1091results about How to "Medication safety" patented technology

The invention discloses a eudesmane typed sesquiterpene acid compound named 5alphaH-eudesmane-11 (13)-alkylene-12 acid, which is characterized by the following: inhibiting the replication of HBsAg and HBV-DNA; fitting for preparing prevention drug of virus B hepatitis; reducing the application in the hepatitis B surface antigen drug.

Secure methods of distributing and prescribing prescription medications and related systems significantly increase prescription medication distribution security. Applications of the present invention are particularly useful in prescribing and distributing lifestyle drugs where an actual physical examination is not necessarily required, but are similarly useful for all prescription medications. A system configured according to a particular embodiment of the present invention involves a prescription request kiosk, a prescription request review terminal, a medical information database, and a pharmacy all associated with a prescription distribution system processor. Particular embodiments of prescriptions of the present invention include a photograph of a prescription requestor on the prescription for added security along with additional follow-up questions to be asked by the pharmacist to the customer. Requestors initiate prescription requests by answering a plurality of questions related specifically to the prescription medications requested.

The invention relates to a levamlodipine besylate tablet, a preparation process thereof and a control method for relevant materials. Each 1000 levamlodipine besylate tablets provided by the invention comprise the following compositions: 2.5g of levamlodipine besylate (measured in besylate), 30 to 50g of lactose (as a filler), 20 to 40g of beta-cyclodextrin (as an inclusion agent), 25 to 45g of microcrystalline cellulose (as a disintegrating agent), 5 to 15g of cross-linked polyvinylpyrrolidone (as a disintegrating agent), 1 to 2g of magnesium stearate (as lubricant), and 50 to 80g of 2.5% HPMC (hydroxypropyl methylcellulose) and 50% ethanol (as an adhesive). The levamlodipine besylate tablet provided by the invention has the advantages of making multi-item improvements on the properties of the levamlodipine besylate, increasing the solubility and apparent dissolution rate of the tablet, improving the stability of the tablet, reducing the excitability of the tablet, significantly reducing the limit of the relevant material, and having better clinical treatment effect, so that the blood pressure lowering of the patient with hypertension is more stable.

The invention provides a clinic medicine control and written order evaluation method comprising the steps of calling an HIS system, and judging whether the order is qualified; if yes, calling a PASS system to perform safe medication examination on the order, and determining a security level of medication in the order; if the medicine in the order is not absolutely forbidden, sending the order, and calling an HIS system again to further examine and control the order and judge whether the order is qualified; if the order is primarily qualified, sending the order to a clinic medication supervision platform or a doctor order comment module in the PASS system to comment on the written order of the clinical doctor. According to the method provided by the invention, the problems that at present orders and medication are uncontrollable, errors are prone to occur, and medical levels of hospitals are relatively poor are solved.

The invention discloses a Chinese herbal microecological preparation for preventing and treating chicken Colibacillosis and a preparation method thereof. The Chinese herbal microecological preparation for preventing and treating chicken Colibacillosis is prepared by adding mixed bacterial liquid of bifidobacteria and bacillus subtilis with a total number of colonies of 0.5-1.0*10<8> CFU/ml into the extract of traditional Chinese medicines and carrying out hermetical anaerobic fermentation on an obtained mixture, wherein the traditional Chinese medicines comprise, by weight, 50 to 200 parts of coptis, 50 to 200 parts of phellodendron, 50 to 200 parts of rheum officinale, 50 to 200 parts of root of large-flowered skullcap, 50 to 200 parts of isatis root and 50 to 100 parts of licorice. The Chinese herbal microecological preparation for preventing and treating chicken Colibacillosis provided in the invention allows pharmaceutical activity of the compatible traditional Chinese medicines to be enhanced after fermentation treatment by using bacterial liquid of bifidobacteria and bacillus subtilis, reduces drug resistance exerted by the medicines on chicken on the basis of guaranteeing a good curative effect and maintains a good treatment effect after many times of administration.

The invention relates to a neo-gambogic acid SLN (solid lipid nanoparticle) and a preparation method thereof. The neo-gambogic acid SLN comprises a therapeutically effective amount of neo-gambogic acid, medicinal phosphatide, a surfactant and a lipid material. In the invention, the neo-gambogic acid is prepared into SLNs (solid lipid nanoparticles), thereby improving the solubility of the neo-gambogic acid, reducing the irritability, improving the bioavailability, and prolonging the action time of medicaments in a human body, in addition, the neo-gambogic acid SLNs can be gathered partially in the human body so as to play the targeted action of the SLNs and exert the anti-cancer therapeutic action of the SLNs better.

The invention relates to application of levorotatory oxiracetamto to the field of pharmacy, and specifically relates to application of levorotatory oxiracetamto preparation of medicaments for preventing or treating cognitive dysfunction. According to the invention, levorotatory oxiracetamto with a purity higher than 99.3% is used as a material, so that hidden trouble of drug toxicity caused by invalid ingredients in a medicament is eliminated to further ensure medications safety. In addition, levorotatory oxiracetamto is a single active ingredient in the medicament of the invention, so that medicament quality is easier to control, and a curative effect is more obvious.

The invention discloses an adverse drug reaction early warning and analyzing system and method. The adverse drug reaction early warning and analyzing system comprises a doctor workstation platform, an early warning system and an analyzing system. The adverse drug reaction early warning and analyzing method comprises the following steps: sending medical history information to the early warning system through the doctor workstation platform; judging whether data according with ADR (Adverse Drug Reaction) trigger rules exist in the medical history information or not through the early warning system, if the data exist, calculating an ADR estimate value and sending to the analyzing system through the early warning system, calculating the ADR occurrence rate and feeding back to the early warning system through the analyzing system, feeding back the ADR occurrence rate to the doctor workstation platform through the early warning system, modifying medication orders or sending medication use reasons to the early warning system and the analyzing system through the doctor workstation platform; and if the data do not exist, feeding back the prompt of executing the medical orders to the doctor workstation platform through the early warning system. The adverse drug reaction early warning and analyzing system and method which are disclosed by the invention have the advantages that in the process of transmitting the medication orders, the reasonability of the medication orders can be judged by means of computers; medical workers are prompted for possible medication use risks; the hospital-wide medical orders are automatically monitored; and the medication use safety is increased.

The invention discloses a traditional Chinese medicine composition for treating senile vaginitis; the oral medicine includes: herba epimedii, angelica sinensis, rhizoma atractylodis macrocephalae, motherwort, astragalus mongholicus, peach kernel, cuscuta chinensis, fructus ligustri lucidi, mulberry, radix polygonum multiflorum, eclipta alba, raspberry, scutellaria baicalensis, dogwood, cape jasmine and ligusticum wallichii; and the external medicine includes: myrrh, radix sophorae flavescentis, fructus cnidii, oldenlandia diffusa, Chinese violet, radix stemonae, sargent gloryvine, patrinia, golden cypress, safflower, fructus kochiae, pearl and motherwort. The traditional Chinese medicine composition in the invention has androgen-like action and estrogen-like action, and can enhance resistance of senile vagina and urethra mucosa; the contained polysaccharide and general flavone components further have antioxidant and anti-aging effects. The traditional Chinese medicine composition further has the effects of clearing heat and detoxicating, killing parasites to relieve itching, and can be used for treating the senile vaginitis and relieving symptoms such as itching, and can diminish inflammation and disinfect; and the traditional Chinese medicine composition is obvious in medical effect, safe in administration, simple and good in compliance of old patients.

The invention discloses application of butylphthalide or derivatives thereof in preparation of medicaments for promoting angiogenesis. According to the invention, butylphthalide and derivatives thereof have significant actions of promoting angiogenesis to a transgenic zebra fish model of which green fluorescent protein is expressed by blood vessel endotheliocyte surface and an in-vitro cultured human umbilical vein endotheliocyte model, thus can be used for preparing the medicaments for promoting angiogenesis and has potential value in application to other ischemic related diseases.

The invention relates to application of a gossypol derivative to preparing an anti-tumor medicament and discloses a novel gossypol derivative, use of the derivative for preparing a medicinal composition for preventing and treat tumors, and the medicinal composition comprising the gossypol derivative and a preparation method thereof.

The invention provides a quality detection method for tibetan medicine rhododendron anthopogonoide and a tibetan medicine rhododendron anthopogonoide preparation. The method includes: determining the total flavonoid content in the rhododendron anthopogonoide and the rhododendron anthopogonoide preparation by ultraviolet-spectrophotometry; simultaneously determining the total quercetin content in the rhododendron anthopogonoide and the rhododendron anthopogonoide preparation in the same chromatograph by high-performance liquid chromatography; and establishing a finger-print chromatogram of flavonoids in the rhododendron anthopogonoide and the rhododendron anthopogonoide preparation by the high-performance liquid chromatography. Therefore, quality of the rhododendron anthopogonoide and the rhododendron anthopogonoide preparation can be guaranteed by detecting whether common peaks exist in the finger-print chromatogram or not, and further medication safety for patients is guaranteed. The quality detection method is stable in sample solution, high in precision and excellent in reproducibility, has certain specificity, is good in separating effect of each characteristic constituent in the finger-print chromatogram, can be used for quality detection of rhododendron anthopogonoide medical materials, and is beneficial to guarantee of safety, effectiveness, controllability in quality and good clinical effect for the tibetan medicine rhododendron anthopogonoide and the tibetan medicine rhododendron anthopogonoide preparation.

The invention provides a synthesis method of high-purity moxifloxacin hydrochloride, which comprises the following steps: protecting carbonyl of ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxoquinolyl-3-carboxylate by using ethyl borate; performing condensation with (S,S)-2,8-diazabicyclo[4.3.0]nonane; deprotecting with hydrochloric acid to obtain a moxifloxacin hydrochloride crude product; dissolving the obtained moxifloxacin hydrochloride crude product with an alkali water solution, extracting with organic solvent, removing the organic phase, and adding hydrochloric acid into the water phase to regulate the pH value to acidity; crystallizing, filtering to obtain a filter cake, and recrystallizing the obtained filter cake with water-containing organic solvent; and finally, filtering, and drying to obtain the high-purity moxifloxacin hydrochloride. The product prepared by the method has the advantages of high purity, high yield and favorable reproducibility, and has very high industrial operation feasibility.

The invention provides a pantoprazole sodium enteric-coated tablet and a preparation method thereof. The pantoprazole sodium enteric-coated tablet comprises a pantoprazole sodium tablet, an isolated layer and an enteric-coated layer, wherein the pantoprazole sodium tablet comprises main drug pantoprazole sodium and auxiliaries; and the auxiliaries include a filler, a disintegrant, a lubricating agent, an adhesive, a pH regulating agent, and the like. The pantoprazole sodium enteric-coated tablet accelerates the disintegration time of the pantoprazole sodium enteric-coated tablet and solves the problem of drug instability during a storage period.

The invention belongs to the field of traditional Chinese medicine pharmacy, in particular to a novel emulsion for intravenous injection of an anti-cancer drug taxol or polyenic taxusol, and a preparation method thereof. The emulsion consists of the taxol or the polyenic taxusol, and oil for injection, emulsion, in particular to glycol laurylhydroxystearate, and other pharmaceutically necessary auxiliary materials. Results via experiments show that the injection emulsion has excellent stability and haemolysis significantly smaller than a commercial taxol injection, and is helpful for improving administration safety and effectiveness of the taxol. The emulsion for intravenous injection can be directly used for intravenous injection, has the advantages of safe administration and small stimulation, can be easily accepted by patients, and can be used as an energy replenisher. The emulsion has the advantages of good stability, large drug loading, convenient use and simple preparation technology method, and is applicable to mass production.

The invention discloses maca superfine powder as well as a preparation method and application thereof. The grain size of the maca superfine powder is measured by a dry method laser granulometry meter and is 0.5-3 micrometers. The preparation method of the powder comprises the following steps: 1 removing impurities and cleansing; 2 freeze-drying, and carrying out sterilization treatment after drying; 3 grinding dry maca powder into coarse powder, then carrying out superfine-grinding in a jet mill, and thus obtaining the superfine powder with the grain size being 0.5-3 micrometers. The conditions of superfine-grinding are as follows: the grinding temperature is 18-25 DEG C, the pressure of a superfine-grinding machine when the powder enters the superfine-grinding machine is 1.5-3Mpa, the grinding pressure is 3-7Mpa, the airflow velocity is 190-300m/s, and the grinding time is 1-3h. The maca superfine powder is used for treating low immunity, physical fatigue and sexual dysfunction and has the advantages of being significant in curative effect and stable in condition of patients, improving the survival quality of patients, increasing the weight of patients, improving the immunologic function of patients, and being safe in medication.

The invention relates to the field of research into pharmaceutical chemistry, and particularly discloses a novel aromatic acid pro-drug with nitrogen monoxide donor, and a preparation method and application thereof in preventing and treating thrombotic diseases. In the invention, natural aromatic acid compounds with strong antithrombotic actions are structurally modified, and the carboxylic acid groups are incorporated with nitrogen monoxide donor to obtain the nitrogen monoxide donor type aromatic acid pro-drug with favorable liposolubility. The aromatic acid pro-drug with nitrogen monoxide donor has favorable solubility, can effectively permeate into the biomembrane lipid bimolecular layer, and can enhance the bioavailability after the human body takes the pro-drug. The pro-drug can be resolved into aromatic acid compounds and release nitrogen monoxide, and the aromatic acid compounds and nitrogen monoxide can cooperate to perform the pharmacological activities of resisting thrombi, resisting platelet aggregation and the like. The aromatic acid pro-drug with nitrogen monoxide donor can be used for preventing and treating thrombotic diseases and cerebral ischemia diseases.

A drug composition for NSCLC (Non Small Cell Lung Cancer) prevention comprises the following raw materials: astragalus membranaceus, radix pseudostellariae, radix ophiopogonis, schisandra chinensis, cordyceps sinensis, codonopsis pilosula, bulbus fritillariae cirrhosae, semen armeniacae amarae, folium eriobotryae, houttuynia cordata, angelica sinensis, pseudo-ginseng, cornua cervi pantotrichum, leech, oldenlandia diffusa, selfheal, sculellaria barbata, calculus bovis and centipede. The drug composition achieves medication safety, has no toxic or side effects, has excellent effect, can be used for effectively solving the problem of poor treatment effect of NSCLC, improves the life quality of patients suffering from the middle and advanced stage NSCLC, and prolongs the lifetime of the patients.

The invention provides an opiates painkiller and opiate receptor antagonist-containing medicinal composition. In the medicinal composition, an opiates painkiller is fentanyl, remifentanil, sufentanil, alfentanil and pharmaceutically acceptable salts thereof; and an opiate receptor antagonist is naloxone, naltrexone, nalmefene and pharmaceutically acceptable salts thereof. The medicinal composition has a pharmacological effect on analgesia. Compared with using the opiates painkiller singly, the composition can prevent and/or lighten side effects in pain treatment, reduce abuse and improve adaptability, and has a reinforcing effect on an analgesic effect of the opiates painkiller.

The invention relates to a plaster for treating cervical spondylosis, lumbar vertebra disease and hyperosteogeny, and belongs to the field of Chinese medicinal prescription. The plaster is prepared from the following raw materials: stiff silkworm, suberect spatholobus stem, panicled fameflower root, eucommia, rhizoma cibotii, angelica, radix angelicae pubescentis, pangolin, hemlock parsley, Chinese angelica, mongshood, common burreed rhizome, curcuma zedoary, gastrodia elata, bidentate achyranthes root, earthworm, large-leaved gentian, asarum, corydalis tuber, divaricate saposhnikovia root, radix stephaniae tetrandrae, cortex acanthopanacis, schizonepeta, pseudo-ginseng, parasitic loranthus, common club moss herb, frankincense, myrrh, fossil fragment, dragon's blood, camphor, kudzuvine root, and cassia twig. The plaster has the characteristics of strong drug effect, remarkable curative effect, safe administration, convenience for use, good curative effect, quick response, fundamentally treatment, walking availability after healing, work influence prevention, relapse prevention and the like, and is well proved and recognized by broad patients.

The invention provides application of dicycloplatin in preparation of an antiviral drug and/or antibacterial drug and application of the dicycloplatin in preparation of an antiviral adjuvant drug and/or antibacterial adjuvant drug. Viruses related in the invention are RNA viruses such as hepatitis B virus, hepatitis C virus, human immunodeficiency virus and influenza virus, and the antibacterial drug is resistant to mycobacterium tuberculosis and/or nontuberculosis mycobacteria, Research results prove that dicycloplatin has the effect of resisting multiple bacteria and viruses, especially has obvious inhibitory effect on drug-resistance bacteria, no obvious cytotoxicity and high medication safety.

The invention relates to a surface coating adopting contraceptive for women, which consists of one or more than one active components such as compound, infiltrating accelerant, and humectant in anti-progestin medicine or progestational hormone medicine and estrogen medicine as well as normal raw materials such as oily component, aqueous component, macromolecule material, surface active agent, bacteriostat, chemical inhibitor and spice and so on. The invention can be made into electuary, emulsion, cream, jellies, spray and liquid cream so as to be used in contraception, urgent contraception, lactation contraception and reproductive health. The contraceptive adopts a method of being coated on the skin or the mucosa surface to reach the aim so as to prevent the first-pass effect and the gastrointestinal tract effect of the oral medicine, thereby reducing the injure to the liver and the kidney, reducing toxic and side effect, providing new preparation, method and route of administration for enlarging the range of the medicine-user, and making the contraception become more simple, convenient, easier and more willing to be accepted.