161 results about "Protocatechuic acid" patented technology

The invention relates to the technical field of fermentation of edible and medicinal fungi, and discloses a phellinus igniarius fermentation method capable of producing high-yield Hispidin and an application of the phellinus igniarius fermentation method. The phellinus igniarius fermentation method comprises the following steps: inoculating a phellinus igniarius strain into a culture medium containing a copper ion compound, and fermenting. The phellinus igniarius mycelium obtained by adopting the fermentation method is rich in Hispidin, and can be widely used for preparing related medicines and health foods for protecting liver, resisting tumors, resisting viruses, resisting oxidation, reducing uric acid and the like. In addition, the invention also discloses a high performance liquid chromatography detection method for analyzing the content of Hispidin, by adopting the method, the content of Hispidin and precursor substances (such as protocatechuic acid, protocatechualdehyde, caffeic acid, osmundone and the like) in the phellinus igniarius leavening and derivative products thereof as well as phellinus igniarius mycelia can be effectively analyzed, and the accuracy of Hispidin detection is favorably improved.

The invention provides a biological fermentation feed for enhancing immunity of aquatic animals and a preparation method of the biological fermentation feed, and relates to the technical field of aquaculture. The biological fermentation feed is prepared by compounding fish bone meal, a rice bran fermentation material, soybean meal, a compound fermentation material, visceral meal, orange peel powder, corn starch, compound vitamins, tea saponin and protocatechuic acid. According to the present invention, the defects in the prior art are overcome, the weight gain growth of the aquatic product is comprehensively ensured through the compound addition of the microbial components of the aquatic product feed and the regulation and control of other components, the immunity of the aquatic product is further improved, and the artificial breeding benefit of the aquatic product is comprehensively ensured.

The invention belongs to the technical field of waterborne polyurethane, and discloses photo-thermal antibacterial, self-enhanced and self-healing vegetable oil-based waterborne polyurethane. The high-temperature-resistant polyurethane elastomer is prepared from a system consisting of the following raw materials in parts by weight: 80 to 120 parts of castor oil, 60 to 80 parts of dicyclohexylmethane diisocyanate, 20 to 40 parts of hexamethylene diisocyanate, 20 to 40 parts of N-methyldiethanolamine, 20 to 50 parts of protocatechuic acid, 2 to 10 parts of metal ions, 2000 to 3000 parts of water and 0.5 to 1 part of a catalyst. Metal ions in the photo-thermal antibacterial, self-enhanced and self-healing plant oil-based waterborne polyurethane and phenolic hydroxyl groups in protocatechuic acid are coordinated and self-assembled to form metal nanoclusters, and the waterborne polyurethane material has self-enhanced and self-healing properties due to a low-bond-energy coordination aggregation state structure; meanwhile, the waterborne polyurethane film is endowed with photo-thermal antibacterial performance by the metal nanoclusters. The invention further discloses a preparation method and application of the photo-thermal antibacterial, self-enhanced and self-healing plant oil-based waterborne polyurethane.

The invention discloses siloxane bridged protocatechuic acid-based epoxy resin as well as a synthesis method and application thereof. Carboxyl of protocatechuic acid is bridged with epoxy groups of polydimethylsiloxane with different chain segment lengths, and then phenolic hydroxyl of protocatechuic acid is subjected to epoxidation reaction through a two-step method, so that the siloxane bridged protocatechuic acid-based epoxy resin is obtained. A novel siloxane bridged protocatechuic acid-based epoxy resin monomer is synthesized, and the structural formula of the monomer is shown as a formula (III). The siloxane-bridged protocatechuic acid-based epoxy resin has the characteristics of low viscosity, high toughening property, low dielectric constant and strong hydrophobicity, the processability of the siloxane-bridged protocatechuic acid-based epoxy resin is improved, and the siloxane-bridged protocatechuic acid-based epoxy resin shows excellent fracture resistance. Through the synergistic improvement, the siloxane bridged protocatechuic acid-based epoxy resin obtained by the invention becomes novel high-performance thermosetting plastic, and has wide application prospects in the fields of electronic packaging and semiconductor industries and architectural coatings.

The invention provides an application of protocatechuic acid in an anti-inflammatory active pharmaceutical composition in dairy cow mammary epithelial cells, belongs to the technical field of bioengineering, and aims to obtain high-purity protocatechuic acid (greater than or equal to 95%) by optimizing a preparation process through the application of protocatechuic acid in inhibition of inflammatory response of dairy cow mammary epithelial cells. Under the concentration of 1-100 mu M, the level of inflammatory factors such as TNF-alpha, IL-6 and the like is remarkably reduced (the inhibition rate is larger than or equal to 60%), the mechanism is that NF-kB and MAPK signal channels are inhibited, cytotoxicity is avoided, and a milk region perfusion agent or a feed additive can be prepared to be used for preventing and treating dairy cow mastitis.

The invention discloses injectable hydrogel for treating periodontitis and a preparation method of the injectable hydrogel. The injectable hydrogel is prepared from protocatechuic acid grafted carboxymethyl chitosan hydrogel and a zinc-metformin complex loaded in the protocatechuic acid grafted carboxymethyl chitosan hydrogel. The hydrogel aims to become a safe and effective treatment method so as to reduce oxidative stress and tissue damage caused by periodontitis. And the hydrogel is designed into an injectable form, so that the clinical operation is facilitated, and the comfort of a patient is improved. Therefore, the treatment effect and life quality of patients with chronic periodontitis are improved, and inconvenience and discomfort in the treatment process are reduced.

The invention relates to the technical field of tissue engineering material preparation, and discloses a gelatin chitosan-based hydrogel preparation method and application thereof, and the gelatin chitosan-based hydrogel preparation method comprises the following steps: dissolving chitosan in an aqueous solution containing alpha-ketoglutaric acid and protocatechuic acid to prepare a chitosan solution; in the process, alpha-ketoglutaric acid reacts with amino of chitosan, and meanwhile, alpha-ketoglutaric acid and protocatechuic acid act synergistically to form a basic reaction system of the solution. The preparation method comprises the following steps: adding gelatin into a chitosan solution, so that chitosan, alpha-ketoglutaric acid, protocatechuic acid and gelatin in the solution are fully mixed through blending to form a uniform pre-reaction system; the mixed solution is placed under a proper temperature condition for incubation, in the process, a series of non-covalent bond effects and local chemical bond effects occur in the system, and the chitosan and the gelatin form a stable network structure. After incubation is completed, the solution is gradually converted into gel with excellent performance. And the finally prepared hydrogel has good biocompatibility and temperature-sensitive characteristics.

The invention discloses an absorbable suture line containing fibroin and a preparation method of the absorbable suture line, and relates to the technical field of absorbable suture lines. The absorbable suture line containing the silk protein is prepared from the following raw materials in parts by weight: 35 to 50 parts of silk protein, 10 to 20 parts of polylactic acid, 15 to 25 parts of polyglycolide-lactide, 1 to 3 parts of antibacterial agent, 2 to 5 parts of modified toughening agent, 1 to 4 parts of nano mineral filler, 0.5 to 2 parts of cross-linking agent and 2 to 5 parts of plasticizer, the preparation method comprises the following steps: reacting protocatechuic acid with ethanolamine to generate an intermediate 1; and reacting the intermediate 1 with 5, 10, 15, 20-tetra (4-carboxyl phenyl) porphyrin to generate the antibacterial agent. The prepared absorbable suture line containing the silk protein has good mechanical performance, self-repairing performance and antibacterial performance.

The invention discloses a compound wintercreeper capsule high performance liquid chromatography fingerprint spectrum analysis method and application thereof, and belongs to the technical field of chemical analysis. A mixed solution of protocatechuic acid, calycosin glucoside, formononin, calycosin and formononetin is used as a standard solution; performing high performance liquid chromatography analysis by taking a methanol extracting solution of the compound wintercreeper capsule as a test solution, and establishing an HPLC fingerprint spectrum of the compound wintercreeper capsule; wherein in the high performance liquid chromatography analysis, an acetonitrile-0. 2% phosphoric acid solution is used as a mobile phase, the elution mode is gradient elution, and the detection wavelength is 254 nm. The method provided by the invention is good in repeatability and high in durability, and can be used for controlling the quality of the compound wintercreeper capsule.

The invention provides an aluminum alloy pretreatment method based on complex reaction, which comprises the following steps: S1, polishing an LDH (Layered Double Hydroxides) growth surface by using abrasive paper, and cleaning and drying; s2, preparing a complexing agent solution, wherein a complexing agent is selected from at least one of tannic acid, gallic acid and protocatechuic acid; s3, the aluminum alloy sample treated in the step S1 is put into the complexing agent solution in the step S2, and constant potential is applied to the aluminum alloy; s4, preparing a mixed solution of Zn (NO3) 2.6 H2O and NH4NO3, and adding an ammonia water solution to adjust the pH value to 6-6.5; s5, immersing the aluminum alloy treated in the step S3 into the mixed solution in the step S4, and putting the aluminum alloy into a constant-temperature water bath kettle to generate a Zn-Al-LDH film; and S6, after the hydrothermal reaction is finished, cooling to room temperature, and washing and drying the obtained reaction product. The surface of the aluminum alloy is pretreated through the complexing agent, the potential between an intermetallic compound and an aluminum matrix can be effectively balanced, the micro-couple effect is fundamentally inhibited, and ideal conditions are created for uniform, compact and defect-free growth of LDH.

Compositions and methods for converting at least one polyphenol to protocatechuic acid (PCA) using Bacillus subtilis 1579, or active variants thereof, are provided. Conversion of polyphenols, such as quercetin, to PCA can decrease inflammation, decrease cortisol levels, and increase milk quality and milk production quantity in milk-producing agricultural animals. Accordingly, provided herein are compositions comprising B. subtilis 1579, or an active variant thereof, for administration to humans for decreasing inflammation or for administration to milk-producing agricultural animals for decreasing inflammation, decreasing cortisol levels, and increasing milk quality and milk production.

This invention discloses the application of reagents for detecting biomarker levels in the preparation of products for identifying obstructive sleep apnea. It relates to the field of biomarker technology and aims to overcome the shortcomings of existing technologies that rely on complex polysomnography (PSG) procedures, poor patient compliance, and a lack of effective molecular markers. The biomarkers used in this application consist of CD36 glycoprotein, 9-octadecenal, and protocatechuic acid 3-O-sulfate. This invention enables rapid and objective identification of obstructive sleep apnea by detecting the levels of the above biomarkers in plasma. The procedure is simple and well-accepted by patients. The combined use of multiple biomarkers can improve the accuracy and stability of the identification, making it suitable for screening or auxiliary diagnosis in medical institutions at different levels.

The invention relates to the technical field of medicines, and discloses a bifidobacterium longum strain GZBAI 01 and application thereof in degradation of benzoic acid and prevention or treatment of colorectal cancer. The strain is separated from faeces of healthy people, genomics identification is carried out, the metabolic profile of the strain is measured through metabonomics, the strain can convert benzoic acid with carcinogenic risk into protocatechuic acid with antitumor activity through unique metabolic capability, meanwhile, the function of regulatory T cells (Treg) in tumor drainage lymph nodes can be inhibited, differentiation of CD8 + T cells is promoted, and the tumor drainage lymph nodes can be inhibited. Therefore, the colorectal cancer is prevented through double ways of eliminating cancerogen and generating therapeutic agents. A colorectal cancer mouse model and a subcutaneous tumor mouse model verify that the strain can significantly reduce the number and volume of tumors, and shows a benzoic acid conversion effect superior to that of other strains in vivo and in vitro, and a new way is provided for prevention and treatment of colorectal cancer.

The invention relates to the technical field of coatings, in particular to bionic raw lacquer prepared from protocatechuic acid and a preparation method of the bionic raw lacquer. According to the specific technical scheme, the method for preparing the bionic raw lacquer from protocatechuic acid comprises the following steps: (1) uniformly mixing protocatechuic acid, an alkylation modifier and a catalyst in a nitrogen atmosphere, carrying out a heating reaction, and after the reaction is completed, washing and drying an organic phase to obtain alkylation modified protocatechuic acid; (2) adding an emulsifier into the aqueous solution of the alkylated modified protocatechuic acid, and uniformly stirring to obtain an alkylated protocatechuic acid emulsion; adding a catalyst into the alkylated protocatechuic acid emulsion, dropwise adding a hydrogen peroxide solution, and reacting to obtain an alkylated protocatechuic acid emulsion polymer; and (3) uniformly mixing the alkylated protocatechuic acid emulsion polymer with a drier or a photoinitiator to obtain the product. The problems that in the prior art, natural raw lacquer resources are limited, and the curing rate of micromolecule bionic raw lacquer monomers is low are solved.

The invention relates to the technical field of biological medicine, in particular to a composition for blocking formation of phage treatment tolerance and application of the composition. The composition comprises a folium ilicis purpurea ethyl acetate extraction active component and a clostridium perfringens specific bacteriophage, the folium ilicis purpurea ethyl acetate extraction active component is prepared from the following components in percentage by mass: 8 to 15 percent of protocatechuic acid and 5 to 10 percent of ethyl gallate, and the mass ratio of the protocatechuic acid to the ethyl gallate is (1.5 to 1) to (2.5 to 1); the clostridium perfringens specific bacteriophage is a virulent bacteriophage capable of specifically cracking a clostridium perfringens NetB toxin positive strain. According to the invention, the shallow thought that the existing compounding technology only pursues synergistic sterilization is subverted, and a deep synergistic mode of bacteriophage splitting attack and folium ilicis purpurea component disintegration bacterial defense program is proposed and verified for the first time. And the formation of tolerance is fundamentally blocked, so that a more thorough and more lasting treatment effect is realized, and the comprehensive production performance of animals is accidentally and greatly improved on the basis of the treatment effect.

The invention relates to a construction method and a detection method of characteristic chromatograms of a Java amomum cardamomum medicinal material, a standard decoction and a traditional Chinese medicine formula granule. According to the method, proper ultra-high performance liquid chromatography conditions are selected, protocatechuic acid, (4R, 6R)-6-hydroxypiperidone, (4R, 5R)-4-Hydroxy-5-isopropyl-2-methylaminohex-2-enone, vanillic acid and (4S, 5R)-4-Hydroxy-5-isopropyl-2-methylaminohex-2-enone are used for preparing a reference substance solution, a Java amomum cardamomum medicinal material, a standard decoction or / and formula granules are used as a test sample for detection, a characteristic spectrum is constructed, and the characteristic spectrum is applied to the detection of the Java amomum cardamomum medicinal material, the standard decoction or / and the formula granules. The characteristic chromatogram contains 9 characteristic peaks, is rich in chromatogram information, can reflect the quality of the Java amomum cardamomum medicinal material, can reflect the quality of standard Java amomum cardamomum decoction and traditional Chinese medicine formula granules, can be used for detecting the quality of the Java amomum cardamomum medicinal material, the standard Java amomum cardamomum decoction and the traditional Chinese medicine formula granules, and has a wide application prospect. The invention provides an effective method for quality detection of the Java amomum cardamomum and the modern preparation thereof, and also provides a scientific experimental basis for research on comprehensive quality evaluation of the Java amomum cardamomum and the modern preparation thereof.

The application belongs to the field of enzyme engineering and biotechnology, and discloses a 4-hydroxybenzoic acid hydroxylase mutant and application thereof in synthesis of gallic acid or a salt thereof. The 4-hydroxybenzoic acid hydroxylase mutant is obtained through directional evolution modification and high-throughput screening, and has an increased protocatechuate hydroxylase activity by more than 4 times. The 4-hydroxybenzoic acid hydroxylase mutant is expressed by using E. coli, and the obtained recombinant E. coli can efficiently catalyze the conversion of protocatechuate into gallic acid. The 4-hydroxybenzoic acid hydroxylase mutant is expressed in the recombinant E. coli for producing protocatechuate, and the obtained recombinant E. coli can de novo synthesize gallic acid from glucose as a substrate, and the yield reaches 58.65 g / L, and the residual amount of protocatechuate is only 0.33 g / L. The application solves the problem of a large amount of residual protocatechuate in the fermentation process of the existing strains, and can provide an efficient enzyme element for the creation of gallic acid industrial strains.

The invention discloses a method for synthesizing gallic acid through double-cell catalysis of terephthalic acid and a strain of the gallic acid through double-cell catalysis of terephthalic acid. The method comprises the following steps: respectively constructing a protocatechuic acid transformation strain for expressing tphAa, tphAb, tphAc and tphB genes in a tphAB gene cluster and a gene tpaK for coding TPA transport protein, and a gallic acid transformation strain for expressing a gene pobA for coding p-hydroxybenzoic acid hydroxylase; bacterial cells of the protocatechuic acid transformation strain and the gallic acid transformation strain are used as catalysts to catalyze a substrate terephthalic acid to synthesize gallic acid. The protocatechuic acid transformed strain constructed by the invention assists terephthalic acid to enter cells by using transporter, so that the intracellular concentration of terephthalic acid is remarkably improved, and the conversion rate of gallic acid produced and synthesized by terephthalic acid is further improved.

Aspects of the present disclosure relate to the use of engineered host cells capable of producing protocatechuic acid (PCA). Aspects of the present disclosure also relate to compositions comprising engineered host cells capable of producing protocatechuic acid and / or cell constituents thereof, and the use of such compositions for altering and / or maintaining biological activity in a subject.

A strain of Acanthopanax senticosus endophytic fungus HASZ2 producing isofraquinone and protocatechuic acid and its application, relating to the field of microorganisms, the Acanthopanax senticosus endophytic fungus HASZ2 is Rhodotorula glutinosus HASZ2, which has been preserved in the China Center for Type Culture Collection, the preservation address is Wuhan University, Wuhan, the preservation date is May 16, 2024, and the preservation number is CCTCC NO: M2024973. The strain has good antioxidant activity. After secondary metabolite analysis of its fermentation broth, it was found that the strain can produce isofraquinone and protocatechuic acid. The present invention is used for anti-oxidation and production of Acanthopanax senticosus secondary metabolites.

The present invention relates to processes for the formation of pyridinedicarboxylic acid (PDCA), in particular, 2,4-pyridinedicarboxylic acid (2,4-PDCA) and 2,5-pyridinedicarboxylic acid (2,5-PDCA), and mono- and diester derivatives thereof, from 3,4-dihydroxybenzoic acid, via a biocatalytic reaction using, for example, a protocatechuate dioxygenase such as protocatechuate 4,5-dioxygenase or protocatechuate 2,3-dioxygenase, and a nitrogen source. The invention also relates to copolymers that comprise the pyridinedicarboxylic acid monomers and derivatives thereof, processes for the formation of the copolymers and uses for the copolymers.

The invention relates to the technical field of pharmaceutical analysis, and discloses a method for simultaneously determining the contents of various components in Shuanling antidiarrheal granules based on a UPLC-QQQ-MS / MS. The contents of 18 components in the Shuanling antidiarrheal granules are simultaneously determined by using an ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometer. The 18 components comprise adenosine, gallic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, liquiritin, ellagic acid, kaempferitrin, narirutin, hesperidin, baicalin, oroxylin A-7-O-beta-D-glucuronide, wogonin, baicalein, wogonin, pachymic acid B and pachymic acid A. The invention further discloses a preparation method of the pharmaceutical composition. Through the UPLC-QTRAP-MS / MS combined technology, the technical prejudice that single component depends on in quality control of the traditional Chinese medicine compound preparation is broken through, the key problems that multiple components in a complex matrix are difficult to separate, low-content components are difficult to detect and the like are solved, efficient, accurate and synchronous determination of 18 components is achieved, and the method is suitable for large-scale popularization and application. A new reference path is opened up for modernized quality control of the traditional Chinese medicine compound preparation.

The invention relates to a traditional Chinese medicine clerodendranthus spicatus extract for treating nephritis. The extract contains tanshinol (content gt; 0.07%), protocatechuic acid (content gt; 0.12%), rosmarinic acid (content gt; 9%), alkannic acid (content gt; 1.2%), helelisters C (the content of gt; 4.0%), salvianolic acid B (content gt; 2.0%), salvianolic acid A (content gt; 2.0%). The invention further provides a pharmaceutical composition containing the extract provided by the invention, and the pharmaceutical composition is selected from any dosage form capable of being taken. The dosage form is selected from tablets, capsules, oral liquid, granules, pills, ointment, dripping pills and injections.

This invention discloses a mitochondrial-targeted nanomaterial for senescent cells and its application in anti-aging. The material is a nucleic acid aptamer-tetrahedral DNA, mainly assembled from four single-stranded DNA sequences, SEQ ID Nos. 1-4. Preparation involves first hybridizing the four single-stranded DNA sequences, then concentrating them to obtain aptamer-modified tetrahedra, which are then coupled with tannic acid (TA) via a Mann reaction in the presence of formaldehyde to obtain the Apt-tFNAs-TA complex. Finally, it is incubated with excess catechins to obtain the final delivery material, Apt-tFNAs@catechin-TA. This invention's material exhibits good biocompatibility and skin tissue compatibility, significantly improving uptake efficiency and mitochondrial localization ability in senescent cells. It can effectively deliver polyphenolic compounds such as catechins and protocatechuic acid, improving mitochondrial function and addressing the technical problems of low delivery efficiency of active ingredients and insufficient targeted enrichment in senescent cells.

The present invention discloses a high performance liquid chromatography fingerprint analysis method for compound Fufangteng capsule and its application, which belongs to the field of chemical analysis technology. A mixed solution of protocatechuic acid, calycosin glucoside, thorn formononetin, calycosin, and formononetin is used as a standard solution, and a methanol extract of compound Fufangteng capsule is used as a test solution for high performance liquid chromatography analysis to establish a compound Fufangteng capsule HPLC fingerprint; wherein, the high performance liquid chromatography analysis uses acetonitrile 0.2% phosphoric acid solution as the mobile phase, the elution mode is gradient elution, and the detection wavelength is 254nm. The method provided by the present invention has good repeatability and high durability, and can be used for compound Fufangteng capsule quality control.

The application discloses an aluminum profile spraying powder coating and a preparation method thereof, and belongs to the technical field of paint. The application introduces modified resin, so that the coating has excellent weather resistance, and adds specific proportion of proto-catechuic acid, 2-(4-thiazolyl) benzimidazole and 8-hydroxyquinoline as an antibacterial agent, and chemically bonds the antibacterial agent to the resin base material, so that efficient, long-lasting and broad-spectrum antibacterial effect is realized, and more significant antibacterial purpose is realized, and the problems of easy migration and easy failure of the surface spraying antibacterial agent are effectively solved. The application optimizes the overall formula, and the components interact with each other, so that the coating has excellent surface flatness and apparent quality, and the defects of pinholes and orange peel commonly existing in traditional coatings are avoided; the overall antibacterial and long-lasting antibacterial properties are significant, and the application is particularly suitable for buildings, medical treatment and household aluminum profiles with high sanitary requirements.

The application discloses a construction method of a UPLC characteristic spectrum of a radix-lithospermi and application thereof, 1) preparation of a control medicinal material reference solution; 2) preparation of a control reference solution: a certain amount of protocatechuic acid, protocatechuic aldehyde, ferulic acid, rosmarinic acid, caffeic acid tetramer and danshensu are taken to prepare a mixed solution by adding methanol, serving as the control reference solution; 3) preparation of a test solution; 4) determination: the control medicinal material reference solution, the control reference solution and the test solution are respectively taken and injected into a liquid chromatograph to determine characteristic spectra, wherein the characteristic spectra include at least 12 characteristic peaks; 5) qualitative analysis of a sample to be determined is carried out by using the characteristic spectra obtained in the above steps. The characteristic spectrum includes 12 characteristic peaks, can effectively distinguish radix-lithospermi (Xinjiang radix-lithospermi) and its pseudo products of different origins, and embodies the integrity of quality control of radix-lithospermi.

The present invention belongs to the technical field of hydrogel preparations, and specifically relates to a dual-responsive hydrogel, a preparation method, and an application thereof. The present invention synthesizes a cross-linked polycationic hydrogel composed of phenylboronic acid-modified sodium alginate, a protocatechuic acid-polyethyleneimine graft polymer, and bevacizumab sustained-release nanoparticles, referred to as a dual-responsive OSPPB hydrogel. This hydrogel blocks neurovascularization at the osteochondral interface by locally clearing extracellular RNA and releasing bevacizumab, thereby alleviating OA pain and disease progression.

The present invention relates to the field of adhesive materials, and in particular to a protocatechuic acid-modified epoxy resin, and its preparation method and application. The preparation method of the modified epoxy resin comprises: using protocatechuic acid and epoxy resin I as raw materials to carry out a chain extension reaction; wherein the epoxy resin I is one or a combination of several of bisphenol A epoxy resin, bisphenol F epoxy resin, ethylene glycol diglycidyl ether, and polypropylene glycol diglycidyl ether. The adhesive made from the modified epoxy resin has good room temperature bonding strength and high temperature bonding strength; specifically, the shear strength of the adhesive at room temperature reaches more than 20MPa, the shear strength at 150°C reaches more than 10MPa, the peel strength at room temperature reaches 3KN / m, and the aging performance at 250°C is also significantly improved.

The invention discloses a plant lactobacillus for producing various active small molecules by fermenting truffles and resisting skin cell aging in multiple mechanisms, and belongs to the technical field of microorganisms. The lactobacillus plantarum CCFM1494 obtained by screening can be used for fermenting the white truffle, degrading cyanidin-3-O-glucoside chloride, and generating a plurality of active small molecules such as hesperetin, phloretin, ganoderenic acid D, gallic acid, myricetin, protocatechuic acid and the like; meanwhile, after the white truffle is fermented by the plant lactobacillus CCFM1494, the promotion effect of the white truffle on the synthesis of skin collagen and the improvement effect on cell senescence can be improved. Therefore, the lactobacillus plantarum CCFM1494 has a huge application prospect in preparation of products for improving skin quality.