129 results about "Vanillic acid" patented technology

The invention belongs to the technical field of microorganisms, and particularly relates to pseudomonas monteilii BDLZ-3 and application thereof in relieving continuous cropping obstacles of crops. The invention discloses a strain of pseudomonas monteilii BDLZ-3, the preservation number of which is CGMCC (China General Microbiological Culture Collection Center) No.34349. The pseudomonas monteilii BDLZ-3 is separated and screened from the nature for the first time, phenolic acid autotoxic substances generated in the ginseng continuous cropping obstacle process can be efficiently degraded, the degradation rate of benzoic acid can reach 95.36%, various phenolic acids such as vanillic acid, cinnamic acid, palmitic acid and gallic acid can be effectively degraded, and the degradation spectrum is wide; when the pseudomonas monteilii BDLZ-3 is applied in a field, the content of benzoic acid in soil can be effectively reduced, meanwhile, the occurrence of ginseng root diseases can be controlled to a certain extent, the prevention and treatment effect reaches 41.23%, the growth indexes such as root length and root thickness are remarkably improved, and the yield increasing effect is achieved.

The invention provides a lactobacillus plantarum MG360 with the efficacy of improving constipation, the preservation number of the lactobacillus plantarum MG360 is CGMCC NO 32953, and the lactobacillus plantarum MG360 is preserved in China General Microbiological Culture Collection Center on February 14, 2025. Meanwhile, the invention further provides a compound probiotic composition of the plant lactobacillus MG360 and the lactobacillus rhamnosus Eupro, the compound probiotic composition can be used for fermenting the coix seed enzymatic hydrolysate, and a fermentation product of the compound probiotic composition is rich in ferulic acid, vanillic acid, short-chain fatty acid, glutamic acid and the like. The fermentation product can obviously shorten the first black excrement discharge time of constipation mice, obviously improve the small intestine propulsion rate and the excrement water content, obviously improve the level of motility hormone (MTL, Gas, AchE, SP and 5-HT) in serum of the constipation mice and obviously reduce the level of inhibitory hormone (SS and VIP), and it is indicated that the fermentation product can relieve constipation by adjusting the gastrointestinal hormone peptide level. The preparation method of the probiotic preparation containing the plant lactobacillus MG360 and the compound probiotic fermentation preparation of the compound probiotic composition is simple, large-scale production can be achieved, and good application prospects are achieved.

The invention relates to the technical field of pesticides, and discloses a weeding composition for preventing and controlling alternanthera philoxeroides in a paddy field as well as a preparation method and application of the weeding composition. The weeding composition is prepared from three main effective components and an auxiliary agent, and the mass percent of each component is as follows: 6.00 to 8.00 percent of fluroxypyr, 14.00 to 18.00 percent of prometryn, 40.00 to 60.00 percent of vanillic acid, 5.00 to 13.00 percent of the auxiliary agent and the balance of deionized water. The weeding composition is applied in a stem and leaf spraying mode, that is, 30-45 days after rice transplanting, 100 g of the weeding composition is mixed with 30 Kg of water per mu to be evenly sprayed to the surfaces of plants at a time, the plant control effect and the biomass control effect on alternanthera philoxeroides in a rice field are remarkably better than those of three single dosages of fluroxypyr, prometryn and vanillic acid 30 days and 60 days after the weeding composition is applied, and the weeding composition is safe to rice and free of pesticide residues. The yield of the rice is increased by more than 10.00%, and the composition has the advantages of safety, high efficiency and long lasting period.

The invention discloses construction and application of a saccharomyces cerevisiae engineering strain for synthesizing vanillin by taking ferulic acid as a substrate, and belongs to the technical field of genetic engineering. The invention provides a recombinant saccharomyces cerevisiae, which is characterized in that a series of genes for producing vanillic acid and vanillyl alcohol from vanillin through oxidation and reduction are knocked out, and feruloyl coenzyme A synthetase FCS and p-hydroxycinnamyl coenzyme A hydratase ECH which are obtained by screening from a metagene library in a West Sichuan hot spring extreme environment are overexpressed. According to the engineering strain VAN002 with high yield of vanillin, the accumulation of vanillin reaches 16.8 g / L, and the molar conversion rate of catalyzing ferulic acid to synthesize vanillin reaches 93%, which is the highest level reported by synthesizing vanillin by saccharomyces cerevisiae at present.

The invention relates to a method for producing vanillin from natural lignocellulose biomass through co-culture of pichia pastoris, which comprises the following steps: respectively constructing a xylan hydrolysis recombinant strain (for releasing ferulic acid) and a vanillin synthesis recombinant strain (for converting ferulic acid) to realize conversion production from a natural xylan substrate to vanillin. In order to reduce the generation of by-products, 15 genes for coding aldehyde dehydrogenase (ALDRs), alcohol dehydrogenase (ADHs) and aldehyde ketoreductase (AKRs) are further knocked out from the vanillin synthesis recombinant strain, so that the vanillin can be further converted into the by-product vanillic acid, thereby improving the yield and purity of the vanillin.

The invention belongs to the field of traditional Chinese medicine prescription extraction process optimization, and particularly relates to a method for optimizing a classic famous prescription Xiaoxiaoxiao decoction extraction process based on orthogonal combination benchmark correlation degree and an AHP-entropy weight method. According to the invention, quality evaluation is carried out on the extraction process by taking the quality of a reference sample as a reference standard, orthogonal design is selected, and a relatively comprehensive quality control system taking the contents of vanillic acid, hypoxanthine, jateorhizine, coptisine, palmatine and berberine as well as fingerprint similarity and dry extract rate as comprehensive evaluation indexes is established; the limitation of the traditional single index on the quality control of the extraction process is avoided. A combined weighting method combining AHP and an entropy weight method is adopted, the defects caused by single weighting are overcome, and a reference is provided for modern preparation development of the classic famous prescription Xiaoxiaoxi decoction.

The invention relates to the technical field of agricultural biological prevention and control, and discloses a biological prevention and control complex microbial inoculant and application thereof.The biological prevention and control complex microbial inoculant is prepared by the steps that natural bio-based compounds vanillin and vanillic acid serve as main raw materials, and a biodegradable trialdehyde monomer is designed and synthesized; a biodegradable trialdehyde monomer and p-phenylenediamine are used as organic building units to assemble and form an ordered porous crystal structure, and the biodegradable COF material is obtained; the preparation method comprises the following steps: loading a basic complex microbial inoculant consisting of bacillus thuringiensis, bacillus subtilis and streptomyces willerigensis on a biodegradable COF material by adopting an impregnation adsorption method, and coating the surface of the biodegradable COF material with tetraethylenepentamine and tannic acid through copolymerization to form a degradable polytannic acid layer, so as to prepare the slow-release complex microbial inoculant, and the effective active components of the slow-release complex microbial inoculant can be slowly released; the lasting period and the utilization rate of the composite microbial agent can be remarkably improved, and the composite microbial agent shows an obvious inhibition effect on pathogenic bacteria such as fusarium oxysporum and botrytis cinerea and can be applied to prevention and treatment of plant diseases.

The invention belongs to the technical field of soil improvement, and discloses a preparation method of a composite microbial agent and application of the composite microbial agent in continuous cropping stress resistance, the active ingredients of the composite microbial agent comprise Gliocladium mucilaginosum, Trichoderma harzianum and Pseudomonas chlororaphis, and a carrier contains a basic carrier, a synergistic component and a soil adaptive component (oyster shell powder or wormcast particles). The preparation method comprises the following steps: strain fermentation, carrier construction, solid-state co-fermentation, and mixing of a dried fermentation product and a carrier. After the compound microbial agent is used, the abundance of gliocladium mucilaginosum, trichoderma harzianum and pseudomonas chlororaphis in continuous cropping crop soil is obviously increased, and the abundance of fusarium oxysporum is obviously reduced; the acidification condition of the acidified soil is obviously improved, the content of organic acids (ferulic acid and vanillic acid) in the soil is obviously reduced, and the soil becomes loose from hardening, so that the root activity is improved, and the plant diseases and insect pests are resisted; the single fruit weight and sugar degree can be remarkably improved, the fruit storage rotting rate is reduced, and the effect is remarkable.

The invention relates to the technical field of preparation of cupanicilib, and discloses a novel preparation method of cupanicilib, which comprises the following steps: by taking vanillic acid as an initial raw material, carrying out methyl esterification, nitration, alkylation reaction with N-3-chloropropylmorpholine hydrochloride, ester group hydrolysis, condensation with urea, nitro reduction, intramolecular condensation and condensation with chloroethylamine hydrochloride to obtain cupanicilib. According to the synthetic scheme, the synthetic route is short, the raw materials are easy to obtain, the yield is high, no dangerous reaction process exists in the reaction process, a highly toxic reagent is not used, and the synthetic scheme is green and efficient.

The invention relates to a method for preparing an intermediate for synthesis of olpinapone. The method comprises the step of nitrating vanillic acid in anhydride by using a nitrating agent. The present invention also relates to an intermediate for the synthesis of olpiapone produced by this process. In addition, the present invention relates to a solution of an intermediate for the synthesis of olpiapone in an anhydride.

The invention belongs to the technical field of medical analysis, and particularly relates to a method for separating chemical components in hemsley rockvine root. According to the present invention, various chromatography methods are adopted to carry out separation and purification, such that sitroside (I), vanillyl glycolII (II), 5-hydroxymaltol (III), vanillic acid (IV), afzelin (V), 2, 3-dihydroxypyrazole (9E, 11E)-13-hydroxypyrazole (9, 11-dienoate), and 2, 3-dihydroxypyrazole (10E, 12E)-9-hydroxypyrazole (10, 12-dienoate) are obtained from hemsley rockvine root. Wherein the compounds II, III, VI and VII are separated from the hemsley rockvine root for the first time, and development and quality control of the hemsley rockvine root medicinal material are facilitated.

The invention belongs to the technical field of organic copper, and particularly relates to copper vanillate as well as a preparation method and application thereof. The invention provides copper vanillate. The chemical formula of the copper vanillate is Cu2 (C8H7O4) 4 (H2O) 2. Copper and vanillic acid are combined to obtain copper vanillate, the multi-component structure can interact with several target positions in bacteria, and the risk of drug-resistant gene enrichment is effectively reduced. Meanwhile, copper and vanillic acid are combined to form copper vanillate, the bioavailability of copper can be improved, copper vanillate has excellent antioxidant activity, broad-spectrum antibacterial activity and excellent antibacterial performance, and organic copper can release Cu < 2 + > under different pH values, so that the risk that Cu induces toxicity can be effectively reduced. The preparation method of the copper vanillate is mild in reaction condition, capable of reacting at room temperature, simple to operate and suitable for large-scale production.

The invention provides a novel application of a raspberry extract. It is found through tests that any one of isoquercitrin, ellagic acid, vanillic acid, oleanolic acid, kaempferol-3-O-rutinoside, kaempferol-3-O-sophoroside, tiliroside, tormentic acid and raspberry extract can remarkably improve the activity of the human ovarian granular cells or remarkably improve the oxidative stress level, and the activity of the human ovarian granular cells can be remarkably improved. According to the present invention, the ovarian function can be effectively protected by the eight components, the ovarian function can be effectively protected by the eight components, or the mitochondrial membrane potential level can be significantly regulated and controlled, or the estrogen level in the microenvironment can be effectively maintained, such that the ovarian function can be effectively protected by the eight components, and the raspberry extract containing the eight components. The invention provides a new choice for ovarian function protection products, and also provides a new application for the substances.

The invention discloses octyl vanillate as well as a preparation method and application thereof, and relates to the field of insulating oil additives. According to the invention, vanillic acid and n-caprylic alcohol are subjected to esterification reaction under the action of the bio-enzyme catalyst to synthesize octyl vanillate, and the synthesis method is efficient, green, environment-friendly and low in cost. The prepared octyl vanillate is added into the synthetic ester insulating oil as an antioxidant active component, a long ester chain in the octyl vanillate has high thermal stability, the oxidation of the synthetic ester insulating oil can still be effectively inhibited at high temperature, and the compatibility between the octyl vanillate and the synthetic ester insulating oil is good. Therefore, compared with traditional antioxidants, the synthetic ester insulating oil has remarkable advantages in the aspect of maintaining excellent oxidation resistance and electrical performance of the synthetic ester insulating oil.

The invention relates to the technical field of catalysts, in particular to a preparation method of an iron-cobalt oxide and Beta molecular sieve composite catalyst and application of the iron-cobalt oxide and Beta molecular sieve composite catalyst to demethoxylation of lignin derivative vanillic acid. Meanwhile, due to the interaction of iron and cobalt species, the acid site of the catalyst is enhanced, and adsorption and activation of a substrate are facilitated; the iron-cobalt oxide is combined with the Beta molecular sieve, and the reaction activity of demethoxylation is improved through cooperation of metal / zeolite; the Co0 / Fe0. 04Co0. 96O-Beta composite catalyst is used for a vanillic acid demethoxylation catalytic reaction, the reaction is performed for 2 hours under the condition of 0.4 MPa H2 and 0.4 MPa CO2, the substrate conversion rate reaches 96.07%, the p-hydroxybenzoic acid selectivity reaches 86.96%, and the target product yield is 83.54%.

The application provides a pharmaceutical composition for functional dyspepsia and a preparation method and application thereof, and belongs to the technical field of medicines, and the pharmaceutical composition comprises the following components: Aucklandia, Atractylodes, Mentha, Agastache, Citrus aurantium, Uncaria, Tribulus terrestris, Guangdong Shenqu, Chrysanthemum, Poria cocos, Radix Trichosanthis, Coix seed, Magnolol, Imperatorin, Isoimperatorin, Oxypeucedanin, Ferulic acid, Vanillic acid, p-Coumaric acid and Puerarin. The pharmaceutical composition comprises traditional Chinese medicine components and compounds, the components interact with each other, the effect of the pharmaceutical composition on improving functional dyspepsia can be improved, and meanwhile, the pharmaceutical composition has excellent stability.

The invention relates to a construction method and a detection method of characteristic chromatograms of a Java amomum cardamomum medicinal material, a standard decoction and a traditional Chinese medicine formula granule. According to the method, proper ultra-high performance liquid chromatography conditions are selected, protocatechuic acid, (4R, 6R)-6-hydroxypiperidone, (4R, 5R)-4-Hydroxy-5-isopropyl-2-methylaminohex-2-enone, vanillic acid and (4S, 5R)-4-Hydroxy-5-isopropyl-2-methylaminohex-2-enone are used for preparing a reference substance solution, a Java amomum cardamomum medicinal material, a standard decoction or / and formula granules are used as a test sample for detection, a characteristic spectrum is constructed, and the characteristic spectrum is applied to the detection of the Java amomum cardamomum medicinal material, the standard decoction or / and the formula granules. The characteristic chromatogram contains 9 characteristic peaks, is rich in chromatogram information, can reflect the quality of the Java amomum cardamomum medicinal material, can reflect the quality of standard Java amomum cardamomum decoction and traditional Chinese medicine formula granules, can be used for detecting the quality of the Java amomum cardamomum medicinal material, the standard Java amomum cardamomum decoction and the traditional Chinese medicine formula granules, and has a wide application prospect. The invention provides an effective method for quality detection of the Java amomum cardamomum and the modern preparation thereof, and also provides a scientific experimental basis for research on comprehensive quality evaluation of the Java amomum cardamomum and the modern preparation thereof.

The present invention relates to a vanillic acid derivative compound which can be formed by a dehydration condensation reaction between vanillic acid and catecholamine. The vanillic acid derivative compound according to the present invention is characterized in that it can be used as a therapeutic preparation for Alzheimer's disease and neuroinflammation. In addition, the present invention relates to a therapeutic composition for Alzheimer's disease and a therapeutic composition for neuroinflammation, each of which comprises the compound.

The invention relates to a carboxylic acid reductase (MACAR) from Mycobacterium agri, and the carboxylic acid reductase (MACAR) shows higher substrate conversion efficiency than that of a source NiCAR (NiCAR) from Nocardia iowensis, and is suitable for the conversion production of vanillin from vanillic acid. A systematic process for efficient screening and verification of carboxylate reductase CAR identifies a plurality of novel CARs with potential industrial application values, and lays a foundation for directed evolution and industrial application.

This invention relates to a polyester polyol, a polyurethane resin, their preparation methods, and applications, belonging to the field of synthetic leather technology. The raw materials for preparing the polyester polyol, by weight percentage, include 7-15% polyethylene glycol, 22-39% p-hydroxybenzoic acid, 31-46% vanillic acid, and 12-24% 1,3-propanediol. The raw materials for preparing the polyurethane resin, by weight percentage, include 4-20% of the above-mentioned polyester polyol, 3-19% aliphatic polycarbonate diol, 1-4% isocyanate A, 1-4% isocyanate B, 1-4% aromatic polyester diol, and 60-80% solvent A. This invention, through formulation design of the polyester polyol and polyurethane resin, produces synthetic leather with high blackness and high gloss, which can maintain this high blackness and high gloss effect for a long time.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a dasatinib vanillic acid crystal form and a preparation method thereof, and in the dasatinib vanillic acid crystal form provided by the invention, the molar ratio of dasatinib to vanillic acid to water is 1: 1: 1. The dasatinib vanillic acid crystal form provided by the invention has relatively good stability and relatively high dissolution rate, and is of great significance for improving the bioavailability of a dasatinib medicine and preparing a preparation.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a minocycline hydrochloride-melatonin compound colon targeting capsule and a preparation method thereof. The capsule comprises a pellet and a capsule shell, wherein the pellet comprises a medicine core and a colon-targeted sustained-release layer wrapping the medicine core. The medicine core comprises active ingredients of minocycline hydrochloride and melatonin; the colon-targeted sustained-release layer comprises a special pH-enzyme colon-targeted response agent and a self-made plasticizer. The pH-enzyme responsive agent is based on a hydroxypropyl methylcellulose grafted vanillin derivative, and can be degraded in response to pH change and azo reductase at the colon part; the plasticizer has good compatibility with a coating material, and can effectively reduce leakage of drugs at the front ends of the stomach and intestines. The capsule prepared by the invention can obviously improve gastrointestinal stimulation of minocycline hydrochloride, realizes targeted release of the medicine at the colon part, and shows an excellent treatment effect on ulcerative colitis while reducing the dosage of antibiotics by utilizing the synergistic effect of melatonin.

A process for lignin depolymerization is disclosed herein. The process comprises providing a solution comprising dissolved lignin; adding an oxidation catalyst to the solution comprising dissolved lignin; and heating the solution to provide a depolymerized lignin product. Also disclosed is a depolymerized lignin product comprising at least one or more of the following: vanillin at 15-25 wt. %; apocynin at 6-12 wt. %; acetosyringone at 12-15%; syringaldehyde at 13-30 wt. %; syringic acid at 16-24 wt. %; vanillic acid at 5-15 wt. % for use as a cosmetic ingredient and / or food additive.

The purpose of the present invention is to provide a microorganism which can selectively produce and / or accumulate vanillic acid while growing with use of not only H-type lignin-derived aromatic compounds but also S-type lignin-derived aromatic compounds as carbon sources, and a method for using the microorganism to produce vanillic acid. The purpose is achieved by, for example: a transformed microorganism, the host microorganism of which is Pseudomonas species (Pseudomonas sp.) NGC7 strain (accession number: NITE BP-03043), and in which a vanA4 gene (SEQ ID NO: 1) or the vanA4 gene and a vanB4 gene (SEQ ID NO: 2) on the chromosome are deleted; and a method for using the transformed microorganism to produce vanillic acid.

Provided is an organic-inorganic compound, and the organic-inorganic compound contains a curable reactive group and includes a structure represented by Formula 1 below:

The invention discloses an L-carnitine-based ionic liquid aqueous two-phase system as well as a preparation method and application thereof, and belongs to the technical field of aqueous two-phase system separation. The prepared L-carnitine-based ionic liquid aqueous two-phase system is a novel ionic liquid aqueous two-phase system which is more efficient when active substances are extracted (extraction and separation can be achieved by stirring for 30 min and centrifuging for 5-8 min at the speed of 6000-8000 rpm), the extraction rate of vanillin, eugenol, p-hydroxybenzaldehyde, syringaldehyde and vanillic acid reaches 85.37% or above, and the L-carnitine-based ionic liquid aqueous two-phase system is a novel ionic liquid aqueous two-phase system. The method can be applied to the fields of organic compound extraction, medicine extraction, environmental protection and the like, and has a great development prospect.

The invention discloses ultraviolet curing epoxy acrylic resin, which is prepared from the following raw materials in parts by weight: 80 to 90 parts of bisphenol A epoxy resin, 20 to 30 parts of methacrylic acid, 20 to 30 parts of modified vanillic acid, 0.1 to 3 parts of trimethyl benzyl ammonium chloride, 0.01 to 1 part of polymerization inhibitor and 1 to 6 parts of photoinitiator, and the modified vanillic acid has higher copolymerization reaction activity; the invention also discloses a preparation method of the ultraviolet-cured epoxy acrylic resin. The ultraviolet curing epoxy acrylic resin provided by the invention is colorless and transparent, has good flame retardant property, low viscosity, good water solubility and excellent mechanical property, and can be widely applied to many fields such as woodware floor paint, plastic paint, template paint, paper gloss oil and the like.

The present invention relates to use of a compound represented by formula (I) or an ester thereof or a pharmaceutically acceptable salt thereof in the treatment of a disease accompanied by fibrosis.

The application discloses vanillyl octyl ester, a preparation method and application thereof, and relates to the field of insulating oil additives. Vanillyl acid and n-octanol are subjected to esterification under the action of a biological enzyme catalyst to synthesize vanillyl octyl ester, and the synthesis method is efficient, green, environmentally friendly and low in cost. The prepared vanillyl octyl ester is added into synthetic ester insulating oil as an antioxidant active ingredient, the long ester chain in the vanillyl octyl ester has high thermal stability, can effectively inhibit the oxidation of the synthetic ester insulating oil at high temperature, and has good compatibility with the synthetic ester insulating oil. Therefore, compared with traditional antioxidants, the vanillyl octyl ester has significant advantages in maintaining excellent antioxidant properties and electrical properties of the synthetic ester insulating oil.