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Photo-curable silk fibroin hydrogel and preparation method thereof

A silk fibroin, light-curing technology, applied in the field of hydrogel materials, can solve the problems affecting the light transmission performance of hydrogels, poor hydrogel resilience, etc., and achieve excellent light transmission performance, high compressive strength, and excellent elasticity. Restorative effect

Active Publication Date: 2019-01-04
NANTONG TEXTILE & SILK IND TECH RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the concentration of riboflavin added is relatively high, which will affect the light transmission properties of the hydrogel, and the prepared hydrogel has relatively poor resilience

Method used

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  • Photo-curable silk fibroin hydrogel and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preparation of silk fibroin aqueous solution: weigh 3g of anhydrous NaHCO 3 and 1 g anhydrous Na 2 CO 3 Put into boiling 4L deionized water, add 80g silkworm cocoon after fully dissolving, adjust the solution state to slightly boil, stir once every 10 minutes with a glass rod, wash it with deionized water after 30 minutes, repeat the above operation 3 times, each time Weigh new anhydrous NaHCO 3 and anhydrous Na 2 CO 3 ; After fully washing, loosen the silk and put it in a 60°C oven for drying. Take 100ml of 9.3mol / L lithium bromide solution and pour it into a conical flask, heat it to 65°C in a constant temperature magnetic stirrer, add 15g of degummed silk fibroin in several times, and dissolve it at 65±2°C for 30~ After cooling for 40 minutes, take it out, put it in a dialysis bag and seal it, place it in deionized water at low temperature for dialysis for 3 to 4 days, after the dialysis is completed, filter the obtained silk fibroin solution with absorbent ...

Embodiment 2

[0029] (1) Preparation of silk fibroin aqueous solution: weigh 3g of anhydrous NaHCO 3 and 1 g anhydrous Na 2 CO 3 Put into boiling 4L deionized water, add 80g silkworm cocoon after fully dissolving, adjust the solution state to slightly boil, stir once every 10 minutes with a glass rod, wash it with deionized water after 30 minutes, repeat the above operation 3 times, each time Weigh new anhydrous NaHCO 3 and anhydrous Na 2 CO 3 ; After fully washing, loosen the silk and put it in a 60°C oven for drying. Take 100ml of 9.3mol / L lithium bromide solution and pour it into a conical flask, heat it to 65°C in a constant temperature magnetic stirrer, add 15g of degummed silk fibroin in several times, and dissolve it at 65±2°C for 30~ After cooling for 40 minutes, take it out, put it in a dialysis bag and seal it, place it in deionized water at low temperature for dialysis for 3 to 4 days, after the dialysis is completed, filter the obtained silk fibroin solution with absorbent ...

Embodiment 3

[0036] (1) Preparation of silk fibroin aqueous solution: weigh 3g of anhydrous NaHCO 3 and 1 g anhydrous Na 2 CO3 Put into boiling 4L deionized water, add 80g silkworm cocoon after fully dissolving, adjust the solution state to slightly boil, stir once every 10 minutes with a glass rod, wash it with deionized water after 30 minutes, repeat the above operation 3 times, each time Weigh new anhydrous NaHCO 3 and anhydrous Na 2 CO 3 ; After fully washing, loosen the silk and put it in a 60°C oven for drying. Take 100ml of 9.3mol / L lithium bromide solution and pour it into a conical flask, heat it to 65°C in a constant temperature magnetic stirrer, add 15g of degummed silk fibroin in several times, and dissolve it at 65±2°C for 30~ After cooling for 40 minutes, take it out, put it in a dialysis bag and seal it, place it in deionized water at low temperature for dialysis for 3 to 4 days, after the dialysis is completed, filter the obtained silk fibroin solution with absorbent co...

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Abstract

The invention discloses photo-curable silk fibroin hydrogel and a preparation method thereof. The photo-curable silk fibroin hydrogel is prepared by: adding riboflavin and horse radish peroxidase intosilk fibroin solution that acts as a raw material, introducing oxygen continuously under ultraviolet irradiation and room temperature, inducing groups in silk fibroin macromolecules to chemically crosslink, and allowing gelling. The silk fibroin in the photo-curable hydrogel provided herein is mainly of random coil; the photo-curable hydrogel has high light transmittance, high compressive strength and high elasticity and is applicable to tissue repair materials.

Description

technical field [0001] The invention relates to a hydrogel material, in particular to a light-cured silk fibroin hydrogel and a preparation method thereof. Background technique [0002] Silk fibroin is a natural polymer fibrous protein extracted from silk, which accounts for about 70% to 80% of silk and contains 18 kinds of amino acids, of which glycine (Gly), alanine (Ala) and serine (Ser) are about Accounting for more than 80% of the total composition. Silk fibroin itself has good mechanical properties and physical and chemical properties, such as good flexibility and tensile strength, breathable moisture permeability, slow release, etc., and can be obtained in different forms after different treatments, such as fiber, solution, powder, film and gel etc. [0003] Hydrogel, an important form of regenerated silk fibroin, has high water content and highly cross-linked spatial network structure, unique physical and chemical properties, and excellent permeability and diffusiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/28C08L89/00
CPCC08J3/075C08J3/28C08J2389/00
Inventor 卢神州姜福建吴峰匡大江
Owner NANTONG TEXTILE & SILK IND TECH RES INST
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