3 results about "Cefuroxime Sodium" patented technology

The invention provides a synthesis method of an aldehyde RSM1 serving as an initial raw material of cefbirome pivoxil sodium, which comprises the following steps: sequentially performing amino protection and esterification on 7-ACA serving as a raw material to obtain an intermediate A; hydrolyzing and oxidizing the intermediate A through a fluid chemical method to obtain an intermediate B; and fully deprotecting the intermediate B to obtain the target product aldehyde RSM1. The preparation method comprises the following steps: starting from a cheap raw material 7-ACA, carrying out amino protection and esterification to obtain an intermediate A; and then hydrolysis and oxidation are integrated in the two-channel tubular reactor by utilizing the thought of fluid chemistry, so that the generation of lactone side reaction is effectively avoided, the yield and purity of the product are greatly improved, and the production operation cost is reduced. The reaction conversion of each step is relatively high, the operation is simple, the reaction flux is large, the equipment requirement is low, and the industrial production in the future is facilitated.

The present application relates to the technical field of pharmaceutical wastewater treatment, and relates to a treatment method of cefuroxime sodium production wastewater. First, the cefuroxime sodium production wastewater is pretreated, and the pH is adjusted to 5.0-7.5; the porous magnetic catalytic aerogel is put into the pretreated wastewater, and mixed treatment is carried out while sunlight irradiation; the porous magnetic catalytic aerogel is taken out, and the treated water is obtained. The 24-hour degradation rate of the cefuroxime sodium and cefuroxime axetil can reach more than 95%, and the COD removal rate is more than 90%. The present application realizes the efficient degradation treatment of antibiotics and organic matters in the cefuroxime sodium production wastewater by using visible light catalysis and through the synergistic mechanism of 'adsorption-enrichment-degradation'.

The present application relates to the technical field of cefuroxime sodium production, and provides a reaction device for cefuroxime sodium production, which comprises a standby liquid preparation kettle and a cefuroxime sodium preparation kettle, the cefuroxime sodium preparation kettle comprises a reaction kettle one and a reaction kettle two, the shell of the reaction kettle one and the reaction kettle two sequentially comprises a reaction shell, a temperature control shell and a heat preservation shell from inside to outside, a temperature control spiral pipe is arranged in the temperature control cavity between the inner wall of the temperature control shell and the outer wall of the reaction shell, the temperature control spiral pipe forms a loop with an external temperature control medium supply end, and an auxiliary electric heating wire is arranged in the temperature control shell. The present application integrates multiple steps of reactions in one device, improves production efficiency, reduces the risk of intermediate product pollution and degradation, and provides a stable thermal environment background for the interior through a unique three-layer shell temperature control structure design, solves the disadvantages of traditional jacket temperature control hysteresis and unevenness, and improves the operability and maintainability of the equipment through an auxiliary jacking assembly.