50 results about "Kidney pathology" patented technology

The invention provides a multi-modal kidney pathological picture processing method and device, electronic equipment and a medium. The method comprises the following steps: acquiring an immunofluorescence picture included in a to-be-processed multi-modal kidney pathological picture and a PAS staining pathological picture corresponding to the immunofluorescence picture; inputting the immunofluorescence pictures into a pre-trained first network model to perform nephropathy type classification to obtain nephropathy types; judging whether the nephropathy type output by a pre-trained first network model belongs to a preset nephropathy type or not; inputting a PAS staining pathological picture corresponding to the immunofluorescence picture into a pre-trained second network model for pathological structure identification when the immunofluorescence picture belongs to the preset nephropathy type, and outputting a label for the identified pathological structure; and adding an Oxford typing label to the to-be-processed multi-modal kidney pathological picture based on a label and a pathological structure output by a pre-trained second network model. According to the scheme, the nephropathy type can be automatically distinguished, the Oxford typing label is added, the processing speed is high, and the accuracy rate is high.

The invention belongs to the field of image analysis, and particularly discloses a kidney pathological image segmentation model, a construction method thereof, a segmentation method and a system, and the method comprises the steps: training a network model through a training set, and enabling the trained network model to be a segmentation model; the training set comprises a kidney pathology image and a corresponding mask label, and the mask label is used for marking the contour of a target area in the kidney pathology image; the network model is constructed based on U-net and comprises an encoder, a KAN module and a decoder, and the encoder adopts a Hira backbone of SAM2; during training, the encoder extracts a feature map based on a kidney pathology image, the KAN module performs marking processing on the feature map, and the decoder generates a segmentation map based on the marked feature map, thereby obtaining a target area contour in the kidney pathology image. According to the invention, accurate segmentation of the kidney tubule contour in the pathological image can be realized, and then representation and analysis of the degree of atrophy of the kidney tubule are provided.

The invention relates to a deep learning-based early-stage amyloidosis nephropathy identification and diagnosis method, belongs to the technical field of amyloidosis nephropathy identification, and solves the problem that early-stage amyloidosis cannot be accurately identified in the prior art. The method comprises the following steps: acquiring kidney pathological section images of different individuals to construct a training sample set; constructing a link model comprising a first region segmentation model, a second region segmentation model and a third region segmentation model; the first region segmentation model is used for segmenting a cortex region in the pathological image; the second region segmentation model is used for segmenting a glomerular region; the third region segmentation model is used for identifying amyloidosis of a glomerular region; training the link model based on the training sample set to obtain a trained link model; and inputting a to-be-identified kidney pathological section image into the trained link model to identify whether amyloidosis exists or not. And efficient and accurate early-stage amyloidosis identification is realized.

The invention discloses a marine fish uric acid lowering peptide with kidney protection activity as well as a preparation method and application of the marine fish uric acid lowering peptide. The marine fish uric acid reducing peptide Trp-Gly-Val-Pro-Glu, WGVPE for short, with kidney protection activity is prepared, and the marine fish uric acid reducing peptide Trp-Gly-Val-Pro-Glu, WGVPE for short, can remarkably reduce the blood uric acid level in a body, promote uric acid excretion and improve pathological damage of the kidney. In addition, the pentapeptide provided by the invention can be used in common food, food additives and functional food for preventing and treating hyperuricemia and kidney injury or health care products or medicines for relieving hyperuricemia and kidney injury, and has a good application prospect.

The invention provides a light microscope kidney pathological image analysis method based on artificial intelligence, and relates to the technical field of image recognition, and the method comprises the steps: obtaining a multi-mode light microscope kidney pathological image; performing positioning analysis on the glomerular structure of the multi-mode light microscope kidney pathological image by using the target detection network to obtain a position prediction result; classifying the position prediction result by using a classification network to obtain a classification result; utilizing a semantic segmentation network to perform pathological feature quantitative extraction on the complete glomerulus in the classification result to obtain a quantitative pathological index; and performing multi-level feature fusion on the classification result and the quantitative pathological indexes, and analyzing the obtained multi-level fusion features by using a multi-instance learning network of hierarchical attention to obtain a multi-modal light microscope kidney pathological image analysis result, thereby completing analysis of the light microscope kidney pathological image. The problem that an existing artificial intelligence method is difficult to accurately quantify the light microscope kidney pathological image is solved.

This invention discloses a kidney pathology image processing method integrating multi-tissue segmentation and quantitative lesion analysis, belonging to the field of medical image processing technology. The method includes the following steps: acquiring and preprocessing PAS-stained whole-slice images of kidney pathology; fine-tuning the segmentation model using an unsupervised domain adaptive strategy to address batch-to-batch staining differences; inputting the preprocessed image into a multi-class semantic segmentation neural network to obtain tissue segmentation results; training the network based on pixel-level annotations, employing a Class-Token mechanism, encoder-decoder architecture, and multi-scale feature fusion, and optimizing the Dice loss and binary cross-entropy loss based on joint weighting of categories and boundaries; performing statistical analysis based on the segmentation results and outputting quantitative analysis results. This invention provides an objective, reproducible, and intelligent auxiliary tool for the accurate assessment and large-scale clinical research of chronic kidney disease.

This invention discloses a method and system for quantitatively assessing the degree of fibrosis in kidney pathological sections, belonging to the field of medical image processing technology. The method includes: performing color normalization and adaptive contrast enhancement preprocessing on Masson stained section images; classifying pixel-level tissue components using a multi-component semantic segmentation network containing a channel-space dual-path attention module; calculating the fibrosis area ratio and outputting a CI score based on the Banff grading standard; generating a fibrosis spatial distribution heatmap; and calculating the annual fibrosis progression rate through longitudinal follow-up comparison.

The invention discloses a folium cortex eucommiae extract and application of the folium cortex eucommiae extract in prevention and treatment of adriamycin nephropathy, and relates to the technical field of medicines, the folium cortex eucommiae extract is prepared from dried folium cortex eucommiae through water extraction, heating at 65 DEG C, ultrasonic assistance and vacuum freeze drying, LC-MS / MS analysis shows that the folium cortex eucommiae extract contains no less than 200 components, the components mainly comprise flavonoids, terpenes and phenylpropanoids, and the content of the flavonoids, the terpenes and the phenylpropanoids is no less than 100%. The folium cortex eucommiae extract has no obvious cytotoxicity to HK-2 and HBZY-1 cells under the concentration of 0-1500mu g / mL, can be used for preparing medicines for preventing and treating adriamycin nephropathy, inhibits kidney cell apoptosis by down-regulating Bax and up-regulating Bcl-2 and obviously reduces the levels of IL-6, IL-1beta and TNF-alpha in serum, and in an animal model, 150-600mg / kg of the folium cortex eucommiae extract is continuously administrated for 21-30 days in an intragastric manner, so that the effect of preventing and treating adriamycin nephropathy is achieved. The traditional Chinese medicine composition can effectively relieve weight loss, reduce urine protein, serum creatinine and urea nitrogen, increase albumin and improve kidney pathological injury, and is suitable for relieving kidney toxicity in a prophylactic or therapeutic mode in subjects receiving adriamycin chemotherapy.

The present invention discloses a method for constructing a mouse tail distal ischemia preconditioning renal protection model and its application, which belongs to the field of ischemia preconditioning technology, and its purpose is to solve the technical problem of poor stability and reliability of renal protection experimental results in the prior art. It is by respectively constructing a tail distal ischemia preconditioning group, a septic acute kidney injury model group and a tail control group; when constructing the tail distal ischemia preconditioning group, a tourniquet is tied on the mouse tail, and blood flow is restored by blocking blood flow and repeating the cycle; and blood and kidney tissue of mice in each group are collected for testing, serum creatinine and serum urea nitrogen indicators are measured, renal tubular pathological damage is assessed, and the expression level of renal reactive oxygen species is assessed. This method proves that tail ischemia reperfusion preconditioning can improve renal pathological damage and reduce renal tubular damage in septic acute kidney injury, inhibit renal oxidative stress in septic acute kidney injury, and reduce the inflammatory response of septic acute kidney injury.

The invention belongs to the field of biological medicines, and particularly discloses application of extracellular vesicles EVs carrying CD35 functional molecules in preparation of medicines for treating sepsis-related multi-organ injury, preferably, the EVs are derived from human podocytes or other cells or tool cells capable of naturally or engineered expressing CD35, and the EVs are administrated through caudal vein injection and can be used for preparing medicines for treating sepsis-related multi-organ injury. Normal saline is taken as a carrier, and the dosage of 1 * 10 < 10 > EVs each time is once every 12 hours and twice continuously. It is proved for the first time that EVs carries CD35 to inhibit circulation mononuclear cell complement activation (the EVs are combined with C3b to block downstream complement cascade reaction), migration of mononuclear cells to the kidney, the heart, the liver and the lung is reduced, and therefore multi-organ inflammation damage and cell apoptosis are relieved. In a cecum ligation perforation (CLP) sepsis model, it is proved that the medicine significantly improves the survival rate of mice, improves renal functions (reduces creatinine / urea nitrogen) and kidney pathological tissue damage, and meanwhile relieves pathological damage of multiple organs of the heart, the liver and the lung. The invention provides a new treatment strategy and drug candidate for sepsis-related multi-organ dysfunction.

This invention relates to the field of biomedical technology, and particularly to the application of crotonin A in the preparation of drugs for treating IgA nephropathy. Pharmacodynamic experiments conducted in vivo on a Thy1 rat model showed that crotonin A effectively reduced 24-hour urinary protein and the urinary protein-to-creatinine ratio in an IgA nephropathy model—an anti-Thy1 rat nephritis model—and inhibited the expression of mRNAs of genes related to renal cortical inflammation, proliferation, and fibrosis, including Cyclin E, α-SMA, FN, CCL2, NF-κB, and IL-6, further improving renal pathology. In in vitro cell models, crotonin A inhibited the proliferation of rat mesangial cells and suppressed the expression of mRNAs of TGF-β, Cyclin E, α-SMA, CCL2, NF-κB, and IL-6, indicating that crotonin A has significant anti-inflammatory, anti-cell proliferation, and anti-fibrotic effects. Brucella oleracea has considerable therapeutic potential, providing a potential new drug option for the clinical prevention and treatment of IgA nephropathy, and is of great significance for the development of safe and effective drugs for the treatment of IgA nephropathy.

The invention relates to an application of a succinate dehydrogenase subunit SDHC protein and a coding gene thereof in preparation of a medicine for preventing and / or treating renal fibrosis, and belongs to the field of biological medicines. The invention proposes and verifies that SDHC gene delivery can alleviate kidney pathological changes of chronic kidney diseases for the first time; the expression level of kidney tissue fibrosis related indexes is reduced; the transdifferentiation of renal tubular epithelial cells to myofibroblasts is inhibited. SDHC gene delivery can achieve the effect of improving the chronic kidney disease, and good development and application prospects are achieved.

This invention relates to the application of Y27632 in the preparation of drugs that promote the repair and / or regeneration of kidney injury, and pertains to the field of pharmaceutical technology. The application of Y27632 in the preparation of drugs that promote the repair and / or regeneration of kidney injury. This invention demonstrates for the first time the significant effect of Y27632 in promoting the repair and regeneration of acute kidney injury in mice, providing strong experimental evidence for the development of novel drugs for the repair and / or regeneration of kidney injury. This invention provides a new and effective means of treating kidney injury, such as acute kidney injury, by using the ROCK signaling pathway inhibitor Y27632. Experiments of this invention confirm that Y27632 can effectively promote the repair and regeneration of kidney injury by inhibiting the ROCK signaling pathway, upregulating SOX-9 expression, activating the endogenous repair mechanism of the kidney, reducing the expression of damage markers, alleviating kidney pathological damage, relieving renal fibrosis, and salvaging kidney function. This has significant clinical application value and broad market prospects.

The invention relates to the technical field of biological medicine, in particular to application of targeted DBC1 in treatment of systemic lupus erythematosus. The application for knocking out or inhibiting the expression of the DBC1 gene as shown in SEQ ID NO.1, or blocking or inhibiting the active function of the DBC1 protein as shown in SEQ ID NO.2 comprises the following applications: 1) inhibiting the transcription of STAT5 and inhibiting the activation of an STAT5 signal channel; 2) the differentiation of Treg cells is promoted, and the differentiation of Tfh and Th2 cells is inhibited; according to the application, DBC1 in DCs is inhibited or knocked out, STAT5 signal activity is lowered, then Treg differentiation is promoted, Tfh and Th2 differentiation is inhibited, and finally the SLE treatment effect is achieved.

The invention discloses an application and a preparation method of a marine fish protein peptide with effects of reducing uric acid and protecting kidneys. The marine fish protein peptide VK with uric acid reduction and kidney protection activity is prepared, and the marine fish protein peptide VK can remarkably reduce the blood uric acid level in the body and improve pathological injury of the kidney. Furthermore, the preparation process is further optimized, and the content of the dipeptide VK in the zymolyte is increased. The preparation method provided by the invention is simple in process, realizes enzymolysis controlled release of the target polypeptide, and can be used in common food, food additives and functional food for preventing and treating hyperuricemia and kidney injury or health care products or medicines for relieving hyperuricemia and kidney injury.

To provide renal disease markers for accurately evaluating and determining a wide range of renal diseases in subjects.SOLUTION: A method of assisting in evaluation of renal disease is provided, the method involving the use of a ratio of reabsorption and excretion of D-serine and / or D-asparagine in the kidney of a subject as an indicator.SELECTED DRAWING: None

This invention discloses a method for improving a mouse model of ANCA-associated vasculitis induced by anti-GBM antibodies, relating to the field of animal model construction. The method involves subcutaneously injecting mice with 20 μg rMPO on Day 0; administering 10 μg rMPO on Day 7; subcutaneously injecting 250 μg / kg GCSF daily from Day 11 to 15; and injecting 100 μl of goat anti-GBM serum via the tail vein on Day 16 to obtain the improved mouse model. This method improves the existing anti-GBM antibody-induced ANCA-associated vasculitis mouse model by injecting GCSF. This model enhances the disease severity in ANCA-associated vasculitis mice, specifically reflecting the disease in renal pathology and proteinuria, making the differences more obvious and effectively improving the success rate of model establishment.

This invention belongs to the field of renal pathology testing technology and discloses a method for detecting type IV collagen expression in renal biopsy tissue, comprising the following steps: dewaxing and hydrating paraffin sections of renal biopsy tissue to obtain processed tissue sections; adding the processed tissue sections to a repair solution, heating to boiling, and then cooling to room temperature to obtain repaired tissue sections; adding protease to the repaired tissue sections for enzymatic digestion to obtain enzymatically digested tissue sections; adding a primary antibody to the enzymatically digested tissue sections for preliminary incubation, followed by adding a fluorescein-labeled secondary antibody against the primary antibody for further incubation. This method for detecting type IV collagen expression in renal biopsy tissue is applicable to cases where renal biopsy tissue lacks glomeruli or has too few glomeruli to detect type IV collagen expression. It has high specificity and can provide a new detection method for Alport syndrome in cases where renal biopsy tissue lacks glomeruli.

The application provides application of a TRPML1 specific small molecule inhibitor ML-SI3 in preparation of a medicine for treating or preventing nephritis. The application has the following beneficial effects: the TRPML1 specific small molecule inhibitor ML-SI3 can significantly reduce the serum anti-dsDNA antibody titer level of MRL / lpr lupus mice, reduce the urine albumin / creatinine ratio level, reduce the serum urea nitrogen level, reduce the swelling degree of the spleen and axillary lymph nodes, improve the kidney pathological changes, has a comprehensive protective effect on nephritis of MRL / lpr lupus mice, and provides application of a TRPML1 specific small molecule inhibitor ML-SI3 in preparation of a medicine for treating or preventing nephritis, provides a new medicine for treating lupus nephritis, and has good market value and clinical application prospect.

The invention relates to the technical field of computer vision and medical image segmentation and recognition, in particular to an immunofluorescence kidney pathological image automatic interpretation method based on a visual basic model, which comprises the following steps: acquiring a fluorescent kidney pathological image to be interpreted and preprocessing; the preprocessed fluorescent kidney pathology images to be interpreted are input into a pre-trained interpretation model, segmentation and attribute discrimination results of the kidney structure are output, the interpretation model is obtained based on training of a training set, the training set comprises a plurality of preprocessed fluorescent kidney pathology images and marked corresponding attributes, and the pre-trained interpretation model is used for interpretation of the kidney structure. And the interpretation model is used for carrying out feature extraction on the preprocessed fluorescent kidney pathological image through image coding, mask decoding and attribute decoding, and carrying out kidney structure segmentation and attribute information discrimination. According to the invention, accurate segmentation and attribute discrimination of the kidney structure can be realized.

The present application relates to the use of LUC7L2 in the diagnosis and treatment of acute kidney injury (AKI). LUC7L2 is significantly up-regulated in cisplatin-induced AKI model, and knocking down LUC7L2 can rescue cell death caused by different concentrations of cisplatin, and improve the accumulation of MDA and ROS caused by cisplatin; knocking down LUC7L2 can reduce the swelling degree of the kidney of cisplatin-induced AKI model, and thus reduce the kidney specific gravity; knocking down LUC7L2 improves the decline of renal function and renal pathological injury caused by cisplatin, and LUC7L2 has the potential to be used as a diagnostic and therapeutic target for AKI.

The application provides a traditional Chinese medicine preparation for treating diabetic nephropathy and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine preparation is prepared from traditional Chinese medicinal materials such as angelica, eucommia ulmoides, helicteres angustifolia, broussonetia papyrifera, radix paeoniae suffruticosae, curcuma longa, dendrobium, polygonatum, radix adnati, ligustrum lucidum, ipomoea purpurea, lagerstroemia indica, kochia scoparia, haes, pyrrosia lingua and herba barbatae, and has the effects of nourishing yin and kidney, promoting blood circulation to remove meridian obstruction and clearing heat and removing dampness. The traditional Chinese medicine preparation can up-regulate the expression levels of podocin and nephrin, inhibit inflammatory mediators, improve the blood sugar, urine protein, kidney function and kidney pathological injury of DN rats, provides a new idea for the treatment of diabetic nephropathy, and has a good development and application prospect.

After several years of illness, a small amount of albumin in the blood of nephritis patients will begin to leak into the urine. At this time, it is easily overlooked due to the insignificant clinical symptoms or being confused with proteinuria caused by other factors such as hypertension and hyperlipidemia, leading to the progression of the disease. However, when it is found that other indicators reflecting renal function, such as β2-microglobulin, α1-microglobulin, transferrin, and immunoglobulin, are also significantly elevated in the urine, it can be confirmed that pathological changes have occurred in renal function. Currently, there is no other effective treatment method except for hormones, and long-term hormone treatment will bring many side effects to patients. If the disease progresses freely, more proteins will leak into the urine and the kidney damage will further increase. Cobra neurotoxin polypeptide molecules can effectively reduce the leakage of the above various proteins in the urine, control and delay the pathological progression of the kidney, improve renal function, and are of extremely important significance for the treatment of nephritis by inhibiting the autoimmune inflammatory reaction of the kidney.

This invention discloses the application of a pharmaceutical composition containing curculigoside in the treatment of type 2 diabetic nephropathy, belonging to the technical field of diabetic nephropathy drugs. The pharmaceutical composition uses curculigoside and astragaloside A as active ingredients, and also includes pharmaceutically acceptable excipients, wherein the mass ratio of curculigoside to astragaloside A is 1:0.2 to 1:1.5. This invention is the first to apply curculigoside to the treatment of type 2 diabetic nephropathy. Through the synergistic effect of curculigoside and astragaloside A, it can significantly improve renal function in patients with type 2 diabetic nephropathy, inhibit inflammatory responses and oxidative stress, reduce renal pathological damage, and delay the progression of renal fibrosis. Furthermore, the pharmaceutical composition has high safety, no obvious adverse reactions, diverse dosage forms, and high medication adherence, overcoming the shortcomings of existing therapeutic drugs with limited efficacy and numerous adverse reactions, and has significant clinical value and broad application prospects.

The invention provides a kidney pathological full-slice image glomerulus detection system, which relates to the technical field of medical image processing and comprises a preprocessing module, a detection module and a mapping output module. The preprocessing module is used for executing kidney tissue region extraction and image preprocessing of the kidney pathology full-slice image, and comprises the following steps: extracting a kidney tissue region mask from the kidney pathology full-slice image under a preset magnification, mapping the mask to a first resolution image, performing overlapping window-sliding slicing on the first resolution image, and screening effective patches; the detection module comprises a multi-scale feature interaction glomerular detection network and is used for performing glomerular detection on the screened patches and outputting a glomerular positioning prediction frame and a corresponding classification prediction result; and the mapping output module is used for restoring the patch-level detection result to the full-slice image coordinate system. According to the method, the robustness and precision of target detection can be effectively improved, and reliable technical support is provided for intelligent analysis and auxiliary diagnosis of kidney pathological images.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a kidney-tonifying and dampness-removing traditional Chinese medicine composition and a preparation method and application thereof. The traditional Chinese medicine composition capable of tonifying kidney and promoting diuresis is prepared from the following raw materials in parts by weight: 60 to 120 parts of radix astragali seu hedysari, 60 to 120 parts of fructus ligustri lucidi, 120 to 240 parts of herba taraxaci, 120 to 240 parts of rhizoma imperatae, 40 to 80 parts of semen persicae, 60 to 120 parts of radix paeoniae rubra, 120 to 240 parts of herba leonuri, 120 to 240 parts of folium pyrrosiae, 20 to 40 parts of flos carthami and 80 to 160 parts of radix ilicis pubescentis. The traditional Chinese medicine composition for tonifying kidney and promoting diuresis provided by the invention regulates immune inflammatory response through multiple mechanisms and multiple targets, improves kidney pathology, and potentially intervenes the action mechanism of intestinal-renal axis disorder.

The invention discloses a traditional Chinese medicine composition for treating hyperuricemia as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from semen hoveniae, radix puerariae, semen phaseoli, raw fructus gardeniae, herba taraxaci, poria cocos and rhizoma dioscoreae. According to the traditional Chinese medicine composition, dissolution of effective components is improved through a combined mode of decocting radix puerariae first and decocting other medicines together, dialectical components are adopted, whole-course intervention of upstream generation inhibition, midstream dissolution and crystallization and downstream excretion promotion on hyperuricemia metabolic disorder can be achieved, and the effect of treating hyperuricemia metabolic disorder can be achieved through physique conditioning, heat clearing and diuresis promoting, spleen strengthening and kidney tonifying, detoxification and turbid descending, collateral dredging and blood stasis dissipating. The blood uric acid level and inflammation balance are successfully recovered to a physiological state, and the action mode is superior to a traditional single uric acid reducing strategy and a traditional Chinese medicine application mode of decocting the whole formula simultaneously. In an animal model, the composition has the effects of remarkably reducing uric acid, regulating inflammation, protecting kidney and improving overall physique, the curative effect of a high-dose group is equivalent to that of a classic uric acid reducing medicine allopurinol, and the composition has more advantages in the aspects of kidney pathological repair and long-term safe conditioning.

The present invention provides methods and materials useful delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the present invention provides methods for delivering saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The delivery methods and materials herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies.

The invention provides an observation device for kidney pathological section preparation, and relates to the field of pathology department observation equipment. An observation device for kidney pathological section preparation comprises a fixing frame, and the top of the fixing frame is fixedly connected with an observation table; a medical microscope used in cooperation with the observation table is arranged in an inner cavity of the fixing frame, and storage assemblies used in cooperation with the medical microscope are arranged on the two sides of the inner cavity of the fixing frame. The two sides of the top of the observation table are each provided with a protection assembly used in cooperation with the medical microscope. According to the observation device for kidney pathological section preparation, through cooperation of the storage assembly and the protection assembly, when a microscope is adopted to conduct pathological observation on a kidney pathological section, automatic lifting and strong light shielding functions are achieved for the microscope used for observation, and the situation that dust and strong light affect the accuracy of the observation result of the kidney pathological section is prevented; through cooperation of the disinfection assembly, the comprehensive disinfection effect of the observation table is achieved according to the pathological section observation requirement.

The present invention relates to a deep learning-based kidney component segmentation method and system, belonging to the field of medical image segmentation technology, and solves the problem of low kidney component segmentation accuracy in the prior art. The method includes: obtaining a kidney pathology image and corresponding component annotation information, segmenting the kidney pathology image, screening a target image from the segmented image, and constructing a sample set based on the target image and the corresponding component annotation information; constructing a multi-channel coded fusion image segmentation model, and training the multi-channel coded fusion image segmentation model based on the sample set to obtain a kidney component segmentation model; segmenting the kidney pathology image to be segmented, screening a target image from the segmented image, and inputting the model into the kidney component segmentation model to obtain a segmentation result corresponding to the target image; and obtaining a component segmentation map of the kidney pathology image to be segmented based on the segmentation result. High-precision kidney component segmentation is achieved.