163 results about "Disodium hydrogen phosphate" patented technology

The invention provides an antibacterial synergy-mineralization regulation difunctional nano material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: mixing a disodium hydrogen phosphate solution and a calcium chloride solution to obtain an amorphous calcium phosphate suspension; mixing the amorphous calcium phosphate suspension with a tannic acid solution to obtain an ACP-TA suspension; and finally, mixing the ACP (at) TA suspension and the hydroxypropyl trimethyl ammonium chloride chitosan solution to obtain the bifunctional nano material. A cross-linked shell is formed through the electrostatic adsorption effect of tannic acid and hydroxypropyl trimethyl ammonium chloride chitosan of the antibacterial layer, amorphous calcium phosphate is effectively wrapped, the crystallization process of amorphous calcium phosphate can be remarkably delayed, long-acting release of calcium and phosphorus ions is ensured, the antibacterial function can be effectively achieved, and the service life of the coating is prolonged. An ideal local microenvironment is provided for remineralization of tooth hard tissue, and finally biomimetic mineralization of enamel and deep mineralization plugging of dentinal tubules are achieved.

The invention discloses a reconstituted tobacco preparation method based on a compound enzyme technology, which comprises the following steps: carrying out surface impurity removal pretreatment on a reconstituted tobacco sheet base to obtain a standby sheet base; dissolving cellulase and pectinase in water according to a certain mass ratio to prepare an enzyme solution; the preparation method comprises the following steps: spraying a citric acid-disodium hydrogen phosphate buffer solution to the surface of a standby film base, then spraying an enzyme solution to the surface of the standby film base, carrying out an enzymatic hydrolysis reaction for 3-5 h under the conditions that the temperature is 40-50 DEG C and the humidity is 50-70%, and then drying the enzymatic hydrolysis film base for 30-50 min at the temperature of 70-80 DEG C. According to the method, a collaborative regulation system of cellulase and pectinase is constructed, the enzymolysis process is optimized, oriented improvement of the sour and sweet taste of the reconstituted tobacco is achieved, the aroma richness is remarkably enhanced, the overall acceptability is greatly improved, the technical problems that in a traditional process, the flavor is single, and enzymolysis regulation is extensive are solved, and the quality of the reconstituted tobacco is improved. And a green and efficient standardized solution is provided for quality upgrading of the reconstituted tobacco.

The invention discloses a microbial odor remover suitable for environment and a preparation method thereof, and relates to the technical field of daily chemical products. The preparation method comprises the following steps: adding pediococcus acidilactici and bacillus velezensis into a citric acid-disodium hydrogen phosphate buffer solution according to a ratio, standing and activating, adding bromelain, lipase, rosmarinic acid nanoemulsion, tea polyphenol and citrus polyphenol-EDTA (Ethylene Diamine Tetraacetic Acid) mixture, homogenizing, adding konjac glucomannan-chitosan gel and a trehalose-glycerol compound according to a ratio, stirring, filtering, and drying to obtain a finished product. And subpackaging in a dark place to prepare the microbial odor remover suitable for the environment. Through the synergistic effect of microorganisms, enzymes and a natural deodorization medium, a multi-stage peculiar smell elimination system is constructed, the dual functions of immediate neutralization and continuous bacteriostasis are achieved, the application scene is wide, corrosion and residues to base materials such as fabric and plastic are avoided, and the concentration of harmful gas can be more effectively controlled and pathogenic microorganisms can be inhibited in large-scale breeding application.

The invention relates to the technical field of microbial fertilizers, in particular to a low-cost compound microbial fertilizer and a preparation method thereof. The low-cost compound microbial fertilizer comprises the following raw materials in parts by mass: 20-40 parts of a fermented organic fertilizer, 10-20 parts of urea, 5-10 parts of ammonium magnesium phosphate, 5-15 parts of a potassium fertilizer, 1-4 parts of sodium humate, 1-4 parts of trehalose, 1-3 parts of gelatin, 0.1-1 part of a stabilizer, 7-19 parts of a mineralized microbial agent load and 1-3 parts of a coating solution, the mineralized microbial inoculum load comprises the following raw materials: 5-15 parts of bamboo charcoal powder, 1-3 parts of a composite microbial inoculum, 1-2 parts of calcium chloride and 1-2 parts of disodium hydrogen phosphate. The fertilizer has the advantages of obviously increasing the fertilizer utilization rate, improving the physical and chemical properties of soil, promoting the formation of granular structures and repairing hardened and ill-conditioned soil, has obvious soil repairing effect and obvious yield increasing, value increasing and quality improving effects, and is suggested to be suitable for large-scale popularization and application when being popularized and applied in production.

The invention relates to the technical field of pavement patching materials, in particular to a pavement patching material with high early strength and toughness and a preparation method thereof. The repairing material is formed by compounding phosphate-based powder A, magnesium oxide-based powder B, a composite retarder C and a fiber material D, the phosphate-based powder comprises phosphate and disodium hydrogen phosphate dodecahydrate; the magnesium oxide-based powder B comprises dead burned magnesium oxide, superfine powder, industrial solid waste powder, cellulose ether and wollastonite whiskers; the composite retarder C comprises borax and nitrite; the fiber material D comprises reinforced fibers. The preparation method is the preparation method of the pavement patching material. The pavement patching material slurry has high early strength, the construction time can be remarkably shortened, and it is guaranteed that a repaired pavement has excellent mechanical performance and durability; according to the preparation method, materials can be prepared respectively, and standardized production, transportation and storage are facilitated; only water needs to be added for preparation on a construction site, and construction is convenient.

The invention provides a novel mineral separation activating agent for sulphide ores and a preparation method of the novel mineral separation activating agent. The cleaning agent comprises 1-2 parts of basic cupric carbonate, 2-4 parts of ammonium chloride, 2-4 parts of nanometer jade powder, 2-3 parts of alginic acid, 1-2 parts of allyl glycidyl ether, 2-3 parts of peregal O, 2-3 parts of sodium di-sec-octyl maleate sulfonate, 2-3 parts of vinyl acetate, 4-7 parts of hydrogen peroxide, 4-6 parts of disodium hydrogen phosphate and 40-50 parts of water. The preparation method comprises the following steps: firstly mixing basic cupric carbonate and ammonium chloride to obtain a first mixture, then mixing the rest components, heating and stirring to obtain a second mixture, and finally uniformly mixing the first mixture and the second mixture. The activating agent overcomes the defects of a traditional activating agent, has efficient activating performance, can improve the beneficiation efficiency of low-grade, complex and refractory sulfide ore, is environmentally friendly, good in stability and high in adaptability, and provides technical support for efficient development of sulfide ore resources.

The present invention belongs to the technical field of rapid detection of drug sensitivity for bacteria. Disclosed are an enrichment culture medium, and a preparation method therefor and the use thereof. The enrichment culture medium comprises the following raw materials in parts by mass: 15.0-20.0 parts of tryptone, 3.5-5.5 parts of peptone, 1.5-3.5 parts of glucose, 5.0-6.5 parts of yeast extract, 2.0-2.5 parts of dipotassium phosphate, 2.0-3.5 parts of disodium hydrogen phosphate, 1.0-1.5 parts of monopotassium phosphate, 2.5-7.5 parts of sodium chloride, 12.0-18.0 parts of proteose peptone, 15.0-22.0 parts of beef heart infusion powder, 8.0-12.0 parts of soya peptone, 1.0-5.0 parts of 0.1% nicotinamide adenine dinucleotide (NAD), 30-100 parts of newborn calf serum inactivated at 56°C for 30 min, 2.0-4.0 parts of mannitol, 3.0-5.0 parts of sodium pyruvate, 0.23-0.45 parts of cycloheximide, 0.8-2.0 parts of 0.05% bromothymol blue, 2.5-4.5 parts of 0.1% methylene blue, and 1000 parts of distilled water, with the pH value of 6.8-7.5. The enrichment culture medium is used to screen effective therapeutic drugs for bacterial diseases in poultry, and is convenient to use and has a single enrichment effect superior to that of respective selective enrichment broths of target bacteria. Therefore, the culture medium can realize rapid proliferation of common pathogenic bacteria in poultry.

The application provides a kind of shaped phase change material and its preparation method.The phase change material includes the following component materials according to mass percentage: 45.8-56.7% of dodecahydrate disodium hydrogen phosphate, 7.9-22.9% of sodium carbonate decahydrate, 7.6-15.9% of sodium sulfate decahydrate, 2.46-4.05% of reinforcing material, and 15-20% of adsorption material.The preparation of the phase change material includes the following steps: 1, preparing materials;2, preparing inorganic salt mixture;3, preparing molten inorganic salt mixture;4, preparing mixture and sealing;5, preparing shaped phase change material.The shaped phase change material prepared by the application has suitable phase change temperature, higher latent heat of phase change, no liquid leakage, no toxicity and non-combustibility, small supercooling degree, and no phase separation;at the same time, for the application occasions requiring transportation and storage between 20-30℃, the shaped phase change material can be used as an effective normal temperature cold storage agent to resist low temperature environment and protect specific chemicals and medicines from temperature fluctuation.

This invention discloses a grouting material suitable for rapid sealing of water-rich strata, its preparation method, and its application, belonging to the field of grouting material technology. The raw materials for its preparation include component A and component B; component A, by mass parts, includes 20-80 parts cement; 10-50 parts fly ash extract; 20-60 parts water; 0.01-1 parts polycarboxylate superplasticizer; 0.025-0.05 parts polyacrylamide; 0.1-0.6 parts hydroxypropyl methylcellulose; 0.5-1 parts disodium hydrogen phosphate; and 1.5-4.5 parts calcium aluminate; component B is water glass, and the volume ratio of component A to component B is 1-5:1. The grouting material provided by this invention possesses properties such as early strength, rapid setting with adjustable setting time, good fluidity, and high water retention rate, which can meet the rapid sealing requirements of underground engineering projects such as tunnels and coal mines.

The invention discloses a scale dissolving agent for rapidly dissolving wet-process phosphoric acid scaling substances as well as a preparation method and application of the scale dissolving agent, and belongs to the technical field of descaling. The scale dissolving agent comprises the following components in percentage by weight: 20-30% of a scale remover, 3-5% of a penetrating agent, 0.3-0.8% of a penetrating aid, 0.5-1% of a surfactant, 0.3-0.5% of a synergist and the balance of water, wherein the descaling agent comprises trisodium citrate dehydrate, sodium ethylene diamine tetracetate and ammonium fluoride; the penetrating agent is prepared from dioctyl sodium sulfosuccinate and perfluoroalkyl ethyl acrylate; the permeation auxiliary agent comprises disodium hydrogen phosphate and sodium carbonate; and the synergist is 1-ethyl-3-methylimidazolium acetate. The scale dissolving agent is specially used for dissolving wet-process phosphoric acid scaling substances and has the advantages of being high in scale dissolving speed, mild in reaction condition, low in formula cost and the like, the pH value of the scale dissolving agent is neutral and slightly alkalescent, and corrosion to production equipment is effectively avoided.

The application discloses a functional probiotic microencapsulated intestinal shield system and a preparation method and application thereof. A core layer comprises four probiotics, i.e., lactobacillus acidophilus La-14, animal bifidobacterium Bb-12, lactobacillus rhamnosus GG and lactobacillus reuteri DSM 17938, and the weight ratio is 3:4:2:1, and the total viable bacterial count is greater than or equal to 10^10 CFU / g. An inner layer is a targeted release control layer, which is composed of ethyl cellulose, polylactic acid, chitosan and lactose, can swell in a pH 5.5 to 6.5 environment and can dissolve in a pH 6.8 to 7.2 environment. A middle layer is a buffer protection layer, which is composed of calcium carbonate, disodium hydrogen phosphate and sodium alginate, and can maintain the internal pH of the microcapsule at 4.5 to 5.5 in a gastric acid environment. An outer layer is an intelligent response protection layer, which is composed of konjac glucomannan, xanthan gum and gum arabic, and can form a protective film in a gastric acid environment with a pH less than 3.0 within 5 minutes. Through the synergistic protection of the four-layer microcapsule structure, the probiotics can achieve a high survival rate in the gastric acid environment of cats, and can be accurately released at specific positions in the intestinal tract, which is helpful to improve the intestinal health of cats.

The application provides a sodium phosphate salt complex, which comprises 15-30 parts by weight of sodium dihydrogen phosphate or a monohydrate thereof, 3-6 parts by weight of disodium hydrogen phosphate, 0.05-0.3 parts by weight of lidocaine hydrochloride, 0-0.04 parts by weight of a fragrance and 0-0.25 parts by weight of a sweetening agent. The sodium dihydrogen phosphate or the monohydrate thereof, the disodium hydrogen phosphate and the lidocaine hydrochloride are prepared into a complex, and are administered simultaneously in use, so that the clinical effect is remarkable when the intestines are cleaned, the drug satisfaction is improved, the enteroscopy quality is improved, the postoperative exhaust defecation time is reduced and postoperative complications are reduced.

This invention discloses a culture medium for the mass sporulation of *Substantia macrantha* and its application. The culture medium comprises the following components: lactose 21-23 g / L, yeast extract 14-16 g / L, potassium chloride 0.4-0.6 g / L, magnesium sulfate 0.4-0.6 g / L, potassium dihydrogen phosphate 0.4-0.6 g / L, disodium hydrogen phosphate 0.55-0.75 g / L, sodium molybdate dihydrate 5-7 mg / L, vitamin B6 50-60 mg / L, arginine 20-30 mg / L, and agar 18-22 g / L, diluted to volume with double-distilled water, with a natural pH. Using the culture medium prepared according to this invention to culture *Substantia macrantha* significantly increases the spore yield (164-fold), reaching 2.21 × 10⁻⁶. 8 conidia / cm 2 This provides a reference for the mass production of the fungal spores.

The invention provides a biological liquid medicine for promoting cartilage tissue regeneration by being injected into knee joints. The biological liquid medicine comprises the following components: 3%-4% of modified xanthan gum, 1.5%-2.5% of chitosan lactate wrapped by lipidosome, 0.2%-0.6% of strontium bromide, 1%-2% of disodium hydrogen phosphate, 1%-2% of sodium dihydrogen phosphate and the balance of water for injection to 100%, the modified xanthan gum is carboxymethylated xanthan gum. According to the biological liquid medicine, modified xanthan gum, chitosan lactate wrapped by lipidosome and strontium bromide are added, long-acting retention of the modified xanthan gum provides a stable release environment for the lipidosome and the strontium bromide, the lipidosome accurately delivers the chitosan lactate to an injured part, and the lipidosome and the strontium bromide act on ions to strengthen cartilage cell proliferation and matrix secretion, so that the cartilage cell proliferation and matrix secretion are enhanced; the three components are combined to improve the cartilage tissue damage repair degree of the knee joint and improve the cartilage tissue regeneration effect.

The utility model provides a preparation device of flaky disodium hydrogen phosphate dihydrate. The preparation device comprises a disodium hydrogen phosphate dodecahydrate melting kettle and a flash chamber which are communicated with each other, the flash chamber is provided with a liquid outlet pipe and a liquid return pipe, and the liquid outlet pipe and the liquid return pipe are communicated with the heat exchanger; the liquid outlet pipe is provided with a first three-way pipe which is communicated with the disodium hydrogen phosphate dodecahydrate melting kettle, and is provided with a second three-way pipe which is communicated with the disodium hydrogen phosphate dihydrate melting kettle; and the disodium hydrogen phosphate dihydrate melting kettle is communicated with a flaker to flake molten disodium hydrogen phosphate dihydrate. The sodium hydrogen phosphate dihydrate production device has the beneficial effects that the prepared sodium hydrogen phosphate dihydrate product is in a sheet shape, and the product in the sheet shape is not easy to generate dust in the transportation process, so that environmental pollution and health risks are reduced. Due to the structural characteristics of the sheet-shaped product, the sheet-shaped product is not prone to hardening, good fluidity can be kept even in the long-time storage and transportation process, and therefore material loss and treatment cost caused by hardening are greatly reduced.

The present application belongs to the technical field of tire manufacturing, and particularly relates to an antiskid tire and a preparation method thereof. The antiskid performance of the tire is significantly improved by adding cerium-doped polyoxometalate-based layered compounds and nitrogen-sulfur co-modified zirconium-based MXene layered compounds in the tread compound. The cerium-doped polyoxometalate-based layered compounds are prepared by hydrothermal reaction and calcination treatment using disodium hydrogen phosphate, sodium molybdate, cerium nitrate and hexanediamine as raw materials. The nitrogen-sulfur co-modified zirconium-based MXene layered compounds are prepared by etching, peeling and co-calcination with thiourea after synthesizing ceramics using titanium powder, aluminum powder, zirconium powder and carbon powder as raw materials. When preparing the tire, the rubber is first mixed with carbon black, the two modified compounds and the additives to obtain a masterbatch, then the vulcanization system components are added to obtain a final rubber compound, and finally the finished product is obtained through extrusion, lamination and vulcanization molding. The antiskid tire prepared by the present application has excellent grip on wet and icy road surfaces.

The invention discloses a method for producing disodium hydrogen phosphate dodecahydrate from industrial monoammonium phosphate mother liquor, which comprises the following steps of: A, reacting the industrial monoammonium phosphate mother liquor and monocalcium phosphate in a primary reactor to obtain reaction slurry; b, the reaction slurry is subjected to filter pressing for solid-liquid separation, ammonium phosphate clear liquid is obtained, and a filter cake is used for producing powdery ammonium phosphate; c, slowly adding solid sodium hydroxide into the ammonium phosphate clear liquid to obtain disodium hydrogen phosphate slurry; and D, carrying out filter pressing on the reaction slurry to obtain a disodium hydrogen phosphate clear solution, and carrying out concentration, water replenishing crystallization, centrifugation and drying to obtain a disodium hydrogen phosphate dodecahydrate finished product and a mother solution. According to the method, the purity of the obtained disodium hydrogen phosphate dodecahydrate is 97% or above, and the defects in the prior art are overcome.

The present invention provides a production method of instant sodium pyrophosphate, comprising the steps of neutralization, spray drying, polymerization, pre-hydration, cooling, and screening to obtain instant sodium pyrophosphate. Food phosphoric acid and soda ash are neutralized to obtain disodium hydrogen phosphate slurry, controlling the pH to 8.8-9.2 and the specific gravity to 1.4-1.5 g / ml; the neutralized slurry is transported to a pressure spray drying tower, and the tower bottom temperature is controlled to 120°C to 150°C; after drying, it enters a dynamic polymerization furnace, with a polymerization time of 30-40 min and a furnace tail temperature of 180°C to 210°C to obtain a semi-finished sodium pyrophosphate product. The semi-finished product passes through a cooling drum, and water mist is sprayed at the drum entrance for pre-hydration and cooling at the same time; the product is sieved to obtain instant sodium pyrophosphate.

Disclosed in the present invention is a high-speed vacuum homogenization-based method for preparing a high-concentration collagen implant. The method comprises the following steps: S1, preparing a collagen solution: placing collagen and a hydrochloric acid solution in a homogenizer, and uniformly mixing and stirring same under vacuum conditions to obtain a collagen solution; S2, preparing a base solution: uniformly mixing disodium hydrogen phosphate, sodium hydroxide, sodium chloride, glucose, mannitol, and water for injection to obtain a base solution; and S3, mixing: adding the base solution to the collagen solution in batches, then placing same in the homogenizer, uniformly mixing and stirring same under vacuum conditions, and performing filling, to prepare a high-concentration collagen implant. The collagen implant prepared using the method of the present invention has a high concentration, a long duration of action, and uniform fibers; the extrusion of the collagen implant is smooth; the collagen implant can be drawn and stacked; and the collagen implant has good stability and a simple preparation process, and requires a short preparation cycle. Thus, the collagen implant shows broad market prospects.

The application discloses a kind of bonding materials for orthopedics repair and preparation method thereof, it is related to medical material technical field.The bonding material for orthopedics repair includes solid phase powder and liquid component;It includes solid phase powder and liquid component;The solid phase powder includes the following weight fraction components: beta-calcium phosphate 40-55 parts, calcium dihydrogen phosphate monohydrate 20-30 parts, hydroxyapatite 10-15 parts, bioactive glass 5-8 parts, modified reinforcing agent 8-12 parts, developing agent 2-3 parts, antibacterial agent 5-8 parts;The liquid component includes the following weight fraction components: disodium hydrogen phosphate 10-20 parts, sodium alginate 4-5 parts, deionized water 50-60 parts.The bonding material for orthopedics repair prepared by the application has good compressive strength and antibacterial property.

This invention discloses a platinum-cobalt phosphate catalyst for the selective electrooxidation of ethylene glycol to glycolic acid, its preparation method, and its application. The preparation method includes: S1, pretreating nickel foam (NF); S2, dissolving disodium hydrogen phosphate dodecahydrate and hexadecyltrimethylammonium bromide in a mixture of water and ethylene glycol, adding cobalt nitrate and stirring to obtain a precursor; S3, immersing the nickel foam in the precursor solution and refrigerating it overnight at low temperature; S4, transferring it to a reaction vessel and hydrothermally heating it at 160 °C for 10 hours to obtain cobalt phosphate (CoPO / NF); S5, using CoPO / NF as the working electrode, electrochemically depositing platinum in an H2PtCl6 and KOH electrolyte using cyclic voltammetry; S6, washing and vacuum drying to obtain the final product. This invention is the first to prepare a platinum-cobalt phosphate catalyst for the selective electrooxidation of ethylene glycol to glycolic acid at 100 mA cm⁻¹. ‑2 With a working potential of only 0.67 V at current density (relative to RHE) and a Faraday efficiency of 100% for glycolic acid, it has significant advantages and application potential in the highly selective production of glycolic acid in the electro-oxidation reaction of ethylene glycol.

The application relates to preparation and application of inorganic eutectic shaped phase change materials with heat preservation function, belonging to the technical field of phase change energy storage. The inorganic eutectic shaped phase change material takes sodium carbonate decahydrate and disodium hydrogen phosphate dodecahydrate as phase change main body materials, and takes sodium silicate nonahydrate as a nucleating agent, so that the supercooling degree is reduced, and the inorganic eutectic phase change material with low supercooling and no phase separation is prepared. Further, the inorganic eutectic shaped phase change material is prepared by using gaseous SiO2 as supporting material. The material prepared by the application has suitable phase change temperature, higher phase change enthalpy and very low supercooling degree, and has no phase separation phenomenon. Moreover, the synthesis process is simple, and the raw material is low in price. Simulation application test shows that the material has excellent building heat buffering performance, and has wide application prospect in the field of building energy saving.

The invention relates to the technical field of preparation of tert-butyl carbamate, in particular to a preparation method of (R)-(1-([1, 1 '-biphenyl]-4-yl)-3-oxopropane-2-yl) tert-butyl carbamate. Comprising the following steps: S1, taking a four-mouth bottle, adding 1780 g of dichloromethane, 165 g of (R)-tert-butyl (1-([1, 1 '-biphenyl]-4-yl)-3-hydroxypropane-2-yl) carbamate, 1.6 g of TEMPO and 2 g of tetrabutylammonium bromide into the four-mouth bottle, and stirring the four-mouth bottle, the dichloromethane, the (R)-tert-butyl (1-([1, 1'-biphenyl]-4-yl)-3-hydroxypropane-2-yl) carbamate, the TEMPO and the tetrabutylammonium bromide; s2, 33.5 g of a sodium bromide solution and 146 g of clear water of a phosphoric acid mixed salt solution are added into the four-opening bottle after stirring in the step S1, and liquid in the four-opening bottle is cooled to a specified temperature; s3, sodium hypochlorite with the available chlorine content being 9-10% is dropwise added into the four-opening bottle cooled in the S2; and S4, after dripping in the step S3 is completed, preserving the heat of the liquid in the four-mouth bottle, and adding 385 g of a sodium thiosulfate solution into the bottle for quenching reaction. And S5, sampling and detecting. The pH value buffering agent of a phosphate system, namely a sodium dihydrogen phosphate-disodium hydrogen phosphate composite salt system, is used, and the yield is 90-96%.

Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water.

The invention belongs to the field of wastewater treatment, and discloses a method for treating vitamin B6 wastewater, which comprises the following steps: 1, diluting filtered vitamin B6 wastewater to CODlt; the concentration is 60000 mg / L, and obtaining first wastewater. And 2, carrying out subcritical water catalytic oxidation on the first wastewater to obtain second wastewater. And 3, adding alkali into the second wastewater for deamination to obtain third wastewater. 4, freezing the third wastewater to extract sodium phosphate dibasic dodecahydrate crystals, so as to obtain fourth wastewater. And 5, circularly carrying out membrane concentration treatment on the fourth wastewater, returning membrane concentrated water to the step 2, carrying out subcritical water catalytic oxidation, carrying out evaporative crystallization on membrane permeate liquid to obtain sodium chloride, and freezing the membrane concentrated water after each time of membrane concentration treatment to extract disodium hydrogen phosphate dodecahydrate crystals. And 6, refining the disodium hydrogen phosphate dodecahydrate wet product to obtain the industrial trisodium phosphate dodecahydrate. According to the method, the high COD removal rate is achieved, and phosphate and sodium chloride are recycled.

The application provides a preparation method of a mineralized collagen scaffold medical material prepared by a polymer-induced liquid precursor, and phosphine polyethyleneimine and polyacrylic acid are used in a high-concentration calcium phosphate solution to prepare a polymer-induced liquid precursor; collagen fiber scaffolds are immersed in the polymer-induced liquid precursor to be mineralized to obtain the mineralized collagen scaffold medical material; the polymer-induced liquid precursor comprises the following components in percentage by mass: 1-3% of phosphine polyethyleneimine, 4-6% of polyacrylic acid, 0.5-1% of calcium chloride, 2.5-3% of disodium hydrogen phosphate and the balance of water. The PILP in the application can penetrate into the inside of the collagen scaffold to be mineralized, the mineralization effect of the collagen scaffold is enhanced, the biocompatibility and osteogenic activity of the collagen scaffold are improved, and the application prospect of the PILP in the field of bone repair materials is wide.

The invention discloses a graphene self-supporting intercalation sodium ferric manganese phosphate pyrophosphate positive electrode material and application, and a preparation method of the positive electrode material comprises the following steps: dissolving a soluble raw material in deionized water to prepare a precursor solution; the soluble raw materials comprise sodium acetate, manganese acetate and ferrous dihydrogen phosphate or disodium hydrogen phosphate, manganous dihydrogen phosphate and ferrous acetate; a carbon source and graphene are added into the precursor solution, or a dispersing agent is added, stirring and sanding are performed to obtain positive electrode slurry, the carbon source comprises one or two of starch, glucose and cane sugar, and polymeric monomers of the dispersing agent comprise ethyl 3-(trifluoromethyl) crotonate, 1, 4-dicyano-2-butene and styrene; and carrying out spray drying and briquetting on the positive electrode slurry, calcining for 10-18 hours at 500-700 DEG C under the protection of nitrogen, and crushing to obtain the positive electrode material with the particle size of 1-6 microns. The material has excellent conductivity and rate performance, is suitable for the sodium ion battery, and promotes the performance breakthrough and industrialization of the positive electrode material of the sodium ion battery.

The application discloses a temperature-sensitive nanocomposite hydrogel for extinguishing and preventing re-ignition of lithium iron phosphate batteries and a preparation method thereof, and relates to the technical field of battery extinguishing and re-ignition prevention. First, a phase change heat storage microcapsule material is prepared by taking a dodecahydrate sodium hydrogen phosphate solution, an alkali compound and an ethanol solution of tetraethyl orthosilicate as raw materials; then, polyphosphoric acid-amino acid polymer is prepared by adding arginine into an ethanol solution of polyphosphoric acid; finally, the temperature-sensitive nanocomposite hydrogel is prepared by adding the phase change heat storage microcapsule material and the polyphosphoric acid-amino acid polymer into a hydrophilic gel material. The temperature-sensitive nanocomposite hydrogel has the comprehensive advantages of efficient extinguishing, rapid cooling and persistent re-ignition prevention, and the temperature-sensitive nanocomposite hydrogel reduces economic losses caused by lithium ion battery fires by combining physical cooling, chemical inhibition and physical isolation.

The present invention relates to GIP / GLP1 agonist compositions. The present invention is a GIP / GLP1 co-agonist peptide pharmaceutical composition for subcutaneous injection. The composition comprises tirzepatide, NaCl, and disodium hydrogen phosphate. The composition provides commercially acceptable shelf-life stability, use-life stability, and an acceptable patient injection site experience. An alternative composition comprises tirzepatide, propylene glycol, and disodium hydrogen phosphate, which also provides acceptable shelf-life stability.

The invention discloses a tolvaptan sodium phosphate freeze-dried composition for injection and a preparation method of the tolvaptan sodium phosphate freeze-dried composition. The composition comprises tolvaptan sodium phosphate, tromethamine, disodium hydrogen phosphate and sodium dihydrogen phosphate, the molar ratio of the tolvaptan sodium phosphate to the tromethamine to the disodium hydrogen phosphate to the sodium dihydrogen phosphate is 1: (1.5-3.5): (2-4): (0.05-0.15). According to the invention, tromethamine is creatively adopted to replace cane sugar in the prior art to be used as a freeze-drying protective agent and a skeleton forming agent, so that the safety risks of high permeability, kidney burden, production pollution and the like possibly caused by the cane sugar are solved. In combination with a specific freeze-drying process comprising a pre-freeze-thawing step, the moisture content of the freeze-dried composition prepared by the invention can be lower than 0.3%, a stable freeze-dried cake-shaped structure is formed, and hydrolytic degradation of a main drug is effectively inhibited. Compared with the prior art, the composition provided by the invention has the beneficial effects of high safety, good stability and excellent product appearance.