19results about How to "Medication safety" patented technology

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine compound composition with a treatment effect on rapid atrial fibrillation and a preparation method of the traditional Chinese medicine compound composition. The traditional Chinese medicine composition comprises radix pseudostellariae, rhizoma polygonati, radix rehmanniae preparata, radix paeoniae alba, spina date seed, mulberry, jujube kernel, schisandra chinensis, Huai wheat, radix ophiopogonis, ligusticum wallichii, salvia miltiorrhiza, radix rehmanniae, coptis chinensis, radix paeoniae rubra, liquorice, fingered citron, calcined dragon bone, calcined oyster shell and rose. The invention aims at the basic pathogenesis of rapid atrial fibrillation dialectically belonging to insufficiency of heart yin, deficiency of essence and blood, unsmooth emotion, blood vessel stasis, stasis depression and fever which are caused by tachycardia and irregular pulse and rhythm. The clinical research proves that the traditional Chinese medicine compound composition can obviously reduce the recurrence frequency and recurrence rate of patients suffering from paroxysmal rapid atrial fibrillation and improve the symptoms of palpitation, chest distress, palpitation and the like of rapid atrial fibrillation, and has the advantages of good clinical curative effect and wide application prospect. The defects of western medicines can be well overcome.

The invention discloses a glycocholic acid sustained release preparation and a production process thereof. The glycocholic acid sustained-release preparation comprises glycocholic acid sustained-release pellets, and the preparation method of the glycocholic acid sustained-release preparation comprises the following steps: firstly, preparing glycocholic acid and auxiliary materials into a drug-containing pellet core according to a formula, then coating the drug-containing pellet core with a sustained-release material to obtain the sustained-release pellets, and finally, filling the sustained-release pellets into capsules to obtain the glycocholic acid sustained-release preparation. The preparation method comprises the following steps: carrying out wet granulation-extrusion rolling to obtain wet pills, drying, and coating with a fluidized bed to obtain the glycocholic acid sustained-release pellets. The quality of the drug-loaded pellet is controlled according to indexes such as roundness, bulk density, yield and the like, the drug release effect of the sustained-release pellet is evaluated according to the dissolution rate, and the release mechanism and the initial stability of the glycocholic acid sustained-release pellet are investigated. The invention has the advantages of favorable sustained-release effect, reduced medication frequency, simple and feasible preparation process, favorable reproducibility and favorable drug stability, is suitable for industrial production, aims at supporting the research and development of the compound sustained-release drug, and has obvious social and economic benefits.

The present invention relates to the field of drug analysis technology, and specifically to a Da Shanzhao Pill HPLC detection method, Da Shanzhao Pill fingerprint and application; the detection method includes Da Shanzhao Pill fingerprint and main index component quantitative method. A systematic investigation was conducted on different extraction methods, extraction time, extraction solvent, and extraction volume of samples to screen out the optimal extraction conditions; and the measurement data was systematically analyzed using chemometric tools. The results of the method are reliable and highly accurate, and can reflect the overall quality of commercially available Da Shanzhao Pills; the method can effectively monitor the quality status of Da Shanzhao Pills, and provide a scientific evaluation strategy for the control of the quality consistency and effectiveness of the preparation.

The invention discloses a traditional Chinese medicine compound composition for treating functional dyspepsia and a preparation method and application thereof. The traditional Chinese medicine compound composition is prepared from 5-20 parts of gordon euryale seeds, 6-12 parts of Chinese yams, 10-30 parts of astragalus membranaceus, 10-30 parts of roasted rhizoma atractylodis macrocephalae, 10-20 parts of smoked plums, 3-15 parts of pericarpium citri reticulatae viride, 10-40 parts of malt, 6-12 parts of roasted endothelium corneum gigeriae galli, 10-20 parts of honey-fried licorice roots and the like. The traditional Chinese medicine composition is prepared according to the theory of treatment based on syndrome differentiation, has the functions of strengthening the spleen and stomach, promotes digestion and absorption, and has an exact treatment effect on related symptoms caused by dyspepsia. Most medicinal materials are medicinal and edible, have small toxic and side effects and are safe and reliable to take.

This invention discloses a compound preparation for treating vascular dementia and its preparation method. The active pharmaceutical ingredient consists of protopanaxadiol and gallic acid in a 1:1 mass ratio, and the dosage form is liposomes. The preparation method includes extraction, mixing, liposome preparation, and optional freeze-drying steps: protopanaxadiol and gallic acid are extracted and purified from ginseng rhizome and Terminalia chebula fruit, respectively. After mixing, they are combined with phospholipids and cholesterol to prepare a lipid membrane. The membrane is then homogenized by hydration, low-temperature ultrasound, and high-pressure microfluidic jet to obtain a homogeneous liposome suspension, which can be further freeze-dried into a freeze-dried powder. The 1:1 composition of protopanaxadiol and gallic acid targets multiple points on the pathological mechanism of vascular dementia, showing significant therapeutic effects and broad application prospects. This preparation uses a liposome dosage form to improve the bioavailability of the active ingredient, the preparation process parameters are controllable, the active ingredient has high purity, the liposomes have uniform particle size, high encapsulation efficiency, and good stability.

The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine composition for treating diabetes and application thereof, a traditional Chinese medicine preparation and a preparation method. The medicine is prepared from the following raw materials in parts by weight: 10-20 parts of astragalus membranaceus, 10-20 parts of radix polygonati officinalis, 5-15 parts of folium mori, 5-15 parts of gynostemma pentaphylla, 5-15 parts of fried medicated leaven, 3-9 parts of coptis chinensis, 1-5 parts of pseudo-ginseng and 0.5-1.5 parts of cinnamon. The traditional Chinese medicine composition is good in monarch, minister, assistant and guide, and has the effect of improving physical and chemical indexes of diabetics and the like through mutual compatibility. Clinical observation finds that the composition disclosed by the invention can well improve symptoms and signs of patients, is safe in medication, stable and reliable in curative effect and suitable for further popularization and application.

The invention belongs to the technical field of traditional Chinese medicine compounds, and provides a depression-resolving and nerve-calming formula for treating insomnia and relieving anxiety and a preparation method thereof, the depression-resolving and nerve-calming formula comprises the following raw materials: 10-30 parts of radix curcumae, 8-24 parts of radix asparagi, 5-15 parts of flos albiziae, 2-6 parts of cortex cinnamomi, 1-3 parts of semen ziziphi spinosae, 1-3 parts of magnetite and 1-3 parts of amber; the depression-resolving and nerve-soothing compound prescription can effectively improve the physical conditions such as eating, hair color and weight of rats with insomnia; the sleep latency period of rats with insomnia is shortened, the sleep duration is prolonged, and the in-vivo 5-HT level is adjusted, so that an exact treatment effect on insomnia is achieved; for a depression rat model, the total activity distance of depression rats can be effectively increased, and the autonomous swimming time and the tail suspension struggling time are prolonged.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition suitable for type II diabetes and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 45 parts of radix astragali seu hedysari, 20 to 30 parts of herba dendrobii, 30 to 45 parts of rhizoma polygonati, 20 to 30 parts of radix ophiopogonis and 20 to 30 parts of corn stigma. According to the traditional Chinese medicine composition, through the synergistic effect of core components such as astragalus membranaceus for tonifying qi, lifting yang, promoting salivation and nourishing blood, dendrobium nobile for tonifying stomach and promoting salivation, polygonatum kingianum for tonifying qi, nourishing yin, moistening lung and tonifying kidney, radix ophiopogonis for nourishing yin and promoting salivation and the like, glucose metabolism balance is effectively adjusted, insulin resistance is improved, and therefore the effect of reducing blood glucose and / or lipid is achieved.

The invention relates to a traditional Chinese medicine composition for treating hyperlipemia, which can effectively solve the medication problem of hyperlipemia. The traditional Chinese medicine composition is prepared from, by weight, 15-25 g of lotus leaves, 13-23 g of rhizoma alismatis, 6-12 g of flos carthami, 6-12 g of peach kernels, 4-8 g of poria cocos, 4-8 g of rhizoma atractylodis macrocephalae, 4-8 g of agastache rugosus, 4-8 g of herba eupatorii, 8-16 g of pinellia ternate, 8-16 g of gynostemma pentaphyllum, 8-16 g of semen cassiae, 6-12 g of ligusticum wallichii and 4-8 g of scutellaria baicalensis. The traditional Chinese medicine composition for treating hyperlipemia has the advantages that the effect of treating hyperlipemia with intermingled phlegm and blood stasis is obvious, the hyperlipemia can be effectively improved, the medication is safe, no obvious adverse reaction exists, and the traditional Chinese medicine composition is an innovation of hyperlipemia treatment medicines.

The invention relates to the technical field of medicine production, and discloses a freeze-drying process and application thereof. The freeze-drying process comprises the step of enabling a sample to sequentially pass through a pre-freezing stage, a primary drying stage and a secondary drying stage to obtain a freeze-dried product, in the pre-freezing stage, a cooling-heating-cooling mode is adopted, and the temperature change range is-50 DEG C to-10 DEG C; the primary drying stage comprises three times of slope heating, and the temperature change range is-50 DEG C to-2 DEG C; the secondary drying stage comprises three times of slope heating, and the temperature change range is-2 DEG C to 30 DEG C. According to the freeze-drying process provided by the invention, by adopting a cooling-heating-cooling pre-freezing mode, the crystallization rate of the sample is effectively improved, the water solubility of the freeze-dried sample is good, the sublimation drying time is effectively shortened, and the freeze-drying efficiency is accelerated; and in the primary drying stage and the secondary drying stage, the heating temperature parameter and the vacuum degree are controlled, so that the freeze-dried sample shows a relatively good appearance and has a proper water content.

The present invention belongs to the technical field of Chinese medicine preparation, and specifically relates to a Chinese medicine composition for treating hypertension or hypertension combined with hyperlipidemia and a preparation method thereof. The Chinese medicine composition for treating hypertension or hypertension combined with hyperlipidemia of the present invention is composed of the following raw materials in parts by weight: 8-20 parts of stinking knotweed, 8-20 parts of polyphemus, 1-5 parts of astragalus, 1-5 parts of mistletoe, 3-6 parts of siler, 1-5 parts of glossy privet, 1-5 parts of oriental rhizome, 1-2 parts of eucommia bark, 1-2 parts of ligusticum, 1-2 parts of ligusticum, 1-2 parts of chuanxiong, and 1-2 parts of earthworm. The Chinese medicine composition of the present invention has good antihypertensive and lipid-lowering effects, can effectively treat hypertension, has little side effects, and is particularly suitable for hypertension combined with hyperlipidemia.

The present application relates to a kind of traditional Chinese medicine composition for treating depression, relate to the technical field of traditional Chinese medicine, by weight parts, the traditional Chinese medicine composition for treating depression includes the following raw materials: 50~80 parts of hair and 10~25 parts of Chinese hackberry.The traditional Chinese medicine composition provided by the present application is mainly hair and supplemented with appropriate Chinese hackberry, both are used in combination, can treat depression together, and the effect of anti-stress depression is remarkable, formula is simple, drug is safer, provides a new means for the treatment of depression patients.

The present invention provides a solution of vilanterol triphenylacetate for inhalation, a preparation method and an application thereof, wherein the inhalation solution comprises an active substance, a solvent and an excipient. The single-dose specification of the inhalation solution is 1 ml, and the single-dose specification comprises 15 to 50 μg / mL of vilanterol triphenylacetate and / or its hydrate as an active substance; the solvent is water for sterile injection, and the excipients comprise an osmotic pressure regulator and a pH regulator, the osmotic pressure regulator has a concentration of 5 to 9 mg / ml, and the pH regulator is added to make the pH value of the inhalation solution preparation be 5.0 to 7.0. The solution of the present invention is packaged in a single dose, does not contain a preservative, is safe and convenient to use, and is used in combination with a liquid nebulizer to provide a safe, effective and stable pharmaceutical dosage form and drug delivery system for inhalation of vilanterol triphenylacetate.

This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a Qi-invigorating and blood-activating granule for heart pain and its preparation method, comprising the following raw materials in parts by weight: 25-35 parts of raw Astragalus membranaceus, 10-20 parts of Angelica sinensis, 5-15 parts of ginseng, 4-8 parts of Panax notoginseng, 10-20 parts of Ligusticum chuanxiong, 8-12 parts of earthworm, and 2-4 parts of leech. This invention precisely targets the core pathogenesis of Qi deficiency and blood stasis syndrome, which is "Qi deficiency as the root and blood stasis as the manifestation," selecting raw Astragalus membranaceus and ginseng as the core Qi-invigorating components, and Panax notoginseng, leech, Ligusticum chuanxiong, Angelica sinensis, and earthworm as the core blood-activating components. The formulation follows the traditional Chinese medicine principle of "invigorating Qi to promote blood circulation without harming the body's vital energy." The dosage of each raw material has been optimized through systematic experiments to form a specific range of parts by weight, solving the technical problems of poor targeting and insufficient synergy in existing formulations.

The invention provides an externally-applied traditional Chinese medicine formula for treating innominate pyogenic infections and a preparation method of the externally-applied traditional Chinese medicine formula, and relates to the technical field of externally-applied traditional Chinese medicines, and the externally-applied traditional Chinese medicine formula comprises rhizoma atractylodis macrocephalae, Mitsubishi, spina gleditsiae, Chinese honeylocust fruit, dried seven roots, croton seeds, centipedes, raw turtle shells, minium, raw pangolin scales, ground beetles, musk, raw ginger, fistular onion stalks and sesame oil. The traditional Chinese medicine is externally applied to treat innominate pyogenic infections, the traditional Chinese medicine is directly attached to the outer surface of the skin to achieve the treatment purpose, oral treatment is not needed, the medicine effect of the formula is not absorbed through the digestive tract, and the influence of various digestive systems and the metabolic function of the liver can be avoided; the traditional Chinese medicine composition is safe and reliable in medication, free of toxic and side effects, free of stimulation to viscera, capable of accelerating metabolism and enhancing the immunity of the body, good in treatment effect and high in cure rate, and provides a safer and more comfortable treatment environment for patients, and external application of the traditional Chinese medicine composition is achieved.

The invention belongs to the field of biological medicine, and particularly relates to a Milsartan potassium photodegradation impurity and a preparation method thereof. The method comprises the following steps: carrying out illumination destruction on Milsartan potassium powder under the condition of contacting with air, enriching with an organic solvent, carrying out column chromatography separation and recrystallization purification to obtain the novel Milsartan potassium photodegradation impurity, and the highest purity of the obtained impurity is 99.6%. The photodegradation impurity disclosed by the invention is actually detected in related substance inspection of a photostability test of a Milsartan potassium raw material medicine and a Milsartan potassium preparation, the detection values are respectively 0.23% and 0.25%, and the photodegradation impurity is one of main degradation impurities and has research necessity; the structure of the impurity compound is represented, and the impurity compound can be used as an impurity reference substance and is used for analysis, detection, quality control and the like of Milsartan potassium bulk drugs and preparations.

The invention is suitable for the technical field of drug-loaded polymer medical preparations, and provides a carbamazepine non-aqueous transdermal absorption patch and a preparation method thereof, the carbamazepine non-aqueous transdermal absorption patch comprises the following components by mass: 0.5%-10% of carbamazepine, 10%-50% of a matrix, 0.1%-1.5% of an antioxidant, 0.5%-10% of a cosolvent, 0.1%-10% of a penetration enhancer, 5%-70% of a plasticizer, and 10%-70% of a tackifier; preferably, the carbamazepine tablet comprises the following components in percentage by mass: 1%-5% of carbamazepine, 10%-30% of the matrix, 0.1%-1% of the antioxidant, 1%-5% of the cosolvent, 0.1%-5% of the penetration enhancer, 10%-50% of the plasticizer and 10%-50% of the tackifier. The prepared patch is convenient and safe to use, the compliance of a patient is greatly improved, the drug release rate is high, the oral absorption rate of carbamazepine is increased, the drug effect is stable, and clinical requirements are met.

The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine preparation for treating allergic rhinitis and a preparation method thereof.The traditional Chinese medicine preparation is prepared from, by weight, 10-60 g of platycodon grandiflorum, 40-70 g of rhizoma zingiberis, 15-65 g of Chinese yam and 25-95 g of honey-fried licorice root. The traditional Chinese medicine composition is used for treating allergic rhinitis and has the advantages of being convenient to use, quick in effect taking, convenient to take, low in price, exact in anti-allergic effect, free of toxic and side effects and safe in medication.

The invention discloses a fumigation bag for treating female dysmenorrhea, amenorrhea and infertility. The fumigation bag is prepared from the following traditional Chinese medicine raw materials in parts by weight: 2-6 parts of radix sophorae flavescentis, 1-4 parts of rhizoma polygonati, 2-6 parts of cynomorium songaricum seeds, 1-3 parts of semen cuscutae, 2-5 parts of radix morindae officinalis, 1-5 parts of mulberry shreds, 1-4 parts of herba epimedii, 1-3 parts of maca, 2-6 parts of oysters, 2-5 parts of burdock roots and 3-7 parts of glossy privet fruits. The traditional Chinese medicine composition follows the medication principle of traditional Chinese medicine, is reasonable in formula, safe in medication, good in curative effect and convenient to use, treats female severe dysmenorrhea, amenorrhea and infertility and other symptoms caused by cold in uterus in a Yao-nationality hip bath mode, and fumigation has the effects of accelerating blood flow and promoting blood circulation to remove blood stasis. The medicine components of the formula are matched with the compatibility taboo of monarch, minister, assistant and guide, so that the medicine effect can be quickly delivered to the uterus and the whole body, and the treatment effect and the treatment speed of the medicine are improved.