31 results about "Ascites" patented technology

The application discloses a compound with the function of purgation and water excretion, which has a chemical structural formula as shown in formula (I). The compound is a new natural product of tetracyclic triterpenes, has good fat solubility and chemical stability, can be conveniently extracted from the rhizome of the herbal medicine Alisma orientale and prepared into an oral or injection dosage form. The application further provides a preparation method and application of the compound. The compound can obviously inhibit the increase of the abdominal volume and the weight of ascites of mice in a dose-dependent manner, and is a new water excretion drug with great potential.

The invention discloses a multi-channel ascites drainage treatment device. Relates to the technical field of ascites drainage appliances and comprises a drainage box and a drainage tube, water outlets are formed in the four ends of the side face of the drainage box, and drainage connecting mechanisms used for being connected with the drainage tube are installed at the water outlets; through cooperation of multiple groups of drainage heads, connecting cylinders, connectors and drainage tubes, the number of the connected drainage tubes can be flexibly selected according to the ascites flow of a patient, and the clinical use convenience is improved; through cooperation of an extrusion ring, a connecting rod, a connecting ring, a first extrusion rod, a second extrusion rod, a double-extrusion plate, a first spring and a second spring, stored ascites is fully extruded, leakage of residual liquid when the device is dismantled is avoided, and drainage thoroughness is guaranteed; through cooperation of a plugging ball, a first spring, a sealing cover, drainage box mucilage glue, a reinforcing paste and a rubber block, liquid leakage of an idle channel is avoided, ascites is effectively prevented from leaking from the periphery of a wound, and clothes and a bed sheet of a patient are kept dry.

The invention discloses clinical ascites drainage equipment for the digestive system department, and belongs to the technical field of ascites drainage, the clinical ascites drainage equipment comprises a drainage cylinder and a puncture assembly puncturing into the abdomen of the human body, the drainage cylinder is communicated with the puncture assembly through a drainage tube assembly, and the puncture assembly comprises a puncture needle used for puncturing into the abdomen of the human body to lead out ascites; the guide cylinder is connected with the rear end of the puncture needle; the drainage cylinder comprises a first drainage cavity which is arranged at the upper half part of the drainage cylinder which is transversely arranged; the second drainage cavity is formed in the end part of the drainage cylinder below the first drainage cavity, and a second drainage opening is formed in one end of the second drainage cavity; the liquid collecting cavities are distributed in the drainage cylinder at the rear end of the second drainage cavity at equal intervals. Through cooperation of the puncture assembly, the drainage tube assembly and the drainage cylinder, the dredging effect is achieved when the drainage tube assembly is blocked, blocking is prevented, and when the ascites amount is too large, ascites is shunted, and the ascites discharging pressure is reduced.

The application discloses a superovulation method based on synergistic effect of composite hormones, which comprises the following steps: injecting PMSG and FSH to induce estrus, and injecting hCG to promote synchronous ovulation. The application adopts synergistic regulation of PMSG (long-acting follicle-stimulating hormone) and FSH (short-acting follicle-stimulating hormone), PMSG completes follicle recruitment, and FSH finely regulates the development stage, thereby avoiding overgrowth of follicles. In the examples, the Burmese cat, the British short cat and the farm cat do not appear OHSS symptoms (such as ovarian enlargement and ascites), and the ovarian state is normal.

This invention provides a traditional Chinese medicine composition for treating renal edema, pyelonephritis with ascites, and nephritis. It consists of over 20 herbs including Atractylodes lancea, Areca catechu, Saposhnikovia divaricata, and Alisma plantago-aquatica (specific formulation details can be found in the original text). It can be prepared as pills, granules, or decoctions for oral administration. Core efficacy: 1. Promotes diuresis and reduces swelling, eliminating renal ascites; 2. Clears heat and detoxifies, anti-inflammatory and antibacterial (synergistic effect on fungal infections and cervical erosion); 3. Regulates renal function and improves abnormal uric acid metabolism. Treatment plan: Mild cases: Use five basic formulas (①-⑤) composed of Codonopsis pilosula, Poria cocos, etc., taken three times daily; Severe cases: Use a potent diuretic formula containing Akebia trifoliata and Euphorbia pekinensis (one spoonful of pills twice daily); Treatment course is approximately one month, with a follow-up examination after three months. Advantages: Cure rate reaches 90%, low recurrence rate – pure traditional Chinese medicine preparation, no significant toxic side effects; also treats complications (fungal infection, cervical lesions). This treatment plan has been clinically verified through three generations and has significant efficacy in treating renal edema, ascites, and nephritis.

This invention belongs to the field of biomedical technology, specifically relating to a human-derived cell line for peritoneal metastasis of gastric cancer and its applications. The invention involves collecting ascites from gastric cancer patients and culturing it into organoids. These organoids are then transplanted subcutaneously into immunodeficient mice to form xenografts (PDOX). The transplanted organoids are digested and passaged in vitro to obtain a purified cell line. The primary isolated cell line is then inoculated into the peritoneal cavity of immunodeficient mice to induce the formation of metastatic ascites. Cells are extracted from the metastatic ascites and cultured again into organoids to construct human gastric cancer ascites cells, named BZGC. The cell line constructed in this invention has the ability to form 100% metastatic ascites in the mouse peritoneal cavity, fully simulating the entire process of ascites formation in gastric cancer peritoneal metastasis. The human-derived gastric cancer ascites cells described in this invention provide a stable, reliable, and highly clinically and pathologically similar in vitro and in vivo model for studying the mechanism of gastric cancer peritoneal metastasis, drug screening, and personalized treatment.

A catgut implant for treating ascites and a preparation method thereof belong to the technical field of catgut preparation. Raw materials are as follows in percentage by mass: 27-31% of Gansui Banxia extract, 25-28% of humectant, 27-31% of water, 0.5-0.8% of glycyrrhizic acid, 5-9% of polyacrylic acid sodium, 1.5-4% of carboxymethyl cellulose sodium, 0.9-2.5% of polyvinylpyrrolidone, 0.03-0.06% of disodium edetate, 0.2-1.3% of organic acid, 0.5-0.9% of filling agent and 0.2-2% of transdermal penetration enhancer. The catgut implant improves the production process of catgut, reduces the production cost of catgut, has good formability and adhesion, and prepares Gansui Banxia decoction for treating ascites into catgut implant with controllable quality.

The invention discloses quantitative suction and specimen subpackaging equipment for ascites detection, which comprises an equipment box, a suction device, a jacking cam divider and a bearing device, and is characterized in that the jacking cam divider is arranged on a mounting frame of the equipment box and is provided with a plurality of mounting stations which are distributed in the circumferential direction and can be lifted; the plurality of bearing devices are detachably arranged on the plurality of mounting stations respectively; the suction device is arranged in the equipment box, and an electromagnetic valve is arranged at the liquid discharge end of the suction device; each bearing device comprises a bearing seat, a trigger structure and a bearing container, and the bearing seats are detachably arranged on the mounting stations; the receiving container is detachably arranged in the receiving seat and is used for receiving liquid discharged from the liquid discharge end of the suction device; the trigger structure is arranged in the bearing seat so as to control opening and closing of the electromagnetic valve; the split charging efficiency is high, the split charging precision is far higher than that of manual operation, and the required bearing device can be quickly disassembled and assembled according to different detection items.

The utility model provides hospital dress trousers suitable for ascites patients, and relates to the field of patient clothes. According to the hospital dress trousers suitable for the ascites patient, a main body of the hospital dress trousers is composed of trouser leg parts and separation blade parts, the separation blade parts are arranged to be of a split type structure, that is, the separation blade parts are provided with back waist separation blades and front abdomen separation blades which are detachably connected through hook-and-loop fasteners, and therefore the waistline of the hospital dress trousers can be flexibly adjusted according to the actual waistline of the patient; the skin of the patient cannot be damaged by extrusion and the like, and the comfort level is high; in addition, the split-type separation blade part can be convenient for the patient to put on and take off. Furthermore, a plurality of catheter through holes are formed in the front abdomen blocking piece of the hospital dress trousers, so that an abdominal cavity drainage tube can be conveniently arranged; the trouser legs of the hospital dress trousers are further provided with the hanging buckle assemblies used for being connected with the drainage bags, and therefore the patient can conveniently get out of a bed to walk.

The invention discloses an ascites drainage control device, and belongs to the technical field of medical instruments, the ascites drainage control device comprises a control assembly, the front end of the control assembly is connected with a first drainage tube, the rear end of the control assembly is connected with a second drainage tube, the first drainage tube is used for being placed in an abdominal cavity, and the second drainage tube is used for being connected with a drainage ball. Complications such as abrupt pressure drop of the abdominal cavity, hypotension and hepatic encephalopathy caused by out-of-control flow velocity of traditional equipment are effectively avoided through the flow velocity adjusting mechanism; through magnetic positioning and fixing buckle design, it is guaranteed that the adjusting state is stable, the pipeline is fixed reliably, and the risks of drainage tube disengagement, displacement, folding, winding and infection are reduced; two-way dredging of the pipeline can be completed without additional instruments, the problem of blood clot and fiber tissue blockage is solved quickly, and drainage interruption is avoided.

Methods, compounds and combinations useful for treating or delaying progression of cancer or reducing ascites formation or volume in an individual comprising administering to the individual an effective amount of a PARP inhibitor and a compound of Formula I: wherein R is H, an in vivo cleavable linker or group, or a leaving group in aqueous solution and R1 and R2 are independently, H, alkyl, an aryl, a substituted alkyl, a substituted phenyl, a substituted aryl, or a combination thereof.

The invention relates to the technical field of drainage equipment, and provides digestive system department clinical ascites drainage equipment which comprises a protective cover, a drainage tube is slidably arranged in the middle of the top of the protective cover, an adjusting assembly is arranged at the top of the drainage tube, a metal ring is arranged at the bottom of the outer side of the drainage tube, and a spring is arranged at the top of the metal ring. Telescopic rods are slidably arranged on the two sides of the top of the metal circular ring, magnets are arranged on the tops of the two telescopic rods, second annular ratchet racks are arranged at the bottoms of the two telescopic rods, protruding blocks are arranged at the bottoms of the two sides of the drainage pipe, the bottom of the outer side of the drainage pipe is sleeved with a connecting pipe, and L-shaped connecting grooves are formed in the two sides of the connecting pipe; a first annular ratchet rack is arranged at the bottom of the outer side of the connecting pipe, and the outer side of the connecting pipe is sleeved with a drainage assembly. The drainage cover can be detached, all-directional cleaning and disinfection are carried out, the cleanliness of the device is improved, and the infection risk of the device to the peritoneal drainage part is reduced.

The invention discloses an application of superior tiderone in treating malignant ascites. In particular, the present invention provides the use of pretiderone or a pharmaceutically acceptable salt thereof for the treatment of malignant ascites. According to the present invention, the stomach cancer patient ascites source organoid model experiment results show that different from the conventional anti-tumor drugs (such as platinum drugs), the superior tiderone can effectively reduce and inhibit the malignant ascites caused by tumors; the invention breaks through the limitation of original indications, and provides a new treatment approach and scheme for reducing and inhibiting generation of malignant ascites.

The application provides a traditional Chinese medicine composition for treating malignant ascites of spleen-kidney yang deficiency, a hot compress bag and a preparation method and application thereof. The traditional Chinese medicine composition has the effects of benefiting qi and removing water by Huangqi, warming yang and dispelling cold, dredging lower energizer by Rougui, Ganjiang, Wuzhuyu and Xiaohuixiang, removing dampness and promoting water excretion by Dafupi, Laiqiezi and Fuling, promoting blood circulation and removing blood stasis by Danggui, and searching and dredging meridians by using worm medicines such as Dilong, Quanxie and Wanglong. The hot compress bag is closely related to the core pathogenesis of malignant ascites of spleen-kidney yang deficiency, and aims to realize the treatment purposes of warming yang qi, dredging Sanjiao and transforming qi to remove water through the comprehensive effects of transdermal absorption of skin acupoints and physical hot compress. The hot compress bag combined with abdominal puncture drainage can reduce the ascites load of patients with malignant ascites of spleen-kidney yang deficiency, and has a positive effect on stabilizing the quality of life of patients and a clear advantage in improving the core syndromes of patients, such as abdominal distension, aversion to cold and fatigue.

The invention relates to the technical field of ascites drainage, and provides a digestive system department ascites drainage device which comprises a shell and a separation baffle vertically and fixedly connected to the inner bottom wall of the shell, and the interior of the shell is divided into a cavity liquid storage bin and an air exhaust bin through the separation baffle; two vertical guide grooves are fixedly formed in the side wall of the shell, and a rolling wheel is arranged between the two guide grooves in a sliding mode. A drainage tube is fixedly arranged on the side wall of the shell; an air exhaust sliding block slides in the air exhaust bin, the upper wall of the air exhaust sliding block is fixedly connected with a guide block, and the guide block and the rolling wheels are arranged in a transmission mode; a one-way exhaust valve is fixedly arranged on the upper wall of the shell. The extrusion degree of the drainage tube is changed by rolling the roller, so that the drainage rate is adjusted; when the roller rolls, the air exhaust sliding block is driven to move, air in the device is exhausted through the one-way exhaust valve, negative pressure is formed, and power is provided for ascites drainage; after drainage is completed, the device is inverted, ascites is discharged through the one-way exhaust valve, the air exhaust sliding block falls down, and ascites emptying can be assisted.

The utility model discloses an anti-leakage medical application for a drainage tube, which comprises an absorption dressing and a pressurization dressing, the absorption dressing comprises a lower absorption layer, the center of the lower absorption layer is provided with a lower tube hole, and the edge of the lower tube hole leading to the lower absorption layer is provided with a lower separation line; the pressurized dressing comprises an upper absorption layer, a silica gel plug and a waterproof layer which are sequentially attached from bottom to top. The shapes and sizes of the cross sections of the lower absorption layer, the upper absorption layer and the silica gel plug are the same and are smaller than the size of the waterproof layer. According to the drainage tube, the puncture opening of the drainage tube is pressurized, the puncture opening is blocked, ascites or pleural fluid possibly leaking out of the puncture opening is absorbed at the same time, the dry and sterile environment in the sterile dressing is guaranteed, the times of dressing replacement and the infection incidence rate are reduced, and the medical compliance of a patient is improved.

The application provides an ascites collection device, and belongs to the technical field of medical devices, to solve the problems of complex structure, high cost and inability to adjust the angle of the puncture needle when puncturing the patient's skin in the prior art. The height-adjustable fixing base is clamped on one side of the hospital bed, and then the needle tip angle adjusting mechanism is used to adjust the needle insertion angle of the puncture needle arranged on the collection needle tube, and then the needle head sliding positioning mechanism is used to adjust the specific position of the puncture needle arranged on the collection tube. Thus, the ascites provided by the application can be matched and connected with any hospital bed on the market, the structure is simple, the installation is convenient, and the needle tip angle adjusting mechanism can adjust the needle insertion angle of the puncture needle on the collection needle tube, which is convenient for medical staff to operate.

The invention relates to the technical field of drainage equipment, and particularly discloses clinical ascites drainage equipment for the gastroenterology department, the clinical ascites drainage equipment comprises a cart, the top end of the cart is fixedly connected with an ascites collecting box, one side of the ascites collecting box is fixedly connected with a drainage hose, and when ascites in the box is accumulated to a preset liquid level, the drainage hose is connected with the ascites collecting box. The floating plate pushes the touch plate to move upwards along with rising of the liquid level, the touch rod makes contact with the touch switch to trigger alarm, medical staff can be reminded of timely treatment in real time, ascites overflow caused by the fact that the medical staff cannot observe in real time is avoided, the medical environment is effectively prevented from being polluted, and the local infection risk caused by the fact that ascites makes contact with a puncture part or the skin of a patient is reduced. Medical staff do not need to stare at the liquid level in real time, other work can be reasonably arranged, meanwhile, treatment can be conducted in time before the collecting box overflows, it is avoided that drainage operation is forced to be interrupted due to the fact that the collecting box overflows, the continuous and stable ascites drainage process is guaranteed, and treatment continuity is guaranteed.

The invention discloses an anti-blocking device for a malignant pleuroperitoneal fluid drainage tube, and belongs to the field of medical instruments. An anti-blocking device for a malignant hydrothorax and ascites drainage tube comprises a detachable injector tube, anticoagulant liquid is contained in the detachable injector tube, the detachable injector tube is connected with a main catheter through a fixing piece, a tail-end needle penetrates through a macromolecule layer diaphragm to reach a cavity of the main catheter, and a medicine injection opening is formed in the wall of the injector tube; the piston is arranged in the main catheter, and a circular groove is formed in the bottom of the piston and matched with a separable connector at the front end of the push rod mechanism; a main body of the push rod mechanism is a high-precision gear-rack mechanism, the mechanism is directly driven by a stepping motor, large-range and small-unit metering injection of the anticoagulant is realized, and an operator can adjust single injection metering through a control panel; the whole device is powered by a battery pack, and the battery pack can be externally connected with a type-C charging line for charging. The injection amount of the anticoagulant medicine solution can be self-defined according to actual requirements, and therefore the effective anti-blocking function of the hydrothorax and ascites drainage tube is achieved.

The utility model relates to medical technology field discloses intelligent nursing abdominal belt control device of ascites drainage, including main control device, the inside fixed connection of main control device has the effusion detection component of judging whether the effusion of patient abdominal puncture part has occurred, the inside electric connection of main control device has internal pressure sensor through signal line, the inside electric connection of main control device has external pressure sensor through signal line, the inside electric connection of main control device has the outer layer air bag inflation pump through control wire, the inside electric connection of main control device has the inner layer air bag inflation pump through control wire, the inside electric connection of main control device has the inner layer air bag deflation valve through control wire, in the utility model, the device detects that ascites exudes at puncture point, then automatically pressurizes and reduces the exosmosis, when patient ascites discharge reaches the preset value, automatically stops discharging, greatly improves work efficiency.

The present application relates to ascites drainage technical field, specifically, it relates to a kind of ascites drainage device for cirrhosis nursing, including the collection component for collecting ascites and the drainage tube component for draining ascites, and the drainage tube component is equipped with the clear block component for cleaning the tissue material blocked in the drainage tube component;Clear block component includes movable sleeve structure, extrusion structure, the pressing structure for triggering extrusion structure contraction extrusion and the press handle structure for pushing the pressing structure, which are movably sleeved on the drainage tube component;Movable sleeve structure includes barrel movable sleeve, mounting groove and pressing groove.The device is provided with clear block component, after the drainage tube is blocked by tissue material when cirrhosis patient is drained, medical staff can hold press handle structure to clear block, it is simple and convenient;After clearing block, through the cooperation of first magnetic buckle, first magnetic attraction slot and limiting bolt, the drainage tube can be further extruded and closed, reduce the infection risk caused by subsequent cleaning collection barrel.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating ascites in liver cirrhosis, its preparation method, and its uses. The traditional Chinese medicine composition is made from raw materials including tortoise shell, turtle shell, polygonatum, glehnia root, ophiopogon root, oyster shell, chicken gizzard lining, schisandra fruit, licorice root, citron, raw atractylodes rhizome, water lily seed, and paper mulberry fruit. It has the effects of nourishing yin and softening hardness, resolving blood stasis and promoting diuresis, and strengthening the spleen and regulating qi. It is mainly used to treat ascites in liver cirrhosis. This invention's traditional Chinese medicine composition targets the core pathogenesis of liver cirrhosis ascites—liver and kidney yin deficiency, blood stasis, and spleen deficiency with dampness—achieving both symptomatic and root-cause treatment, effectively improving patient symptoms and enhancing clinical efficacy. Furthermore, this invention provides a preparation method for the traditional Chinese medicine composition, ensuring its stable and controllable quality, suitable for industrial production.

The invention belongs to the technical field of medical instruments, and particularly provides a digestive system department ascites drainage device which comprises two supporting mechanisms symmetrically arranged, a pull-out type bearing mechanism is arranged on the upper portions of the supporting mechanisms, a positioning mechanism is movably arranged on the pull-out type bearing mechanism, a transition mechanism is arranged on the positioning mechanism, and the transition mechanism is connected with the supporting mechanisms. The transition mechanism is connected with a puncture needle, and the pull-out type bearing mechanism is further provided with a magnetomotive adjusting mechanism. According to the ascites drainage device for the gastroenterology department, the body position of a patient and the position of the puncture needle can be stabilized conveniently, the electromagnetic principle is combined with an assembly type structure, and the arranged magnetomotive adjusting mechanism is used, so that the drainage speed can be dynamically adjusted according to the ascites amount in the abdominal cavity of the patient on the premise that the shape of the catheter is not changed in the ascites drainage process; when ascites in the abdominal cavity of the patient is reduced, the drainage speed is reduced in time, drainage is stopped in time when the drainage bag reaches the fixed drainage amount, and discomfort of the patient is avoided.

The invention relates to the technical field of medical instruments, and discloses an ascites puncture point leakage prevention device which comprises a leakage prevention mechanism. The hemispherical cover body can store ascites and is of a hollow structure, and the adhesive is arranged at the opening end of the hemispherical cover body and can be adhered to the skin of a patient. The threaded drainage end can be connected with an ascites discharge pipeline in a threaded mode, and the annular installation opening is formed in the middle of the hemispherical cover body and used for installation of a drainage tube in a penetrating mode. The device for preventing the ascites puncture point from leaking can be used after puncture drainage work and can also be used during puncture drainage work, so that the use scene of the device is effectively improved, and in addition, the device can effectively prevent the ascites from leaking outwards.

The invention discloses a culture medium and a culture method of a gastric cancer ascites source organoid. The culture medium is prepared by compounding a gastric cancer organ culture medium (hereinafter referred to as a GCO culture medium) and treated gastric cancer ascites supernatant according to a specific proportion, can efficiently simulate an in-vivo microenvironment, supports and maintains the activity and characteristics of gastric cancer ascites-derived tumor cells, and has a good application prospect. And an organ-like model which is highly faithful to the primary tumor in phenotype and genotype is successfully constructed. According to the culture method provided by the invention, the preferable standard of an ascites sample is defined, the operation is standard, the repeatability is high, and a stable and reliable in-vitro research model is provided for disease research, drug screening and individualized treatment of gastric cancer, especially advanced gastric cancer accompanied by malignant ascites.

The invention discloses a novel endoscopic aspirator with an ascites collection function, and belongs to the technical field of aspirators. The novel endoscopic aspirator comprises a handle and an aspiration tube, and the handle is connected with the aspiration tube; the second valve comprises an inner pipe and an outer pipe, a partition plate is fixedly connected to the interior of the inner pipe, the liquid collecting cavity communicates with a suction arc opening, the outer pipe is provided with a suction opening communicating with the suction arc opening all the time, the liquid collecting cavity further communicates with a flowing opening, and a liquid opening and a collecting opening are formed in the side, located on the liquid collecting cavity, of the outer pipe; the outer pipe is provided with a gas port and an output port on the side of the gas collecting cavity, and the inner pipe is provided with an auxiliary gas port and an auxiliary output port; the collecting opening communicates with a collecting bottle through a connecting pipe, and the top of the collecting bottle communicates with the output opening through a connecting pipe. The device is simple and easy to operate, ascites can be directly sucked into the liquid collecting cavity through negative-pressure suction force by directly rotating the twisting block, then the ascites flows into the collecting bottle to be stored, operation is convenient, and one-hand operation can be achieved.

The utility model discloses a bellyband type ascites absorption towel which comprises a bellyband and an absorption towel, the bellyband and the absorption towel are fixedly connected through a hook-and-loop fastener, and a transparent observation opening is formed in the middle of the absorption towel. A composite layer structure is arranged in the middle of the bellyband and comprises an attaching layer, an absorbing layer, a conducting layer and a fixing layer. PH test paper is arranged on the conducting layer. The bellyband type ascites absorption towel integrates multiple functions of ascites absorption, observation and monitoring, comfortable fixation and the like, and a comprehensive and convenient nursing solution is provided for ascites patients. The ascites problem can be effectively solved, convenience can be provided for patients and medical staff in daily nursing, the nursing efficiency and quality are improved, the patients can better manage diseases, and the life quality is improved.

Ascites and pleural effusion are common complications, and clinical interventions primarily based on symptomatic treatment often result in poor prognoses. Guided by the new theory of "inflammation-cancer" transformation, this invention discloses a traditional Chinese medicine composition for the prevention and treatment of ascites and pleural effusion, along with its preparation methods for internal and external use. The composition comprises the following medicinal materials in parts by weight: Codonopsis pilosula 3-20 parts, Atractylodes macrocephala 3-20 parts, Cinnamomum cassia 3-18 parts, Trichosanthes kirilowii 3-18 parts, Panax notoginseng 3-12 parts, Lobelia chinensis 3-15 parts, Polygonum bistorta 3-15 parts, Euphorbia helioscopia 3-15 parts, and Lepidium apetalum 3-15 parts. This traditional Chinese medicine composition possesses the effects of strengthening the body's resistance, removing blood stasis, detoxifying, eliminating dampness, promoting diuresis, and reducing swelling. It is effective in preventing and treating inflammatory and malignant ascites and pleural effusion, as well as the associated symptoms such as dyspnea, chest pain, cough, loss of appetite, abdominal pain, abdominal distension, fatigue, and night sweats. It can be prepared as a decoction, granules, pills, capsules, or powder. This invention helps promote the absorption and drainage of pleural and peritoneal effusions, reduce inflammation and fight cancer, adjust and restore the physiological functions of internal organs, and improve the quality of life of patients.

The invention provides an application of a DANA combined anti-PD-1 antibody in preparation of a medicine for treating ovarian cancer. The application comprises an application in preparation of a medicine for enhancing sensitivity of a patient to the anti-PD-1 antibody and an application in preparation of a medicine for enhancing proliferation and killing activity of CD8 + T cells of the patient. It is found for the first time that DANA treatment can remarkably enhance the treatment effect of the anti-PD-1 antibody in ovarian cancer, and it is indicated that the combination of DANA and the anti-PD-1 antibody is a new strategy for ovarian cancer combined immunotherapy; dANA treatment can significantly inhibit in-situ growth, ascites formation and abdominal cavity metastasis of ovarian cancer; the DANA treatment can significantly enhance the proliferation ability and killing ability of ovarian cancer CD8 + T cells by targeting NEU4, and the anti-PD-1 antibody treatment has a synergistic activation effect.