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Phenolic acid compound and use thereof in the preparation of anticomplementary medicaments

A technology of compounds and phenolic acids, which is applied in the field of preparing anti-complement drugs, can solve the problems such as compounds that have no inhibitory effect on the complement system, and achieve a good inhibitory effect.

Inactive Publication Date: 2010-09-01
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

Clinically, it can be used alone or in combination with other traditional Chinese medicines to treat acute and chronic nephritis, acute hepatitis A, acute bronchitis, tuberculosis and hemoptysis, but so far there have been no reports of compounds that have an inhibitory effect on the complement system

Method used

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  • Phenolic acid compound and use thereof in the preparation of anticomplementary medicaments
  • Phenolic acid compound and use thereof in the preparation of anticomplementary medicaments
  • Phenolic acid compound and use thereof in the preparation of anticomplementary medicaments

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Abstract

The invention relates to a phenolic acid compound and use thereof in the preparation of anticomplementary medicaments. The phenolic acid compound has a chemical structure formula shown in the specification; when R1 is COOH, and R2 is OCH3, the compound is vanillic acid; and when R1 is-CH=CH-COOH, and R2 is H, the compound is para-hydroxycinnamic acid. The invention has the advantages that the phenolic acid compound is directly extracted from natural product, and the compounds of vanillic acid and para-hydroxycinnamic acid have better inhibition function to the classical pathway of a complement system.

Description

technical field The present invention relates to a phenolic acid compound, in particular to a phenolic acid compound and its use in the preparation of anti-complement drugs. Background technique Excessive activation of the complement system can lead to systemic lupus erythematosus, rheumatoid arthritis, acute respiratory distress syndrome and other diseases. The study of anti-complement drugs has been the focus and focus of the world's pharmaceutical research for many years. At present, there is no ideal drug for the treatment of such diseases, so there is an urgent need for a new type of complement inhibitor with high efficiency, low toxicity and specificity in clinical practice. The cost of researching and developing complement inhibitors directly from natural products is low, and most active ingredients can be directly digested and absorbed by the body as part of natural products. more and more attention. Scholars at home and abroad have isolated a large number of mono...

Claims

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Application Information

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IPC IPC(8): C07C65/21C07C59/52A61K31/192A61P37/00
Inventor 刘荣华陈道峰付丽娜
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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