The invention discloses a new traditional Chinese medicine composition for treating the disease of chronic nephritis and a preparation method thereof. The composition mainly comprises the following raw medicines: tuckahoe, notopterygium root, atractylodes macrocephala koidz, oriental waterplantain rhizome, plantain seed, rhizoma atractylodis, officinal magnolia bark, areca peel, rheum officinale,chrysanthemum, taraxacum officinale root, amur corktree bark, rhizoma cyperi, eucommia bark, zanthoxylum pipertum, talc, Japanese climbing fern spore, glossy privet fruit, epimedium herb, semen alliituberose, angelica, pyrrosia lingua, akebiaquinata, medicated leaven, malt, gizzard pepsin, cape jasmine, immature bitter orange, pericarpium zanthoxyli, Chinese eaglewood, loosestrife, pollen typhaecarbonisatus, cacumen biotae carbonisatus and semen euryales. The composition can be prepared into any one common oral preparation according to the conventional traditional Chinese medicine preparation method. The composition can obviously improve the symptoms such as abdominal fullness and distention, anasarca, fatigue and heaviness, chest stuffiness and poor appetite, aching and limp waist and knees, extreme chilliness, palpitation and severe palpitation and the like, and features confirmed clinical effects, obvious and quick effects. The composition basically combines the medicinal and editable medicines specified in the State Pharmacopoeia, thus having the advantages of low cost and no toxic side effects basically, etc.