159 results about "Sodium lactate" patented technology

The invention discloses a concrete crack self-repairing material based on microorganism immobilization and a preparation method of the concrete crack self-repairing material, and belongs to the crossing field of microorganism materials and civil engineering. The material is prepared from peptone, sodium lactate, volcanic rock, bacillus pasteurii and other raw materials through the steps of culture medium preparation, carrier modification, microorganism immobilization, microcapsule and gel protection layer formation and the like, the prepared volcanic rock-chitosan carrier provides an inhabiting environment for microorganisms, and the survival rate of the microorganisms in a high-alkali environment is increased to 70%. When the concrete cracks and the alkaline environment triggers the protective layer to disintegrate, the bacillus pasteurii and the desulfurization vibrio are subjected to a reduction reaction with sulfate through urealysis, and calcium carbonate and calcium sulfide are generated to fill cracks. The 28-day repair rate of the material is larger than or equal to 99%, the maximum crack repair width reaches 1.2 mm, the compressive strength recovery rate is larger than or equal to 85%, excellent durability and environment friendliness are achieved, and the concrete crack repair problem is effectively solved.

The invention provides a new energy automobile battery flexible disassembling adhesive and a preparation method thereof, and belongs to the technical field of new energy automobile batteries, the flexible disassembling adhesive comprises the following components by weight: 45-50 parts of deionized water; 8 to 10 parts of gamma-butyrolactone; 5 to 8 parts of propylene glycol methyl ether acetate; 2 to 3 parts of microencapsulated lipase; 2 to 3 parts of nano cellulose immobilized protease; 6 to 8 parts of urea peroxide; 0.5 to 1 part of nano manganese dioxide; 0.7 to 1.1 parts of a sodium citrate / sodium lactate buffer solution; 1.5 to 2.5 parts of polyvinylpyrrolidone K30; 0.8 to 1.2 parts of hydroxypropyl methyl cellulose; 0.05 to 0.1 part of a graphene oxide nanosheet; 0.5 to 0.8 part of a benzotriazole derivative; 0.1 to 0.3 part of sodium molybdate; 6 to 8 parts of sorbitol; and 5-7 parts of ascorbic acid. The flexible disassembly adhesive solves the problems of low efficiency, serious environmental pollution, high safety risk and low material recovery rate in traditional battery disassembly.

The invention discloses a preparation method of high-viscosity cationic starch, which belongs to the technical field of modified starch, and comprises the following steps: crosslinking epichlorohydrin, ball-milling and cationizing; the epoxy chloropropane crosslinking comprises the following steps: mixing starch, calcium hydroxide and deionized water, stirring at 40-50 DEG C, adding sodium stearoyl lactylate, stirring at 50-55 DEG C, naturally cooling to room temperature, adding sodium chloride and epoxy chloropropane, stirring, dropwise adding a potassium hydroxide aqueous solution, stirring, adjusting the pH value to 6, filtering, taking filter residues, washing and drying to obtain crosslinked starch; in the step of ball milling, calcium hydroxide, sucrose fatty acid ester SE-11 and deionized water are mixed and then subjected to ball milling, and a ball-milled material is obtained; the prepared high-viscosity cationic starch is high in paste liquid viscosity and cationic substitution degree, good in paste liquid viscosity stability, uniform in substitution degree and paste liquid viscosity, high in reaction efficiency in cationization and low in alkali consumption.

The invention relates to the technical field of normal-temperature preservation of cooked meat products, in particular to a normal-temperature preservation method of cooked meat products based on natural components. The invention provides a method for improving the fresh-keeping degree of cooked meat products during normal-temperature storage, which comprises the following steps: applying a preset amount of compound preservative to the cooked meat products according to the expected fresh-keeping degree requirement, the compound preservative is prepared from epsilon-polylysine salt, nisin and sodium lactate. According to the method provided by the invention, the fresh-keeping degree of the cooked meat product can be comprehensively improved, so that the existing storage limitation is broken through while multiple requirements of consumers on safety, nutrition and flavor are met.

The invention discloses an ionic conductive gelatin hydrogel with high compression strength and a preparation method thereof. The preparation method of the ionic conductive gelatin hydrogel with high compression strength comprises the following steps: respectively preparing a gelatin solution and a montmorillonite dispersion liquid; adding sodium lactate into the gelatin solution, and heating and stirring to obtain a gelatin-sodium lactate mixed solution; adding the montmorillonite dispersion liquid into the gelatin-sodium lactate mixed solution, heating and stirring to obtain a precursor solution, and cooling to obtain the gelatin-sodium lactate-montmorillonite hydrogel. According to the preparation method provided by the invention, the defects of poor mechanical property, poor ionic conductivity and the like of the gelatin hydrogel can be improved, and then the gelatin hydrogel with high compression strength and ionic conductivity is prepared.

The invention relates to the technical field of feeds, in particular to a diatomite carrying agent enriched rice polysaccharide feed and a preparation method thereof. The raw materials comprise diatomite, rice, glutinous rice, flour, dry yeast, beer yeast, rhizopus sweet rice wine koji, raw rice flour, glutinous rice flour, brown sugar, soybean meal, saccharifying enzyme, sodium propionate, sodium lactate, astragalus membranaceus, liquorice, angelica sinensis, radix angelicae, clove, malt, momordica grosvenori, codonopsis pilosula and flaccid knotweed herb. The diatomite carrying agent enriched rice polysaccharide feed disclosed by the invention contains extremely rich polysaccharides, and is safe and nutritional; the preparation process of the feed is ecological and environment-friendly, can be fully copied, is easy to prepare, low in price and remarkable in economic benefit, meanwhile, the value of the rice is increased, and the feed has great strategic significance for maintaining food safety.

The invention discloses a composition for regulating scalp micro-ecology, which comprises a component A and a component B, the component A is prepared from the following components in parts by weight: 5 to 15 parts of amur corktree bark extract, 3 to 14 parts of rhizoma coptidis root extract, 5 to 15 parts of radix sophorae flavescentis extract, 2 to 8 parts of rhus chinensis insect gall extract, 2 to 18 parts of fructus cnidii extract, 3 to 10 parts of pericarpium zanthoxyli extract, 1 to 5 parts of camphor tree root extract, 3 to 12 parts of ginger root extract, 5 to 15 parts of radix polygoni multiflori extract and 5 to 25 parts of swertia japonica extract; 10-30 parts of a Chinese arborvitae twig and leaf extract; the component B is prepared from the following components in parts by weight: 70 to 90 parts of cocamidopropyl-PG-sodium dimethyl ammonium chloride phosphate, 10 to 30 parts of sodium isostearoyl lactylate and 1 to 10 parts of dichlorobenzyl alcohol; the weight ratio of the component A to the component B is 10: 1. The composition can effectively regulate scalp micro-ecological balance, remarkably inhibit overgrowth and reproduction of common harmful bacteria on scalp, protect or moderately promote growth of beneficial bacteria on scalp, maintain healthy flora structure and diversity, fundamentally improve scalp health by recovering and maintaining the balance state of scalp micro-ecology, and improve scalp quality. The shampoo has multiple good effects of controlling oil, preventing alopecia, relieving itching and removing dandruff.

The invention belongs to the field of polymer chemistry and biological medicine materials, and relates to application of a polymer polysaccharide slow-release carrier in medicinal and edible components and a preparation method of the polymer polysaccharide slow-release carrier. The carrier is composed of phytic acid-genipin cross-linked modified chitosan, tannic acid, sodium lactate, glycerin, vitamin E acetate, sodium alginate and deionized water. The phytic acid-genipin cross-linked modified chitosan is prepared by reacting chitosan with phytic acid and genipin, and has reversible cross-linking and polydentate coordination properties; the tannic acid and the modified chitosan can form a multi-point hydrogen bond and esterification network. The carrier is prepared through sol-gel forming or spray drying, is stable in structure, good in dispersity, high in drug loading capacity, stable in an acid environment and controllable in release under a neutral condition, remarkably improves the slow release performance and bioavailability of medicinal and edible components, and is suitable for functional food and drug delivery systems.

The invention belongs to the technical field of cosmetics, and particularly discloses a hair follicle nourishing composition containing tripeptide-1 and a preparation method of the hair follicle nourishing composition. Comprising the following components in parts by mass: 36.5-47.3 parts of a Korean ginseng extract, 24-30 parts of a green alga extract, 20-28 parts of lactobacillus / soybean extract fermentation product filtrate, 1-5 parts of sodium polyglutamate, 1-4 parts of hydrogenated vegetable oil glyceride, 0.5-1.5 parts of sodium lactate and 0.2-1 part of tripeptide-1. On the basis that sodium polyglutamate, hydrogenated vegetable oil glycerides, sodium lactate and tripeptide-1 are added, through the synergistic interaction of the Korean ginseng extract, the green alga extract and the lactobacillus / soybean extract fermentation product filtrate, the composition capable of effectively inhibiting the activity of malassezia furfur, relieving or eliminating scalp inflammation, preventing and treating scalp inflammation and the like is obtained. Human hair papilla cell proliferation is promoted, and hair follicles are effectively nourished.

The invention belongs to the technical field of biochemistry and functional polymer materials, and particularly relates to a polysaccharide-oligopeptide co-assembled intestinal flora regulation and control material and a preparation method thereof. The material is prepared from imine-boric acid ester double dynamic crosslinking modified chitosan, glycyl-tryptophan dipeptide, sodium lactate, citric acid, glycerol and a phosphate buffer solution. A reversible imine bond and a borate bond are introduced into chitosan molecules to construct a polysaccharide network with a double-dynamic crosslinking characteristic, and then the polysaccharide network and oligopeptide molecules are synergistically self-assembled to form a three-dimensional gel structure. The material has pH responsiveness, self-repairing property and slow-release function, and can realize continuous release of short peptides and selective regulation and control of probiotics in an intestinal environment. The prepared material is high in gel strength, good in structural stability and stable in oligopeptide release, and has remarkable promotion and inhibition selectivity on intestinal flora. The method provides an innovative co-assembly strategy for polysaccharide functionalization and micro-ecological intervention, and has a good application prospect.

The invention discloses a cell protection solution for venous transfusion as well as a preparation method and application of the cell protection solution. The cell protection liquid comprises 4 to 8 mg / ml of sodium chloride, 0.1 to 0.5 mg / ml of potassium chloride, 2.8 to 3.5 mg / ml of sodium lactate, 0.1 to 0.3 mg / ml of calcium chloride, 0.15 to 0.3 [mu] g / ml of glucose, 0.01 to 0.03 ml / ml of 20% human serum albumin, 4 to 8 [mu] g / ml of vitamin E, 0.2 to 2 [mu] g / ml of vitamin B12, 0.5 to 2 [mu] g / ml of folic acid, 4 to 8 [mu] g / ml of L-aspartic acid and 0.5 to 2 [mu] g / ml of glutathione. The cell preserving fluid provided by the invention can effectively protect cells for a long time, can be directly transfused back through veins, does not need special treatment, is convenient for clinical application, and has better application prospect and development potential in the development of the clinical treatment of the cells towards the drug direction.

The invention belongs to the field of pharmaceutical preparations, and provides a medical composition for treating premature delivery and a preparation method thereof. The progesterone nanocrystal (D50 is 250-350 nm) and poloxamer 407 / 188 thermosensitive gel-forming system composite design is adopted, hydroxypropyl methylcellulose or carbomer 974P and a functional adhesion polymer (carbomer-cysteine or carbomer-catechol) are matched, the pH is adjusted to 4.0-4.5 through a lactic acid / sodium lactate buffer system, and the progesterone nanocrystal / poloxamer composite gel-forming agent is prepared. The excellent performance that the sol-gel transition temperature is 30-34 DEG C, the elastic modulus is not smaller than 150 Pa at 37 DEG C, the modulus retention rate is not smaller than 60% after the emulsion is diluted by 5-10 times, the adhesion work is not smaller than 0.60 N.s, and the anti-flushing retention rate is not smaller than 70% after the emulsion is diluted by 5-10 times is achieved. The invention solves the problem of synergy of high-modulus gel strength, rapid self-repairing ability and anti-dilution and anti-flushing stability, realizes unification of long-acting drug release and excellent biological adhesion performance in vagina physiological fluid dilution and mechanical flushing environments, and has wide clinical application value.

This invention provides an injectable cefminox sodium preparation and its preparation method, belonging to the field of pharmaceutical preparation technology. The preparation, by weight, comprises: 1 part of refined cefminox sodium, 0.5 parts of sodium lactate Ringer's solution, 0.2 parts of vitamin B12 injection, 0.1-0.3 parts of a modified composite antioxidant, and 3 parts of physiological saline. The preparation method of the modified composite antioxidant is as follows: S1, add 1 part by weight of poloxamer to 20 parts by weight of distilled water and stir for 6-8 minutes to obtain a solution; S2, after passing 1 part by weight of natural vitamin C through a 100-mesh sieve, mix it into the solution obtained in S1, and sonicate for 10-15 minutes to obtain a vitamin C solution; S3, mix 0.5 parts by weight of vitamin D into the vitamin C solution obtained in S2, and sonicate for 15-20 minutes to obtain the modified composite antioxidant. The formulation of this invention exhibits excellent stability and stable content of cefminox sodium when exposed to environments of 35℃±2℃, 65%±5%RH and natural light, ensuring the safety and reliability of medication.

The application relates to a preparation method and application method of a mesenchymal stem cell protective agent composition, and relates to the technical field of stem cell treatment, in particular to a protective agent composition, a preparation technology of the protective agent composition and an application technology of the protective agent composition in mesenchymal stem cell treatment. The application solves the problems of insufficient cell stemness maintenance, complex formula or cell toxicity in the existing mesenchymal stem cell cryopreservation. The protective agent composition prepared by the preparation method comprises a deferoxamine pretreatment protective agent and a sodium lactate Ringer injection storage solution. The application method inhibits low-temperature-induced ferroptosis through DFO pretreatment, so that the mesenchymal stem cells can still maintain the multi-directional differentiation potential, the immunoregulatory function and the proliferation ability after being treated at 4 DEG C for 24-48 hours, the serum or complex nutritional ingredients do not need to be added, and the protective agent composition has the advantages of clear composition, high safety, simple operation and the like. The application is suitable for the fields of stem cell treatment, regenerative medicine, pet medical treatment and the like.

The invention provides a sour soup dumpling compound preservative as well as a preparation method and application thereof, and relates to the technical field of food storage. The compound preservative for the dumplings in the sour soup is prepared from the following raw materials in parts by weight: 2.5 to 3.5 parts of D-sodium erythorbate, 0.5 to 1.5 parts of phospholipid and 0.3 to 0.5 part of sodium lactate. The prepared preservative can better delay oxidation of meat stuffing of the red sour soup dumplings, maintain the flavor of the red sour soup, delay quality deterioration of the red sour soup dumplings and improve the storage stability.

The invention relates to a method for improving PD-1 titer produced by Chinese hamster ovary cells. The method comprises the following steps: inoculating the Chinese hamster ovary cells into an initial culture medium for culturing; after the culture is performed for 48 hours, feeding a fed-batch culture medium every day, and maintaining the glucose concentration in the culture medium to be 1.3-1.7 g / L, the galactose concentration to be 0.6-1.0 g / L and the L-sodium lactate concentration to be 14-16 mM; the culture temperature is reduced, a fed-batch culture medium is fed every day, the glucose concentration in the culture medium is maintained at (2-2.8) g / L, the galactose concentration is maintained at (1.7-2.2) g / L, and cells are harvested. Galactose is introduced to serve as a second carbon source, and control over the culture initial metabolism environment and the carbon source in the culture stage is combined, so that the maximum accumulation amount of lactic acid is obviously reduced, the cell culture period is remarkably prolonged, and the maximum titer of the PD-1 antibody is remarkably improved compared with an existing process.

To provide a method for promoting the biosynthesis of a polyphenol that can promote biosynthesis of a polyphenol in a site in a plant capable of biosynthesizing a polyphenol without supplying a plasma irradiation aqueous solution to soil in which the plant is grown.SOLUTION: A method for promoting the biosynthesis of a polyphenol comprises a step for performing such a treatment that a plasma irradiation aqueous solution obtained by irradiating an aqueous solution containing sodium L-lactate with atmospheric plasma is applied to a site in a plant having a site capable of biosynthesizing a polyphenol. The method for promoting the biosynthesis of a polyphenol can increase the amount of the polyphenol accumulated in the site. The treatment is preferably performed by injecting or applying the plasma irradiation aqueous solution into or to the site.SELECTED DRAWING: Figure 1

The application relates to the technical field of ceramicizing agents, in particular to a nano ceramicizing agent and a preparation method thereof. The nano ceramicizing agent is prepared from the following raw materials in parts by weight: 0.5-4 parts of a silane coupling agent, 0.4-4 parts of a titanate coupling agent, 1-10 parts of a zirconium salt, 3-5 parts of an alcohol solvent, 0.5-2 parts of nitric acid or a nitrate, 0.2-2 parts of modified nano clay, 0.01-0.03 parts of sodium hexametaphosphate, 1-5 parts of hydrogen peroxide, 0.1-0.5 parts of sodium lactate, and 60-80 parts of deionized water or tap water. The silane coupling agent and the titanate coupling agent are used as the basis of the ceramicizing agent, a protective film with good protection performance is formed on the metal surface, the zirconium salt chemically reacts with the metal base layer, so that a dense electrochemical protection passivation layer is formed on the metal surface, the adhesion of the film layer is improved, the use of fluorides is reduced through the addition of the modified nano clay, and the environmental protection performance of the product is further improved.

The present invention relates to iron removal from silica sand, and specifically to a biological reduction method and system for iron removal from silica sand. By using Shewanella sp. bacteria to reduce crystalline iron, and simultaneously improving the iron removal rate through the synergistic effect of sodium lactate, sulfur-containing compounds and electron mediators, and accelerating the iron removal speed by washing with organic acids. Compared with the existing methods, the biological reduction method for iron removal from silica sand of the present invention can not only effectively remove crystalline iron in silica sand, but also recycle Shewanella sp. bacterial liquid and organic acid solution.

The invention relates to a biological fermentation sodium lactate preparation method and a fermentation device, and relates to the technical field of sodium lactate preparation. An integrally connected inner container is arranged in the fermentation tank, a controller for controlling water vapor in the fermentation tank is further arranged on the outer wall of the fermentation tank, and an extraction part for extracting fermentation materials is further arranged at the top of the fermentation tank; the extraction component can extract materials in the fermentation tank under the condition that the fermentation tank is not opened, and can extract materials with different depths in the fermentation tank, so that the flexibility of material extraction is improved, and the accuracy of material monitoring is improved; and secondly, the controller can adsorb water vapor extracted from the fermentation tank, so that the flow of gas in the fermentation tank is ensured, and the activity of materials in the fermentation tank is improved, thereby indirectly ensuring the stability of material fermentation.

The invention relates to the technical field of cosmetics, and particularly discloses an anti-wrinkle moisturizing brightening emulsion and a preparation method thereof. The anti-wrinkle moisturizing and brightening emulsion is prepared from the following raw materials in parts by weight: 78.594955 to 86.62996 parts of a solvent, 5.5 to 6.0 parts of a moisturizing agent A, 0.01 to 0.5 part of a moisturizing agent B, 0.1 to 3 parts of an emulsifying agent, 5.0 to 6.0 parts of an emollient, 1.5 to 2.5 parts of a skin conditioning agent A, 0.4 to 0.5 part of a skin conditioning agent B, 0.2 to 0.25 part of a skin conditioning agent C, 0.1 to 1 part of an antioxidant A, 0.05 to 0.055 part of an antioxidant B, 0.5 to 0.6 part of a thickening agent, 0.01 to 1 part of an anti-wrinkle agent and 0.000040 to 0.000045 part of arginine / lysine polypeptide, the anti-wrinkle agent is a mixture prepared from glycerol, water, sodium lactate, xanthan gum, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. The emulsion provided by the invention has good anti-wrinkle and brightening effects.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to an indocyanine green preparation and a preparation method and application thereof. The preparation is a liquid preparation or a freeze-dried preparation, raw materials for preparing the preparation include indocyanine green, phospholipid, cholesterol, a freeze-drying protective agent, water and a pH regulator, the pH regulator is selected from one or more of sodium citrate, potassium citrate, sodium tartrate, sodium acetate, sodium lactate and sodium succinate, and the pH of the preparation is adjusted to 6.0-8.5. By means of a specific organic acid salt buffer system and a specific preparation process (the freeze-drying protective agent is added before lipid film deposition), the application can specifically inhibit the growth of impurities with RRT 0.7 and RRT 0.3, respectively, and significantly improve the chemical stability of the preparation. Meanwhile, the preparation can realize accurate positioning of sentinel lymph nodes and second and third lymph nodes, and can be used for preparing a lymph tracer. The application effectively solves the technical problems of rapid impurity growth, poor stability and inaccurate multi-stage lymph positioning of the existing ICG preparation.

Disclosed is an efficacious, low-pH skin care composition that provides good sensory properties and has a low skin irritation potential. The low-pH composition includes an effective amount of a vitamin B3 compound and, optionally, one or more additional skin care actives to provide a skin health and / or appearance benefit. The low-pH composition also includes a pH buffer comprising lactic acid and sodium lactate, a polymer thickener comprising polyacrylate crosspolymer-6, and a silicone fluid having a kinematic viscosity of 100 cSt or less at 25° C. The pH of the low-pH composition can range from 2.0 to 5.0.

The application provides application of lactate in preparation of a medicine for promoting growth and repair of bone / cartilage tissue, and the medicine has the effect of any one of 1) to 2): 1) promoting growth of bone / cartilage tissue; and 2) promoting repair and healing of bone / cartilage tissue. The lactate includes one or more of magnesium lactate, sodium lactate, potassium lactate, ferrous lactate, chromium lactate, copper lactate, manganese lactate, zinc lactate, lithium lactate, aluminum lactate, chitosan lactate, halofuginone lactate, trimethoprim lactate, 1-ethyl-3-methyl imidazole L-(+)-lactate, 2-hydroxyethyl-trimethyl ammonium L-(+)-lactate and L-lactic acid-tetrabutyl ammonium salt. The chitosan lactate and the like can promote growth and repair of bone / cartilage tissue for the first time, and a new way is provided for growth and repair of bone / cartilage tissue.

The application discloses a micro-slit net interface modified far-end strong sand-carrying fracturing fluid and a preparation method thereof, and relates to the technical field of oil and gas field exploitation. The fracturing fluid comprises, in terms of weight parts, 20-50 parts of low-molecular-weight polyacrylamide, 10-30 parts of polyhydroxyethyl acrylamide, 30-75 parts of diethylene glycol ethyl ether acetate, 2-10 parts of fumed silica, 3-12 parts of a titanate coupling agent, 2-7 parts of a gemini cationic surfactant, 2-7 parts of an alkyl polyoxyethylene ether, and 2-7 parts of an intermediate S. The intermediate S comprises, in terms of weight parts, 10-25 parts of zirconium oxychloride, 5-25 parts of sodium lactate, and 65-85 parts of diethylene glycol ethyl ether acetate. The preparation comprises the following steps: S1, preparation of the intermediate S; and S2, preparation of the finished product R. The fracturing fluid has the characteristics of high resistance reduction, low damage and strong sand carrying, and can realize gas guiding and oil increasing by modifying the surface characteristics of reservoir rocks, thereby improving the yield of oil and gas wells.

The invention relates to the technical field of reconstituted tobacco, in particular to a treating agent for reconstituted tobacco and a reconstituted tobacco processing method. The treatment agent comprises a deep-eutectic solvent, and the deep-eutectic solvent takes polyglycerol as a hydrogen bond donor and takes at least one of betaine, sodium lactate and disodium dihydrogen pyrophosphate as a hydrogen bond receptor. According to the method, the reconstituted tobacco is processed by adopting the polyglycerol type eutecticevaporate solvent of the specific hydrogen bond receptor, so that the water holding capacity of the reconstituted tobacco under different temperature and humidity conditions is improved, particularly the water holding capacity of the reconstituted tobacco under the low-temperature drying condition is improved, and the water holding capacity reaches the tobacco level; and thus, the flavoring and charging uniformity of shred making is improved, and the product quality and the sensory evaluation quality of the product are improved. In addition, based on the matching of the characteristics of polyglycerol macromolecules and polyhydroxy, hydrogen bond acceptor electrostatic repulsion or / and permeation plasticizing characteristics or / and competitive cross-linking characteristics and the characteristics of the reconstituted tobacco, the tensile strength of the reconstituted tobacco can be reduced so as to be matched with the natural tobacco.

This application relates to the field of water pollution control technology and discloses a method for preparing a sediment microecological reconstruction and pollutant-targeted immobilization conditioner. The method includes: modifying mesoporous silica with amino- and thiolated compounds and mixing it with biochar to obtain an adsorbent material; dispersing ferrous sulfate, sodium thiosulfate, and hydroxyapatite with the adsorbent material in a sodium alginate solution and adding it dropwise to a calcium chloride solution for cross-linking and chitosan coating to obtain microcapsules; compounding riboflavin, humic acid, carbon source nutrients, and adding signaling molecules to obtain a metabolic enhancer; compounding metalloenzyme inhibitors and activating them with microorganisms to obtain an activator; granulating and coating calcium carbonate, magnesium hydroxide, ferrous sulfate, sulfur powder, calcium peroxide, and sodium lactate to obtain buffer particles; mixing the adsorbent material, microcapsules, and buffer particles, spraying, adding the metabolic enhancer and activator, adding binders and pore-forming agents, granulating, drying, sieving, and spraying a protective film to obtain the conditioner. This application solves the technical problems of existing sediment conditioners, such as single function, uncontrolled release, and microecological imbalance.

The invention belongs to the technical field of drug detection and analysis, and particularly provides a method for determining the content of impurity 3-DG in icodextrin peritoneal dialysis fluid, which comprises the following steps: selecting a reversed-phase chromatographic column AgilentZORBAX SB-C18 (250mm * 4.60 mm, 5 [mu] m), taking methanol and an acetic acid aqueous solution (50-55: 50-45, v / v) with the pH value of 3 as mobile phases, realizing that the separation degree of a 3, 4-DGE peak and a 3-DG peak is greater than 4.5, the separation degree of a sodium lactate peak and the 3, 4-DGE peak is greater than 3.0, and the separation degree of a sodium lactate peak and the 3, 4-DGE peak is greater than 3.0. The 3-DG can be rapidly, effectively and accurately determined, the quality of the icodextrin peritoneal dialysis solution can be accurately controlled, and the clinical medication safety is guaranteed.

The invention provides a method for detecting methyl lactate in a sodium lactate solution, a gas chromatography is combined with a headspace sampling technology, and chromatographic conditions are as follows: a chromatographic column is a capillary column taking polyethylene glycol or a compound with similar polarity as a stationary liquid; a sample inlet is 180 DEG C, and headspace sample injection is performed; a flame ionization detector is adopted, and the temperature is 230 DEG C; the carrier gas is nitrogen, the flow velocity is 2.0 ml / min, and the split ratio is 10: 1; the column temperature program is as follows: 35 DEG C is maintained for 3 minutes, the temperature is raised to 90 DEG C at 5 DEG C / min and maintained for 3 minutes, and then the temperature is raised to 200 DEG C at 15 DEG C / min and maintained Headspace conditions are as follows: the balance temperature of a headspace bottle is 90 DEG C, and the time is 30 minutes; a quantitative loop is 100 DEG C; the temperature of the transmission line is 110 DEG C; the circulation time is 40 minutes. The method can accurately and quantitatively detect methyl lactate, is convenient to operate, and has great significance in improving the quality control level of the sodium lactate solution, guaranteeing the application safety of the sodium lactate solution in the fields of medicines and foods and perfecting a quality standard system.