6 results about "Random coil" patented technology

This invention provides an innovative means and method for coupling dialkylamines and polypeptides or peptides capable of forming random coil conformations. This invention also provides innovative compounds prepared by the methods detailed herein, wherein the compounds are characterized by formula (I): A-[B-] b C-D. The compounds comprise polypeptides / peptides capable of forming a random coil conformation, an N-terminal protecting group, a dialkylamino group, and optionally a linker. Furthermore, the present invention provides lipid nanoparticles comprising the compounds characterized in formula (I), and means and methods for preparing the lipid nanoparticles. Formulations comprising the compounds of the present invention and / or lipid nanoparticles are also provided. Furthermore, the present invention relates to the use of the innovative compounds, lipid nanoparticles, and / or formulations disclosed herein.

The present invention provides a novel silk fibroin crosslinking agent, a method for preparing the same, and use thereof. In the silk fibroin crosslinking agent, the silk fibroin has a structure that can easily form crosslinked microcrystals, and includes silk fibroin having less than 40% of random coil structure. The present invention also provides a gel formed using the crosslinking agent and a method for preparing the same.

The application discloses a dry-wet type biological adhesive and a preparation method thereof, and the preparation method comprises the following steps: mixing a polypeptide aqueous solution and a polyethylene glycol dimaleimide aqueous solution, adjusting the pH to 7-8 to obtain R-liquid; and mixing the R-liquid with a chelating agent and drying to obtain the dry-wet type biological adhesive. The Switcch polypeptide designed in the application can complex Zn ions, and after the introduction of Zn ions into the R-liquid, the Switcch polypeptide performs a conformational transition from a random coil mode to a helical coil mode, and the change brought by the conformational transition is mainly reflected in that the hydrophilic and hydrophobic amino acids of the polypeptide are rearranged in space according to the rules of the helical coil winding; the hydrophilic amino acids are completely exposed on the outside, the hydrophobic amino acids are orderly arranged on the inside, the hydrophobic side chains are completely stretched, the hydrophobic amino acid side chains complete the high-strength adhesion of the polypeptide and the interface, and the biological adhesive realizes the adhesion effect according to the principle.

The present invention provides novel uricase conjugates comprising a first domain and a second domain. The first domain comprises a uricase polypeptide and the second domain is an unstructured, random coil polypeptide domain comprising at least about 100 amino acids. Methods for using the uricase conjugates of the invention, for example, in the treatment of tumor lysis syndrome and / or gout, are also provided.

This invention relates to a transparent Bordeaux mixture nanosuspension and its preparation method, wherein the basic copper sulfate particles in the suspension are smaller than 100 nanometers. The basic copper sulfate particles in the nanosuspension are suspended and dispersed in water in a random coil morphology using a water-soluble polymeric dispersant.

The application discloses a silk fibroin-based piezoelectric sensing film induced by BTO conformation transition and a preparation method thereof. The sensing film is composed of regenerated silk fibroin (SF) and tetragonal barium titanate (BaTiO3) nanoparticles by electrospinning technology. The core of the application is that the polar surface charge of BaTiO3 nanoparticles is used to in-situ induce the silk fibroin molecular chain to transform from random coil to beta sheet crystal phase with piezoelectric activity under the synergistic effect of high-voltage electric field in electrospinning, and a double piezoelectric synergistic system of organic crystal phase and inorganic ceramic phase is constructed. Experiments prove that the sensing film has excellent flexibility, biocompatibility and extremely high low-frequency sensitivity (0.25Hz-1Hz), and is stable under 10000 times of cyclic loading. The application has important application value in the fields of flexible self-powered physiological sensing such as heart sound monitoring and pulse recognition.