One-step recovery and preparation method of cefuroxime sodium

Abstract

The invention relates to a one-step recovery and preparation method of cefuroxime sodium. The method comprises: dispersing cefuroxime sodium in a water-containing or non-aqueous mixed solvent of alcohol and ketone, adding hydrochloric acid or sulfuric acid at a temperature of 0-50°C, and reacting for 0.5-3 hours, and cefuroxime sodium is gradually converted into cefuroxime Fuuroctanoic acid is dissolved in the reaction system, and the by-product sodium chloride or sodium sulfate generated simultaneously is insoluble in the reaction system; Then, activated carbon is added for decolorization, filtered, and the by-product and activated carbon are filtered to obtain the cefuroxime acid solution; the obtained Cefuroxime sodium solution is mixed with sodium lactate or sodium isooctanoate aqueous or non-aqueous organic solvent solution to precipitate cefuroxime sodium crystals. The present invention adopts a one-step method for the recovery and preparation of cefuroxime sodium, without the need to separate and dry cefuroxime acid, thereby reducing the damage to cefuroxime acid, and the water content of the system is low during the recovery and preparation process, which is not suitable for unstable cefuroxime sodium Has a good protective effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a recovery and preparation method of cephalosporins, more specifically, to a one-step recovery and preparation method of cefuroxime sodium. Background technique [0002] Cefuroxime sodium is a semi-synthetic second-generation cephalosporin, which is effective against Staphylococcus aureus, Streptococcus, meningococcus, influenza bacillus, Klebsiella, Escherichia coli, Proteus mirabilis, Salmonella, Shigella, etc. Has a high antibacterial effect. This product can resist β-lactamase and is effective against penicillin-resistant Staphylococcus aureus. Clinically, it is mainly used for respiratory tract infection, pyelonephritis, urinary tract infection and bone, joint, ear, nose and throat, soft tissue infection caused by sensitive bacteria. This product has a sufficient amount to enter the cerebrospinal fluid during meningitis, and has a significant effect on meningitis caused by ...

AI Technical Summary

Problems solved by technology

If it is not dried, first, it is not suitable for storage, and the color of the wet product of cefuroxime acid changes rapidly; second, it is not suitable for feeding and using, because the wet product of cefuroxime acid contains a large amount of water, which will bring a lot of water to the system for preparing cefuroxime sodium. Enter a large amount of water, affect the preparation of cefuroxime sodium

Therefore, the wet product of cefuroxime acid generally needs to be dried, and the drying process takes a long time. Generally, 100 kg of cefuroxime acid needs to be dried at 30-50 degrees for as long as 5-10 hours. During the drying process, cefuroxime acid is in a state of high temperature and high humidity, which will cause the color and impurities of cefuroxime acid to increase, and the quality of recovered cefuroxime sodium is not good

[0009] 2. Method 2 seems simple, and there is no drying process of adding acidic substances and cefuroxime acid in method 1. However, recrystallization of unqualified cefuroxime sodium in water and organic solvents often results in fine particles of cefuroxime sodium. Moreover, the impurities are not easy to remove, the product is not easy to dry, and the product quality and yield are not satisfactory

And above-mentioned two recovery methods all will use a large amount of water to carry out the dissolving of cefuroxime sodium, so the quality of the cefuroxime sodium that reclaims is often not good

If the dissolution time in industrial production is prolonged, the recovered cefuroxime sodium may even appear darker than the original cefuroxime sodium

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