14 results about "Chronic nephritis" patented technology

The invention provides application of enhanced mesenchymal stem cells and exosomes in chronic nephritis and renal failure, and belongs to the technical field of biological medicine manufacturing. Through composite pretreatment of salidroside and astragalus polysaccharide, the treatment potential of exosomes secreted by the mesenchymal stem cells is remarkably enhanced, a new thought is provided for intervention of the chronic kidney diseases, and various pathologies of the chronic kidney diseases are covered. In addition, a 3D microenvironment constructed by fibrin gel is combined to simulate an in-vivo extracellular matrix, the natural growth state of the stem cells is better fitted, directional differentiation and function regulation of the stem cells are promoted, and therefore the biological activity and targeting performance of the exosome are improved.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a ginseng and licorice root formula for treating renal hematuria, its preparation method, and its application. The ginseng and licorice root formula for treating renal hematuria of this invention comprises the following raw materials in parts by weight: 5-15 parts of Codonopsis pilosula, 15-30 parts of Rehmannia glutinosa, 5-15 parts of Ligustrum lucidum, 5-15 parts of Eclipta prostrata, 5-15 parts of Imperata cylindrica, 5-15 parts of Rubia cordifolia, 5-15 parts of Cirsium japonicum, 5-15 parts of Taraxacum mongolicum, 5-8 parts of Prunus persica, and 3-5 parts of Glycyrrhiza uralensis. Clinical trials have shown that the ginseng and licorice root formula for treating renal hematuria of this invention not only reduces urinary red blood cells but also improves traditional Chinese medicine clinical symptoms such as lower back and knee weakness, fixed or stabbing lower back pain, pale complexion, fatigue, dry mouth, bitter taste, sore throat, rough skin, and poor appetite. It has good therapeutic effects, reliable safety, and can significantly improve the treatment efficacy of chronic nephritis syndrome.

The application discloses a RAP polypeptide analogue and medical use thereof, and belongs to the polypeptide medical field, and the amino acid sequence of the RAP polypeptide analogue is Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-Xaa17, and the N terminal of the RAP polypeptide analogue is acetylated, and the C terminal amino acid is amidated. Compared with the natural RAP polypeptide, the analogue has higher stability, bioavailability and drug efficacy, meanwhile, the dosage is low, the toxic and side effects are not obvious, the production cost is low, and the analogue has good popularization and clinical application prospects. The analogue is suitable for preventing and treating acute and chronic nephritis, chronic nephropathy and renal fibrosis caused by the acute and chronic nephritis, pulmonary inflammation and pulmonary fibrosis caused by the pulmonary inflammation, chronic liver disease and liver fibrosis caused by the chronic liver disease and the like.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chronic nephritis and a preparation method and application thereof. The traditional Chinese medicine composition for treating chronic nephritis is prepared from the following raw materials in parts by weight: radix angelicae sinensis, roasted rhizoma atractylodis macrocephalae, radix stephaniae tetrandrae, radix saposhnikoviae, poria cocos, herba epimedii, fructus rosae laevigatae, radix astragali and rhizoma curcumae. After a chronic nephritis patient is treated by the traditional Chinese medicine composition, indexes such as serum creatinine and 24-hour urine protein can be remarkably improved, clinical symptoms are remarkably relieved, and a better product is provided for treating the chronic nephritis patient.

The invention provides application of a composition in preparation of a medicine for treating chronic nephritis, and relates to the field of traditional Chinese medicine preparations. The composition is prepared from the following components in parts by weight: 1 to 4 parts of radix rehmanniae total iridoid glycoside extract, 2 to 6 parts of fructus corni total iridoid glycoside extract and 0.5 to 1.5 parts of fructus corni total triterpene acid extract. The composition shows remarkable drug effects in the aspects of improving the survival state of rats with chronic nephritis, reducing 24-hour urine protein, reducing kidney indexes, reducing hematuria, inhibiting inflammation and the like, and has excellent multiple treatment effects, particularly, the effect of the composition in a specific combination proportion range is equivalent to that of a positive control drug prednisone acetate group, and the composition has good clinical application prospects. And the performance is even better in some indexes.

The present invention provides a codonopsis pilosula nnannf particle solid beverage and a production method thereof, the codonopsis pilosula nnannf particle solid beverage is prepared by selecting genuine codonopsis pilosula nnannf, cleaning, extracting, concentrating and drying through modern equipment, taking crushed cane sugar, glucose, maltodextrin and an extract according to a ratio of 1: 2: 5: 2, mixing, granulating, drying, finishing and inspecting, and the codonopsis pilosula nnannf particle solid beverage is obtained. The particle solid beverage is convenient to take, appropriate in taste, easy to absorb and easy to preserve, a proper amount of the particle solid beverage is taken, the particle solid beverage is brewed with boiled water and stirred until being completely dissolved, and the particle solid beverage is taken after being cooled to be warm, can be taken for multiple times a day and is suitable for long-term application. According to the preparation method, the side effect of dryness of raw codonopsis pilosula nnannf is removed, the effects of harmonizing the stomach, strengthening the spleen, benefiting qi and nourishing blood are obviously enhanced, and the traditional Chinese medicine composition can be applied to clinical patients suffering from chronic gastritis, chronic nephritis, infantile diarrhea, anemia in the obstetrics and gynecology department, spleen and lung qi deficiency after radiotherapy and chemotherapy and the like in an auxiliary mode and is more suitable for the old, weak, infants, pregnant women and other people suffering from immunity deficiency.

The invention discloses a traditional Chinese medicine ointment formula for treating kidney deficiency and damp-heat syndrome type chronic glomerulonephritis as well as a preparation method and application thereof. The ointment formula is prepared from astragalus membranaceus, codonopsis pilosula, bighead atractylodes rhizome, donkey-hide gelatin, radix aconiti lateralis preparata, semen cuscutae, eucommia ulmoides, the root of kudzu vine, dried ginger, medicated leaven, rhizoma polygonati, gynostemma pentaphylla, teasel root, lucid ganoderma, divaricate saposhnikovia root, ligusticum wallichii, the root of bidentate achyranthes, parasitic loranthus, deer-horn glue, angelica sinensis, pulp of dogwood fruit, caulis spatholobi, gastrodia elata and pyrrosia lingua. According to the pathogenesis characteristics of the chronic glomerulonephritis, according to clinical practice, treatment based on syndrome differentiation, emphasis on tongue vein change, emphasis on combination of four diagnoses, mastering of yin and yang, and taking flat as a period; five internal organs are harmonized, and spleen and kidney are used as the basis; warm and clear effects are combined, and dynamic and static effects are combined; clinical test results show that after the ointment provided by the invention is used for treatment, the improvement condition of a treatment group is obviously superior to that of a control group, and the total effective rates of the treatment group and the control group in the treatment effect of the traditional Chinese medicine syndromes are 93.3% and 46.7% respectively; therefore, the ointment has a remarkable curative effect in the aspect of relieving the traditional Chinese medicine syndromes of the patients with the kidney-deficiency damp-heat syndrome type chronic nephritis.

The invention discloses a traditional Chinese medicine compound for improving chronic nephritis and application, and relates to the technical field of traditional Chinese medicine preparations. Comprising 15-30 parts of gastrodia elata, 15-30 parts of cistanche, 10-20 parts of eucommia ulmoides, 10-20 parts of schisandra chinensis, 15-30 parts of herba epimedii, 10-20 parts of semen raphani, 15-30 parts of semen cuscutae, 15-30 parts of morinda officinalis, 10-20 parts of fructus rosae laevigatae, 15-20 parts of fructus lycii, 20-40 parts of mulberries, 15-30 parts of American ginseng, 10-20 parts of cornu cervi pantotrichum, 10-20 parts of gordon euryale seeds, 10-20 parts of rhizoma polygonati, 10-20 parts of astragalus membranaceus, 10-20 parts of Chinese yam, 20-40 parts of Chinese chive seeds, 20-40 parts of Chinese dates and 20-40 parts of coix seeds. And adding one or more pharmaceutically acceptable auxiliary materials, and preparing pills or solvents according to a conventional process. The traditional Chinese medicine compound can improve the renal function of mice with chronic nephritis, reduce the ratio of urinary albumin / creatinine and the level of serum creatinine and blood urea nitrogen, and inhibit the expression of inflammatory factors interleukin-1beta and interleukin-6 and tumor necrosis factor-alpha.

The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine composition for treating chronic nephritis and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following substances in parts by weight: 11-19 parts of garden balsam stem, 6-14 parts of cowherb seed, 11-19 parts of pubescent holly root, 6-14 parts of artemisia anomala, 11-19 parts of sambucus williamsii, 11-19 parts of mistletoe and 5-10 parts of cortex periplocae. The traditional Chinese medicine composition has the following effects that the curative effect on chronic nephritis is remarkable, the effects of reducing urine protein and traditional Chinese medicine syndrome integration and the like are achieved, and the safety is high.

The application provides an application of enhanced mesenchymal stem cells and exosomes in chronic nephritis renal failure, and belongs to the technical field of biological medicine manufacturing.The application significantly enhances the treatment potential of exosomes secreted by mesenchymal stem cells through the composite pretreatment of rhodioside and astragalus polysaccharide, provides a new idea for the intervention of chronic kidney disease, and covers various pathologies of chronic kidney disease.The application also combines a 3D microenvironment simulated by a fibrin gel constructed extracellular matrix in the body, is more suitable for the natural growth state of stem cells, promotes the directional differentiation and functional regulation of stem cells, and thus improves the biological activity and targeting of the exosomes.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for improving glomerular capillary microcirculation. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of radix paeoniae alba, 4-14 parts of lucid ganoderma, 1-11 parts of wine-treated rhubarb, 4-14 parts of ground beeltle, 7-17 parts of astragalus membranaceus, 4-14 parts of stiff silkworm, 1-11 parts of leech and 1-11 parts of honey-fried licorice root. The traditional Chinese medicine composition is used for improving glomerular capillary microcirculation, and can effectively delay the progress of chronic nephritis, protect the renal function, reduce the occurrence of complications and improve the life quality of patients. Therefore, the method has a good application prospect.

The invention relates to the technical field of biological medicines, and particularly discloses a tripterygium wilfordii outer vesicle as well as an extraction method and application thereof. The extraction method comprises the following steps: taking tripterygium wilfordii raw juice, carrying out stepped centrifugation on the tripterygium wilfordii raw juice by virtue of 6000-7000 g and 8000-12000 g to remove impurities, extracting by virtue of a plant tissue external vesicle extraction kit, carrying out centrifugation on the tripterygium wilfordii raw juice by virtue of 10000-14000 g and 12000-15000 g in combination with low-temperature standing to separate and precipitate, carrying out resuspension on the precipitate, and taking supernate again, so as to obtain the tripterygium wilfordii external vesicles. Animal experiment results show that the kidney coefficient, urea nitrogen, urine protein and cholesterol levels of mice with chronic nephritis can be remarkably reduced by intragastric administration of 0.1 mg of tripterygium wilfordii external vesicles per day, the pathological injury improvement effect is superior to that of traditional tripterygium wilfordii polyglycoside tablets, and a new way for effectively relieving chronic nephritis is provided.

The application discloses a traditional Chinese medicine composition for treating chronic nephritis hematuria and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 18-22 parts of Astragalus membranaceus, 10-14 parts of female ligustrum lucidum, 10-14 parts of euphorbia humifusa, 10-14 parts of panax notoginseng, 2-4 parts of rhizoma cimicifugae, 18-22 parts of herba viola, 18-22 parts of rubia cordifolia, 1-3 parts of vinegar schisandra, 5-7 parts of gold cherry fruit, 5-7 parts of gordon euryale seed and 5-7 parts of calcined oyster shell. The traditional Chinese medicine composition for treating chronic nephritis hematuria can reduce the serum creatinine, urea nitrogen and urine protein levels of a nephritis hematuria model rat, plays a kidney function protection role, reduces the number of red blood cells in urine and the whole blood viscosity, plays a blood-activating and stasis-removing hemostatic role, can obviously improve the hematuria symptoms of the rat, and the symptoms are stable after drug withdrawal and no rebound phenomenon occurs.

The application discloses a TRPC5 inhibitor and a preparation method and application thereof, and the TRPC5 inhibitor comprises a compound of formula I, stereoisomers of the compound, isotope-labeled derivatives of the compound, pharmaceutically acceptable salts of the compound, prodrugs of the compound or solvates of the compound. The compound has a good inhibiting effect on a TRPC5 ion channel, and is expected to be used for treating various diseases related to the TRPC5, such as cancers, depression, chronic nephritis and the like.