in enhancing the toxicity of trifluoro-sassen ester. By inhibiting the expression of the farnesol dehydrogenase, the toxicity of the trifloxystrobin can be improved, and the pest control effect of the trifloxystrobin is improved. The result of the embodiment shows that the expression of the aedes aegypti farnesol dehydrogenase FDL22 and the expression of the green peach aphid farnesol dehydrogenase FDL242 are silenced by dsRNA, and the toxicity of the trifluorocide to the aedes aegypti and the green peach aphid can be remarkably improved. The juvenile hormone analogue S-(+)-methoprene is used in combination with the trifluoro-nematicidal ester, so that the toxicity of the trifluoro-nematicidal ester to aedes aegypti larvae can be remarkably improved.

The application relates to the technical field of daily chemicals, and particularly discloses a bacteriostatic and deodorizing fragrance composition as well as a preparation method and application thereof. The bacteriostatic and deodorizing fragrance composition is made of raw materials and comprises the following components: a chemical reaction type deodorizing fragrance base, a sensory modification and receptor blocking fragrance base and a bacteriostatic synergistic fragrance base. The chemical reaction type deodorizing fragrance base is a combination of one or more of citral, citronellal, decanal, damascone, ionone and methyl dihydrojasmonate; the sensory modification and receptor blocking fragrance base is a combination of one or more of menthol and its derivatives, linalyl acetate, dihydromyrcenol and eucalyptol; and the bacteriostatic synergistic fragrance base is a combination of one or more of farnesol, eugenol, thymol, tea tree oil and rosemary extract. The bacteriostatic and deodorizing fragrance composition can keep a better balance and coordination of the sensory modification, chemical deodorization and bacteriostatic components in the fragrance, and thus can exert excellent deodorization and bacteriostatic effects.

The application belongs to the technical field of cosmetics, and discloses a composition with instant soothing effect, a preparation method and application thereof. The composition comprises components: hydroxyphenylpropionamide benzoic acid and / or mother chamomile flower oil, farnesol and / or hydroxyl asperosaponin, kava pepper leaf / root / stem extract and / or menthol lactate, and edelweiss callus extract. The composition has significant soothing effect and can instantly soothe, thereby instantly relieving the uncomfortable feeling such as stinging, burning, swelling and itching, through reasonable compounding of hydroxyphenylpropionamide benzoic acid and / or mother chamomile flower oil, farnesol and / or hydroxyl asperosaponin, kava pepper leaf / root / stem extract and / or menthol lactate, and edelweiss callus extract.

This invention relates to the field of gene technology, specifically disclosing a method for enhancing the secretion of secondary metabolites based on the regulation of quorum sensing signal molecules. This method activates the expression of bacterial secondary metabolite synthesis gene clusters through bacterial-fungal interaction, comprising the following steps: (a) co-culturing bacteria and fungi in contact or non-contact mode; (b) during co-culturing, the fungi secrete the quorum sensing signal molecule farnesol; (c) the bacteria sense farnesol through a two-component system, activating the expression of secondary metabolite synthesis genes. This invention effectively overcomes the gene silencing problem caused by metabolic load or lack of regulation in natural strains by activating the originally trace expression of secondary metabolite synthesis gene clusters in bacteria using the fungal-derived quorum sensing signal molecule farnesol.

The invention belongs to the technical field of cosmetics, and particularly relates to a mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition and a preparation method thereof. The invention provides a mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition. The hair conditioner comprises the following components: selenium disulfide, bisabolol, ceramide, polypeptide, vitamin E, hydrolyzed keratin, amino acid, panthenol, a humectant, a chelating agent, a macromolecular hair conditioner, a thickener, a cationic hair conditioner, an emulsifier, a silicone oil hair conditioner, a vegetable oil hair conditioner, a pH regulator, a preservative and an aromatic. Correspondingly, the invention further provides a preparation method of the mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition. According to the mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition disclosed by the invention, the dandruff is removed by utilizing the selenium disulfide, conditioning and mild raw materials are synergistically compounded with the selenium disulfide, and the mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition disclosed by the invention is obtained by optimizing the optimal proportion of the raw materials.

The invention provides a method for reducing the content of farnesol in (-)-alpha-bisabolol based on an oxidation process, and belongs to the technical field of medicinal chemistry and biosynthesis. The method comprises the following steps: (1) impurity removal: mixing a (-)-alpha-bisabolol or (-)-alpha-bisabolol solution, an organic solvent and metal salt for reaction; (2) post-treatment; after the reaction is finished, an alkaline aqueous solution is added into a reaction solution obtained in the step (1), phase splitting is conducted, an organic phase is taken to be distilled and concentrated, a purified (-)-alpha-bisabolol product is obtained, and the content of farnesol is smaller than or equal to 0.05%. Compared with an existing method, the method has the advantages of being easy to operate, free of by-products, low in cost, easy to amplify production and the like, a brand new solution is provided for improving the quality and use safety of the bisabolol, and an efficient, green and safe industrialization scheme is provided for application of the bisabolol in the field of cosmetics.

The invention belongs to the technical field of biological medicine, and particularly relates to application of farnesol in preparation of a medicine for resisting senescence of mesenchymal stem cells. The invention discloses farnesol as a traditional Chinese medicine monomer for the first time, which can effectively slow down the aging of adriamycin-induced adipose-derived stem cells in vitro, and can be used for preparing the anti-aging medicines for the mesenchymal stem cells. The farnesol can be used for removing aged adipose-derived stem cells and maintaining the steady state of a cell microenvironment. After treatment with 2 [mu] M farnesol for 24 h, key senescence markers such as P53 and P21 in adriamycin-induced senescence adipose-derived stem cells are significantly reduced, which indicates that farnesol can down-regulate senescence signal pathways in cells.

The invention discloses a moisturizing, soothing, refreshing, light, thin and easy-to-smear sunscreen rod, and belongs to the technical field of cosmetics. According to the sunscreen stick prepared by the invention, the polymer (ethylhexyl acrylate / methyl methacrylate copolymer) is firstly mixed with the ultraviolet absorbent for coating, so that the SPF value is increased, and meanwhile, the damage of the ultraviolet absorbent to the skin is avoided; meanwhile, the plant extracts (centella asiatica, aloe and saussurea involucrata) and a mixed system of bisabolol and menthol are mixed and matched with each other to achieve synergistic interaction, so that the moisturizing and soothing effects are achieved. In addition, the formula and the content of the grease and the thickening agent can be further optimized, and the prepared sunscreen stick is lighter, thinner and easy to smear.

The invention relates to a lasioderma serricorne pest attractant and a trapper. The attractant is composed of a sex pheromone composition and a food source odor compound. The sex pheromone composition is prepared from 4S, 6S-dimethyl-7S-hydroxy-3-nonanone and cis-9-tricosene, and the food source odor compound is prepared from beta-caryophyllene, farnesol and anisyl phenylacetate. The trap contains the attractant. The sex pheromone composition and the food source smell volatile matter have a synergistic effect, so that the attractant has a very good attraction effect on the lasioderma serricorne, can be used for monitoring and large-area prevention and control of the lasioderma serricorne, and has a relatively good application prospect.

The present application relates to the field of cosmetic technology, and discloses a kind of externally used cosmetic composition.The composition includes the following weight parts of effective component: azelaic acid 0.1-30 parts, farnesol 0.01-2 parts, white willow bark extract 0.01-5 parts, Egyptian blue lotus flower extract 0.01-5 parts, kale extract 0.01-5 parts and yarrow extract 0.1-5 parts.The present application also provides the use of the composition, which has the effect of bacteriostasis and anti-inflammation, and improves skin sebum secretion, so that it can be used for acne, fade acne marks, and repair various skin damage caused by acne, and for preparing various externally used cosmetic preparations, such as essence, emulsion, cream, etc.for anti-acne repair.In addition, the effective components contained in the composition include natural plant extracts, which can effectively reduce the irritation of azelaic acid to the skin, and help the composition to maintain a good skin feel of mildness and non-irritation.

The present application relates to the technical field of medicine and daily chemical products, and discloses a composition, a product containing the same, a preparation method of the composition, and application of the composition.The composition comprises 0.8-1.2 parts of zinc pyrithione, 0.5-0.8 parts of salicylic acid, 0.1-0.2 parts of farnesol, 0.2-0.4 parts of gentiana scabra extract, 0.3-0.5 parts of portulaca oleracea extract, 0.5-1.0 parts of camellia sinensis seed cake extract, 0.1-0.3 parts of caffeine, and 0.3-0.5 parts of rosemary extract, in terms of mass fraction.The composition realizes improvement in aspects of skin lesion area, water content in the scalp stratum corneum, trans-epidermal water loss, oil secretion, high-temperature stability, centrifugal stability, freeze-thaw cycle stability, dandruff removal, anti-inflammatory effect, hair fixing, and / or anti-itching effect.

The invention relates to rhodiospora yunnanensis, a biological preparation, a preparation method and application, and belongs to the technical field of microbial fermentation and tobacco processing. The preservation number of the provided Erythrobasidium yunnanense SC-9 is CGMCC (China General Microbiological Culture Collection Center) No.34233, and the preservation number of the provided Erythrobasidium yunnanense SC-9 is CGMCC No.34233. The provided strain can directionally regulate and control the fermentation process of cigar tobacco leaves, and through the unique metabolic capability of the strain, aroma substances, such as megastigmatrienone, 3, 3, 4, 6-tetramethyl-2, 3-dihydrobenzofuran-2-one, 5, 6-epoxy-7-megastigmatriene-3, 6-dione, 3, 3, 4, 6-tetramethyl-2, 3-dihydrobenzofuran-2-one, 5, 6-epoxy-7-megastigmatriene-3, 6-dione, 3, 3, 4, 6-tetramethyl-2, 3-dihydrobenzofuran-2-one, 3, 3, 4, 6-tetramethyl-2-one, 3, 3, 4, 6-tetramethyl-2, 3 The composition is prepared from 1, 9-diol, farnesol, acorene, alpha-ionol, cedar enediol, sclareol, betulinic aldehyde and the like, and meanwhile, the content of nicotine can be reduced.