12 results about "Cefuroxime Sodium" patented technology

The present invention belongs to the technical field of drug preparation, and specifically relates to a preparation system and method for the conversion of cefuroxime sodium crystals, which includes a reaction unit, a drying unit, and a preparation unit. The reaction unit mixes different drugs through a reaction kettle and transports them to the drying unit for drying. The dried medicine is transported to the preparation unit to prepare finished medicine; the reaction kettle includes a device main body, a feed inlet, and a discharge outlet; the reaction kettle further includes a pre-storage cylinder, which is installed at the top of the feed inlet and is located at the top of the device main body; during the process of the drug being scattered and flipped, the gas supply device transports inert gas with a preset temperature and humidity into the rotating cylinder, and the inert gas contacts the scattered drug. On the one hand, the temperature and humidity parameters of the drug are adjusted through the inert gas, and on the other hand, the contact area between the drug and the inert gas is enlarged through scattering, improving the efficiency of drug conditioning, reducing the degree of influence on the drug, and thus improving the preparation effect of the drug.

The invention relates to the technical field of pharmaceutical wastewater treatment, in particular to a treatment method of cefuroxime sodium production wastewater. The method comprises the following steps: firstly, pretreating the cefuroxime sodium production wastewater, and adjusting the pH value to 5.0-7.5; putting the porous magnetic catalytic aerogel into the pretreated wastewater, and performing mixed treatment while performing sunlight irradiation; and taking out the porous magnetic catalytic aerogel to obtain the treated water. The 24-hour degradation rate of the cefuroxime sodium and the cefuroxime axetil can reach 95% or above, and the COD removal rate exceeds 90%. According to the method disclosed by the invention, efficient degradation treatment of antibiotics and organic matters in the cefuroxime sodium production wastewater is realized by utilizing visible light catalysis and a synergistic mechanism of adsorption, enrichment and degradation.

The invention provides a method for determining the content of lactic acid and / or acetic acid in cefuroxime sodium by an HPLC (High Performance Liquid Chromatography) method. High performance liquid chromatography is adopted, and chromatographic conditions are as follows: a chromatographic column takes octadecyl silane bonded silica gel resistant to a 100% water phase as a filler; a phosphoric acid aqueous solution is used as a mobile phase A, and methanol or acetonitrile is used as a mobile phase B; and gradient elution. According to the method, the content of acetic acid and the content of lactic acid can be measured at the same time, the separation and detection efficiency is improved, and it is ensured that the quality of cefuroxime sodium is controllable.

The utility model relates to the technical field of medicine production equipment, in particular to equipment for preparing cefuroxime sodium for injection, which is characterized in that a push plate mounting seat is fixedly mounted on the surface of a rack, and a push plate guide groove is formed in the surface of the push plate mounting seat; the material distributing disc is arranged above the rack, a material distributing groove is formed in the surface of the material distributing disc, and a convex block and a groove are arranged on the side wall of the material distributing groove; the push plate is arranged between the distribution disc and the push plate mounting seat, and a rotating shaft and a push plate guide block are arranged on the surface of the push plate; the device has the beneficial effects that the push plate is arranged below the material distributing disc, when storage bottles move to the rear conveying belt through the material distributing disc and an inner sinking groove, a rotating wheel moves into a protruding block from the surface of a groove, and at the moment, under the action of resilience force of a compression spring, a push plate guide block drives the push plate to push the storage bottles; and the storage bottles are separated from the interior of the material distributing groove, so that the rear conveying belt can smoothly convey the storage bottles.

The invention relates to a method for detecting polymer impurities in a product containing cefuroxime sodium and application of the method. The detection method comprises the following steps: detecting a product containing the cefuroxime sodium by adopting a reversed-phase liquid chromatography-mass spectrometry method to obtain the variety and content of polymer impurities in the product containing the cefuroxime sodium, mobile phases of the reversed-phase liquid chromatography comprise a mobile phase A and a mobile phase B, the mobile phase A is an ammonium acetate buffer solution, and the mobile phase B is acetonitrile. According to the detection method, the polymer impurities can be comprehensively and accurately controlled, 15 polymer impurities can be directly detected, all the detected polymer impurity types belong to one another, and the structure speculation of 12 polymer peaks is completed. The detection method is strong in specificity, high in accuracy and good in reproducibility, can effectively control the quality of the cefuroxime sodium for injection, and has positive significance on storage of the cefuroxime sodium for injection and polymer control during clinical use.

The invention provides a synthesis method of an aldehyde RSM1 serving as an initial raw material of cefbirome pivoxil sodium, which comprises the following steps: sequentially performing amino protection and esterification on 7-ACA serving as a raw material to obtain an intermediate A; hydrolyzing and oxidizing the intermediate A through a fluid chemical method to obtain an intermediate B; and fully deprotecting the intermediate B to obtain the target product aldehyde RSM1. The preparation method comprises the following steps: starting from a cheap raw material 7-ACA, carrying out amino protection and esterification to obtain an intermediate A; and then hydrolysis and oxidation are integrated in the two-channel tubular reactor by utilizing the thought of fluid chemistry, so that the generation of lactone side reaction is effectively avoided, the yield and purity of the product are greatly improved, and the production operation cost is reduced. The reaction conversion of each step is relatively high, the operation is simple, the reaction flux is large, the equipment requirement is low, and the industrial production in the future is facilitated.

The invention relates to the technical field of cefuroxime sodium medicines, in particular to a method for preparing and purifying cefuroxime sodium, which comprises the following steps: dissolving cefuroxime acid in an acetone aqueous solution, adding a sodium acetate ethanol aqueous solution, and stirring for reaction to obtain a mixed solution; pumping the mixed solution into a nanofiltration assembly containing a bacterial cellulose nanofiltration membrane for nanofiltration concentration to obtain a concentrated solution; adjusting the pH value of the concentrated solution, adding an ethanol-acetone mixed solution, uniformly mixing, adding a cefuroxime sodium seed crystal, controlling the temperature, stirring, carrying out primary crystallization, cooling at a constant speed, and carrying out secondary crystallization to obtain a crystallized product; and filtering and drying the crystallized product to obtain the cefuroxime sodium crystal. According to the preparation method, the purity and chromaticity of the cefuroxime sodium product are remarkably improved, and the purity can reach 99.7% or above. The biodegradable bacterial cellulose nanofiltration membrane is used as a separation medium, the problem of environmental pollution caused by a traditional petroleum-based polymer membrane is avoided, and the method conforms to the green chemistry principle.

The invention relates to the technical field of cefuroxime sodium production, and provides a reaction device for cefuroxime sodium production, the reaction device comprises a standby liquid preparation kettle and a cefuroxime sodium preparation kettle, the cefuroxime sodium preparation kettle comprises a reaction kettle I and a reaction kettle II, a shell of the reaction kettle I and a shell of the reaction kettle II sequentially comprise a reaction shell, a temperature control shell and a heat preservation shell from inside to outside, a temperature control spiral pipe is arranged in a temperature control cavity between the inner wall of the temperature control shell and the outer wall of the reaction shell, the temperature control spiral pipe and an external temperature control medium supply end form a loop, and an auxiliary electric heating wire is arranged in the temperature control shell. The multi-step reaction is integrated in one device, the production efficiency is improved, the risks of pollution and degradation of intermediate products are reduced, a unique three-layer shell temperature control structure design provides a stable thermal environment background for the interior, the defects of lagging and non-uniformity of traditional jacket temperature control are overcome, and the production cost is reduced. And the operability and maintainability of the equipment are improved through the auxiliary jacking assembly.

The present application relates to the technical field of pharmaceutical wastewater treatment, and relates to a treatment method of cefuroxime sodium production wastewater. First, the cefuroxime sodium production wastewater is pretreated, and the pH is adjusted to 5.0-7.5; the porous magnetic catalytic aerogel is put into the pretreated wastewater, and mixed treatment is carried out while sunlight irradiation; the porous magnetic catalytic aerogel is taken out, and the treated water is obtained. The 24-hour degradation rate of the cefuroxime sodium and cefuroxime axetil can reach more than 95%, and the COD removal rate is more than 90%. The present application realizes the efficient degradation treatment of antibiotics and organic matters in the cefuroxime sodium production wastewater by using visible light catalysis and through the synergistic mechanism of 'adsorption-enrichment-degradation'.

The invention discloses a method for detecting the content of a polymer in a cefuroxime sodium medicine, and relates to the technical field of detection of the content of the polymer in the medicine, the method for detecting the content of the polymer in the cefuroxime sodium medicine comprises the following operation steps: S1, setting chromatographic conditions; s2, preparing a solution; s3, obtaining a chromatogram map; and S4, calculating the content of the polymer. According to the method for detecting the content of the polymer in the cefuroxime sodium medicine, the content of the polymer in the cefuroxime sodium medicine is accurately determined by matching a main component external standard method with a mobile phase, namely an aqueous solution as a blank reagent, a test solution and a contrast solution, and the detection time is greatly shortened on the basis of the accuracy of a detection result.

The present application relates to the technical field of cefuroxime sodium production, and provides a reaction device for cefuroxime sodium production, which comprises a standby liquid preparation kettle and a cefuroxime sodium preparation kettle, the cefuroxime sodium preparation kettle comprises a reaction kettle one and a reaction kettle two, the shell of the reaction kettle one and the reaction kettle two sequentially comprises a reaction shell, a temperature control shell and a heat preservation shell from inside to outside, a temperature control spiral pipe is arranged in the temperature control cavity between the inner wall of the temperature control shell and the outer wall of the reaction shell, the temperature control spiral pipe forms a loop with an external temperature control medium supply end, and an auxiliary electric heating wire is arranged in the temperature control shell. The present application integrates multiple steps of reactions in one device, improves production efficiency, reduces the risk of intermediate product pollution and degradation, and provides a stable thermal environment background for the interior through a unique three-layer shell temperature control structure design, solves the disadvantages of traditional jacket temperature control hysteresis and unevenness, and improves the operability and maintainability of the equipment through an auxiliary jacking assembly.

The invention provides a method for degrading cefuroxime sodium so as to enrich an impurity A and an impurity H, and the impurity A and the impurity H are collected by a liquid phase preparation method. The method is simple and easy to implement, the purity is relatively high, the prepared impurity A and impurity H are relatively large in amount, and the quality research of the cefuroxime sodium impurity reference substance is met.