105 results about "Epicatechin gallate" patented technology

The invention described herein encompasses methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins with reduced levels of EGCg, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds.

The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds.

A nutrient pharmaceutical formulation composition useful for treating cancer comprising ascorbic acid, L-lysine, L-proline and at least one polyphenol compound selected from the group consisting of epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, catechin and the use of the composition in treating cancer and other tumors are provided.

The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of catechins and proanthocyanadins. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). Compositions of proantho-cyanains include, but are not limited to, blue fruit extracts. The unique compositions of the invention contain various combinations of the catechins and proanthocyanadins, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses various modes of administration of the therapeutic compounds, including formulations which may be used as a dietary or nutritional supplement or as a therapeutic compound.

The invention discloses a method for identifying the quality of Biluochun tea, which comprises the following steps of: after soaking the Biluochun tea, scanning the soaked solution by using an ultraviolet and visible spectrophotometer; and, after leaching and extracting another Biluochun tea, measuring the contents of epigallocatechin, epigallocatechin epicatechol gallate, epicatechin and epicatechin epicatechol gallate in the tea from the leached and extracted solution by adopting a high efficiency liquid chromatography. According to the method disclosed by the invention, a technology for identifying the quality of the Biluochun tea is established by adopting (a technology that spectrum and chromatograph are combined) spectrum and chromatograph analysis; the comprehensive evaluation data of green tea quality is provided; the method has the characteristics of being accurate, reliable, simple, convenient and efficient; and the method can be popularized and applied in the field of the green tea quality counterfeit identifying technology.

The invention discloses a method for preparing tea polyphenol rich in methylated catechin from tea cultivated in China. The method comprises the following steps: taking the tea cultivated in China, with higher content of methylated catechin, as a raw material, extracting with hot water, and drying to obtain a crude extract; treating the crude extract with a macroporous resin A to obtain a tea polyphenol component I (with content of methylated catechin being about 18%) rich in methylated catechin; separating and purifying the tea polyphenol component I rich in methylated catechin with a Toyopearl HW-40S resin to obtain monomer components (with purity being more than 95%) of (-)-epigallocatechin3-O-(3-O-methyl) gallate (EGCG3''Me) and (-)-3-O-methyl-epicatechin gallate (ECG3' Me) respectively; and treating the tea polyphenol component I rich in methylated catechin with a macroporous resin B to obtain a tea polyphenol II (with content of methylated catechin being more than 60%) rich in methylated catechin. As a preparation process with the advantages of low cost, high efficiency and environment friendliness, the method is easy to implement industrial production and has broad application prospects.

The invention provides a new tea leaf and a manufacturing method and applications thereof. In the manufacturing method, fresh leaves of a special camellia crassicolumna var. multiplex (Changet Tan) Ming) are taken as the raw material and the tea leaf is manufactured through processing techniques such as deactivation of enzymes, rolling and drying and is characterized by not containing purines alkaloid such as caffeine and theocin; composition and content of tea polyphenol of the tea leaf is similar to the composition and content of the tea leaf made of usually seen tea tree (Camellia sinensis and ribes heterotrichum) and the tea leaf is rich in tea polyphenolic components such as epicatechin (EC), Epicatechin gallate(ECG), epigallocatechin gallate (EGCG) and features obvious oxidation resistance and antibiosis. The tea leaf can be used for qualify tea drinks, functional health care food, cosmetics for special purpose and natural medicine and used as food additive applied to food-processing industry.

The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of therapeutically effective amount of catechins, a group of polyphenols found in green tea, and Capsicum extracts. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins and Capsicum extracts, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.

The invention relates to method for using plant extractive catechin to prepare drug, wherein it uses green tea extractive as material; extracts in organic solvent; removes caffeine; uses HPLC to separate the catechin, as epigallocatechin, etc. The inventive drug can be used to treat virus infection of respiratory tract.

Disclosed herein are green tea plant material extracts, and methods of using the extracts, comprising at least one green tea catechin selected from the group consisting of epi-gallocatechin, catechin, epicatechin, epigallocatechin-3-gallate, gallocatechin gallate, epicatechin-3-gallate, catechin gallate, and gallocatechin, wherein the compositions of the disclosure provide greater bioavailability of at least one green tea catechin.

The invention provides a preparation method of high-purity epicatechin gallate (ECG), belonging to the technical field and domain of organic chemistry. The ECG content is 98.0-99.9%. The preparation method comprises the procedures of abstraction, extraction, chromatographic separation and crystallization. According to the invention, the preparation process has favorable reproducibility; and the obtained epicatechin gallate has the advantages of high content, high yield, no organic solvent residue, low cost, stable and controllable quality and short production cycle, is green, environment-friendly and suitable for industrial production, and conforms to the requirements for clean production.

The invention relates to an application of natural compound epicatechin gallate obtained from tea and derivatives thereof for treating or preventing myocardial infarction and other ischemic heart diseases. The compound is used for preventing the myocardial injury of the heart caused by ischemia-reperfusion, and is a medicament for potentially treating or preventing the heart ischemia/reperfusion injury. Particularly, the compound has a novel effect on protecting the heart and has a function that the enhancement of the myocardial contractility does not depend on the increase of the concentration of calcium ions in myocardial cells. In the invention, it is discovered that the epicatechin gallate (ECG) and the derivatives thereof have pharmacological pre-adaptation functions and have pharmacological post-adaptation functions for the first time, thus the ECG and the derivatives thereof are possibly novel medicaments for treating or preventing myocardial infarction and other ischemic heart diseases. The ECG and the derivatives thereof not only can be used for clinically treating congestive heart diseases through pharmacological post-adaptation but also can be used for medically preventing the patient who suffers from myocardial infarction and then is cured from being subjected to myocardial infarction again through pharmacological pre-adaptation.

A disclosed nontoxic natural preservative agent comprises an antioxidant extracted from tea leaves, natural vitamin E, a pectin decomposer and phytic acid (PA), and is characterized in that: the antioxidant extracted from tea leaves is a mixture of epigallocatechin, epigallocatechin-3-gallate, epicatechin gallate and catechin with a mass ratio of 1:3:2:3. The nontoxic natural preservative agent is no harmful to human body and natural and healthy.

The invention relates to a processing method of eagle tea oolong tea. The processing method comprises 6 technique links of (1) picking fresh leaves; (2) performing withering; (3) performing rolling; (4) performing fermenting; (5) performing drying; and (6) performing sieving and packing. According to the physical and chemical index detection and organoleptic review results of products processed according to different technologies of plant actinodaphne cupularis of eagle tea raw materials, and according to unique physical and chemical quality and organoleptic quality evaluation standards of excellent high-quality black tea, a black tea technology suitable for scaleable processing of actinodaphne cupularis is optimized and established. The technical parameters of picking fresh leaves, withering, rolling, fermenting, drying and the like are reported for the first time. The product pollutants, residues and the likes of products are lower than relevant limit values of hygienic indexes of NY5196-2002 organic tea, and the eagle tea oolong tea has the quality characteristics of being high in contents of caffeine and epicatechin gallate, having black, moistening and golden hairs, being orange and bright in soup color, being rich in fruity flavor, having cinnamomum longepaniculatum fragrance, and being rich and mellow in sweet after taste.

Compositions and methods of increasing the bioavailability of catechins are presented. Compositions for increasing the bioavailability of catechins include compositions where the catechin is added to a solution of ethanol and water; compositions where the catechin is encapsulated within a nanoparticle; and compositions in which a nanoparticle complex is formed between the catechin and the nanoparticle. Each of these compositions was shown to increase bioavailability of EGCG and is useful in treating diseases such as Alzheimer's and HIV-associated dementia.

The invention discloses an environmentally-friendly anti-microbial inactivator for treating human papilloma virus infection. The environmentally-friendly anti-microbial inactivator is prepared from the components in percentage by mass: 0.1 to 0.2 percent of cation antimicrobial, 1.2 to 2.0 percent of epicatechin gallate, 1.2 to 2.0 percent of honeysuckle flower, 2.0 to 4.0 percent of radix paeoniae rubra, 2.0 to 5.0 percent of ethyl alcohol, 0.6 to 1.0 percent of herba menthae, and the balance of purified water to complement to 100 percent. According to the environmentally-friendly anti-microbial inactivator provided by the invention, an antibacterial effect is good after dodecyl dimethyl benzyl ammonium chloride, didecyl dimethyl ammonium chloride and ammonium dimethylalkyl oxide are mixed, the antibacterial rate of a cation antimicrobial on poliomyelitis virus sterilization log value is larger than 4 within 1 minute.

Disclosed is a method for protecting living body in radialization of UV-B using catechuic acid, wherein catechuic acid is employed to preventing living body from radialization damage of UV-B, or recovering the living body damaged by UV-B. The content of [(-)-epigallocatechin-3-gallate(EGCG)] in the catechin is not lower than 40%, the content of ECG is not lower than 15%, the content of caffeine is no less than 2.5%.