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267 results about "Disodium hydrogen phosphate" patented technology

Antibacterial synergy-mineralization regulation difunctional nano material as well as preparation method and application thereof

ActiveCN120713863AAntibacterial agentsInorganic phosphorous active ingredientsHydroxypropyltrimethyl ammonium chloride chitosanHard tissue
The invention provides an antibacterial synergy-mineralization regulation difunctional nano material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: mixing a disodium hydrogen phosphate solution and a calcium chloride solution to obtain an amorphous calcium phosphate suspension; mixing the amorphous calcium phosphate suspension with a tannic acid solution to obtain an ACP-TA suspension; and finally, mixing the ACP (at) TA suspension and the hydroxypropyl trimethyl ammonium chloride chitosan solution to obtain the bifunctional nano material. A cross-linked shell is formed through the electrostatic adsorption effect of tannic acid and hydroxypropyl trimethyl ammonium chloride chitosan of the antibacterial layer, amorphous calcium phosphate is effectively wrapped, the crystallization process of amorphous calcium phosphate can be remarkably delayed, long-acting release of calcium and phosphorus ions is ensured, the antibacterial function can be effectively achieved, and the service life of the coating is prolonged. An ideal local microenvironment is provided for remineralization of tooth hard tissue, and finally biomimetic mineralization of enamel and deep mineralization plugging of dentinal tubules are achieved.
Owner:GUANGXI MEDICAL UNIVERSITY

Collagen polypeptide firming and anti-wrinkle freeze-dried powder

The invention discloses collagen polypeptide firming and anti-wrinkle freeze-dried powder, and relates to the technical field of cosmetics. The invention relates to a biological preservative which is prepared from water, butanediol, a bacillus / soybean fermentation product extract, soluble collagen, acetyl hexapeptide-8, panthenol, 1, 2, 4-trimethyl-1, 3-pentanediol and a proper amount of water. The cosmetic is prepared from 1, 2-hexanediol, tetrahydromethylpyrimidine carboxylic acid, hydroxypropyl tetrahydropyrantriol, tremella polysaccharide, saccharide isomeride, a bifidus yeast fermentation product lysate, sodium hyaluronate, DNA sodium, a radix gentianae extract, mannitol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, oligopeptide-1, decapeptide-4, oligopeptide-3, hydrolyzed royal jelly protein, folic acid and disodium hydrogen phosphate. The additive is composed of sodium dihydrogen phosphate, citric acid and sodium citrate. The mask can provide rich nutrients for skin, deeply care the skin, moisturize and relieve the skin, tighten the skin, resist wrinkles and make the skin moisturized, glossy, elastic and tight, and is high in use safety and wide in application prospect.
Owner:JIKE BIOTECHNOLOGY (GUANGZHOU) CO LTD

Composition with instant and long-acting anti-aging effect and application thereof

The invention provides a composition with an instant and long-acting anti-aging effect and application thereof. The composition comprises a component A, a component B and a component C, the mass ratio of the raw materials is (1-10): (1-4): (0.05-0.2); the component A is prepared from the following components in parts by weight: 0.01 to 0.5 part of acetyl octapeptide-3, 0.01 to 0.5 part of dipeptide diaminobutyryl benzyl amide diacetate, 0.001 to 0.2 part of arginine / lysine polypeptide, 0.3 to 1 part of caprylyl glycol and 96 to 100 parts of water; the component B is prepared from the following components in parts by weight: 0.001 to 0.2 part of soluble collagen, 5 to 30 parts of glycerol, 0.01 to 0.5 part of sodium dihydrogen phosphate, 0.001 to 0.2 part of disodium hydrogen phosphate and 65 to 100 parts of water; and the component C is tripeptide-29. According to the invention, the quadruple wrinkle fading polypeptide is adopted to block wrinkles in a multi-target full-link manner, so that the product has a very good effect of fading various wrinkles in real time.
Owner:GUANGDONG MARUBI BIOLOGICAL TECH CO LTD

Cooling crystallization device for disodium hydrogen phosphate production

The utility model relates to a cooling crystallization device for producing disodium hydrogen phosphate, which is characterized in that stirring blades (13) are of arc-shaped structures, water storage cavities (14) are formed in the stirring blades (13), a water inlet channel (15) and a water outlet channel (16) are arranged in a rotating shaft (12), the water inlet channel (15) is communicated with the water storage cavity (14) of one stirring blade (13), the water outlet channel (16) is communicated with the water storage cavity (14) of the other stirring blade (13), and the water outlet channel (16) is communicated with the water storage cavity (14) of the other stirring blade (13). The water storage cavities (14) of the two stirring blades (13) are communicated with each other; the rotating shaft (12) drives the two stirring blades (13) to rotate so as to stir a disodium hydrogen phosphate solution in the container (10), meanwhile, water flowing in the water storage cavities (14) of the stirring blades (13) is used for uniformly cooling the disodium hydrogen phosphate solution, the solution cooling is accelerated, the cooling crystallization efficiency is improved, and meanwhile, the stirring blades (13) of an arc-shaped structure rotate at a low speed so as to reduce bubbles generated by the solution and improve the crystallization efficiency. The influence on crystallization is avoided.
Owner:HENAN YUANHENG FINE CHEM CO LTD

Composite hydrogel capable of stopping bleeding, resisting bacteria and promoting alveolar bone repair as well as preparation method and application of composite hydrogel

The invention relates to the technical field of hydrogel, in particular to composite hydrogel capable of stopping bleeding, resisting bacteria and promoting alveolar bone repair, a preparation method and application. The composition comprises a polyacrylic acid solution, a calcium chloride solution, a disodium hydrogen phosphate solution, platelet-rich plasma (including plasma, platelet lysis buffer, platelet-rich fibrin and fibrin of high-concentration concentrated growth factors) and nano clay (hectorite). The preparation method has the advantages of simple process, easily available raw materials, environment-friendly production process, safety and short preparation period. The composite hydrogel is good in biocompatibility and injectable, and can be widely applied to the field of biomedical materials.
Owner:ZHEJIANG UNIV OF TECH +2

Fluticasone propionate cream and preparation method thereof

PendingCN120284856AOrganic active ingredientsAerosol deliveryFluticasone propionatePropanoic acid
The invention discloses fluticasone propionate emulsifiable paste and a preparation method thereof. The preparation method of the fluticasone propionate emulsifiable paste comprises the following steps: S1, mixing liquid paraffin, isopropyl myristate and other auxiliaries, and heating to obtain an oil phase; s2, purified water, propylene glycol, disodium hydrogen phosphate dodecahydrate and other auxiliaries are mixed to obtain a water phase; and S3, adding the oil phase into the water phase, adding fluticasone propionate and the like after complete emulsification, uniformly stirring, and standing to obtain the cream. Compared with the prior art, the fluticasone propionate emulsifiable paste prepared by the invention is not easy to layer at high and low temperatures, and the obtained emulsifiable paste has better stability and is very beneficial to transportation, storage and the like of the product.
Owner:JIANGSU SEMPOLL PHARMA

Grouting material suitable for rapid plugging of water-rich stratum as well as preparation method and application of grouting material

The invention discloses a grouting material suitable for rapid plugging of a water-rich stratum as well as a preparation method and application of the grouting material, and belongs to the technical field of grouting materials. The preparation raw materials comprise a component A and a component B, the component A comprises the following components in parts by mass: 20-80 parts of cement; 10-50 parts of a fly ash extract; 20 to 60 parts of water; the concrete admixture is prepared from the following components in parts by weight: 0.01 to 1 part of polycarboxylate superplasticizer, 0.025 to 0.05 part of polyacrylamide, 0.1 to 0.6 part of hydroxypropyl methyl cellulose, 0.5 to 1 part of disodium hydrogen phosphate and 1.5 to 4.5 parts of calcium metaaluminate. The component B is water glass, and the volume ratio of the component A to the component B is (1-5): 1. The grouting material provided by the invention has the properties of early strength, rapid setting, adjustable setting time, good fluidity, high flowing water retention rate and the like, and can meet the rapid plugging requirements of grouting of underground engineering such as tunnels, coal mines and the like.
Owner:SHANDONG UNIV

Reconstituted tobacco preparation method based on compound enzyme technology

The invention discloses a reconstituted tobacco preparation method based on a compound enzyme technology, which comprises the following steps: carrying out surface impurity removal pretreatment on a reconstituted tobacco sheet base to obtain a standby sheet base; dissolving cellulase and pectinase in water according to a certain mass ratio to prepare an enzyme solution; the preparation method comprises the following steps: spraying a citric acid-disodium hydrogen phosphate buffer solution to the surface of a standby film base, then spraying an enzyme solution to the surface of the standby film base, carrying out an enzymatic hydrolysis reaction for 3-5 h under the conditions that the temperature is 40-50 DEG C and the humidity is 50-70%, and then drying the enzymatic hydrolysis film base for 30-50 min at the temperature of 70-80 DEG C. According to the method, a collaborative regulation system of cellulase and pectinase is constructed, the enzymolysis process is optimized, oriented improvement of the sour and sweet taste of the reconstituted tobacco is achieved, the aroma richness is remarkably enhanced, the overall acceptability is greatly improved, the technical problems that in a traditional process, the flavor is single, and enzymolysis regulation is extensive are solved, and the quality of the reconstituted tobacco is improved. And a green and efficient standardized solution is provided for quality upgrading of the reconstituted tobacco.
Owner:CHINA TOBACCO YUNNAN IND

Production method of instant sodium pyrophosphate

The invention provides a production method of instant sodium pyrophosphate. The production method comprises the following steps: neutralizing, spray-drying, polymerizing, pre-hydrating, cooling and screening to obtain the instant sodium pyrophosphate. Food phosphoric acid and sodium carbonate are neutralized to obtain disodium hydrogen phosphate slurry, the pH is controlled to be 8.8-9.2, and the specific gravity is 1.4-1.5 g / ml; conveying the neutralized slurry to a pressure spray drying tower, and controlling the temperature of the tower bottom to be 120-150 DEG C; after drying, the mixture enters a dynamic polymerization furnace, the polymerization time is 30-40 min, the furnace tail temperature is 180-210 DEG C, and a sodium pyrophosphate semi-finished product is obtained. The semi-finished product passes through a cooling roller, water mist is sprayed at an inlet of the roller for pre-hydration, and meanwhile cooling is conducted; and sieving the product to obtain the instant sodium pyrophosphate.
Owner:HUBEI XINGFA PHOSPHORUS CHEM RES INST CO LTD

Microbial peculiar smell removing agent suitable for environment and preparation method of microbial peculiar smell removing agent

The invention discloses a microbial odor remover suitable for environment and a preparation method thereof, and relates to the technical field of daily chemical products. The preparation method comprises the following steps: adding pediococcus acidilactici and bacillus velezensis into a citric acid-disodium hydrogen phosphate buffer solution according to a ratio, standing and activating, adding bromelain, lipase, rosmarinic acid nanoemulsion, tea polyphenol and citrus polyphenol-EDTA (Ethylene Diamine Tetraacetic Acid) mixture, homogenizing, adding konjac glucomannan-chitosan gel and a trehalose-glycerol compound according to a ratio, stirring, filtering, and drying to obtain a finished product. And subpackaging in a dark place to prepare the microbial odor remover suitable for the environment. Through the synergistic effect of microorganisms, enzymes and a natural deodorization medium, a multi-stage peculiar smell elimination system is constructed, the dual functions of immediate neutralization and continuous bacteriostasis are achieved, the application scene is wide, corrosion and residues to base materials such as fabric and plastic are avoided, and the concentration of harmful gas can be more effectively controlled and pathogenic microorganisms can be inhibited in large-scale breeding application.
Owner:HONG KONG HUAYUAN BIOTECHNOLOGY (SHANWEI) CO LTD

Low-cost compound microbial fertilizer and preparation method thereof

The invention relates to the technical field of microbial fertilizers, in particular to a low-cost compound microbial fertilizer and a preparation method thereof. The low-cost compound microbial fertilizer comprises the following raw materials in parts by mass: 20-40 parts of a fermented organic fertilizer, 10-20 parts of urea, 5-10 parts of ammonium magnesium phosphate, 5-15 parts of a potassium fertilizer, 1-4 parts of sodium humate, 1-4 parts of trehalose, 1-3 parts of gelatin, 0.1-1 part of a stabilizer, 7-19 parts of a mineralized microbial agent load and 1-3 parts of a coating solution, the mineralized microbial inoculum load comprises the following raw materials: 5-15 parts of bamboo charcoal powder, 1-3 parts of a composite microbial inoculum, 1-2 parts of calcium chloride and 1-2 parts of disodium hydrogen phosphate. The fertilizer has the advantages of obviously increasing the fertilizer utilization rate, improving the physical and chemical properties of soil, promoting the formation of granular structures and repairing hardened and ill-conditioned soil, has obvious soil repairing effect and obvious yield increasing, value increasing and quality improving effects, and is suggested to be suitable for large-scale popularization and application when being popularized and applied in production.
Owner:TIANJIN FANDE TECHNOLOGY DEVELOPMENT CO LTD

Pavement patching material with high early strength and toughness and preparation method thereof

The invention relates to the technical field of pavement patching materials, in particular to a pavement patching material with high early strength and toughness and a preparation method thereof. The repairing material is formed by compounding phosphate-based powder A, magnesium oxide-based powder B, a composite retarder C and a fiber material D, the phosphate-based powder comprises phosphate and disodium hydrogen phosphate dodecahydrate; the magnesium oxide-based powder B comprises dead burned magnesium oxide, superfine powder, industrial solid waste powder, cellulose ether and wollastonite whiskers; the composite retarder C comprises borax and nitrite; the fiber material D comprises reinforced fibers. The preparation method is the preparation method of the pavement patching material. The pavement patching material slurry has high early strength, the construction time can be remarkably shortened, and it is guaranteed that a repaired pavement has excellent mechanical performance and durability; according to the preparation method, materials can be prepared respectively, and standardized production, transportation and storage are facilitated; only water needs to be added for preparation on a construction site, and construction is convenient.
Owner:SHIJIAZHUANG TIEDAO UNIV

Novel sulphide ore beneficiation activating agent and preparation method thereof

The invention provides a novel mineral separation activating agent for sulphide ores and a preparation method of the novel mineral separation activating agent. The cleaning agent comprises 1-2 parts of basic cupric carbonate, 2-4 parts of ammonium chloride, 2-4 parts of nanometer jade powder, 2-3 parts of alginic acid, 1-2 parts of allyl glycidyl ether, 2-3 parts of peregal O, 2-3 parts of sodium di-sec-octyl maleate sulfonate, 2-3 parts of vinyl acetate, 4-7 parts of hydrogen peroxide, 4-6 parts of disodium hydrogen phosphate and 40-50 parts of water. The preparation method comprises the following steps: firstly mixing basic cupric carbonate and ammonium chloride to obtain a first mixture, then mixing the rest components, heating and stirring to obtain a second mixture, and finally uniformly mixing the first mixture and the second mixture. The activating agent overcomes the defects of a traditional activating agent, has efficient activating performance, can improve the beneficiation efficiency of low-grade, complex and refractory sulfide ore, is environmentally friendly, good in stability and high in adaptability, and provides technical support for efficient development of sulfide ore resources.
Owner:HAINAN CHENPU TECHNOLOGY CO LTD

Enrichment culture medium, and preparation method therefor and use thereof

The present invention belongs to the technical field of rapid detection of drug sensitivity for bacteria. Disclosed are an enrichment culture medium, and a preparation method therefor and the use thereof. The enrichment culture medium comprises the following raw materials in parts by mass: 15.0-20.0 parts of tryptone, 3.5-5.5 parts of peptone, 1.5-3.5 parts of glucose, 5.0-6.5 parts of yeast extract, 2.0-2.5 parts of dipotassium phosphate, 2.0-3.5 parts of disodium hydrogen phosphate, 1.0-1.5 parts of monopotassium phosphate, 2.5-7.5 parts of sodium chloride, 12.0-18.0 parts of proteose peptone, 15.0-22.0 parts of beef heart infusion powder, 8.0-12.0 parts of soya peptone, 1.0-5.0 parts of 0.1% nicotinamide adenine dinucleotide (NAD), 30-100 parts of newborn calf serum inactivated at 56°C for 30 min, 2.0-4.0 parts of mannitol, 3.0-5.0 parts of sodium pyruvate, 0.23-0.45 parts of cycloheximide, 0.8-2.0 parts of 0.05% bromothymol blue, 2.5-4.5 parts of 0.1% methylene blue, and 1000 parts of distilled water, with the pH value of 6.8-7.5. The enrichment culture medium is used to screen effective therapeutic drugs for bacterial diseases in poultry, and is convenient to use and has a single enrichment effect superior to that of respective selective enrichment broths of target bacteria. Therefore, the culture medium can realize rapid proliferation of common pathogenic bacteria in poultry.
Owner:QINGDAO AGRI UNIV

A shaped phase change material and a method of making the same

The application provides a kind of shaped phase change material and its preparation method.The phase change material includes the following component materials according to mass percentage: 45.8-56.7% of dodecahydrate disodium hydrogen phosphate, 7.9-22.9% of sodium carbonate decahydrate, 7.6-15.9% of sodium sulfate decahydrate, 2.46-4.05% of reinforcing material, and 15-20% of adsorption material.The preparation of the phase change material includes the following steps: 1, preparing materials;2, preparing inorganic salt mixture;3, preparing molten inorganic salt mixture;4, preparing mixture and sealing;5, preparing shaped phase change material.The shaped phase change material prepared by the application has suitable phase change temperature, higher latent heat of phase change, no liquid leakage, no toxicity and non-combustibility, small supercooling degree, and no phase separation;at the same time, for the application occasions requiring transportation and storage between 20-30℃, the shaped phase change material can be used as an effective normal temperature cold storage agent to resist low temperature environment and protect specific chemicals and medicines from temperature fluctuation.
Owner:SOLEE (WUHAN) SCI & TECH CO LTD

Feed additive and pellet feed for large-scale feeding of mutton sheep and preparation method of feed additive and pellet feed

The invention relates to the technical field of feed additives, and particularly discloses a feed additive for large-scale feeding of mutton sheep, a pellet feed and a preparation method. The feed additive comprises a microcapsule core material and a wall material wrapping the microcapsule core material, and according to the total weight of the microcapsule core material, the microcapsule core material comprises 40-50 parts of soybean peptide, 30-40 parts of sodium alginate and 5-10 parts of calcium lactate; the wall material is prepared from the following components in parts by weight: 20 to 30 parts of chitosan, 10 to 15 parts of tannic acid, 10 to 15 parts of hydroxypropyl methyl cellulose, 5 to 8 parts of gelatin, 3 to 5 parts of disodium hydrogen phosphate and 2 to 3 parts of disodium ethylene diamine tetraacetate. The pellet feed comprises the following raw materials in parts by weight: 40-50 parts of corn, 15-25 parts of soybean meal, 10-20 parts of alfalfa meal, 5-10 parts of bran, 1-3 parts of a feed additive, 1-2 parts of calcium hydrogen phosphate and 0.2-0.8 part of table salt. The feed additive disclosed by the invention can be slowly released in rumens of mutton sheep and quickly released in intestinal tracts, so that the feeding effect is favorably improved.
Owner:JINCHANGBODU GRASS IND CO LTD

Preparation method of porous starch with stable structure

ActiveCN119798769AFreeze-dryingCentrifugation
The invention discloses a preparation method of porous starch with a stable structure, which comprises the following steps: firstly, adding hydrophilic colloid into deionized water to prepare a solution, then adding starch, uniformly mixing to obtain a compound suspension, heating the compound suspension at a crystal melting starting temperature, and then carrying out vacuum freeze drying, grinding and sieving to obtain molten coated starch; the preparation method comprises the following steps: adding starch into a citric acid-disodium hydrogen phosphate buffer solution, uniformly mixing to obtain a starch-buffer solution suspension, adding an enzyme, carrying out an oscillating reaction, adjusting the reaction solution to be alkaline after the reaction is finished to terminate the reaction, then adjusting to be neutral, and finally centrifuging, washing, carrying out vacuum freeze drying, grinding and sieving to obtain the starch. The method is simple in process and low in manufacturing cost, the prepared porous starch has excellent adsorbability, structural stability and thermal stability, and the problems that in the prior art, the manufacturing process is complex, the preparation time is long, and the prepared porous starch is poor in structural stability, limited in pore-forming effect and the like are solved.
Owner:YANGZHOU UNIV

A grouting material suitable for rapid sealing of water-rich formations, its preparation method and application

This invention discloses a grouting material suitable for rapid sealing of water-rich strata, its preparation method, and its application, belonging to the field of grouting material technology. The raw materials for its preparation include component A and component B; component A, by mass parts, includes 20-80 parts cement; 10-50 parts fly ash extract; 20-60 parts water; 0.01-1 parts polycarboxylate superplasticizer; 0.025-0.05 parts polyacrylamide; 0.1-0.6 parts hydroxypropyl methylcellulose; 0.5-1 parts disodium hydrogen phosphate; and 1.5-4.5 parts calcium aluminate; component B is water glass, and the volume ratio of component A to component B is 1-5:1. The grouting material provided by this invention possesses properties such as early strength, rapid setting with adjustable setting time, good fluidity, and high water retention rate, which can meet the rapid sealing requirements of underground engineering projects such as tunnels and coal mines.
Owner:SHANDONG UNIV

Pemirolast potassium eye drops and preparation method thereof

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to pemirolast potassium eye drops and a preparation method thereof. The pemirolast potassium eye drops are composed of pemirolast potassium, hydroxypropyl ethyl cellulose, an osmotic pressure regulator, disodium hydrogen phosphate, a pH regulator and water for injection, and the prescription does not contain a bacteriostatic agent, so that the irritation of the eye drops to eye tissue cells is reduced; the pemirolast potassium eye drops provided by the invention are simple in prescription process, stable and controllable in quality and high in safety.
Owner:SHANDONG NEW TIME PHARMA CO LTD

Scale dissolving agent for rapidly dissolving wet-process phosphoric acid scaling substances as well as preparation method and application of scale dissolving agent

The invention discloses a scale dissolving agent for rapidly dissolving wet-process phosphoric acid scaling substances as well as a preparation method and application of the scale dissolving agent, and belongs to the technical field of descaling. The scale dissolving agent comprises the following components in percentage by weight: 20-30% of a scale remover, 3-5% of a penetrating agent, 0.3-0.8% of a penetrating aid, 0.5-1% of a surfactant, 0.3-0.5% of a synergist and the balance of water, wherein the descaling agent comprises trisodium citrate dehydrate, sodium ethylene diamine tetracetate and ammonium fluoride; the penetrating agent is prepared from dioctyl sodium sulfosuccinate and perfluoroalkyl ethyl acrylate; the permeation auxiliary agent comprises disodium hydrogen phosphate and sodium carbonate; and the synergist is 1-ethyl-3-methylimidazolium acetate. The scale dissolving agent is specially used for dissolving wet-process phosphoric acid scaling substances and has the advantages of being high in scale dissolving speed, mild in reaction condition, low in formula cost and the like, the pH value of the scale dissolving agent is neutral and slightly alkalescent, and corrosion to production equipment is effectively avoided.
Owner:SHIKEFENG CHEM IND CO LTD

A preparation method of disodium hydrogen phosphite

ActiveCN119461275BPhosphorous acidPhosphorous acidPhysical chemistry
The present application relates to the technical field of preparation of disodium hydrogen phosphite, and discloses a method for preparing disodium hydrogen phosphite, comprising the following steps: S1, dissolving phosphorous acid and sodium hydroxide in distilled water under an inert gas atmosphere, wherein the molar ratio of phosphorous acid to sodium hydroxide is 1:(1.9-2.3), and stirring for reaction; S2, evaporating and concentrating the solution obtained in S1 to 1 / 4-1 / 3 of the original volume, cooling the solution to 25-35°C, and filtering to obtain solid disodium hydrogen phosphite; S3, adding disodium hydrogen phosphite seed crystals to the filtrate obtained in S2, cooling the solution to 15-25°C while stirring, and filtering when the crystals no longer increase to obtain disodium hydrogen phosphite; the amount of disodium hydrogen phosphite seed crystals added is 0.5-3% by weight of the phosphorous acid added in S1; the method has the advantages of improving the purity and production efficiency of disodium hydrogen phosphite.
Owner:RUDONG ZHENFENG YIYANG CHEM CO LTD

A functional probiotic microencapsulated intestinal shield system and methods of making and using the same

PendingCN122642495ABiotechnologyCellulose
The application discloses a functional probiotic microencapsulated intestinal shield system and a preparation method and application thereof. A core layer comprises four probiotics, i.e., lactobacillus acidophilus La-14, animal bifidobacterium Bb-12, lactobacillus rhamnosus GG and lactobacillus reuteri DSM 17938, and the weight ratio is 3:4:2:1, and the total viable bacterial count is greater than or equal to 10^10 CFU / g. An inner layer is a targeted release control layer, which is composed of ethyl cellulose, polylactic acid, chitosan and lactose, can swell in a pH 5.5 to 6.5 environment and can dissolve in a pH 6.8 to 7.2 environment. A middle layer is a buffer protection layer, which is composed of calcium carbonate, disodium hydrogen phosphate and sodium alginate, and can maintain the internal pH of the microcapsule at 4.5 to 5.5 in a gastric acid environment. An outer layer is an intelligent response protection layer, which is composed of konjac glucomannan, xanthan gum and gum arabic, and can form a protective film in a gastric acid environment with a pH less than 3.0 within 5 minutes. Through the synergistic protection of the four-layer microcapsule structure, the probiotics can achieve a high survival rate in the gastric acid environment of cats, and can be accurately released at specific positions in the intestinal tract, which is helpful to improve the intestinal health of cats.
Owner:BEIJING ZHONGKE CHONGMENG TIANXIA TECH CO LTD

Active peptide energy liquid for skin repair as well as preparation and application of active peptide energy liquid

The invention relates to the technical field of biological medicine, and discloses an active peptide energy liquid for skin repair as well as preparation and application thereof, and the active peptide energy liquid comprises the following raw materials in content range: 96-99% of water; the content of the trehalose is 0.5%-1.5%; the content of the oligopeptide-1 is 0.05%-0.15%; the content of the oligopeptide-3 is 0.01%-0.1%; the content of the heptapeptide-6 is 0.01%-0.1%; the content of sodium dihydrogen phosphate is 0.01%-0.1%; the content of disodium hydrogen phosphate is 0.1%-0.3%, three active peptide components including oligopeptide-1, oligopeptide-3 and heptapeptide-6 are introduced, and the characteristics of low molecular weight and high biological activity of active peptides are utilized, so that the active peptides can penetrate into skin cells and promote collagen synthesis, cell regeneration and skin barrier repair, and therefore, the anti-wrinkle, whitening and repairing capacities of the skin are improved, and the anti-wrinkle, whitening and repairing effects of the skin are improved. The technical means of strict temperature control, multi-stage stirring speed optimization and nitrogen protection are adopted in the preparation process to ensure that the active peptide is not aggregated or inactivated in the preparation process, and meanwhile, oxidation and microbial pollution are prevented.
Owner:GUANGDONG XUANYUAN BIOTECHNOLOGY CO LTD

A serum-free and DMSO-free cryopreservation solution for mesenchymal stem cells, its preparation method and application

The present invention belongs to the field of cell culture and preservation, and specifically discloses a serum-free and DMSO-free mesenchymal stem cell cryopreservation solution, its preparation method and application. The cryopreservation solution contains the following components: a basic diluent 40-80 v / v%, a permeable cryoprotectant 5-20 v / v%, a non-permeable cryoprotectant 1-10 v / v%, a cell membrane protectant 5-20 v / v%, a cell activity additive 5-20 v / v%, and a plant-derived natural antioxidant composition; the basic diluent contains the following components: sodium chloride, potassium chloride, potassium dihydrogen phosphate, disodium hydrogen phosphate, sodium bicarbonate, D-glucose, HEPES, and sodium pyruvate; the plant-derived natural antioxidant composition is cyanidin-3-O-glucoside C3G and epigallocatechin gallate EGCG; this cryopreservation solution does not contain serum or DMSO, and creatively combines the two plant-derived natural antioxidants C3G and EGCG. The sources and dosages of all components are clear, it does not contain any cytotoxic components, is easy to use, has a high cell recovery viability after cryopreservation, and has a wide range of applications.
Owner:CYAGEN BIOSCIENCES (SUZHOU) INC

Sodium phosphate salt complexes, methods of making and using the same

The application provides a sodium phosphate salt complex, which comprises 15-30 parts by weight of sodium dihydrogen phosphate or a monohydrate thereof, 3-6 parts by weight of disodium hydrogen phosphate, 0.05-0.3 parts by weight of lidocaine hydrochloride, 0-0.04 parts by weight of a fragrance and 0-0.25 parts by weight of a sweetening agent. The sodium dihydrogen phosphate or the monohydrate thereof, the disodium hydrogen phosphate and the lidocaine hydrochloride are prepared into a complex, and are administered simultaneously in use, so that the clinical effect is remarkable when the intestines are cleaned, the drug satisfaction is improved, the enteroscopy quality is improved, the postoperative exhaust defecation time is reduced and postoperative complications are reduced.
Owner:SICHUAN JIAN NENG PHARM CO LTD

A large-spore culture medium of hypocrea disciformis and application thereof

PendingCN122503295ABiotechnologyVitamin b6
This invention discloses a culture medium for the mass sporulation of *Substantia macrantha* and its application. The culture medium comprises the following components: lactose 21-23 g / L, yeast extract 14-16 g / L, potassium chloride 0.4-0.6 g / L, magnesium sulfate 0.4-0.6 g / L, potassium dihydrogen phosphate 0.4-0.6 g / L, disodium hydrogen phosphate 0.55-0.75 g / L, sodium molybdate dihydrate 5-7 mg / L, vitamin B6 50-60 mg / L, arginine 20-30 mg / L, and agar 18-22 g / L, diluted to volume with double-distilled water, with a natural pH. Using the culture medium prepared according to this invention to culture *Substantia macrantha* significantly increases the spore yield (164-fold), reaching 2.21 × 10⁻⁶. 8 conidia / cm 2 This provides a reference for the mass production of the fungal spores.
Owner:FUJIAN AGRI & FORESTRY UNIV

Biological liquid medicine for promoting cartilage tissue regeneration for knee joint injection

The invention provides a biological liquid medicine for promoting cartilage tissue regeneration by being injected into knee joints. The biological liquid medicine comprises the following components: 3%-4% of modified xanthan gum, 1.5%-2.5% of chitosan lactate wrapped by lipidosome, 0.2%-0.6% of strontium bromide, 1%-2% of disodium hydrogen phosphate, 1%-2% of sodium dihydrogen phosphate and the balance of water for injection to 100%, the modified xanthan gum is carboxymethylated xanthan gum. According to the biological liquid medicine, modified xanthan gum, chitosan lactate wrapped by lipidosome and strontium bromide are added, long-acting retention of the modified xanthan gum provides a stable release environment for the lipidosome and the strontium bromide, the lipidosome accurately delivers the chitosan lactate to an injured part, and the lipidosome and the strontium bromide act on ions to strengthen cartilage cell proliferation and matrix secretion, so that the cartilage cell proliferation and matrix secretion are enhanced; the three components are combined to improve the cartilage tissue damage repair degree of the knee joint and improve the cartilage tissue regeneration effect.
Owner:GUANGDONG CELL BIOTECHNOLOGY CO LTD

Preparation device of flaky disodium hydrogen phosphate dihydrate

The utility model provides a preparation device of flaky disodium hydrogen phosphate dihydrate. The preparation device comprises a disodium hydrogen phosphate dodecahydrate melting kettle and a flash chamber which are communicated with each other, the flash chamber is provided with a liquid outlet pipe and a liquid return pipe, and the liquid outlet pipe and the liquid return pipe are communicated with the heat exchanger; the liquid outlet pipe is provided with a first three-way pipe which is communicated with the disodium hydrogen phosphate dodecahydrate melting kettle, and is provided with a second three-way pipe which is communicated with the disodium hydrogen phosphate dihydrate melting kettle; and the disodium hydrogen phosphate dihydrate melting kettle is communicated with a flaker to flake molten disodium hydrogen phosphate dihydrate. The sodium hydrogen phosphate dihydrate production device has the beneficial effects that the prepared sodium hydrogen phosphate dihydrate product is in a sheet shape, and the product in the sheet shape is not easy to generate dust in the transportation process, so that environmental pollution and health risks are reduced. Due to the structural characteristics of the sheet-shaped product, the sheet-shaped product is not prone to hardening, good fluidity can be kept even in the long-time storage and transportation process, and therefore material loss and treatment cost caused by hardening are greatly reduced.
Owner:SHANDONG WEIFANG RAINBOW CHEMICAL CO LTD

Electrolyte for electrolyzed water and preparation method thereof

The invention relates to an electrolyte for electrolyzed water and a preparation method thereof. The electrolyte comprises K3 [Fe (CN) 6] serving as a redox medium, a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate serving as a buffering agent, an aqueous solvent and a pH regulator. The method comprises the following steps: S1, dissolving K3 [Fe (CN) 6], sodium dihydrogen phosphate (NaH2PO4) and disodium hydrogen phosphate (Na2HPO4) in the aqueous solvent to obtain an intermediate solution, and S2, adding the pH regulator into the intermediate solution to obtain the electrolyte. The electrolyte disclosed by the invention can be used for stably carrying out electrolytic reaction, and the volume ratio of hydrogen to oxygen can be accurately regulated and controlled by changing the concentration of an oxidation-reduction medium in the electrolyte. The method provided by the invention is simple and safe in process, can be repeatedly and stably carried out at low cost, and realizes large-scale production.
Owner:JILIN UNIVERSITY

Non-slip tire and method of making same

PendingCN122356600ACerium nitrateVulcanization
The present application belongs to the technical field of tire manufacturing, and particularly relates to an antiskid tire and a preparation method thereof. The antiskid performance of the tire is significantly improved by adding cerium-doped polyoxometalate-based layered compounds and nitrogen-sulfur co-modified zirconium-based MXene layered compounds in the tread compound. The cerium-doped polyoxometalate-based layered compounds are prepared by hydrothermal reaction and calcination treatment using disodium hydrogen phosphate, sodium molybdate, cerium nitrate and hexanediamine as raw materials. The nitrogen-sulfur co-modified zirconium-based MXene layered compounds are prepared by etching, peeling and co-calcination with thiourea after synthesizing ceramics using titanium powder, aluminum powder, zirconium powder and carbon powder as raw materials. When preparing the tire, the rubber is first mixed with carbon black, the two modified compounds and the additives to obtain a masterbatch, then the vulcanization system components are added to obtain a final rubber compound, and finally the finished product is obtained through extrusion, lamination and vulcanization molding. The antiskid tire prepared by the present application has excellent grip on wet and icy road surfaces.
Owner:HEBEI WANJUN TIRE CO LTD