Acorus gramineus total phenylpropanoid extraction and total phenols extraction and method for preparing simultaneously

A technology of total phenylpropanoid and extract, applied in the field of medicine

Inactive Publication Date: 2007-12-12
石任兵 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, only one published invention patent 97106786.4 concerning the pharmacological activity, application and preparation method of the chemical components of Acorus calamus has been found, which involves the preparation method of alkaloid components in Acorus calamus, and there is no reference to the total phenylpropanoid extract and total phenylpropanoids of Acorus calamus. Patents on phenolic extracts and their preparation methods and uses

Method used

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  • Acorus gramineus total phenylpropanoid extraction and total phenols extraction and method for preparing simultaneously
  • Acorus gramineus total phenylpropanoid extraction and total phenols extraction and method for preparing simultaneously

Examples

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Effect test

Embodiment 1

[0056] Embodiment 1: Preparation process of total phenylpropanoid extract and total phenol extract of Shichangpu

[0057] Take 1kg of Shichangpu decoction pieces, reflux extraction with 10L of 50% ethanol for 2 times, extract for 2 hours each time, recover the solvent under reduced pressure to obtain the extract, add a certain volume of water to disperse and dissolve, so that the volume ratio of the amount of medicinal material to the dispersed solution is 1:6 . Then centrifuge at a speed of 5000 rpm for 40 minutes, pour out the supernatant, reflux the precipitate with 2500 mL of petroleum ether for 3 times, each time for 1.0 hour, combine the petroleum ether extract, recover the solvent under low temperature and reduced pressure, and dry the residue under reduced pressure , that is the total phenylpropanoid extract of Shichangpu. The supernatant was passed through 10L AB-8 macroporous adsorption resin, the adsorption flow rate was 1.0mL / min, the diameter-to-height ratio of t...

Embodiment 2

[0059] Embodiment 2: Preparation process of total phenylpropanoid extract and total phenol extract of Shichangpu

[0060] Take 1kg of Shichangpu decoction pieces, reflux extraction with 15L of 50% ethanol for 3 times, extract for 1.5 hours each time, recover the solvent under reduced pressure to obtain the extract, add a certain volume of water to disperse and dissolve, so that the volume ratio of the amount of medicinal material to the solution after dispersion is 1:7 . Then centrifuge at a speed of 5000 rpm for 40 minutes, pour out the supernatant, reflux the precipitate with 3000mL petroleum ether for 3 times, 1.0 hour each time, combine the petroleum ether extract, recover the solvent under low temperature and reduced pressure, and dry the residue under reduced pressure , that is the total phenylpropanoid extract of Shichangpu. The supernatant was passed through 12L AB-8 macroporous adsorption resin, the adsorption flow rate was 1.0mL / min, the diameter-to-height ratio of ...

Embodiment 3

[0062] Embodiment 3: Preparation process of total phenylpropanoid extract and total phenol extract of Shichangpu

[0063] Take 1 kg of Shichangpu decoction pieces, extract 2 times with 12L of 70% ethanol under reflux, extract for 2 hours each time, recover the solvent under reduced pressure to obtain the extract, add a certain volume of water to disperse and dissolve, so that the volume ratio of the amount of medicinal material to the dispersed solution is 1:8 . Then centrifuge at a speed of 5000 rpm for 40 minutes, pour out the supernatant, reflux the precipitate with 2500nL petroleum ether for 3 times, 1.0 hour each time, combine the petroleum ether extract, recover the solvent under low temperature and reduced pressure, and dry the residue under reduced pressure , that is the total phenylpropanoid extract of Shichangpu. The supernatant was passed through 12L AB-8 macroporous adsorption resin, the adsorption flow rate was 1.0mL / min, the diameter-to-height ratio of the resin...

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Abstract

The invention discloses total phenyl propanoid extract and total phenol extract extracted from grassleaved sweetflag rhizome and its preparation method. Total phenyl propanoid extract mainly comprises beta -asaricin, alpha -asaricin, eudesmin, galgravin, veraguensin and other derivant with veraguensin as mother nuclide. Total phenol extract mainly comprises caffeic acid, protocatechuic acid, ferulic acid, vanillic acid and glucosides with vanillic acid as mother nuclide and other derivants. Total phenyl propanoid extract and total phenol extract of grassleaved sweetflag rhizome can be extracted through one or more of methods of solvent-extraction, solvent extraction, precipitation method, macroporous adsorbent resin, extraction by supercritical fluid, column chromatography, and liquid-liquid countercurrent distribution chromatography. Total percentage content of phenyl propanoids in the obtained total phenyl propanoid extract of Grassleaved sweetflag rhizome is 5-100% (w/w), wherein content of beta -asaricin and alpha -asaricin occupy 5-100% (w/w).Total percentage content of phenols in total phenol extract of grassleaved sweetflag rhizome is 5-100% (w/w), wherein content of caffeic acid and protocatechuic acid occupy 5-100% (w/w).

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the total phenylpropanoid extract and the total phenol extract of the traditional Chinese medicine Shichangpu, a preparation method thereof, a quality control method, and an application in the fields of medicine and health food. Background technique [0002] Acorus calamus is a commonly used traditional Chinese medicine, derived from the dried rhizomes of Acorus tatarinowii Schott. and other plants of the same genus. Traditional Chinese medicine theory believes that Shichangpu has the effects of resuscitating phlegm, refreshing the mind, improving ears and eyesight, dispelling dampness and appetizing, dispelling cold and eliminating numbness, and mainly treating coma, epilepsy, mania, coronary heart disease, angina pectoris, arrhythmia, stroke, Vertigo, tinnitus, deafness, atrophic gastritis, traumatic brain injury, mental retardation, sinusitis and other syndromes, m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/06A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P1/04A61P25/00A61P25/08A61P27/16A61P29/00C07B63/00
CPCY02P20/54
Inventor 石任兵刘斌董玉
Owner 石任兵
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