2214 results about "Gout" patented technology

One embodiment of the present invention relates to an ankle prosthesis. Another embodiment of the present invention relates to a total ankle replacement prosthesis. Another embodiment of the present invention relates to an ankle replacement (partial or total) which is adapted, for example: (a) to treat arthritis of the ankle (e.g., ankle arthritis of any cause: after precious trauma; primary; malalignment induced; after hindfoot fusion; from recurrent ankle instability; rheumatoid or inflammatory arthritis; gout; local growth; dysplasia; growth plate arrest; avascular necrosis; hemophilia; distant septic event); (b) to revise a fused ankle; and / or (c) to treat trauma. The ankle replacement may be carried out by replacing one or more joint surfaces of an ankle joint. Another embodiment of the present invention relates to a method for inserting an ankle prosthesis.

The present invention relates to compounds of Formula (I),methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury / loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

The invention relates to a high bioavailability febuxostat oral solid dosage and a preparation method thereof. The invention is characterized in that the solid dosage comprises: a) febuxostat is C, H, I or J crystal form; b) the average grain diameter of the febuxostat crystal form ranges from 3.5-10mum, preferably 3.5-7mum. The preferable oral solid dosage is tablet, has the advantages of simple preparation technique, low cost and relatively high bioavailability, and can be used for treating diseases relative to extremely-high uric acid, such as gout, and reducing uric acid in blood.

The invention disclosed the application of celery seed coumarins and flavanoid in preparing arthrifuge, anti-inflammatory agent or health food, which belongs to the natural occurring drugs and medical technology domain. The coumarins and flavanoid is the extract from acetic ether. The preparing method includes the following steps: selecting 10kg celery dry seed, adding 15-20 times of 75-95%(V / V) as the seed or extracting with 4-5 times of 75-95%(V / V) alcohol at higher temperature, heating for 1-1.5h every time; vacuum condensing the extracts until nearly all the alcohol is away; adding 1-2 times of water, extracting with 1 / 3 volume of the diluted solution sherwood oil (60-90DEG C) for 2-3 times; reclaiming the sherwood oil; extracting the water layer with 1 / 3 volume of acetic ether for 4 times; reclaiming the acetic ether to get the extracts. The invention has very simple preparing technologies; the product in the invention has obvious anti-inflammatory function; it can also decrease the amount of serum uric acid of rats.

Disclosed are methods for the treatment and / or prevention of gout, comprising administering to a subject an effective amount of anti-IL-1β antibody or fragment thereof.

An extract of mulberry twigs is dislcosed, which can be used to prepare the food or the medicine to cure hyperuricemia and gout diseases. The said extract is prepared from mulberry twigs through extracting in solvent (aqueous solution of alcohol, chloroform, acetone, etc) at 10-100 deg.C more than one time, mergint the liquid extracts, recovering solvent, regulating pH value to 7.5-9.5, centrifugal separation to obtain supernatant, regulating pH value to 4-6, deposition, water washing wand drying. Several other approaches for purifying it are also disclosed.

The invention relates to application of celery seed extract to preparation of medicine or health-care food for resisting to hyperuricemia and gout and further provides medicine or health-care food for treating hyperuricemia and gout. Celery seed extract serves as the active constituent, and an appropriate number of medical carriers or auxiliary constituents are added, so that a preparation is obtained. The medicine for health-care food is simple in preparation process, the celery seed extract can obviously lower serum uric acid of model mice suffering from hyperuricemia caused by oteracil potassium salt, lower the activity of xanthine oxidase to different degrees, achieve an obvious inhibition effect on arthritis of the mice, prevent and treat hyperuricemia or gout and be applied to preparation of the medicine or health-care food for resisting to hyperuricemia and gout.

The present invention relates to compounds of Formula (I),methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury / loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

The invention discloses a weak alkali plant alcohol intoxication-alleviating beverage and a method for preparing the same. The beverage comprises the following components: plant extract, corrective, pH adjusting agent and pure water. The preparation method comprises the following steps that: firstly, the plant extract is decocted and filtered, and the obtained filtrate is cooled down to obtain the plant extract; secondly, the plant extract is mixed with the corrective, and the mixture is dissolved in water; and thirdly the mixed solution is added with proper amount of pH adjusting agent so as to adjust the pH value of the mixed solution to between 6.5 and 8.5, and the mixed solution is subjected to constant volume, filtering, homogenization, sterilization, filling, packaging and checking-up to obtain the weak alkali plant alcohol intoxication-alleviating beverage. The weak alkali plant alcohol intoxication-alleviating beverage has the advantages of removing alcohol toxins, alleviating the alcohol intoxication and protecting the liver, replenishing vital essence and clearing heat, promoting urination and releasing toxin and effectively preventing cardio-cerebral-vascular diseases, osteoporosis, gout, hypertension, high blood fat and the like, along with strong controllability of the production process, good quality reproductivity, fresh and good taste and the suitability for taking at four seasons.

The invention discloses special dietary seafood special for hyperuricemia patients. The seafood is characterized by being prepared by taking food-derived marine bioactive polysaccharides as main raw materials, adding algae powder and mixing the food-derived marine bioactive polysaccharides and the algae powder with the auxiliary materials including nutritional amino acids, oligosaccharides, vitamins and minerals. The seafood can be powdery or granular and is eaten after being dissolved in warm water. The seafood is easy to dissolve, has maximum biological absorbance and maximum bioavailability in human bodies, provides marine active factors and nutritional components for human bodies, supplements various vitamins and minerals essential to human bodies, is beneficial to improving the nutritional status of the hyperuricemia patients and can assist in reducing the uric acid level and controlling the hyperuricemia level, improving the immune of the human bodies and preventing gout throughsynergy of such factors as bioactive components in the food-derived marine bioactive polysaccharides, the algae powder, the nutritional amino acids and the like, thus being suitable for the hyperuricemia patients.

Insulin sensitivity enhancers, such as troglitazone, have the ability to treat and / or prevent hyperuricemia and may thus be used for the therapy or prophylaxis of such diseases as gout, urinary calculus, hyperuricemic nephropathy and Lesch-Nyhan syndrome.

Provided herein are methods and compositions and kits related to uricase compositions and / or compositions comprising synthetic nanocarriers comprising an immunosuppressant. Also provided herein are methods and compositions and kits for the treatment of subjects, including subjects with hyperuricemia, gout or a condition associated with gout, and for preventing gout flare.

The invention belongs to the field of pharmacogenomics and genetic diagnosis, and relates to a method used for detecting HLA-B*5801 alleles. The method comprises following steps: a DNA sample to be detected is taken, three pairs of specific primers and a pair of internal primers are taken, amplification of DNA segments is realized by using sequence specific primer method, and then the results of the amplification are analyzed by agarose gel electrophoresis; or sample DNA is extracted, a pair of specific primers, a pair of internal primers and three fluorescence probes are taken, amplification of DNA segments is realized by Taqman probe method using a fluorescence ration PCR instrument, and then the amplification curve is analyzed so as to obtain results. Results analysis methods such as agarose gel electrophoresis, high resolution melting curve and SYBRGreen fluorogenic quantitative PCR are employed in the method. The method has advantages of speediness, convenience, flexibility, high resolution and no contamination; is suitable for detection of HLA-B*5801 alleles in samples such as peripheral blood and hair; and can be used for determining the probability of severe skin adverse reaction of patients with gout or hyperuricemia caused by taking of allopurinol.

The invention relates to an orally taken traditional Chinese medicine capsule special for treating neck, waist and leg pains caused by various causes, which comprises the following formulation by weight (in terms of preparing 1,000 granules of orally taken capsules as standard): 9 to 90 grams of wild celery, 9 to 90 grams of radix gentianae macrophyllae, 9 to 90 grams of parsnip, 3 to 30 grams of wild ginger, 12 to 120 grams of loranthus parasiticus, 9 to 90 grams of angelica, 9 to 90 grams of white paeony root, 8 to 80 grams of Szechuan lovage rhizome, 9 to 90 grams of prepared rhizome of rehmannia, 10 to 100 grams of eucommia bark, 10 to 100 grams of achyranthis root, 9 to 90 grams of desertliving cistanche, 12 to 120 grams of teasel root, 5 to 50 grams of cinnamon core, 12 to 120 grams of radix codonopsitis, 12 to 120 grams of hoantchy root, 6 to 60 grams of rhizoma gastrodiae, 12 to 120 grams of Chinese wolfberry, 10 to 100 grams of kudzuvine root, 10 to 100 grams of akebia stem, 10 to 100 grams of Atractylis ovata, 10 to 100 grams of clematis root, 6 to 60 grams of safflower, 6 to 60 grams of cortex moutan, 6 to 60 grams of libanotus, 6 to 60 grams of myrrh, 10 to 100 grams of papaya, 12 to 120 grams of rhizoma drynariae, 12 to 120 grams of caulis milletiae, 10 to 100 grams of notoginseng, 10 to 100 grams of ophidian, 9 to 90 grams of scorpion, 2 to 15 chilopod, 10 to 100 grams of daemonorops draco, 12 to 120 grams of eupolyphaga, and 0 to 30 grams of radix glycyrrhizae preparata; and the quality of the 36 gouts of traditional Chinese medicine accords with prescription of Chinese pharmacopoeia, and the components are prepared into powder according to a preparation method for the traditional Chinese medicine, and canned into capsules.

The invention discloses novel plant small-molecule peptides, particularly relates to small-molecule peptides of a sunflower head as well as a preparation method and medical application of the small-molecule peptides, and further discloses medical application of the small-molecule peptides of the sunflower head to treatment of gout diseases. The small-molecule peptides of the sunflower head are low in molecular weight of proteins and can be directly absorbed by a human body without the digestion system; the peptides can be absorbed quickly and takes effect efficiently; a related extracting and separating process is simple and is easy to operate; no special equipment is required, and the cost is low; reagents used are pollution-free to the environment. The small-molecule peptides are suitable for large-scale industrial production.

A novel 1,2,4-triazole compound which is useful as a therapeutic agent for hyperuricemia and gout due to hyperuricemia is provided. A compound is represented by the following general formula (1):wherein R2 represents an unsubstituted or substituted pyridyl group, R1 represents a similar pyridyl group, a pyridine-N-oxide group corresponding to these pyridyl groups, or a phenyl group, and R3 represents hydrogen or a lower alkyl group substituted with pivaloyloxy group and R3 bonds to a nitrogen atom in the ring. A process for production of a compound by reacting a nitrile and a hydrazide, and a therapeutic agent, particularly a xanthine oxidase inhibitor are also provided.

A composition composed of a Lactobacillus bacterium, Bifidobacterium longum, and xylooligosaccharide is provided for use in reducing uric acid levels in the blood and preventing or treating hyperuricemia or gout.

The present invention discloses one kind of Chinese medicine composition and its preparation process. The Chinese medicine composition contains the effective components of atractylodes rhizome, coix seed, earthworm, tetramdra root, phellodendron bark and other seven kinds of Chinese medicinal materials. It may be prepared into granule, tablet, capsule or other common Chinese preparation form. It has the functions of dispelling wind, eliminating dampness, clearing away heat, relieving swelling, dredging meridian and relieving pain, and may be used in treating rheumatic arthritis, rheumatoid arthritis and gout.

The invention provides a uric acid reducing food composition which comprises the following components in parts by weight: 22-28 parts of marine fish oligopeptide powder, 25-35 parts of lophatherum gracile powder, 18-22 parts of poria cocos powder and 450-550 parts of soybean peptide. The composition provided by the invention has the following technical effects: 1) uric acid is reduced, and gout is relieved; 2) the composition is safe without side effects and causes no burden to body; and 3) the component marine fish oligopeptide can inhibit the synthesis of uric acid, the diuresis effect of lophatherum gracile and poria cocos can promote excretion of uric acid, and the soybean peptide supplements the proteins necessary to body and improves the basic metabolic capability and has a function of accelerating metabolism of uric acid in body.

The invention relates to soybean dietary fiber bread which is produced by using soybean dregs as a main raw material and a preparation method thereof. The preparation method comprises the following steps of: treating the soybean dregs in high-pressure steam, mixing 450 to 500-mesh ground soybean dietary fibers and flour, milk, eggs, cream, sugar, table salt and the like, and fermenting and baking to prepare the soybean dietary fiber bread, wherein the soybean dietary fibers account for 30 to 60 percent, and the soybean dietary fiber bread also contains protein, bifidus factors, isoflavone, phospholipid, unsaturated fatty acid, saponin, and multiple trace elements and vitamin such as calcium, zinc, phosphorus, selenium, ferrum, magnesium, potassium, vitamin B (VB) and the like, so four side effects of goiter, discomfort in intestines and stomach and nausea, flatulence, beany flavor, bitter and puckery favor, easiness for gout and the like which are intrinsic in the soybean dietary fibers are eliminated completely, and the problems of high dietary fiber content and difficult fermentation are solved.

The invention belongs to the field of health beverages, and in particular relates to a gynura procumbens compound preparation as well as a preparation method and application thereof. The gynura procumbens compound preparation is characterized by being prepared from the following raw materials in percentage by weight: 75-85% of gynura procumbens, 5-10% of barley seedlings, 3-6% of common lophatherum herb, 2-5% of frostbitten mulberry leaves, 2-4% of kudzuvine root and 1-3% of poria cocos. The preparation method of the gynura procumbens compound preparation comprises the following steps: performing weighing, drying and small fire baking on gynura procumbens, then mixing with other weighed raw materials, and crushing. The preparation disclosed by the invention is safe, healthy and natural, has various effects of treating gout in multiple ways comprehensively, can play roles in adjusting uric acid metabolism, promoting excretion of uric acid, preventing uric acid crystallization, diminishing inflammation and relieving pain, and controlling arthralgia, swelling and inflammations in an attack stage of gout, also can be used for reducing the blood lipid and blood sugar and strengthening kidney metabolism, can be used for treating both symptoms and root causes and achieving the effects of preventing and treating gout, and has the characteristics of natural compounds and natural health maintenance; and the preparation method disclosed by the invention is simple and convenient, and can be used for keeping original components of the raw materials to the greatest extent.

The invention discloses a novel traditional Chinese medicine composition for treating the symptoms of renal calculus and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw materials of medicines: scaly anteater, rhizoma sparganii, rhizoma zedoariae, sweetgum fruit, immature bitter orange, Chinese eaglewood, dalbergia wood, tangerine peel, TurmericRoot-tuber, chicken's gizzard-membrane, radix notoginseng, rhizoma ligustici wallichii, red peony root, peach kernel, safflower, logwood, mastic, myrrh, draconis sanguis, Chinese polyphaga, rhizoma cyperi, tuckahoe, radix puerariae, rhizoma alismatis, manchurian dutchmanspipe, japanese fern spore, semen lepidii, talcum, rosa banksiae, green tangerine peel, toosendan fruit, areca peel, dahurian angelica root, rhizoma atractylodis, schisandra fruit and motherwort. The traditional Chinese medicine composition can be prepared into any common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can obviously improve the symptoms of the metabolic balance maladjustment of colloids and crystals, infection, nutrition metabolic disturbance, the calculus and the urine stasis of the urinary system, lumbago, renal colic, bloody urine and the like in the body of a patient with the symptoms of the renal calculus, can improve the symptoms of gout, diabetes, hypertension, acute pyelonephritis, chronic renal failure, uremia and the like caused by the symptoms of the renal calculus and has definite clinical curative effect, obvious curative effect and quick acting. Because of basically adopting medicine-food homologous medicines specified by the dispensatory of China for combination, the traditional Chinese medicine composition has the advantages of low cost, no toxic or side effect basically and the like.

The present invention relates to a novel purpose of mangiferin compound for preventing and remedying hyperuricemia and gout. A study shows that the mangiferin compound has very strong anti-gout effect; 0.002mmol / kg (0.78mg / kg) of the dosage can reduce the serum uric acid level of a mouse with the hyperuricemia obviously; the mangiferin compound has higher activity than allopurinol and has little toxic and side effect; the maximum gastric infusion tolerance dose of the mouse is 47.4mmol / kg (20g / kg), which is lower than that of current clinical applied anti-gout medicines, such as colchicines, the allopurinol, sulphinpyrazone, etc.; the present invention can be applied to prepare for oral anti-gout medicines and health care products.

The invention discloses an alga ferment healthcare solid drink. The alga ferment healthcare solid drink is prepared from the following raw materials in percentage by weight: 5-13% of spirulina platensis, 8-10% of spirulina maxima, 5-15% of chlorella pyrenoidosa powder, 10-12% of haematococcus pluvialis, 10-13% of euglenophyta, 10% of alpha-amylase, 5% of lipase, 10% of cellulase, 5% of protease and 15% of fructo-oligosaccharides. A preparation process of the alga ferment healthcare solid drink comprises the following steps: (1) selecting and baking the materials; (2) drying; (3) adding the fructo-oligosaccharides; (4) crushing, purifying and sterilizing; (5) mixing; (6) carrying out incense enhancing and equalization treatment; (7) packaging. Compared with the prior art, the alga ferment healthcare solid drink has the advantages that natural raw materials serve as effective ingredients, and the intake and absorption of villi are controlled in the intestinal tract; the metabolic balance of the intestinal tract is regulated, and the value of uric acid in blood can be more effectively reduced; gout is prevented and improved, the propagation of beneficial bacteria of the intestinal tract is improved, the breeding of miscellaneous bacteria of the intestinal tract is inhibited, and the content of oxygen in the blood is increased; the immune system is regulated, and the immunity is enhanced.

The present invention provides a medicine composition for preventing or curing gout, comprising Anisomeles indica abstract as an active component, wherein the Anisomeles indica abstract comprising Anisomeles indica lactone, Radices Sileris oxalic acid or the composition thereof.

The invention discloses a Chinese medicament for treating pharyngitis, which is a preparation processed by using the following Chinese medicaments in part by weight: 14 to 16 parts of dwarf lilyturf tuber, 14 to 16 parts of coastal glehnia root, 10 to 14 parts of skullcap root, 8 to 12 parts of golden thread, 14 to 16 parts of honeysuckle, 14 to 16 parts of indigowoad leaf, 14 to 16 parts of weeping forsythia, 14 to 16 parts of reed root, 8 to 12 parts of mint, 8 to 12 parts of platycodon root, 8 to 12 parts of blackberrykiky rhizome, 8 to 12 parts of raw rhubarb, 14 to 16 parts of dandelion, 14 to 16 parts of scrophularia root, 8 to 12 parts of burdock seed, 8 to 12 parts of liquorice root and 8 to 12 parts of Vietnamese sophora root. The seventeenth gouts of Chinese medicinal materials are chopped or crushed and then decocted or refluxed and extracted twice by adding water, the decoction is combined, the concentrated medicinal liquid is used for processing aerosol or oral liquid and the like, and the medicinal liquid is further concentrated to obtain extract for processing lozenge or granules and the like. The Chinese medicament has remarkable curative effect of treating sore throat, swelling, inflammation with lymphangoncus and the like, and has quick response; and the total effective rate is more than or equal to 95 percent.

The invention discloses a compound biological soil improver taking a compound biological bacterium as a core. The invention also discloses a preparation method of the compound biological soil improver, which comprises the following steps of: respectively carrying out liquid deep-layer high-density culture on the soil improver to obtain fermentation broth; carrying gout centrifugal treatment on the fermentation broth and then collecting bacterial mud; adding a protective agent to prepare frozen dry powder; and taking the compound biological bacterium as the core and mixing the required powdery organic fertilizer and perlite to obtain the compound biological soil improver. The compound biological soil improver has high active bacterial quantity, can be preserved at normal temperature for a long term, can be mixed with organic soil and inorganic soil improvers for use without being influenced and has remarkable effect for preventing and controlling the soil-borne disease.

The invention belongs to the field of externally-used traditional Chinese medicines, in particular to an externally-used hot compress mud plaster for treating pains of a human body and a preparation method thereof. The externally-used hot compress plaster comprises the following raw materials: 10-15% of natural jade mud powder, 3-5% of tourmaline micro powder, 3-5% of far infrared ceramic micro powder, 15-25% of Chinese medicinal herb, 10-20% of mud plaster matrix, 25-35% of beeswax and 5-15% of red lead. The externally-used hot compress mud plaster is used for acupuncture points of the human body. The mud plaster is heated to melt; after about 10-15 minutes, the cooling melted mud plaster is sticked to a pain area after being cleaned, so as to activate the vigor of skins, and expel toxins of the skins. The hot compress mud plaster has the advantages of heat absorption and heat preservation, even heat dissipation, consistent temperature, can get through the meridians, dispel the wind and remove the cold, activate blood circulation to dissipate blood stasis, eliminate goiter and tumour, thoroughly remove the pain, treat headache, toothache, prosopalgia, sore-throat, chest and hypochondriac pain, epigastric pain, bellyache, gout, backleg pain and cerv shoulder pain, herniated disk, ischialgia, rheumatalgia, and spinal pain; and the plaster in the invention is convenient to stick to the different parts of the human body, does not harden and flow, solidifies after taking away from the human body, and can be reused by repeated heating.

The invention discloses a soda water beverage and a preparation method thereof. The soda water beverage comprises raw materials in parts by weight added to every 1,000 kg of water as follows: 100-300 g of sodium bicarbonate, 40-120 g of acesulfame, 15-45 g of magnesium sulfate, 1-3 g of potassium chloride and 75-225 g of lemon essence, and the PH value of the soda water beverage is 7.1-8.5. The technological process of the soda water beverage comprises following steps: (1), equipment cleaning and sterilization; (2), raw water treatment; (3), blending; (4), soda water sterilization; (5), bottle and bottle cap disinfection; (6), filling and packaging. The soda water beverage is helpful to relieve symptoms such as indigestion, constipation and the like and is helpful to uric acid excretion, thereby having prevention and treatment functions on hyperuricemia or gout; in hot summer, sodium in the soda water can supplement sodium lost through sweat volatilization, and the soda water beverage is quite popular fashion drink; primary and secondary reverse osmosis devices are adopted for an efficient desalination technology, impurities such as inorganic ions, bacteria, viruses, metal ion organic matters, colloids and the like in raw water can be removed, high-quality highly-pure water is obtained, the operating cost is saved, and environmental protection is facilitated.