The invention relates to a traditional Chinese medicine for anti-inebriation and sobering-up, comprising the ingredients with the following weight percentages: 5 to 10 percent of American ginseng, 5 to 15 percent of haricot bean, 1 to 8 percent of villous amomum fruit, 5 to 15 percent of dark plum fruit, 5 to 10 percent of tea, 5 to 10 percent of mulberry fruit, 5 to 10 percent of agaric, 10 to 20 percent of oriental waterplantain rhizome, 1 to 8 percent of flower of lobed kudzuvine, 1 to 5 percent of grassleaf sweelflag rhizome, 1 to 5 percent of tuber fleeceflower root and 10 to 20 percent of raisin tree seed. Multiple medicines of the invention are combined for usage, thus having the effects of sobering-up, protecting liver, dilating blood vessels, helping digestion and inducing diuresis, when alcohol enters the liver for metabolism, the alcohol can be excreted quickly, thus not causing damage of the liver, improving intelligence, inducing resuscitation and resuscitating brain. The traditional Chinese medicine has simple production, low cost, significant effects of sobering-up and health care and no toxicity or side effects, thus being in line with the national health requirements.