104 results about "Cefuroxime Sodium" patented technology

The invention discloses a preparation method of high-purity cefuroxime acid which is an intermediate for synthesizing second-generation cephalosporins cefuroxime sodium and cefuroxime axetil. The preparation method comprises the following steps: based on 7-aminocephalosporanic acid (7-ACA) as a raw material, carrying out an N-acylation reaction on the 7-ACA and furoyl acetylcholine at the 7-position; at a low temperature, hydrolyzing 3-acetyl with a sodium hydroxide solution, crystallizing, filtering and drying so as to obtain the intermediate 3-deformamido cefuroxime acid (DCC); quantitatively adding the DCC in a tetrahydrofuran solvent, dropwise adding chlorosulfonyl isocyanate for a nucleophilic addition reaction so as to generate chlorosulfonyl cefuroxime acid, and adding purified water for hydrolysis so as to prepare a cefuroxime acid reaction liquid; adding sodium bicarbonate for salifying; removing by-reactant lactone and other unsaponifiable impurities in the reaction liquid with a ternary compound extracting agent of dichloromethane, ethyl acetate and tetrahydrofuran, layering, and adding hydrochloric acid in a water phase for acidification; adding the ternary compound extracting agent to extract and separate out the cefuroxime acid; and removing water-soluble impurities, crystallizing and filtering a distilled organic phase, and then drying so as to obtain the high-purity cefuroxime acid with the purity of more than or equal to 99%.

The invention relates to a method for synthesizing cefuroxime sodium, which comprises the following steps: 1, performing the N- acylation reaction of 3-deacetyl-7aminocephalosporanic acid and methoxyaminofuranyl ammonium salt which serve as raw materials and adjusting the pH value with hydrochloric acid to less than 7 in a mixed solvent phase to precipitate crystals to obtain 3-deoxyformyl cefuroxime acid; 2, performing the addition reaction of the 3-deoxyformyl cefuroxime acid and chlorosulfonyl isocyanate serving as a strong ammonia formylating agent in an organic solvent to obtain chlorosulfonyl cefuroxime acid, dehydrating the chlorosulfonyl cefuroxime acid to obtain the cefuroxime acid, decarburizing and concentrating the cefuroxime acid, crystallizing the cefuroxime acid in a solvent phase, and drying the crystals under vacuum to obtain a solid product of cefuroxime acid; and 3, dissolving the cefuroxime acid in alkaline solution, decarburizing the resulting product, crystallizing the resulting product in a mixed solvent phase, filtering crystals, and drying the crystals under vacuum to obtain the cefuroxime sodium.

The invention provides cefuroxime sodium and a preparation method thereof. The preparation method comprises the following steps that: (1) 7-aminocephalosporanic acid reacts with 2-(furan-2-base)-2-(methoxyimino) acetyl chloride to produce 3-deacety-7-aminocephalosporanic acid; (2) crystallization is conducted after the 3-deacety-7-aminocephalosporanic acid reacts with chlorosulfonyl isocyanate to produce cefuroxime acid; and (3) the cefuroxime acid is salified to obtain the cefuroxime sodium, wherein solvent for crystallization is selected from one or more of petroleum ether, normal hexane, cyclohexane, solvent oil and tetrahydrofuran. Since the preparation method adopts solvents such as petroleum ether for crystallization in the process of the preparation of the cefuroxime acid, the invention has the advantages that the yield of the product is effectively improved, the product purity is further improved, the impurity content is reduced, the product quality is compliant with Chinese Pharmacopoeia of version 2005, the operation of the method is simple, the raw materials can be easily obtained, the cost is relatively low and the industrial production can be realized easily.

The invention relates to a method for recrystallizing cefuroxime sodium, which is used for solving the problem of the refining of cefuroxime sodium raw material medicaments with darker colors. In the technical scheme, white crystalline powder recrystallized by the cefuroxime sodium is prepared by the following four steps of: a, preparing crude product solution; b, preparing a crystallization solvent; c, crystallizing; and d, discharging. By the method, the yield is over 83 percent, and the color level and the pH value of final products meet the pharmacopoeial standard; and the method is suitable for recrystallizing the raw material medicaments with unqualified color levels.

The invention provides a composition of cefuroxime sodium and sulbactam sodium for injection, which comprises cefuroxime sodium and sulbactam sodium by the weight ratio of 15:1. The composition has good antibiotic action and low cost of production.

The invention relates to a bispecific oligopeptide-lidamycin energized fusion protein Ec-LDP-Hr-AE. The fusion protein comprises two oligopeptides of targeted epidermal growth factor receptors EGFR and HER2, a lidamycin apoprotein and a lidamycin activity chromophore, and researches show that the fusion protein in vitro can be combined with the epidermal growth factor receptors EGFR and HER2 for expressing the specificities of the tumor cells, has strong damaging effect for the tumor cells and remarkable therapeutic effect for the transplanted tumor of nude mice for the ovarian cancer SK-OV-3 after the in vivo test, displays the characteristics of miniaturization and high efficiency of targeting drugs and has good application prospect.

The invention relates to a synthesis art of a chemical product, in particular to a new synthesis art for 3-deacetyl cefuroxime acid (DCCF). The art of the invention uses SMIA acyl chloride and 3-deacetyl cephalosporin acid (D-7-ACA) as the main synthesis ingredients to replace the SMIA acyl chloride and the 7-ACA, which reduces the chemical reaction process needed in the synthesis, shortens the production cycle, reduces the using solvent species, facilitates the solvent recovery and improves the product synthesis rate.

The present invention discloses a cefuroxime sodium powder preparation for injection. The preparation is prepared by the following steps: (1) preparing a sodium acetate solution by dissolving sodium acetate with a solvent for standby; (2) adding the solvent and water, and adding cefuroxime acid with stirring until complete dissolution; adding activated carbon, decolorizing, filtering, mixing with the solvent, washing the residue and a filter bottle, and filling a crystallization tank with the filtrate; (3) applying the particle process morphology and molecular assembly process crystal product molecular assembly and shape-state optimization technology by Hebei Huamin Pharmaceutical Co. Ltd. of North China Pharmaceutical Co. Ltd., controlling the temperature and stirring speed, and dropwise adding sodium acetate solution; and adding a solvent agent according to the flow rate; (4) carrying out pumping filtration, washing, vacuum drying, weighing, and packing; and 5) packing the preparations in different specifications to obtain the cefuroxime sodium for injection. The cefuroxime sodium powder prepared by the method has the advantages of excellent hydrodynamic performance, perfect crystal shape, uniform particle size distribution, and greatly improved color grade, clarification, purity and stability.

The invention relates to a new method for preparing a cefuroxime sodium compound. A target product is prepared by using triphosgene and triphenylphosphine oxide as catalysts, reacting 7-amino-cephalosporanic acid with (Z)-methoxyl imido furylacetic acid ammonium salt and sequentially adding chlorosulfonyl isocyanate and sodium iso-octoate for reaction. The cefuroxime sodium compound prepared by the method is greatly enhanced in purity and yield coefficient and has advantages of inexpensive using materials, simple synthesizing technology and equipment and easy production separation and purification.

The invention provides a cefuroxime sodium compound and a new preparation method thereof. The method comprises the following steps: performing acid-base reaction, absorbing with activated carbon, and separating and purifying with a chromatographic column. By adopting the method, the purity and content of cefuroxime sodium can be greatly increased, the product quality of the preparation can be increased, the toxic or side effects can be reduced and the safety of the preparations of the medicines for curing respiratory tract infection and urinary tract infection can be ensured; and compared with the prior art, the method has the advantages of simple and practical technology, mild reaction conditions, low cost, high yield and high product purity and is suitable for industrial production.

The invention discloses a cefuroxime sodium powder preparation for injection, belonging to the technical field of medicine preparation. The cefuroxime sodium powder preparation for injection is prepared by the following steps: preparation of a sterile formed sodium agent solution, preparation of a sterile cefuroxime acid solution, crystallization and sub-packaging, wherein a two-time grain growing technology is adopted for the crystallization, so that the crystallization quality is improved. With good color and high stability, the product disclosed by the invention greatly improves the quality and safety of cefuroxime sodium, is favorable for improving the national health level, and realizes remarkable economic and social benefits.

The invention relates to a one-step recovery and preparation method of cefuroxime sodium. The method comprises: dispersing cefuroxime sodium in a water-containing or non-aqueous mixed solvent of alcohol and ketone, adding hydrochloric acid or sulfuric acid at a temperature of 0-50°C, and reacting for 0.5-3 hours, and cefuroxime sodium is gradually converted into cefuroxime Fuuroctanoic acid is dissolved in the reaction system, and the by-product sodium chloride or sodium sulfate generated simultaneously is insoluble in the reaction system; Then, activated carbon is added for decolorization, filtered, and the by-product and activated carbon are filtered to obtain the cefuroxime acid solution; the obtained Cefuroxime sodium solution is mixed with sodium lactate or sodium isooctanoate aqueous or non-aqueous organic solvent solution to precipitate cefuroxime sodium crystals. The present invention adopts a one-step method for the recovery and preparation of cefuroxime sodium, without the need to separate and dry cefuroxime acid, thereby reducing the damage to cefuroxime acid, and the water content of the system is low during the recovery and preparation process, which is not suitable for unstable cefuroxime sodium Has a good protective effect.

The invention discloses a technology for preparing cefuroxime sodium for injection. The technology includes the steps that a sodium acetate solution is dropwise added into a cefuroxime acid solution, and a cefuroxime sodium crude product is prepared with the crystallization technology; then the cefuroxime sodium crude product is extracted with the supercritical fluid extraction technology, recrystallization is carried out with the crystallization technology, and the cefuroxime sodium for injection is finally obtained. The cefuroxime sodium prepared with the technology is small in impurity number and good in stability, the problems that existing cefuroxime sodium is large in impurity number, deep in color, poor in stability and the like are solved, and the requirements for an injection can be completely met.

A composite cefuroxime sodium is prepared from cefuroxime sodium or its salt and beta-lactamase inhibitor in weight ratio of (4-8):1.

The invention discloses a cefuroxime sodium compound entity which is relatively poor in hygroscopicity, relatively good in storage stability and applicable to preparation of drugs for treating or preventing respiratory system infection, five-organ infection, urinary system infection, pelvic cavity infection, septicemia, skin soft-tissue infection, bone and joint infection, gonorrhea and meningitis of human or animals, caused by sensitive gram positive or negative bacteria.

The invention provides a cefuroxime sodium suspension powder injection. The cefuroxime sodium suspension powder injection comprises the following components by weight part: 1 part of cefuroxime sodium, 2 to 10 parts of surfactant and 3 to 18 parts of lyoprotectants. The cefuroxime sodium suspension powder injection is characterized in that the surfactant is a combination of cholesterol and tween-80 in a weight ratio of 6:1-4:1. The cefuroxime sodium suspension powder injection is prepared unexpectedly by using the emulsification and suspension technologies through specific surfactant after freezing and drying and solves the problem of poor stability of the cefuroxime sodium.

The invention relates to the technical field of pharmaceutical and chemical industries and particularly discloses a cefuroxime sodium synthesizing method. The synthesizing method comprises the steps:dropwise adding alkali solution into 7-aminocephalosporanic acid aqueous solution for hydrolysis reaction, and then subjecting the mixture and (Z)-2-furyl-2-methoxyimino acetic acid p-toluene sulfonicanhydride to amidation to obtain 7-[(Z)-2-furyl-2-methoxyiminoacetamido]-3-hydroxymethyl-4-cephalosporanic acid; dissolving the 7-[(Z)-2-furyl-2-methoxyiminoacetamido]-3-hydroxymethyl-4-cephalosporanic acid into organic solvents to sequentially perform nucleophilic addition and hydrolysis reaction with chlorosulfonyl isocyanate, then adding sodium iso-octoate solution, and performing devitrification, filtering, washing and drying to obtain cefuroxime sodium. According to the synthesizing method, raw materials are wide and easy to obtain, the cost is low, the steps are simple, operation is simple, and side reaction is less.

The invention discloses a Cefuroxime sodium lyophilized powder and a method for preparing the same. The method is characterized in that a Cefuroxime sodium solution is added with active carbon, decolored, subjected to decarbonization and aseptic filtration and washed by purified water; a mixture of a filtrate and an eluant is pressed into a feed tray or a penicillin bottle of a freezedryer; a product with the moisture of Cefuroxime sodium of less than 2 percent is prepared by a lyophilization method; and the method simplifies a process, reduces labor intensity, aseptic risk, production cost and pollution and has rapid dissolution speed, good stability and high yield.

The invention discloses a cefuroxime sodium new crystal type compound and a crystallizing preparation method thereof. The cefuroxime sodium new crystal type compound is prepared through a particle process crystal product molecular assembly and form optimizing technology. A stability test proves that the new crystal type compound has the advantages of being high in purity, low in impurity content, low in hygroscopicity and good in stability. Meanwhile, the invention discloses a preparation, cefuroxime sodium for injection. The preparation is prepared from cefuroxime sodium.

The invention discloses bacillus tequilensis Am101 capable of degrading various beta-lactam antibiotics and an application of the bacillus tequilensis Am101. The strain is preserved in China General Microbiological Culture Collection Center on November 18, 2019, and a preservation number is CGMCC NO. 18965. The strain Am101 disclosed by the invention can be used for simultaneously degrading various beta-lactam antibiotics and can be used for efficiently degrading benzylpenicillin potassium, amoxicillin, cefuroxime sodium and ceftiofur sodium. The strain Am101 can be applied to degradation treatment of residual beta-lactam antibiotics in livestock and poultry manure, can also be applied to restoration of water and soil polluted by the beta-lactam antibiotics, and has the wide application prospect.