41 results about "Vanillic acid" patented technology

The invention belongs to the technical field of medical analysis, and particularly relates to a method for separating chemical components in hemsley rockvine root. According to the present invention, various chromatography methods are adopted to carry out separation and purification, such that sitroside (I), vanillyl glycolII (II), 5-hydroxymaltol (III), vanillic acid (IV), afzelin (V), 2, 3-dihydroxypyrazole (9E, 11E)-13-hydroxypyrazole (9, 11-dienoate), and 2, 3-dihydroxypyrazole (10E, 12E)-9-hydroxypyrazole (10, 12-dienoate) are obtained from hemsley rockvine root. Wherein the compounds II, III, VI and VII are separated from the hemsley rockvine root for the first time, and development and quality control of the hemsley rockvine root medicinal material are facilitated.

The invention provides a novel application of a raspberry extract. It is found through tests that any one of isoquercitrin, ellagic acid, vanillic acid, oleanolic acid, kaempferol-3-O-rutinoside, kaempferol-3-O-sophoroside, tiliroside, tormentic acid and raspberry extract can remarkably improve the activity of the human ovarian granular cells or remarkably improve the oxidative stress level, and the activity of the human ovarian granular cells can be remarkably improved. According to the present invention, the ovarian function can be effectively protected by the eight components, the ovarian function can be effectively protected by the eight components, or the mitochondrial membrane potential level can be significantly regulated and controlled, or the estrogen level in the microenvironment can be effectively maintained, such that the ovarian function can be effectively protected by the eight components, and the raspberry extract containing the eight components. The invention provides a new choice for ovarian function protection products, and also provides a new application for the substances.

The invention relates to the technical field of catalysts, in particular to a preparation method of an iron-cobalt oxide and Beta molecular sieve composite catalyst and application of the iron-cobalt oxide and Beta molecular sieve composite catalyst to demethoxylation of lignin derivative vanillic acid. Meanwhile, due to the interaction of iron and cobalt species, the acid site of the catalyst is enhanced, and adsorption and activation of a substrate are facilitated; the iron-cobalt oxide is combined with the Beta molecular sieve, and the reaction activity of demethoxylation is improved through cooperation of metal / zeolite; the Co0 / Fe0. 04Co0. 96O-Beta composite catalyst is used for a vanillic acid demethoxylation catalytic reaction, the reaction is performed for 2 hours under the condition of 0.4 MPa H2 and 0.4 MPa CO2, the substrate conversion rate reaches 96.07%, the p-hydroxybenzoic acid selectivity reaches 86.96%, and the target product yield is 83.54%.

The present invention relates to a vanillic acid derivative compound which can be formed by a dehydration condensation reaction between vanillic acid and catecholamine. The vanillic acid derivative compound according to the present invention is characterized in that it can be used as a therapeutic preparation for Alzheimer's disease and neuroinflammation. In addition, the present invention relates to a therapeutic composition for Alzheimer's disease and a therapeutic composition for neuroinflammation, each of which comprises the compound.

The invention relates to a carboxylic acid reductase (MACAR) from Mycobacterium agri, and the carboxylic acid reductase (MACAR) shows higher substrate conversion efficiency than that of a source NiCAR (NiCAR) from Nocardia iowensis, and is suitable for the conversion production of vanillin from vanillic acid. A systematic process for efficient screening and verification of carboxylate reductase CAR identifies a plurality of novel CARs with potential industrial application values, and lays a foundation for directed evolution and industrial application.

This invention relates to a polyester polyol, a polyurethane resin, their preparation methods, and applications, belonging to the field of synthetic leather technology. The raw materials for preparing the polyester polyol, by weight percentage, include 7-15% polyethylene glycol, 22-39% p-hydroxybenzoic acid, 31-46% vanillic acid, and 12-24% 1,3-propanediol. The raw materials for preparing the polyurethane resin, by weight percentage, include 4-20% of the above-mentioned polyester polyol, 3-19% aliphatic polycarbonate diol, 1-4% isocyanate A, 1-4% isocyanate B, 1-4% aromatic polyester diol, and 60-80% solvent A. This invention, through formulation design of the polyester polyol and polyurethane resin, produces synthetic leather with high blackness and high gloss, which can maintain this high blackness and high gloss effect for a long time.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a dasatinib vanillic acid crystal form and a preparation method thereof, and in the dasatinib vanillic acid crystal form provided by the invention, the molar ratio of dasatinib to vanillic acid to water is 1: 1: 1. The dasatinib vanillic acid crystal form provided by the invention has relatively good stability and relatively high dissolution rate, and is of great significance for improving the bioavailability of a dasatinib medicine and preparing a preparation.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a minocycline hydrochloride-melatonin compound colon targeting capsule and a preparation method thereof. The capsule comprises a pellet and a capsule shell, wherein the pellet comprises a medicine core and a colon-targeted sustained-release layer wrapping the medicine core. The medicine core comprises active ingredients of minocycline hydrochloride and melatonin; the colon-targeted sustained-release layer comprises a special pH-enzyme colon-targeted response agent and a self-made plasticizer. The pH-enzyme responsive agent is based on a hydroxypropyl methylcellulose grafted vanillin derivative, and can be degraded in response to pH change and azo reductase at the colon part; the plasticizer has good compatibility with a coating material, and can effectively reduce leakage of drugs at the front ends of the stomach and intestines. The capsule prepared by the invention can obviously improve gastrointestinal stimulation of minocycline hydrochloride, realizes targeted release of the medicine at the colon part, and shows an excellent treatment effect on ulcerative colitis while reducing the dosage of antibiotics by utilizing the synergistic effect of melatonin.

The purpose of the present invention is to provide a microorganism which can selectively produce and / or accumulate vanillic acid while growing with use of not only H-type lignin-derived aromatic compounds but also S-type lignin-derived aromatic compounds as carbon sources, and a method for using the microorganism to produce vanillic acid. The purpose is achieved by, for example: a transformed microorganism, the host microorganism of which is Pseudomonas species (Pseudomonas sp.) NGC7 strain (accession number: NITE BP-03043), and in which a vanA4 gene (SEQ ID NO: 1) or the vanA4 gene and a vanB4 gene (SEQ ID NO: 2) on the chromosome are deleted; and a method for using the transformed microorganism to produce vanillic acid.

The present invention relates to use of a compound represented by formula (I) or an ester thereof or a pharmaceutically acceptable salt thereof in the treatment of a disease accompanied by fibrosis.

The invention discloses an upatinib eutectic crystal form as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The invention provides an eutectic crystal form I formed by upatinib and vanillic acid and an eutectic crystal form G formed by upatinib and syringic acid, which have definite and reproducible characteristic X-ray powder diffraction pattern and melting point, have excellent solubility in an aqueous medium, do not generate crystal form transformation after being stored for 1 month under the condition of relative humidity of 40 DEG C / 75%, and can be used for preparing a crystal form of upatinib. And the stability is good. The preparation process route is short, the operation condition is mild, the used solvent is conventional, the target eutectic can be efficiently and repeatedly obtained, the defects that some existing eutectic preparation processes are complex, long in period or harsh in condition are overcome, and the method has good process amplification and industrialization prospects.

The application relates to the technical field of packaging printing ink, and discloses a packaging printing ink capable of being cured by ultraviolet light and a production process thereof, the packaging printing ink comprises additives such as wear-resistant fillers and antioxidant fillers, wherein the wear-resistant fillers are prepared by grafting vinyl ester resin on the surface of nano-hydroxyapatite, the vinyl ester resin can improve the compatibility of the nano-hydroxyapatite and a base material, can directly bear and disperse part of pressure and shear force, avoids stress concentration on the base material, reduces a friction coefficient, thereby reducing wear, meanwhile, the vinyl ester resin has good toughness, and can improve the folding resistance of an ink film; the antioxidant fillers are prepared by introducing vanillic acid into butyronitrile rubber with alkenyl groups, the vanillic acid has antioxidant property, the alkenyl group can participate in subsequent curing, the vanillic acid is introduced into a molecular chain of the ink, meanwhile, migration of the vanillic acid is avoided.

The application discloses a detection method of Yichangleng composition, and the method comprises the following steps: S1, preparation of reference solution; S2, preparation of test solution; S3, preparation of mixed control solution; S4, respectively, precisely sucking Yichangleng test solution of S2 and mixed control solution of S3; injecting into a liquid chromatograph; S5, exporting Yichangleng characteristic spectrum obtained in S4, selecting chromatographic peaks existing in chromatograms of Yichangleng solution as characteristic peaks; calculating relative peak area and relative retention time of each characteristic peak; and according to the retention time of the chromatogram of the mixed control solution, labeling the components of the peaks in the control characteristic spectrum, the method can be used for detecting gallic acid, vanillic acid, paeoniflorin, uncarine, thalictrifolin, 5-O-methylvisamminol glycoside, quercetin, kaempferol and atractylochide II, and can realize overall quality control of Yichangleng solution.

The application provides a construction method of UPLC characteristic spectrum of Qinglongyi medicinal material, standard decoction and formula granules, comprising the following steps: dissolving and extracting raw materials of the test sample by using a solvent to obtain a test solution; determining the test solution by using high performance liquid chromatography to obtain the UPLC characteristic spectrum of Qinglongyi medicinal material, standard decoction and formula granules; and the high performance liquid chromatography conditions are as follows: a C 18 column is used as the chromatographic column; acetonitrile solution is used as mobile phase A, and 0.1% formic acid aqueous solution is used as mobile phase B, and gradient elution is adopted. The application adopts the high performance liquid chromatography, selects acetonitrile-0.1% formic acid solution as the mobile phase for gradient elution, takes protocatechuic acid, vanillic acid, syringic acid, ellagic acid, rutin and quercitrin as the reference substances, establishes the UPLC characteristic spectrum method of Qinglongyi medicinal material, standard decoction and formula granules, and provides more scientific technical means for controlling the medicinal quality of Qinglongyi medicinal material, standard decoction and formula granules.

The invention belongs to the cross technical field of microbial genetic engineering and food fermentation production, and particularly relates to a vanillin degradation related gene, application and an engineering strain for producing vanillin. The gene for regulating and controlling the production of vanillin by microorganisms is a 3-ketoacyl-ACP reductase gene, and the base sequence of the gene is shown in SEQ ID NO: 1. The 3-ketoacyl-ACP reductase gene is applied to regulation and control of degradation of vanillin. And the 3-ketoacyl-ACP reductase gene is knocked out from the chassis strain to obtain the 3-ketoacyl-ACP reductase. According to the invention, the fact that the fabG gene participates in the conversion of vanillin into vanillic acid is found for the first time, then the fabG gene is further utilized to modify the strain, the modification mode is highly targeted and has a remarkable effect, and through directional knockout of fabG and further knockout of vdh genes, phdB, fabG and modABC genes, the degradation pathway of vanillin is effectively blocked, and the product loss is reduced.

The invention discloses a mcl-PHA production method based on a wood and agricultural waste composite carbon source, and relates to the technical field of bio-manufacturing, the method comprises the following steps: adopting Pseudomonas putida BWCC66157 to carry out fermentation in an improved M9 minimum culture medium; a lignin-derived carbon source (such as vanillic acid) is used as a basic substrate; respectively introducing rubber wood hydrolysate and oil palm pomace palm oil as co-substrates; the directional regulation and control of the composition of the mcl-PHA monomer are realized by regulating and controlling the ratio of the co-substrate; and extracting the PHA by adopting a conventional method and detecting the monomer composition of the PHA. The PHA yield can be increased, new monomer components can be obtained, high-valued utilization of wood carbon sources and agricultural waste is achieved, and a new technical approach is provided for production of low-cost and degradable biological materials.

The invention discloses a method for rapidly determining various phenolic acid substances in a fermentation product, and belongs to the technical field of detection. The determination method comprises the following steps: 1. Taking a to-be-detected substance, and extracting phenolic acid substances in the to-be-detected substance through an alcohol precipitation-SAX solid-phase extraction combined technology to obtain a to-be-detected sample; analyzing the to-be-detected sample by adopting ultra-high performance liquid chromatography tandem triple quadrupole mass spectrometry to obtain the content of the target substance in the to-be-detected substance; the target substance is a non-volatile phenolic acid substance. Accurate quantification of trace and trace caffeic acid, dihydrocaffeic acid, ferulic acid, chlorogenic acid, gallic acid, vanillic acid, syringic acid, p-coumaric acid, salicylic acid and (+ / -)-catechin in fermentation products within 8-15 min is achieved by combining impurity removal and concentration pretreatment with ultra-high performance liquid chromatography tandem triple quadrupole mass spectrometry. According to the method, the pretreatment mode is convenient to operate, the detection process is fast, and the detection result is accurate.

The present invention relates to a method for preparing an intermediate for the synthesis of opicapone, which comprises the nitration of vanillic acid in an acid anhydride using a nitrating agent. The present invention also relates to an intermediate for the synthesis of opicapone produced by the process. Furthermore, the present invention relates to a solution of the intermediate for the synthesis of opicapone in an acid anhydride.

The application relates to an unsaturated polyester resin with low styrene volatility and a preparation method thereof, and belongs to the technical field of unsaturated polyester resins. The unsaturated polyester resin with low styrene volatility is composed of the following components: unsaturated polyester resin, sodium octenyl succinate starch, composite lignin sulfonate, pine bark polyphenol, vanillic acid and styrene. The composite lignin sulfonate is composed of calcium lignosulfonate and sodium lignosulfonate in a weight ratio of 1.93-1.95:1. The preparation steps are as follows: 1) respectively weighing and drying calcium lignosulfonate and sodium lignosulfonate and sieving; 2) respectively weighing and drying pine bark polyphenol and vanillic acid; 3) adding sodium octenyl succinate starch, pine bark polyphenol, vanillic acid into the unsaturated polyester resin to mix, adding calcium lignosulfonate to mix, adding sodium lignosulfonate to mix, and then adding styrene to mix to obtain the unsaturated polyester resin with low styrene volatility. The unsaturated polyester resin with low styrene volatility has the characteristics of good inhibition effect and low cost.

The invention discloses a bio-based plasticizer as well as a preparation method and application thereof, and relates to the technical field of plasticizers, and the structural formula of the bio-based plasticizer is shown in the specification. According to the bio-based plasticizer, abundant polar groups are obtained by introducing oligomeric lactic acid into a vanillic acid skeleton, and meanwhile, the proportion of non-polar groups of the plasticizer is expanded by introducing n-heptanol, so that the plasticizing performance, migration resistance and the like of the plasticizer are effectively improved, and the application of the bio-based plasticizer in polyvinyl chloride products is realized.

The invention relates to a bio-based liquid crystal copolyester, a fiber and a preparation method of the bio-based liquid crystal copolyester, the structure of the liquid crystal copolyester is shown as a formula (1), wherein 30 < = x < = 60, 30 < = y < = 130, and 15 < = z < = 100. The bio-based liquid crystal copolyester disclosed by the invention is formed by polymerizing three monomers, namely 6-hydroxy-2-naphthoic acid, 4-hydroxybenzoic acid and vanillic acid, and the bio-based liquid crystal copolyester can be used for preparing fibers with good mechanical properties.

The present invention relates to methods and uses of preventing or treating cancer The method or use may comprise administration of a cancer therapy together with a compound of Formula (I). In the compound of Formula (I) A is a substituted heteroaryl comprising at least one ring nitrogen; and D includes an optionally substituted: phenyl, N-linked 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, N-linked 10H-phenoxazinyl, indole, pyridinyl, pyrimidinyl, pyrazolo[1,5-a]pyridinyl or thienyl (or R3' and D together form a five or six membered ring). The compound of Formula (I) may be an inhibitor of transient receptor potential vanilloid 6 (TRPV6). The cancer therapy may be a chemotherapeutic agent. The present invention also relates to pharmaceutical compositions and kits comprising a compound of Formula (I) and / or a chemotherapeutic agent.

The application discloses a HPLC fingerprint spectrum establishing and content determination method of Zha Dihu, and belongs to the technical field of drug chemical component analysis. The application establishes a HPLC fingerprint spectrum, confirms that six common peaks in test sample solutions of 14 batches are p-hydroxybenzoic acid, vanillic acid, p-hydroxybenzaldehyde, shatavari glycoside, paeoniflorin and p-hydroxycinnamic acid, adopts SPSS 27 and SIMCA14.1 analysis software, carries out cluster analysis, principal component analysis and orthogonal partial least square discriminant analysis on peak areas of the six identified common peaks in the fingerprint spectrum of the Zha Dihu medicinal materials of the 14 batches, and carries out main component content determination. The chemical component composition of the Zha Dihu is determined, the characteristic components are revealed, and the main components are quantitatively analyzed, so as to provide a scientific basis for quality evaluation, efficacy research and subsequent development and utilization of the Zha Dihu.

The invention provides Rhodococcus qingsheng and application thereof in relieving continuous cropping obstacles of crops, and belongs to the technical field of microorganisms. The Rhodococcus qingsheng JA11 is separated and screened from the nature for the first time, phenolic acid autotoxic substances generated by ginseng continuous cropping obstacles can be efficiently degraded, the degradation rate of benzoic acid can reach 91.51%, various phenolic acids such as vanillic acid and cinnamic acid can be effectively degraded, and the degradation spectrum is wide; when the Rhodococcus qingsheng JA11 is applied under field conditions, the content of benzoic acid in soil for continuous cropping of ginseng can be effectively reduced, meanwhile, the root diseases of ginseng can be controlled to a certain extent, the growth indexes such as the survival rate and the root length of ginseng are remarkably improved, and a certain yield increasing effect is achieved.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a minocycline hydrochloride-melatonin compound colon-targeting capsule and a preparation method thereof. The capsule comprises pellets and a capsule shell, the pellets comprise a drug core and a colon-targeting sustained-release layer wrapped outside the drug core. The drug core contains active ingredients of minocycline hydrochloride and melatonin; the colon-targeting sustained-release layer contains a specially prepared pH-enzyme colon-targeting response agent and a self-prepared plasticizer. The pH-enzyme response agent is based on hydroxypropyl methylcellulose grafted vanillic acid derivatives, and can be degraded in the colon in response to pH changes and azo reductase; the plasticizer has good compatibility with coating materials, and can effectively reduce drug leakage in the stomach and the front end of the intestine. The capsule prepared by the application can significantly improve the gastrointestinal irritation of minocycline hydrochloride, realize targeted release of the drug in the colon, and utilize the synergistic effect of melatonin to reduce the dosage of antibiotics while showing excellent therapeutic effect on ulcerative colitis.

The invention discloses unsaturated polyester resin with low styrene volatility and a preparation method thereof, and belongs to the technical field of unsaturated polyester resin. The adhesive is prepared from the following components: unsaturated polyester resin, starch sodium octenylsuccinate, composite lignosulfonate, pine bark polyphenol, vanillic acid and styrene. The composite lignosulfonate is composed of calcium lignosulfonate and sodium lignosulfonate according to the weight ratio of (1.93-1.95): 1; the preparation method comprises the following steps: 1) respectively weighing calcium lignosulphonate and sodium lignosulphonate, drying and sieving; 2) respectively weighing pine bark polyphenol and vanillic acid, and drying; and 3) adding starch sodium octenylsuccinate, pine bark polyphenol and vanillic acid into the unsaturated polyester resin, mixing, adding calcium lignosulphonate, mixing, adding sodium lignosulphonate, mixing, adding styrene, and mixing to obtain the unsaturated polyester resin with low styrene volatility. The unsaturated polyester resin with low styrene volatility has the characteristics of good inhibition effect and low cost.

The present invention provides lipids of Formula (I) and (II) or subformulae thereof, or pharmaceutically acceptable salts thereof. Said lipids can be useful for the delivery and expression of mRNA and encoded protein, e.g. as a component of liposomal delivery vehicles, and accordingly can be useful for treating various diseases, disorders, and conditions, such as those associated with deficiency of one or more proteins. Compositions comprising lipid compounds of Formulae (I) and (II) and subformulae thereof, and mRNA encoding a peptide or protein may be administered to subjects in need thereof intramuscularly.

Disclosed in the present invention is the use of a water extract of Amomi fructus and / or a vanillic acid in the preparation of a drug for preventing and / or treating preeclampsia. Further disclosed in the present invention is the use of the water extract of Amomi fructus and / or the vanillic acid in the preparation of a drug for preventing and / or treating hypertension caused by preeclampsia, or a drug for preventing and / or treating proteinuria caused by preeclampsia, or a drug for reversing a reduction in placental weight caused by preeclampsia, or a drug for restoring fetal intrauterine growth restrictions caused by preeclampsia, or a drug for restoring pathological damage to placental tissue or placental dysfunction caused by preeclampsia, or a drug for reversing the reduction in placental efficiency caused by preeclampsia, or a drug for repairing colonic barrier damage or increased intestinal permeability caused by preeclampsia, or a drug for enriching the intestinal tract of a patient with preeclampsia with Bifidobacterium bifidum. The present invention overcomes the limitations of current drugs for treating preeclampsia which exhibit limited single therapeutic effects and gastrointestinal adverse reactions.

The present application relates to the technical field of detection of phenolic acid, and discloses a quantitative detection method of phenolic acid components in rape root exudates based on UPLC-MS / MS, wherein the phenolic acid in the rape root exudates is p-hydroxybenzoic acid, vanillic acid, syringic acid, ferulic acid and hesperidin. The method comprises the following steps: (1) mixing freeze-dried rape root exudate powder with an extraction solvent, fully shaking and mixing, centrifuging the obtained mixture to obtain root exudate extract; (2) preparing a mixed mother liquor of p-hydroxybenzoic acid, vanillic acid, syringic acid, ferulic acid and hesperidin standard substances, and drawing a standard curve; (3) determining the root exudate extract prepared in step (1) in a UPLC-MS / MS multiple reaction monitoring mode according to the operation method and conditions of step (2). The method can be used for rapid quantitative detection of phenolic acid components in rape root exudates.