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103 results about "Tyrosol" patented technology

Tyrosol is a phenylethanoid, a derivative of phenethyl alcohol. It is a natural phenolic antioxidant present in a variety of natural sources. The principal source in the human diet is olive oil. It is also one of the main natural phenols in argan oil.

Glycosyl transferase mutant and application thereof in salidroside synthesis

According to the glycosyl transferase mutant provided by the invention, the region selectivity of tyrosol is remarkably improved from 51% of a wild type to 99% or above, and when the glycosyl transferase mutant is applied to catalytic synthesis of salidroside, a single glycosylation product salidroside can be generated; besides, the catalytic activity of the microbial glycosyl transferase mutant to tyrosol is remarkably improved, the specific enzyme activity is improved to 97 mU / mg from 14 mU / mg of a wild type, and the substrate conversion rate is higher than 99%; according to the invention, the key problems of difficult glycosyl transferase expression, low regioselectivity and low activity in the salidroside preparation process are successfully solved, and the salidroside has a very great industrial application prospect.
Owner:WEST ANHUI UNIV

Hydroxytyrosol-ergothioneine eutectic and preparation method and application thereof

The invention discloses a hydroxytyrosol-ergothioneine eutectic crystal as well as a preparation method and application thereof, and belongs to the technical fields of medicines, foods, daily chemicals and the like. The invention provides a hydroxytyrosol-ergothioneine eutectic crystal. The X-ray powder diffraction pattern of the hydroxytyrosol-ergothioneine eutectic crystal has characteristic diffraction peaks at least corresponding to the positions where the 2 theta value is 4.21 degrees + / -0.2 degrees, 8.36 degrees + / -0.2 degrees, 12.29 degrees + / -0.2 degrees, 15.29 degrees + / -0.2 degrees, 19.40 degrees + / -0.2 degrees, 20.98 degrees + / -0.2 degrees, 23.12 degrees + / -0.2 degrees and 28.73 degrees + / -0.2 degrees. According to the hydroxytyrosol-ergothioneine eutectic, the melting point of hydroxytyrosol is increased, the hygroscopicity of hydroxytyrosol is remarkably reduced, and meanwhile the stability of hydroxytyrosol and ergothioneine is enhanced. In addition, after the ergothioneine hydroxytyrosol forms the eutectic crystal, the ergothioneine hydroxytyrosol can also play better anti-oxidation and anti-aging effects.
Owner:SHENZHEN SIYOMICRO BIO TECH CO LTD

Anti-oxidation composition based on reverse micelle synergistic technology as well as preparation method and application of anti-oxidation composition

The invention relates to an anti-oxidation composition based on a reverse micelle synergistic technology and a preparation method and application thereof, the anti-oxidation composition comprises a reverse micelle structure and an aqueous solution containing an anti-oxidation active matter, and the reverse micelle structure wraps the aqueous solution containing the anti-oxidation active matter. The reverse micelle structure is used for wrapping the water-soluble antioxidant active matter, oxidation or degradation discoloration of the water-soluble antioxidant active matter is prevented, after the antioxidant active matter such as hydroxytyrosol, ergothioneine and dipotassium glycyrrhizinate is wrapped by the reverse micelle, the stability and the effect are remarkably improved, and after the reverse micelle wrapping, the effect of the antioxidant active matter is improved by 17% or above compared with an aqueous solution before wrapping.
Owner:GUANGDONG MARUBI BIOLOGICAL TECH CO LTD

Application of hydroxytyrosol or 3, 4-dihydroxyphenethyl alcohol-O-beta-D-glucoside in preparation of melanogenesis promoting drugs or blackening products

The invention discloses a novel application of hydroxytyrosol or 3, 4-dihydroxyphenethyl alcohol-O-beta-D-glucoside in promotion of melanogenesis, and relates to a preparation method of hydroxytyrosol or 3, 4-dihydroxyphenethyl alcohol. Hydroxytyrosol is a phenolic plant chemical substance, has good pharmacological effects in the aspects of microorganism resistance, inflammation resistance, tumor resistance, oxidation resistance, cardiovascular disease and metabolic syndrome treatment, detoxification and the like, and is widely applied to various fields. The pharmacological action of hydroxytyrosol or 3, 4-dihydroxyphenethyl alcohol-O-beta-D-glucoside in promoting melanogenesis is verified by analyzing the melanogenesis condition of hydroxytyrosol or 3, 4-dihydroxyphenethyl alcohol-O-beta-D-glucoside on recombinant human tyrosinase, mouse B16 cells and wild zebra fish melanin of AB strains. The invention finds that the hydroxytyrosol or the 3, 4-dihydroxyphenylethanol-O-beta-D-glucoside can obviously promote the generation of melanin, a new thought can be provided for blackening, treating hypopigmentation diseases, blackening hair and the like by utilizing the new biological activity of the hydroxytyrosol or the 3, 4-dihydroxyphenylethanol-O-beta-D-glucoside, and the new medical application of the hydroxytyrosol or the 3, 4-dihydroxyphenylethanol-O-beta-D-glucoside is expanded.
Owner:CHINA PHARM UNIV

Grifola frondosa liquid culture medium and culture method and application thereof

The invention provides a grifola frondosa liquid culture medium as well as a culture method and application thereof, and relates to the technical field of fermentation. The invention provides a grifola frondosa liquid culture medium, which contains glucose, peptone, KH2P2O4, MgSO4, vitamin B1, gibberellin and tyrosol, can significantly improve the growth of grifola frondosa thalli and the secretion of exopolysaccharides, and can be used for the preparation of food, drugs and health care products.
Owner:HENAN ZHONGWO IND CO LTD

Skin-care composition for relieving allergy and repairing as well as preparation method and application of skin-care composition

The invention relates to an anti-allergy and repairing skin care composition and a preparation method and application thereof.The anti-allergy and repairing skin care composition comprises an oil-phase raw material, a water-phase raw material and a surfactant which are emulsified, the oil-phase raw material comprises hydroxytyrosol, olive oil and kojic acid dipalmitate, and the water-phase raw material comprises hydroxytyrosol, olive oil and kojic acid dipalmitate; the water-phase raw materials comprise a cyclodextrin-included eurotium cristatum fermentation extract, Ectoine and water. According to the skin care composition disclosed by the invention, the eurotium cristatum fermentation extract is included by the cyclodextrin, so that the stability, the solubility and the bioavailability of the eurotium cristatum fermentation extract are improved, and the irritation is reduced; according to the skin care composition, the hydroxytyrosol, the olive oil, the kojic acid dipalmitate, the cyclodextrin-included eurotium cristatum fermentation extract and the Ectoine are compounded, and all the components have a synergistic effect in the aspect of improving the allergy-relieving and repairing effects of the product.
Owner:GUANGDONG SAIMEI PHARMACEUTICAL TECHNOLOGY CO LTD

Solid lipid nanoparticles wrapping hydroxytyrosol as well as preparation method and application of solid lipid nanoparticles

The invention belongs to the technical field of preparations, and particularly relates to solid lipid nanoparticles wrapping hydroxytyrosol as well as a preparation method and application of the solid lipid nanoparticles. According to the method, an acid environment is created by adjusting the pH value, hydroxytyrosol is dissolved in grease, and then possibility is provided for wrapping hydroxytyrosol by the grease; hydroxytyrosol is wrapped by solid grease, then the solid lipid nanoparticle emulsion is prepared, and the stability of hydroxytyrosol is remarkably improved.
Owner:BEIJING QINGYAN BOSHI HEALTH MANAGEMENT CO LTD

Use of tyrosol as a physiological enhancer of creatine and its application in continuous high intensity exercise

The present invention discloses the use of tyrosol as an enhancer of the physiological effects of creatine and its application in continuous high-intensity exercise. The enhancement of physiological effects includes, but is not limited to, improves muscle endurance, reduces decline in muscle strength, enhances utilization of creatine by muscles, stimulation of the endurance-enhancing effects of creatine, reduces the decline of endurance levels, accelerates resynthesis of phosphocreatine, increases phosphocreatine levels, improves resistance performance, and enhances endurance exercise performance. Particularly, muscle endurance after continuous high-intensity exercise does not decrease or does not decrease significantly.
Owner:MOLTEK NUTRITION CO LTD

Modified boron nitride-benzoxazine resin composite material as well as preparation method and application thereof

ActiveCN119613648ATyrosolPolymer science
The invention relates to the technical field of polymer composite materials, in particular to a modified boron nitride-benzoxazine resin composite material and a preparation method and application thereof. The preparation method comprises the following steps: mixing tyrosol, 1, 10-diaminodecane and paraformaldehyde, and carrying out Mannich condensation reaction to obtain a benzoxazine monomer containing alcoholic hydroxyl groups; and mixing the modified boron nitride containing the epoxy group with a benzoxazine monomer, and carrying out curing treatment to obtain the modified boron nitride-benzoxazine resin composite material. According to the modified boron nitride-benzoxazine resin composite material obtained by the preparation method, chemical grafting of modified boron nitride and benzoxazine monomers is realized, the problems of poor compatibility and uneven dispersion caused by a physical blending method are solved, and the modified boron nitride-benzoxazine resin composite material has excellent heat-conducting property.
Owner:GUILIN UNIV OF ELECTRONIC TECH

Yarrowia lipolytica strain for producing tyrosol as well as construction method and application of Yarrowia lipolytica strain

The invention relates to a yarrowia lipolytica strain for producing tyrosol as well as a construction method and application of the yarrowia lipolytica strain, and belongs to the technical field of genetic engineering. According to the present invention, ScADH6, ScARO10F138L and D218G genes are expressed in the yarrowia lipolytica W29 [delta] KU70; the shikimic acid feedback inhibition is relieved by expressing the Y1ARO3K225L gene, the Y1ARO4K2214 gene and the Y1AR07G139S gene; pmLAAD, EcTyrAM53I and A354V genes are introduced, so that the conversion from FAD to FADH2 is promoted, and the supply of NADH (Nicotinamide Adenine Dinucleotide Hormone) in cytoplasm is enhanced; a 4-hydroxyphenylpyruvate dioxygenase (HPD) gene is knocked out; and overexpressing Y1DHS1, Y1DHS2 and Y1DHS3 genes of a shikimic acid pathway to obtain the yarrowia lipolytica strain HY5 for producing tyrosol. The invention lays a foundation for industrial production of tyrosol, and has important social significance and economic value.
Owner:YUNNAN AGRICULTURAL UNIVERSITY

Modified hydroxytyrosol, flavored hydroxytyrosol, preparation methods of modified hydroxytyrosol and flavored hydroxytyrosol, functional food and cosmetics

The invention discloses modified hydroxytyrosol, flavored hydroxytyrosol, a preparation method of the modified hydroxytyrosol, a preparation method of the flavored hydroxytyrosol, functional food and cosmetics. Activated carbon loaded p-toluenesulfonic acid is used as a catalyst to catalyze papain to modify hydroxytyrosol, so that the effect activity of the modified hydroxytyrosol raw material is reserved, and meanwhile, the bad flavor generated by impurities in industrial production of the hydroxytyrosol raw material is remarkably reduced; furthermore, the smell and the flavor of the hydroxytyrosol raw material are remarkably improved, the application effect of the hydroxytyrosol raw material in related fields is improved, and the use sensory experience of the product is improved. The flavor of hydroxytyrosol is improved in an enzyme preparation catalysis mode, and the process method is green and safe.
Owner:BEIJING QINGYAN BOSHI HEALTH MANAGEMENT CO LTD +1

Aqueous system for improving stability of EUK-134 and application of aqueous system in preparation of cosmetics

The invention relates to the technical field of cosmetics, and particularly discloses a water-based system for improving EUK-134 stability and application of the water-based system in preparation of cosmetics. The water-based system for improving the stability of the EUK-134 is prepared from the EUK-134, hydroxytyrosol, 1, 3-butanediol and water. Most preferably, in the aqueous system, the mass percentages of EUK-134, hydroxytyrosol, 1, 3-butanediol and water are as follows: 0.1% of EUK-134, 0.1% of hydroxytyrosol, 0.1% of 1, 3-butanediol and the balance of water. 2% of hydroxytyrosol; 20% of 1, 3-butanediol; and 77.9% of water. Researches show that hydroxytyrosol, 1, 3-butanediol and EUK-134 are added into water together to prepare a water-based system; and the stability is greatly higher than that of an EUK-134 aqueous solution.
Owner:SHANGYAN INT COSMETICS RES INST BAIYUN MEIWAN BAIYUN DISTRICT GUANGZHOU CITY

Medical use of tyrosol for the preparation of a formulation for reducing the toxic effect of penicillin thiazole acid

This invention provides the medical use of tyrosol in the preparation of formulations that reduce the toxicity of penicillin-thiazolic acid (PTA). It discloses a novel medical use of tyrosol in preparing formulations that reduce PTA toxicity. By using tyrosol to prevent and treat the residual toxicity of PTA, unnecessary antibiotic replacement regimens can be avoided, significantly reducing the economic burden. A method for preventing and treating PTA residual toxicity is provided, which can significantly reduce the toxicity of PTA and has good preventive and therapeutic effects. The prevention and treatment of PTA residual toxicity has significant socio-economic implications for controlling the hygiene and quality of animal-derived foods, protecting consumer health, and ensuring industrial production.
Owner:JILIN UNIVERSITY

Method and system for dynamic monitoring of polyphenol components in olive leaf based on principal component analysis

The application provides a kind of dynamic monitoring method and system of olive leaf polyphenol components based on principal component analysis, it is related to computer technology field, comprising: obtaining original data;According to the original data, the spectrum interval is separated, and the purified polyphenol characteristic spectrum sequence is obtained;According to the purified polyphenol characteristic spectrum sequence, spectral deconvolution processing is carried out, and the polyphenol subcomponent concentration evolution matrix is obtained;According to the polyphenol subcomponent concentration evolution matrix, the principal component is reconstructed, and the reconstruction result is obtained;According to the reconstruction result, track fitting is carried out, by fitting the principal component score track into the kinetic network model containing hydroxytyrosol glycoside hydrolysis and oxidative condensation step, the fitting result is obtained;According to the fitting result, prediction is carried out, the evolution end point of hydroxytyrosol free state content and its derivative relative proportion is predicted, and the dynamic monitoring result is obtained.The application realizes the accurate monitoring and prediction of the dynamic conversion process of specific polyphenol components such as hydroxytyrosol glycoside and oleuropein in olive leaves.
Owner:CHINA WEST NORMAL UNIVERSITY

Rhodiola rosea extract product as well as preparation method and application thereof

PendingCN119139154AHigh synergistic effectWork around app restrictionsCosmetic preparationsToilet preparationsBiotechnologyTyrosol
The invention relates to the technical field of cosmetics, in particular to a rhodiola rosea extract product and a preparation method and application thereof. The rhodiola rosea extraction product is prepared from the following components in parts by mass: 114 to 164 parts of salidroside, 25 to 36 parts of tyrosol and 0.108 to 0.157 part of quercetin. The mass ratio of the salidroside to the total flavonoids in the rhodiola rosea extract product is (8-12): 1. The invention provides a rhodiola rosea extract product which contains salidroside, tyrosol and quercetin with higher concentration under the condition that the content of total flavonoids is not changed basically, so that the whitening effect, the safety and the synergistic interaction effect on nicotinamide and tranexamic acid of the product can be enhanced, and the problem that the application of plant extracts in cosmetics is limited is solved.
Owner:BEIJING ACAD OF TCM BEAUTY SUPPLEMENTS CO LTD

Hydroxytyrosol content detection method and system for food quality inspection

The invention relates to the technical field of spectral analysis, in particular to a hydroxytyrosol content detection method and system for food quality inspection.The method comprises the steps that spectral data of an olive oil food sample are collected, liquid chromatographic data of the food sample are obtained, a peak point, a chromatographic peak sequence and a chromatographic peak half-and-half sequence are determined, a chromatographic peak shape interference coefficient is obtained, and a hydroxytyrosol content detection result is obtained. Acquiring a peak shape symmetric inclination coefficient based on the chromatographic peak shape interference coefficient and the difference before and after peak points in the chromatographic peak half-and-half sequence, determining a self-adaptive asymmetric penalty coefficient, acquiring chromatographic data of the corrected olive oil food sample, and judging whether the content of hydroxytyrosol in the olive oil food sample reaches the standard or not. The method aims at solving the problems that in a traditional BEADS algorithm, an asymmetric penalty factor cannot be dynamically adjusted according to the liquid chromatogram data of the olive oil food sample, so that the liquid chromatogram data of the olive oil food sample is excessively corrected and is not sufficiently corrected.
Owner:BEIJING DAMILI TECH CO LTD

A pt-fa based flame retardant bio-based copolymer resin and a method of making the same

ActiveCN119241793BHydroxytyrosolTyrosol
The application discloses a kind of flame-retardant bio-based copolymer resin based on PT-fa, to obtain mixed resin with bio-based benzoxazine monomer PT-fa and bisphenol A-aniline type benzoxazine BA-a as raw material, then, mixed resin is heat cured to obtain flame-retardant bio-based copolymer resin Poly (PT-fa / BA-a) based on PT-fa, the obtained copolymer resin has high thermal stability and high flame retardant performance;The PT-fa is prepared by solvent-free synthesis method with hydroxyl tyrosol, furfurylamine and polyformaldehyde as raw material, the obtained monomer has high purity.The glass transition temperature T g of the Poly (PT-fa / BA-a) is 180-300 DEG C;The temperature T di of 5% thermal weight loss under nitrogen atmosphere is 328-340 DEG C, the carbon residue rate Y c at 800 DEG C is 38-60%;Heat release capacity HRC is 80-175 J / g·K, and the total heat release THR is 10-21 kJ / g.The preparation method comprises the following steps: 1, the preparation of bio-based benzoxazine monomer PT-fa;2, the preparation of flame-retardant bio-based copolymer resin based on PT-fa.
Owner:GUILIN UNIV OF ELECTRONIC TECH

Application of olive pomace polyphenol extract-hydroxytyrosol as a biogenic nitrogen fertilizer synergist

The present invention relates to the field of biogenic nitrogen fertilizer synergists, and in particular to an application of an olive pomace polyphenol extract-hydroxytyrosol as a biogenic nitrogen fertilizer synergist. The biogenic nitrogen fertilizer synergist component prepared by the present invention is an olive pomace polyphenol extract-hydroxytyrosol. After the olive pomace is deoiled, it is extracted under acid hydrolysis conditions, and an alkaline solution of sodium hydroxide is used to adjust the pH value to neutral to obtain the corresponding hydroxytyrosol. The abundance of soil nitrifying microorganisms (ammonia oxidizing bacteria and ammonia oxidizing archaea) and the conversion of mineral nitrogen in the soil can be effectively suppressed, the effectiveness of nitrogen in the soil can be improved, nitrogen can be more effectively absorbed and utilized by crops, the olive pomace is effectively recycled, and the problems of huge environmental pollution and waste of resources caused by the olive pomace can be effectively avoided.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

Application of tyrosol in preparation of medicine for preventing and treating radioactive intestinal injury

The invention belongs to the technical field of medicines, and particularly relates to application of tyrosol in preparation of a medicine for preventing and treating radioactive intestinal injury. The CAS number of the tyrosol provided by the invention is 501-94-0, and SMILES is C1 = CC (= CC = C1CCO) O; the radioactive intestinal injury is intestinal injury caused by ionizing radiation and comprises acute radioactive intestinal injury and chronic radioactive intestinal injury. An animal model is utilized, it is proved from the cellular level that the tyrosol can be used for preventing and treating the radioactive intestinal injury, safety is high, the tyrosol is suitable for acute radiation disease patients, nuclear employees, astronauts, radiotherapy patients and the like, the tyrosol can be used before treatment or during task execution, and a new medicine choice is provided for preventing and treating the radioactive intestinal injury.
Owner:FUDAN UNIVERSITY

Temperature-induced escherichia coli with high yield of tyrosol and hydroxytyrosol as well as construction method and application of escherichia coli

The invention discloses temperature-induced Escherichia coli for high yield of tyrosol and hydroxytyrosol as well as a construction method and application of the temperature-induced Escherichia coli, and belongs to the technical field of microbial synthesis. On the basis of escherichia coli with high tyrosine yield, a temperature induction system is utilized for the first time, AroGfbr, ARO10, ADHs and TyrAfbr genes are over-expressed, and de novo synthesis of tyrosol is achieved; and screening ARO10 and ADHs genes to obtain the strain with high yield of tyrosol. On the basis, an HpaB / C gene is over-expressed, meanwhile, pykA, tyrB and mhpB genes are knocked out on a genome, glf and glk genes are knocked into a ptsG site, the yield of hydroxytyrosol is remarkably increased, the shake flask yield reaches 1.28 g / L, and the yield of a 5L reactor reaches 4.97 g / L. The method lays a foundation for low-cost and high-efficiency industrial production of tyrosol and hydroxytyrosol, and has a wide application prospect.
Owner:ZHEJIANG UNIV OF TECH +1

A selectively improved glycosyltransferase mutant and uses thereof

The present application relates to a kind of selectively improved glycosyltransferase UGTBL1 mutant and its catalytic synthesis of application of salidroside, belong to genetic engineering and enzyme engineering field.The mutant obtained by single point mutation technology includes the amino acid sequence of 132th amino mutation, the amino acid sequence of the glycosyltransferase is as shown in SEQ ID NO:1.The research results show that the glycosyltransferase mutant S132V, S132G described in the application has good selectivity, can efficiently catalyze tyrosol and uridine diphosphate glucose to synthesize salidroside, and the selectivity is 89%, suitable for the enzyme preparation of salidroside, with wide application prospect.
Owner:NANJING TECH UNIV

Method for preventing and controlling alternaria alternata by using tyrosol

The application provides a method for preventing and controlling pear ring rot by using tyrosol, and the pear ring rot is prevented and controlled by spraying tyrosol aqueous solution externally; the concentration of tyrosol in the tyrosol aqueous solution is 1-5 mg / ml. The application takes 'Dangshan' pear as experimental material, and proves that tyrosol has a significant inhibitory effect on pear ring rot fungus through in-vitro antibacterial experiment and ring rot fungus inoculation experiment, can effectively inhibit the development speed of ring rot fungus spots, reduces the occurrence and spread of diseases, and thus reduces the invasion of ring rot fungus on plants. Tyrosol is a natural compound in plants, has low toxicity, and when applied to the prevention and control of pear ring rot, can enhance the defense mechanism of the plants, improve the natural resistance of the plants to ring rot, simultaneously reduces or replaces the use of chemical pesticides, and reduces the potential risks to the environment and human health.
Owner:NANJING AGRICULTURAL UNIVERSITY

Method for preparing hydroxytyrosol by combining compound enzyme with molecular imprinting adsorption

The invention is applicable to the technical field of hydroxytyrosol preparation, and provides a method for preparing hydroxytyrosol by combining compound enzyme with molecular imprinting adsorption, which comprises the following steps: crushing fresh olive fruits, and collecting olive fruit pulp; putting the olive pulp into an enzymolysis tank, adding cellulose-pectin compound enzyme and citric acid, and performing enzymolysis; transferring the olive pulp subjected to enzymolysis into a microwave extraction tank, adding purified water, carrying out intermittent irradiation extraction, centrifuging after the extraction is completed, collecting supernate, and carrying out vacuum concentration; and adsorbing the concentrated supernate by using a chromatographic column filled with a hydroxytyrosol imprinted polymer, eluting with water and an ethanol solution in sequence, collecting ethanol eluent, and concentrating to obtain extract, namely the high-purity hydroxytyrosol. The problems that an existing fermentation method is low in yield and high in cost are solved. Generation of byproducts is reduced, and the separation and purification process is simplified; green and sustainable hydroxytyrosol industrial production is realized; and the purification period is shortened to be within 5 hours.
Owner:SHAANXI FUHENG(FH) BIOTECHNOLOGY CO LTD +1

Extraction method for improving oleuropein conversion rate and hydroxytyrosol content in olive pomace

The invention provides an extraction method for increasing the oleuropein conversion rate and the hydroxytyrosol content in olive pomace, and belongs to the technical field of natural product extraction. Based on the analysis of the characteristics of the olive pomace material, firstly, the compact structure of the olive pomace is destroyed through steam explosion pretreatment, and pores are loosened; then carrying out compound enzyme enzymolysis, cooperatively hydrolyzing wrapped binding protein by adopting acid protease and hemicellulase in a combined manner, destroying a polysaccharide wrapping barrier in the pomace, and promoting rapid release of oleuropein; finally, high static pressure extraction is adopted, ultrahigh pressure is used for accelerating solvent permeation, the conversion rate of oleuropein is increased, and the content of hydroxytyrosol is comprehensively increased. The method is green and efficient, the oleuropein conversion rate can be increased to the maximum extent, and the content of hydroxytyrosol is increased; the degradation loss of hydroxytyrosol in the extraction process is reduced, and the economic benefits of the olive pomace are comprehensively improved.
Owner:WUHAN POLYTECHNIC UNIVERSITY +2

Compositions and methods for reducing the rate of type 1 diabetes

Described herein are methods of treating a human child including administering to the human child a compound selected from epigallocatechin gallate (EGCG), or a derivative thereof selected from epicatechin (EC), epigallocatechin (RGC) and epicatechin gallate (ECG), sulforaphane, olive oil, phylloquinone, quercetin, safranal, hydroxtyrosol, menaquinone-4, menaquinone-7, oleocanthal, peptide Ins-1 B9-23 19CAM22R-E, peptide Ins-1 B12-23-19CAM, peptide Ins-1 B12-23 19CAM22R-E, or a combination of any of the foregoing, wherein administration of the treatment is started between birth and six months of age. Also described are methods of treating a pregnant human or a nursing human mother who has recently given birth to an infant. Further described are insulin B chain mimotope peptides.
Owner:WISCONSIN ALUMNI RES FOUND

Olive leaf polyphenol component dynamic monitoring method and system based on principal component analysis

The invention provides an olive leaf polyphenol component dynamic monitoring method and system based on principal component analysis, and relates to the technical field of computers, and the method comprises the following steps: obtaining original data; performing spectrum interval separation according to the original data to obtain a purified polyphenol characteristic spectrum sequence; performing spectrum deconvolution processing according to the purified polyphenol characteristic spectrum sequence to obtain a polyphenol subcomponent concentration evolution matrix; performing principal component reconstruction according to the polyphenol subcomponent concentration evolution matrix to obtain a reconstruction result; performing trajectory fitting according to a reconstruction result, and fitting a principal component score trajectory into a dynamic network model containing hydroxytyrosol glycoside hydrolysis and oxidative condensation steps to obtain a fitting result; and performing prediction according to the fitting result, predicting an evolution end point of the free-state content of hydroxytyrosol and the relative proportion of the hydroxytyrosol derivative, and obtaining a dynamic monitoring result. According to the method, the dynamic conversion process of specific polyphenol components such as hydroxytyrosol glucoside and oleuropein in the olive leaves is accurately monitored and predicted.
Owner:CHINA WEST NORMAL UNIVERSITY

Hydroxytyrosol inclusion with stabilizing effect and preparation method thereof

The invention discloses a hydroxytyrosol inclusion with a stabilizing effect and a preparation method thereof. The raw materials of the hydroxytyrosol inclusion of the invention include hydroxytyrosol, solid lipids, an emulsifier and water. The invention adopts a water-in-oil method to prepare the hydroxytyrosol inclusion, combines supramolecular technology with solid nanolipid technology, and dissolves hydroxytyrosol in solid fats and oils by designing and screening solid lipids, and rapidly emulsifies and rapidly cools to prepare the hydroxytyrosol inclusion with a stabilizing effect. The hydroxytyrosol inclusion prepared by the invention has good stability, and long-term storage will not cause precipitation and discoloration of active substances. At the same time, the application scenarios are wider and can better meet the system types of most daily chemical products.
Owner:JIANGNAN UNIV

Preparation method of deodorizing anion graphene quantum dot cloud wool

The application discloses a preparation method of deodorizing anion dopamine modified graphene quantum dot cloud wool, and relates to the technical field of cloud wool.The hydroxyl tyrosol 3-sodium sulfate salt and sebacic acid are used in polyester polymerization reaction to prepare elastic polyester particles, so that the deformation resistance of the cloud wool is improved; meanwhile, the sulfate radical has the effects of antistatic and antibacterial; finally, the polyester chip is used as a core layer, the elastic polyester particles, dopamine modified graphene quantum dots and modified antibacterial agent are used as a skin layer, and melt spinning is carried out to prepare the deodorizing anion dopamine modified graphene quantum dot cloud wool, so that the effects of antibacterial, deodorization and antistatic are realized.The modified antibacterial agent uses 1,6-dibromoisoquinoline-3-amine and N,N,N',N'-tetramethyl-2-butene-1,4-diamine to form a double quaternary ammonium salt structure, so that the antibacterial effect of the cloud wool is improved, the elastic polyester particles are assisted, and the deodorization effect is improved; finally, tea polyphenol is added in the melt spinning process, a three-dimensional structure is formed, the skin layer protection capability is improved, and the deformation resistance is improved.
Owner:江苏海科纤维有限公司

Olive juice wine as well as preparation method and application thereof

The invention relates to the technical field of wine preparation, in particular to olive juice wine as well as a preparation method and application thereof. The method comprises the following steps: (1) adjusting the water content of the olive pomace to 50-60% by using an olive distillate to obtain a mixture; and (2) soaking the mixture in base liquor for 30-40 days, filtering, taking filtrate to obtain intermediate liquor, and clarifying the intermediate liquor to obtain the olive juice liquor. The liqueur prepared by the method disclosed by the invention is high in content of total sugar, total acid, total flavone, total phenol and hydroxytyrosol, rich in volatile substances and high in sensory score. Theoretical basis and practical guidance are provided for storage and utilization of the olive byproducts and development of new products of the olive juice wine.
Owner:SICHUAN UNIV