24 results about "Farnesol" patented technology

Described herein is the farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts, solvates, and formulations thereof.

The invention provides a mild whitening composition and application thereof, and relates to the technical field of cosmetics. The nicotinamide, the tranexamic acid, the Grass rose extract, the bisabolol and the plant zymolyte are matched, the optimal compatibility dosage is given, all the components take effect in a synergistic mode, irritation of a traditional whitening component can be obviously reduced, and the whitening effect is improved. The invention also finds that the Grass rose extract, the bisabolol and the plant zymolyte are added into the whitening component, so that the whitening effect of the whitening component can be obviously improved.

The invention discloses a preparation method of all-trans-farnesol through a three-enzyme cascade reaction. The invention firstly provides a mutant of farnesyl pyrophosphate synthase, and the amino acid sequence of the mutant is shown as SEQ ID No.3. Compared with a wild type, the mutant is applied to enzyme catalytic synthesis of farnesol, so that the conversion rate of a gold product is remarkably improved. The invention also provides a three-enzyme cascade reaction preparation method of farnesol, which comprises the following steps: in the same reaction system, dimethyl allyl diphosphate is used as a substrate; according to the method, isopentenyl diphosphate isomerase, farnesyl pyrophosphate synthase or a mutant thereof and farnesyl pyrophosphatase are used as catalytic enzymes for enzymatic reaction to prepare all-trans-farnesyl alcohol. According to the invention, in a single reaction system, three key enzymes are combined for application, so that continuous catalysis, high-efficiency and high-selectivity preparation of all-trans-farnesol is realized, process steps are simplified, and a new way is provided for green and efficient preparation of farnesol.

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of teprenone. The invention aims to solve the technical problems that the existing teprenone synthesis route is complicated, the stereo configuration of a synthesis precursor is difficult to control and the like. According to the method, alpha-farnesene, beta-farnesene, farnesol and nerolidol which are sourced from microbial fermentation are used for preparing a farnesyl acetone crude product, and then high-purity all-trans (5E, 9E)-farnesyl acetone is obtained through rectification, or all-trans (5E, 9E)-farnesyl acetone is directly synthesized from beta-farnesene and farnesol. Therefore, commercial teprenone with qualified quality can be obtained through subsequent reaction.

The application relates to the technical field of pharmaceutical preparations, and provides an ivermectin external pharmaceutical composition, a preparation method and application.The ivermectin external pharmaceutical composition is mainly composed of ivermectin, a permeation enhancer combination, oil ingredients, an emulsifier, a viscosity regulator and a carrier; the ivermectin content is 0.60%-1.00% w / w; the permeation enhancer combination is a combination of diethylene glycol monoethyl ether, decyl umbelliferrone polyoxyethylene ether 8 and farnesol, and the content is 10%-15% w / w.The application overcomes the defects of the prior art, the composition not only has improved skin permeability and retention, but also is stable and non-greasy, and meanwhile, the production process has scalability, and can ensure uniform dispersion of active ingredients and auxiliary materials.

The invention discloses a plant extract-containing composition applied to eczema and application of the plant extract-containing composition, and belongs to the technical field of cosmetics. The composition is prepared from the following components in parts by mass: 2 to 20 parts of folium mori extract, 2 to 20 parts of aloe barbadensis leaf polysaccharide, 2 to 20 parts of colloidal oat powder, 0.5 to 12 parts of bisabolol, 2 to 20 parts of ceramide, 15 to 40 parts of herba portulacae extract, 15 to 40 parts of radix gentianae extract and 15 to 40 parts of radix arnebiae seu lithospermi extract. The composition provided by the invention breaks through the limitation of a traditional single target spot, realizes four-dimensional regulation and control of inflammation control, targeted soothing, micro-ecological regulation and barrier reconstruction, and has a better treatment effect on eczema.

The present disclosure relates in some aspects to compositions, such as pharmaceutical compositions for topical administration, which are useful for treating or preventing hair loss, hair graying, and dermatological conditions in a subject, such as comprising a terpene, for example farnesol. Also provided are kits comprising the compositions, and methods of using the compositions for treating or preventing hair loss, hair graying, and dermatological conditions.

The application relates to the technical field of daily chemicals, and particularly discloses a bacteriostatic and deodorizing fragrance composition as well as a preparation method and application thereof. The bacteriostatic and deodorizing fragrance composition is made of raw materials and comprises the following components: a chemical reaction type deodorizing fragrance base, a sensory modification and receptor blocking fragrance base and a bacteriostatic synergistic fragrance base. The chemical reaction type deodorizing fragrance base is a combination of one or more of citral, citronellal, decanal, damascone, ionone and methyl dihydrojasmonate; the sensory modification and receptor blocking fragrance base is a combination of one or more of menthol and its derivatives, linalyl acetate, dihydromyrcenol and eucalyptol; and the bacteriostatic synergistic fragrance base is a combination of one or more of farnesol, eugenol, thymol, tea tree oil and rosemary extract. The bacteriostatic and deodorizing fragrance composition can keep a better balance and coordination of the sensory modification, chemical deodorization and bacteriostatic components in the fragrance, and thus can exert excellent deodorization and bacteriostatic effects.

The application belongs to the technical field of cosmetics, and discloses a composition with instant soothing effect, a preparation method and application thereof. The composition comprises components: hydroxyphenylpropionamide benzoic acid and / or mother chamomile flower oil, farnesol and / or hydroxyl asperosaponin, kava pepper leaf / root / stem extract and / or menthol lactate, and edelweiss callus extract. The composition has significant soothing effect and can instantly soothe, thereby instantly relieving the uncomfortable feeling such as stinging, burning, swelling and itching, through reasonable compounding of hydroxyphenylpropionamide benzoic acid and / or mother chamomile flower oil, farnesol and / or hydroxyl asperosaponin, kava pepper leaf / root / stem extract and / or menthol lactate, and edelweiss callus extract.

This invention relates to the field of gene technology, specifically disclosing a method for enhancing the secretion of secondary metabolites based on the regulation of quorum sensing signal molecules. This method activates the expression of bacterial secondary metabolite synthesis gene clusters through bacterial-fungal interaction, comprising the following steps: (a) co-culturing bacteria and fungi in contact or non-contact mode; (b) during co-culturing, the fungi secrete the quorum sensing signal molecule farnesol; (c) the bacteria sense farnesol through a two-component system, activating the expression of secondary metabolite synthesis genes. This invention effectively overcomes the gene silencing problem caused by metabolic load or lack of regulation in natural strains by activating the originally trace expression of secondary metabolite synthesis gene clusters in bacteria using the fungal-derived quorum sensing signal molecule farnesol.

The invention belongs to the technical field of cosmetics, and particularly relates to a mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition and a preparation method thereof. The invention provides a mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition. The hair conditioner comprises the following components: selenium disulfide, bisabolol, ceramide, polypeptide, vitamin E, hydrolyzed keratin, amino acid, panthenol, a humectant, a chelating agent, a macromolecular hair conditioner, a thickener, a cationic hair conditioner, an emulsifier, a silicone oil hair conditioner, a vegetable oil hair conditioner, a pH regulator, a preservative and an aromatic. Correspondingly, the invention further provides a preparation method of the mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition. According to the mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition disclosed by the invention, the dandruff is removed by utilizing the selenium disulfide, conditioning and mild raw materials are synergistically compounded with the selenium disulfide, and the mild conditioning type selenium disulfide anti-dandruff itching-relieving hair care composition disclosed by the invention is obtained by optimizing the optimal proportion of the raw materials.

The invention provides a method for reducing the content of farnesol in (-)-alpha-bisabolol based on an oxidation process, and belongs to the technical field of medicinal chemistry and biosynthesis. The method comprises the following steps: (1) impurity removal: mixing a (-)-alpha-bisabolol or (-)-alpha-bisabolol solution, an organic solvent and metal salt for reaction; (2) post-treatment; after the reaction is finished, an alkaline aqueous solution is added into a reaction solution obtained in the step (1), phase splitting is conducted, an organic phase is taken to be distilled and concentrated, a purified (-)-alpha-bisabolol product is obtained, and the content of farnesol is smaller than or equal to 0.05%. Compared with an existing method, the method has the advantages of being easy to operate, free of by-products, low in cost, easy to amplify production and the like, a brand new solution is provided for improving the quality and use safety of the bisabolol, and an efficient, green and safe industrialization scheme is provided for application of the bisabolol in the field of cosmetics.

The invention belongs to the technical field of biological medicine, and particularly relates to application of farnesol in preparation of a medicine for resisting senescence of mesenchymal stem cells. The invention discloses farnesol as a traditional Chinese medicine monomer for the first time, which can effectively slow down the aging of adriamycin-induced adipose-derived stem cells in vitro, and can be used for preparing the anti-aging medicines for the mesenchymal stem cells. The farnesol can be used for removing aged adipose-derived stem cells and maintaining the steady state of a cell microenvironment. After treatment with 2 [mu] M farnesol for 24 h, key senescence markers such as P53 and P21 in adriamycin-induced senescence adipose-derived stem cells are significantly reduced, which indicates that farnesol can down-regulate senescence signal pathways in cells.

The invention discloses a moisturizing, soothing, refreshing, light, thin and easy-to-smear sunscreen rod, and belongs to the technical field of cosmetics. According to the sunscreen stick prepared by the invention, the polymer (ethylhexyl acrylate / methyl methacrylate copolymer) is firstly mixed with the ultraviolet absorbent for coating, so that the SPF value is increased, and meanwhile, the damage of the ultraviolet absorbent to the skin is avoided; meanwhile, the plant extracts (centella asiatica, aloe and saussurea involucrata) and a mixed system of bisabolol and menthol are mixed and matched with each other to achieve synergistic interaction, so that the moisturizing and soothing effects are achieved. In addition, the formula and the content of the grease and the thickening agent can be further optimized, and the prepared sunscreen stick is lighter, thinner and easy to smear.

The present application relates to the technical field of medicine and daily chemical products, and discloses a composition, a product containing the same, a preparation method of the composition, and application of the composition.The composition comprises 0.8-1.2 parts of zinc pyrithione, 0.5-0.8 parts of salicylic acid, 0.1-0.2 parts of farnesol, 0.2-0.4 parts of gentiana scabra extract, 0.3-0.5 parts of portulaca oleracea extract, 0.5-1.0 parts of camellia sinensis seed cake extract, 0.1-0.3 parts of caffeine, and 0.3-0.5 parts of rosemary extract, in terms of mass fraction.The composition realizes improvement in aspects of skin lesion area, water content in the scalp stratum corneum, trans-epidermal water loss, oil secretion, high-temperature stability, centrifugal stability, freeze-thaw cycle stability, dandruff removal, anti-inflammatory effect, hair fixing, and / or anti-itching effect.

The invention relates to the technical field of cosmetics, in particular to a preparation method and application of a wrinkle-removing and firming composition for improving the young state of skin. The composition comprises nanoparticles, a laminaria wedges extract, menthol acetate and farnesol which have a synergistic compounding effect, and can regulate the hydration capacity of epidermal layer cells, improve the reaction capacity of the dermal layer cells to external pressure, promote the resilience force of fibers, adjust the fiber trend, prevent uniform wrinkle directions, prevent deep lines generated by repeated external pressure and improve the skin elasticity of the skin. The function of an epidermis granular layer can be improved, the effect of filtering ultraviolet rays of the skin is enhanced, elastic hyperplasia wrinkles generated by light aging are prevented, and therefore the effects of removing the wrinkles, tightening the wrinkles and improving the young state of the skin are achieved. The composition not only has an excellent effect, but also has good safety and applicability, and has a wide market application prospect.

The application discloses a method for preparing farnesol from nerolidol, wherein a composite catalytic system composed of a phosphate and a vanadate or molybdate is used to perform isomerization reaction on nerolidol to prepare farnesol. The synthetic route of the application is simple, the catalytic system is simple and easy to obtain, the reaction process is simple, the isomerization reaction has very high chemical selectivity and stereoselectivity, and the synthesis method of farnesol is greatly simplified.

The invention relates to an oral care composition capable of preventing tooth decay and resisting saccharic acid and application of the oral care composition. The oral care composition comprises sodium monofluorophosphate, zinc citrate, calcium glycerophosphate, vitamin C, tocopheryl acetate, stevia rebaudiana leaf / stem extract, ginger root extract and bisabolol. By reasonably compounding various active components, the components can synergistically play a role, excellent tooth decay prevention and saccharic acid resistance effects are shown, the fluorine content is low, and the composition is suitable for children to use.

This application discloses a composition for combating necrotizing enteritis in chickens and its application. The active ingredients in the composition, by weight, consist of 5 parts paeonol, 5 parts farnesol, and 1 part soy saponin. This composition can also be formulated into oral liquids, tablets, granules, or powders using paeonol, farnesol, and soy saponin as active ingredients and excipients, with a dosage of 100-1000 mg / kg body weight; or the composition can be directly added to feed at a dosage of 0.1%-1% of the total weight of the chicken feed. The composition formed by paeonol, farnesol, and soy saponin provided in this application, as a drug, has high safety and no toxic side effects. It can effectively inhibit the proliferation of chicken-derived pathogens such as Clostridium perfringens, Salmonella, and Escherichia coli, effectively increase the antibody titer of Newcastle disease vaccine, and alleviate the reduction in chicken production performance, the increase in pro-inflammatory cytokines, and the impairment of intestinal absorption and barrier function caused by coccidiosis and necrotizing enteritis.

The application provides application of a reagent for detecting farnesol content in preparation of a kit, and the kit is used for diagnosing tumors and / or judging tumor prognosis. Through detection of the farnesol content, tumors can be accurately diagnosed, and the prognosis effect of the tumors can be judged, and the kit has scientific research value and clinical application value.

The invention relates to application of a composition and application of farnesol in preparation of an aspergillus fumigatus resistant medicine, and belongs to the technical field of aspergillus fumigatus resistant medicines. The drug combination composition is prepared from farnesol and amphotericin B. The invention further discloses a preparation method of the drug combination composition. Farnesol is used as a synergist for resisting aspergillus fumigatus, the combined composition of farnesol and amphotericin B is obtained, and the minimum inhibitory concentration of amphotericin B for resisting aspergillus fumigatus can be synergistically reduced; farnesol and amphotericin B are combined for use, so that the growth of aspergillus fumigatus hyphae can be synergistically inhibited; farnesol and amphotericin B are combined for use, so that an aspergillus fumigatus biological membrane can be synergistically destroyed, and the defect of high toxicity caused by single use of amphotericin B in the background technology is overcome.

The invention discloses a composition containing ganoderma sinensis fermented filtrate and application of the composition in skin repairing and whitening. The invention belongs to the technical field of cosmetics, and provides a composition which comprises ganoderma sinensis fermentation filtrate, tocopheryl acetate, ascorbyl glucoside, bisabolol, madecassic acid and ferulic acid. The natural multi-effect Ganoderma sinensis fermentation filtrate is taken as a core basis, two core pain points of skin barrier damage and melanin deposition are solved in a targeted manner, specific components are compounded, and multi-dimensional synergistic interaction of skin repair'anti-inflammation-infiltration promotion-active reconstruction 'and whitening'enzyme inhibition-reduction-stabilization-antioxidation' is realized, so that the skin care effect is improved, and the skin care effect is achieved. Meanwhile, the skin microenvironment and the stability of active ingredients are optimized, a synergistic effect is achieved through multiple channels, multi-directional repairing is achieved, the obvious effects of promoting skin barrier repairing, reducing inflammatory hyperpigmentation and inhibiting melanogenesis are achieved, and the composition can be used for preparing more cosmetics for repairing skin and whitening and brightening the skin.

Described herein is the use of farnesoid X receptor (FXR) agonists, alone or in combination with additional treatments, in the treatment or prevention of diseases, conditions, or disorders that would benefit from treatment with an FXR agonist.

The invention discloses an application of penicillium kluyvei in improving stress resistance of plants, and relates to the technical field of microorganisms. According to the application, a composite microbial agent containing penicillium kirschweri is prepared and used for planting plants and improving the stress resistance of the plants, and the composite microbial agent comprises penicillium kirschweri, streptomyces flavus HKS1408, bacillus velezensis NKY1 and farnesol; wherein the name of the penicillium kenii strain is penicillium kenii 23301-20, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.41049, the preservation time is January 22, 2024, and the preservation unit is China General Microbiological Culture Collection Center. The complex microbial inoculant has a prominent effect in the aspect of improving the stress resistance of plants. By adding farnesol, the effect of improving the stress resistance of the plant by the fungicide is enhanced.