Collagen polypeptide firming and anti-wrinkle freeze-dried powder

The composition of collagen polypeptide firming anti-wrinkle freeze-dried powder can be deeply repaired, and the problem that existing freeze-dried powder cannot deeply repair the skin is solved, achieving deep moisturizing, firming and anti-wrinkle effects, and ensuring safety in use.

CN120324280APending Publication Date: 2025-07-18JIKE BIOTECHNOLOGY (GUANGZHOU) CO LTD
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Patent Information

Application Number
CN202410059824.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-01-16
Publication Date
2025-07-18

AI Technical Summary

Technical Problem

The existing freeze-dried powder cannot repair the skin in depth, the firming and anti-wrinkle effect is not obvious, and the safety performance is not high, and there are side effects.

Method used

Collagen polypeptide firming anti-wrinkle freeze-dried powder is used, which contains water, butyl glycol, Bacillus/soy fermentation product extract, soluble collagen, acetyl hexapeptide-8 and other components. Through deep care of the skin, it promotes collagen synthesis and skin cell regeneration, provides rich nutrients, improves skin elasticity and firming effect.

Benefits of technology

It achieves deep moisturizing and soothing, firming and anti-wrinkle, moist and shiny skin, elastic and firm, safe and without side effects, and has broad market application prospects.

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Abstract

The invention discloses collagen polypeptide firming and anti-wrinkle freeze-dried powder, and relates to the technical field of cosmetics. The invention relates to a biological preservative which is prepared from water, butanediol, a bacillus / soybean fermentation product extract, soluble collagen, acetyl hexapeptide-8, panthenol, 1, 2, 4-trimethyl-1, 3-pentanediol and a proper amount of water. The cosmetic is prepared from 1, 2-hexanediol, tetrahydromethylpyrimidine carboxylic acid, hydroxypropyl tetrahydropyrantriol, tremella polysaccharide, saccharide isomeride, a bifidus yeast fermentation product lysate, sodium hyaluronate, DNA sodium, a radix gentianae extract, mannitol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, oligopeptide-1, decapeptide-4, oligopeptide-3, hydrolyzed royal jelly protein, folic acid and disodium hydrogen phosphate. The additive is composed of sodium dihydrogen phosphate, citric acid and sodium citrate. The mask can provide rich nutrients for skin, deeply care the skin, moisturize and relieve the skin, tighten the skin, resist wrinkles and make the skin moisturized, glossy, elastic and tight, and is high in use safety and wide in application prospect.
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Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and specifically relates to a freeze-dried powder of collagen polypeptide for firming and anti-wrinkle effects. Background Art

[0002] With the increase of age and the deterioration of living environment, the protective function of people's skin is decreasing day by day. Moisture is easy to lose, wrinkles and sagging are prone to appear, and the skin metabolism is low. Along with the improvement of living standards, people pay more and more attention to skin care, and cosmetics are increasingly widely used. Through cosmetics, the skin can be maintained, metabolism can be promoted, moisture can be supplemented for the skin, the elasticity of the skin can be improved, aging can be delayed, and problems such as rough skin and fine lines can be solved.

[0003] There are a wide variety of cosmetics. Among them, freeze-dried powder, as one of them, is a sterile powder injection formed by freezing the liquid medicine into a solid state in a sterile environment, pumping out the vacuum to sublimate and dry the moisture, and retaining its original drug effect. The existing freeze-dried powders on the market cannot fundamentally repair the skin. Their firming and anti-wrinkle effects are average, the effects are not obvious, they can only solve the surface problems of the skin, cannot penetrate deep into it, and the safety performance during use is not high, and there are certain side effects on the human body. Based on this, it is particularly necessary to develop a freeze-dried powder of collagen polypeptide for firming and anti-wrinkle effects. Summary of the Invention

[0004] Aiming at the deficiencies in the prior art, the purpose of the present invention is to provide a freeze-dried powder of collagen polypeptide for firming and anti-wrinkle effects, which can provide rich nutrients for the skin, deeply care for the skin, moisturize and soothe, firm and anti-wrinkle, make the skin moist, shiny, elastic and firm, and has high safety during use and is easy to be popularized and used.

[0005] To achieve the above object, the present invention is realized by the following technical solutions: Collagen polypeptide firming and anti-wrinkle freeze-dried powder is composed of the following components by mass percentage: water 72 - 78%, butylene glycol 4.25 - 5.15%, Bacillus / soybean ferment extract 3.555 - 3.876%, soluble collagen 2.8 - 3.2%, acetyl hexapeptide-8 0.1 - 0.2%, panthenol 0.8 - 1.1%, 1,2-hexanediol 0.655 - 0.686%, ectoine 0.5 - 0.9%, hydroxypropyltetrahydropyrantriol 0.5 - 1%, tremella polysaccharide 0.42 - 0.52%, carbohydrate isomerate 0.15 - 0.35%, bifida ferment lysate 4.8 - 5.2%, sodium hyaluronate 0.13 - 0.25%, sodium DNA 0.12 - 0.22%, gentiana root extract 0.11 - 0.18%, mannitol 4.5 - 5.5%, palmitoyl tripeptide-1 0.15 - 0.18%, palmitoyl tetrapeptide-7 0.13 - 0.17%, oligopeptide-1 0.12 - 0.18%, decapeptide-4 0.14 - 0.19%, oligopeptide-3 0.03 - 0.06%, hydrolyzed royal jelly protein 0.0045 - 0.006%, folic acid 0.002 - 0.004%, disodium hydrogen phosphate 0.006 - 0.009%, sodium dihydrogen phosphate 0.0035 - 0.0056%, citric acid 0.0015 - 0.0027%, sodium citrate 0.0015 - 0.0025%.

[0006] Preferably, the collagen polypeptide firming and anti-wrinkle freeze-dried powder is composed of the following components by mass percentage: water 74%, butylene glycol 4.69%, Bacillus / soybean ferment extract 3.565%, soluble collagen 3%, acetyl hexapeptide-8 0.15%, panthenol 1%, 1,2-hexanediol 0.666%, ectoine 0.55%, hydroxypropyltetrahydropyrantriol 0.55%, tremella polysaccharide 0.45%, carbohydrate isomerate 0.25%, bifida ferment lysate 5%, sodium hyaluronate 0.18%, sodium DNA 0.15%, gentiana root extract 0.13%, mannitol 5%, palmitoyl tripeptide-1 0.16%, palmitoyl tetrapeptide-7 0.15%, oligopeptide-1 0.14%, decapeptide-4 0.17%, oligopeptide-3 0.03%, hydrolyzed royal jelly protein 0.0045%, folic acid 0.002%, disodium hydrogen phosphate 0.006%, sodium dihydrogen phosphate 0.0035%, citric acid 0.0015%, sodium citrate 0.0015%.

[0007] Preferably, the collagen polypeptide firming and anti-wrinkle lyophilized powder is composed of the following components by mass percentage: water 73%, butylene glycol 5.08%, Bacillus / soybean fermentation product extract 3.822%, soluble collagen 3.2%, acetyl hexapeptide-8 0.2%, panthenol 0.9%, 1,2-hexanediol 0.686%, ectoine 0.65%, hydroxypropyltetrahydropyrantriol 0.65%, tremella polysaccharide 0.5%, carbohydrate isomerate 0.15%, bifida ferment lysate 4.8%, sodium hyaluronate 0.21%, sodium DNA 0.16%, gentiana root extract 0.12%, mannitol 5.2%, palmitoyl tripeptide-1 0.18%, palmitoyl tetrapeptide-7 0.14%, oligopeptide-1 0.13%, decapeptide-4 0.16%, oligopeptide-3 0.04%, hydrolyzed royal jelly protein 0.0051%, folic acid 0.003%, disodium hydrogen phosphate 0.007%, sodium dihydrogen phosphate 0.0037%, citric acid 0.0016%, sodium citrate 0.0016%.

[0008] Preferably, the collagen polypeptide firming and anti-wrinkle lyophilized powder is composed of the following components by mass percentage: water 74.3%, butylene glycol 4.38%, Bacillus / soybean fermentation product extract 3.67%, soluble collagen 2.8%, acetyl hexapeptide-8 0.1%, panthenol 1.1%, 1,2-hexanediol 0.676%, ectoine 0.6%, hydroxypropyltetrahydropyrantriol 0.5%, tremella polysaccharide 0.46%, carbohydrate isomerate 0.2%, bifida ferment lysate 5.2%, sodium hyaluronate 0.15%, sodium DNA 0.12%, gentiana root extract 0.11%, mannitol 4.9%, palmitoyl tripeptide-1 0.17%, palmitoyl tetrapeptide-7 0.16%, oligopeptide-1 0.15%, decapeptide-4 0.18%, oligopeptide-3 0.05%, hydrolyzed royal jelly protein 0.0047%, folic acid 0.004%, disodium hydrogen phosphate 0.008%, sodium dihydrogen phosphate 0.0041%, citric acid 0.0017%, sodium citrate 0.0015%.

[0009] Advantages of the present invention: This lyophilized powder can provide rich nutrients for the skin, deeply care for the skin, promote skin blood circulation, moisturize and soothe, firm and anti-wrinkle, make the skin moist, shiny, elastic and firm, and has high safety in use, no side effects, and broad application prospects. Embodiment

[0010] In order to make the technical means, creative features, achieved purposes and effects of the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0011] The following technical solutions are adopted in this specific embodiment: The collagen polypeptide firming and anti-wrinkle freeze-dried powder is composed of the following components by mass percentage: water 72 - 78%, butylene glycol 4.25 - 5.15%, Bacillus / soybean ferment extract 3.555 - 3.876%, soluble collagen 2.8 - 3.2%, acetyl hexapeptide-8 0.1 - 0.2%, panthenol 0.8 - 1.1%, 1,2-hexanediol 0.655 - 0.686%, ectoine 0.5 - 0.9%, hydroxypropyltetrahydropyrantriol 0.5 - 1%, tremella polysaccharide 0.42 - 0.52%, carbohydrate isomerate 0.15 - 0.35%, bifida ferment lysate 4.8 - 5.2%, sodium hyaluronate 0.13 - 0.25%, sodium DNA 0.12 - 0.22%, gentiana root extract 0.11 - 0.18%, mannitol 4.5 - 5.5%, palmitoyl tripeptide-1 0.15 - 0.18%, palmitoyl tetrapeptide-7 0.13 - 0.17%, oligopeptide-1 0.12 - 0.18%, decapeptide-4 0.14 - 0.19%, oligopeptide-3 0.03 - 0.06%, hydrolyzed royal jelly protein 0.0045 - 0.006%, folic acid 0.002 - 0.004%, disodium hydrogen phosphate 0.006 - 0.009%, sodium dihydrogen phosphate 0.0035 - 0.0056%, citric acid 0.0015 - 0.0027%, sodium citrate 0.0015 - 0.0025%.

[0012] The functions of each component added in this specific embodiment are as follows: Butylene glycol has the functions of moisturizing, hydrating and nourishing the skin, can relieve skin dryness, fade skin fine lines and inhibit bacteria; Bacillus / soybean ferment extract has the effects of moisturizing, antioxidant, anti-allergy, improving skin quality and shrinking pores; Panthenol is used as a humectant and skin conditioner, can promote the metabolism of proteins, fats and carbohydrates in the human body, protect the skin, prevent and treat small wrinkles and inflammation; 1,2-Hexanediol is used for moisturizing, emollient and bacteriostatic, ectoine has the effects of moisturizing, repairing the skin, anti-aging, anti-inflammatory and anti-radiation, etc., hydroxypropyltetrahydropyrantriol can help the skin anti-aging, delay the generation of fine lines, moisturize and nourish the skin, repair damaged skin, has a good repair effect on the skin, and at the same time can promote collagen synthesis, promote the repair of skin fine lines, make the skin plump, firm and elastic. Tremella polysaccharide can improve the stratum corneum, increase the moisture of the surface skin, repair skin mucosa, promote the body's metabolism and blood circulation, make the skin in a healthy state, and the amino acid components contained in it have a certain antioxidant ability, can scavenge free radicals generated in the skin and condition skin tone.

[0013] Soluble collagen has effects on the skin such as moisturizing, elasticity, firming, repair, and whitening. It can help the skin lock in moisture, enhance the water retention ability of the skin, promote the regeneration of skin cells, reduce the appearance of wrinkles and fine lines. At the same time, it can promote the regeneration of skin cells and the production of collagen, lift the facial contour, and firm the skin.

[0014] Saccharide isomerate has good skin-friendly properties. By binding to the free amino acid groups of lysine on keratin in stratum corneum cells, it can assist the keratin in the stratum corneum to bind with water, achieving a long-lasting moisturizing effect, improving cell communication, achieving an anti-aging effect, and improving the problem of wrinkles.

[0015] The lysate of Saccharomyces boulardii fermentation product contains various bioactive ingredients that maintain healthy skin and repair damaged skin, including collagen, enzymes, various peptide compounds, various amino acids, phospholipids, various vitamins, various mineral trace elements, polysaccharides, organic acids and other water-soluble components of cells. It can brighten the skin tone, make the skin delicate, reduce skin sensitivity, and strengthen the skin's self-repair ability.

[0016] Sodium hyaluronate has high water solubility and chargeability. It can form a protective film through water absorption to prevent water loss. At the same time, it can store a large amount of water on the skin surface to maintain the water balance of the skin. It can increase in volume by absorbing water and provide lubrication inside the skin, improving skin elasticity and luster. Sodium hyaluronate can also stimulate the growth of collagen and elastic fibers, promoting the repair and regeneration of skin tissue. Sodium DNA plays an antioxidant role. It can effectively promote cell division and cell proliferation, and improve skin problems such as dryness, roughness, and wrinkles. The skin care effects of gentian extract include anti-inflammatory, moisturizing, anti-aging, etc.

[0017] As a polypeptide molecule, acetyl hexapeptide-8 has strong moisturizing properties. It can lock in the moisture of the skin, keep the skin moist, increase the synthesis of collagen and elastin, improve the elasticity of the skin, and make the skin younger and firmer. Acetyl hexapeptide-8 has the effect of inhibiting the release of neurotransmitters. When it acts on the human skin, it can inhibit the release of acetylcholine and reduce muscle contraction. Since the formation of wrinkles is mainly caused by muscle contraction, the application of acetyl hexapeptide-8 can further inhibit the contraction of facial expression muscles in humans, shallow the depth of wrinkles, and reduce the formation of wrinkles. Secondly, acetyl hexapeptide-8 can also increase the activity of collagen, improve the luster and smoothness of the skin, and maintain the epidermal renewal ability.

[0018] Mannitol, as a freeze-dried powder excipient, can lock in moisture and keep the skin hydrated. It can scavenge free radicals in the body, not only inhibit skin damage, but also scavenge free radicals in the body, maintain the activity of oligopeptides, help condition the skin, enable the skin to quickly absorb moisture, and lock in moisture. Oligopeptide-1 can promote the growth, division and metabolism of cells in the deep layer of the skin and epithelial cells, promote the growth of microvessels, and improve the microenvironment for cell growth; Oligopeptide-3 promotes skin tissue growth, accelerates metabolism, repairs the skin, enhances cell vitality, and moisturizes. Palmitoyl tripeptide-1 can promote skin metabolism, stimulate cell proliferation, make the skin regain elasticity, become fair, bright, and remove skin wrinkles. Palmitoyl tetrapeptide-7 can promote collagen synthesis and stimulate an increase in the hyaluronic acid content in the skin, maintaining skin elasticity. Decapeptide-4 can penetrate the dermis to stimulate the synthesis of collagen and elastin, stimulate the proliferation of elastic fibers and hyaluronic acid, etc., and increase the water content of the skin.

[0019] Trace components of hydrolyzed royal jelly protein and folic acid can enhance the content of skin collagen, relieve skin irritation and prevent the formation of wrinkles and sagging. It has strong antioxidant ability, can eliminate free radicals and prevent skin aging. Disodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, and sodium citrate, as a buffer system, can stabilize the formulation and the activity of polypeptides.

[0020] When this specific embodiment needs to be used in conjunction with a solvent solution, the usage method is as follows: Take out one bottle of freeze-dried powder and one bottle of solvent solution, remove the lid according to the direction indicated on the bottle cap, pour the solvent solution into the bottle of freeze-dried powder, mix well, attach a dropper, and after cleansing the skin, take an appropriate amount of the mixed and shaken liquid and apply it to the facial skin, gently massage until absorbed.

[0021] This specific embodiment contains collagen, polypeptides and plant extracts, which can provide rich nutrients for the skin, fundamentally repair the skin, deeply care for the skin, moisturize and soothe, tighten and anti-wrinkle, make the skin moist, bright, elastic and firm. Moreover, it has high safety performance, no side effects on the human body, and has broad market application prospects.

[0022] Example 1: Collagen polypeptide firming and anti-wrinkle lyophilized powder, composed of the following components by mass percentage: water 74%, butylene glycol 4.69%, Bacillus / soybean fermentation product extract 3.565%, soluble collagen 3%, acetyl hexapeptide-8 0.15%, panthenol 1%, 1,2-hexanediol 0.666%, ectoine 0.55%, hydroxypropyltetrahydropyrantriol 0.55%, tremella polysaccharide 0.45%, isomerized sugar 0.25%, bifida ferment lysate 5%, sodium hyaluronate 0.18%, sodium DNA 0.15%, gentiana root extract 0.13%, mannitol 5%, palmitoyl tripeptide-1 0.16%, palmitoyl tetrapeptide-7 0.15%, oligopeptide-1 0.14%, decapeptide-4 0.17%, oligopeptide-3 0.03%, hydrolyzed royal jelly protein 0.0045%, folic acid 0.002%, disodium hydrogen phosphate 0.006%, sodium dihydrogen phosphate 0.0035%, citric acid 0.0015%, sodium citrate 0.0015%.

[0023] Example 2: Collagen polypeptide firming and anti-wrinkle lyophilized powder, composed of the following components by mass percentage: water 73%, butylene glycol 5.08%, Bacillus / soybean fermentation product extract 3.822%, soluble collagen 3.2%, acetyl hexapeptide-8 0.2%, panthenol 0.9%, 1,2-hexanediol 0.686%, ectoine 0.65%, hydroxypropyltetrahydropyrantriol 0.65%, tremella polysaccharide 0.5%, isomerized sugar 0.15%, bifida ferment lysate 4.8%, sodium hyaluronate 0.21%, sodium DNA 0.16%, gentiana root extract 0.12%, mannitol 5.2%, palmitoyl tripeptide-1 0.18%, palmitoyl tetrapeptide-7 0.14%, oligopeptide-1 0.13%, decapeptide-4 0.16%, oligopeptide-3 0.04%, hydrolyzed royal jelly protein 0.0051%, folic acid 0.003%, disodium hydrogen phosphate 0.007%, sodium dihydrogen phosphate 0.0037%, citric acid 0.0016%, sodium citrate 0.0016%.

[0024] Example 3: Collagen polypeptide firming and anti-wrinkle lyophilized powder, which is composed of the following components by mass percentage: water 74.3%, butylene glycol 4.38%, Bacillus / soybean ferment extract 3.67%, soluble collagen 2.8%, acetyl hexapeptide-8 0.1%, panthenol 1.1%, 1,2-hexanediol 0.676%, ectoine 0.6%, hydroxypropyltetrahydropyrantriol 0.5%, tremella polysaccharide 0.46%, carbohydrate isomerate 0.2%, bifida ferment lysate 5.2%, sodium hyaluronate 0.15%, sodium DNA 0.12%, gentiana root extract 0.11%, mannitol 4.9%, palmitoyl tripeptide-1 0.17%, palmitoyl tetrapeptide-7 0.16%, oligopeptide-1 0.15%, decapeptide-4 0.18%, oligopeptide-3 0.05%, hydrolyzed royal jelly protein 0.0047%, folic acid 0.004%, disodium hydrogen phosphate 0.008%, sodium dihydrogen phosphate 0.0041%, citric acid 0.0017%, sodium citrate 0.0015%.

[0025] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. What is described in the above embodiments and the specification only illustrates the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of the present invention claimed is defined by the appended claims and their equivalents.

Claims

1. Collagen polypeptide firming and anti-wrinkle lyophilized powder, characterized in that, It consists of the following components by mass percentage: water 72 - 78%, butylene glycol 4.25 - 5.15%, Bacillus / soybean ferment extract 3.555 - 3.876%, soluble collagen 2.8 - 3.2%, acetyl hexapeptide - 8 0.1 - 0.2%, panthenol 0.8 - 1.1%, 1,2 - hexanediol 0.655 - 0.686%, ectoine 0.5 - 0.9%, hydroxypropyltetrahydropyrantriol 0.5 - 1%, tremella polysaccharide 0.42 - 0.52%, carbohydrate isomerate 0.15 - 0.35%, bifida ferment lysate 4.8 - 5.2%, sodium hyaluronate 0.13 - 0.25%, sodium DNA 0.12 - 0.22%, gentiana root extract 0.11 - 0.18%, mannitol 4.5 - 5.5%, palmitoyl tripeptide - 1 0.15 - 0.18%, palmitoyl tetrapeptide - 7 0.13 - 0.17%, oligopeptide - 1 0.12 - 0.18%, decapeptide - 4 0.14 - 0.19%, oligopeptide - 3 0.03 - 0.06%, hydrolyzed royal jelly protein 0.0045 - 0.006%, folic acid 0.002 - 0.004%, disodium hydrogen phosphate 0.006 - 0.009%, sodium dihydrogen phosphate 0.0035 - 0.0056%, citric acid 0.0015 - 0.0027%, sodium citrate 0.0015 - 0.0025%.

2. The collagen polypeptide firming and anti-wrinkle freeze-dried powder according to claim 1, wherein It consists of the following components by mass percentage: water 74%, butylene glycol 4.69%, Bacillus / soybean ferment extract 3.565%, soluble collagen 3%, acetyl hexapeptide - 8 0.15%, panthenol 1%, 1,2 - hexanediol 0.666%, ectoine 0.55%, hydroxypropyltetrahydropyrantriol 0.55%, tremella polysaccharide 0.45%, carbohydrate isomerate 0.25%, bifida ferment lysate 5%, sodium hyaluronate 0.18%, sodium DNA 0.15%, gentiana root extract 0.13%, mannitol 5%, palmitoyl tripeptide - 1 0.16%, palmitoyl tetrapeptide - 7 0.15%, oligopeptide - 1 0.14%, decapeptide - 4 0.17%, oligopeptide - 3 0.03%, hydrolyzed royal jelly protein 0.0045%, folic acid 0.002%, disodium hydrogen phosphate 0.006%, sodium dihydrogen phosphate 0.0035%, citric acid 0.0015%, sodium citrate 0.0015%.

3. The collagen polypeptide firming and anti-wrinkle freeze-dried powder according to claim 1, wherein Composed of the following components by mass percentage: water 73%, butylene glycol 5.08%, Bacillus / soybean ferment extract 3.822%, soluble collagen 3.2%, acetyl hexapeptide-8 0.2%, panthenol 0.9%, 1,2-hexanediol 0.686%, ectoine 0.65%, hydroxypropyltetrahydropyrantriol 0.65%, tremella polysaccharide 0.5%, carbohydrate isomerate 0.15%, bifida ferment lysate 4.8%, sodium hyaluronate 0.21%, sodium DNA 0.16%, gentiana root extract 0.12%, mannitol 5.2%, palmitoyl tripeptide-1 0.18%, palmitoyl tetrapeptide-7 0.14%, oligopeptide-1 0.13%, decapeptide-4 0.16%, oligopeptide-3 0.04%, hydrolyzed royal jelly protein 0.0051%, folic acid 0.003%, disodium hydrogen phosphate 0.007%, sodium dihydrogen phosphate 0.0037%, citric acid 0.0016%, sodium citrate 0.0016%.

4. The collagen polypeptide firming and anti-wrinkle lyophilized powder according to claim 1, wherein Composed of the following components by mass percentage: water 74.3%, butylene glycol 4.38%, Bacillus / soybean ferment extract 3.67%, soluble collagen 2.8%, acetyl hexapeptide-8 0.1%, panthenol 1.1%, 1,2-hexanediol 0.676%, ectoine 0.6%, hydroxypropyltetrahydropyrantriol 0.5%, tremella polysaccharide 0.46%, carbohydrate isomerate 0.2%, bifida ferment lysate 5.2%, sodium hyaluronate 0.15%, sodium DNA 0.12%, gentiana root extract 0.11%, mannitol 4.9%, palmitoyl tripeptide-1 0.17%, palmitoyl tetrapeptide-7 0.16%, oligopeptide-1 0.15%, decapeptide-4 0.18%, oligopeptide-3 0.05%, hydrolyzed royal jelly protein 0.0047%, folic acid 0.004%, disodium hydrogen phosphate 0.008%, sodium dihydrogen phosphate 0.0041%, citric acid 0.0017%, sodium citrate 0.0015%.

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