79 results about "Vena porta" patented technology

The invention provides a portal vein pressure adjusting support and a production method thereof, and belongs to the technical field of medical instruments.The adjusting support comprises a cylindrical support body, the support body is provided with a first section and a second section which are integrally arranged, and the side wall of the first section is provided with a film-shaped component used for sealing and isolating the outer side and an inner cavity of the support body; a pressure adjusting valve is arranged in an inner cavity of the first section, is opened for blood flow to pass through when the pressure in the portal vein is larger than a set threshold value, and is closed to cut off the blood flow when the pressure in the portal vein is smaller than the set threshold value; the stent can automatically adjust the opening and closing state of the shunt channel according to the portal vein real-time pressure, and ineffective shunt is reduced to the maximum extent while it is ensured that the portal vein pressure is reduced to a safe range, so that the occurrence risk of hepatic encephalopathy is reduced.

The invention belongs to the technical field of medical diagnosis, and discloses a marker for evaluating the curative effect of treating hepatocellular carcinoma by combining TACE with Czodili monoclonal antibody and bevacizumab, and a construction method and application of an FAAP prognostic scoring model. The invention develops and verifies an FAAP prognostic scoring system, and a novel composite model integrates four indexes of fibrin degradation product / cholinesterase ratio * 1000 (FCR), aspartate aminotransferase (AST), alpha fetoprotein (AFP) and portal vein tumor thrombus (PVTT), and is used for predicting the survival condition of uHCC patients subjected to TACE-Czodimab-bevacizumab triple therapy. The tool has an instant clinical value, can optimize patient selection, guides adaptive treatment upgrading, and provides a standardized curative effect evaluation basis for a clinical test for exploring a TACE-immunotherapy-anti-angiogenesis combined scheme.

The present application relates to a kind of stent delivery device and stent delivery system.The stent delivery device includes inner tube, outer tube, limiting sleeve and release sleeve;Limiting sleeve, release sleeve are sleeved on the outside of inner tube, outer tube is sleeved on the outside of limiting sleeve, release sleeve, limiting sleeve is located at the distal end side of release sleeve;The distal end of release sleeve is provided with restraint wire, and the bare section of stent is restrained outside limiting sleeve by restraint wire, release sleeve can move towards the proximal end of outer tube under the action of external force until the bare section is released by restraint wire.The stent delivery device, when releasing the film section of stent in advance, the bare section is restrained outside limiting sleeve by restraint wire, so that itself cannot be self-inflating, and the stent cannot "front jump", so as to reduce the risk of blocking portal vein branch.

The utility model relates to an automatic adjustment hepatic duodenal ligament portal vein and hepatic arterial blood flow on-off device which comprises a soft rubber sleeve, a handle, a connecting pipe, a first clamping strip, a second clamping strip, a rotating shaft, a flexible wire and a flexible wire control mechanism. The first clamping strip and the second clamping strip are sleeved with the soft rubber sleeve, one end of the connecting pipe is connected to the soft rubber sleeve, the other end of the connecting pipe is connected to the handle, the flexible wire control mechanism is arranged on the handle, the flexible wire is inserted into the connecting pipe in a penetrating mode, one end of the flexible wire is connected to the first clamping strip, and the other end of the flexible wire is connected to the flexible wire control mechanism. According to the utility model, the defects of the existing porta hepatis occlusion technology can be overcome, more accurate, safer and more convenient blood flow occlusion and conduction control can be realized, and the surgical risk and liver injury can be reduced.

A TIPS (Transient Invasive Stent) for flow restriction includes a bare stent with a fixed stent connected to one side. A flow-restricting stent is disposed inside the fixed stent. The flow-restricting stent has a conical structure, with the larger end of the conical stent connected to the inner side of the fixed stent, and the smaller end of the conical stent facing the other end of the fixed stent. A drug-eluting layer is disposed inside the fixed stent. In this application, the flow-restricting stent is a streamlined cone shape with a diameter that gradually decreases from one end to the other. This conical design reduces blood flow turbulence and recirculation, lowers the risk of thrombosis, maintains high stent patency, and more rationally balances the relationship between portal hypertension and hepatic encephalopathy, thus improving patients' quality of life. In some patients, it can more stably maintain the postoperative portal vein pressure gradient within the safe range of 10-12 mmHg. The conical structure achieves a smooth pressure gradient change through a gradually decreasing diameter, which is more in line with the principles of fluid dynamics and has high clinical value in preventing hepatic encephalopathy.

The invention provides an image-clinical characterization-combined multi-endpoint prognosis evaluation method for transjugular vein intrahepatic portal vein shunt, which comprises the following steps of: constructing a few-label portal vein segmentation module to obtain a preoperative CT portal vein label of a full-dose patient, and extracting deep learning features and radiomics features of the region; establishing a multi-modal interactive representation learning module for implementation, and performing cross-modal fusion with clinical features to form unified representation; and designing a multi-endpoint prognosis prediction module, inputting the data to a plurality of prognosis task decoders for postoperative survival, portal vein pressure gradient, hepatic encephalopathy prediction and the like, and adopting a multi-task learning optimization model to obtain a postoperative multi-endpoint prognosis evaluation result. According to the method, efficient fusion and multi-endpoint prognosis prediction of images and clinical information can be realized under limited labeling, clinical doctors can be assisted in preoperative patient screening and treatment scheme making, and the method has good clinical application value.

The invention discloses a method for blood vessel segmentation, feature value extraction and data integration based on V-net, and relates to the technical field of medical image analysis. Comprising the steps that S1, a CT image of a patient is acquired and preprocessed; s2, constructing and training a V-net neural network, inputting the preprocessed CT image into the trained V-net neural network, and reconstructing a blood vessel model; s3, feature value extraction is carried out on the blood vessel model. By constructing and training the V-net neural network, the blood vessels in the patient's abdomen CT medical image are segmented and reconstructed to obtain portal vein, hepatic artery, aorta and other blood vessel models with good segmentation effects, and feature values of the blood vessel models are extracted and data are standardized through an algorithm, so that the accuracy of the blood vessel models is improved. Therefore, the CT image information can show the blood vessel form and the characteristic value in a model and datamation form, and the concerned blood vessel characteristic information can be obtained from the complex CT image.

The invention discloses a multi-modal feature fused portal vein pressure gradient acquisition method and system, and relates to the technical field of portal vein pressure acquisition, and the method comprises the steps: S1, obtaining a CT image of a patient, and carrying out the preprocessing of the CT image, and obtaining the related feature data of the CT image; s2, constructing a multi-modal feature model based on liver blood vessels in the CT image; inputting the preprocessed CT image data, the related feature data and the corresponding to-be-predicted portal vein pressure gradient label value into a model for training; and S3, inputting the preprocessed CT image data and the related feature data into the trained model, and performing prediction to obtain a portal vein pressure gradient value corresponding to the CT image. Through an innovative multi-modal fusion architecture and a two-stage training strategy, pathological characteristics of geometric structure information and physical parameter information of a three-dimensional model are fully utilized, and high-precision and high-robustness non-contact prediction of PPG values under the condition that only CT image blood vessel model input exists is realized.

The invention relates to a method implemented by a computer device for detecting at least one lesion of the pancreas of a patient in at least one medical image, such as portal phase computed tomography (CT). And training the segmentation network in a five-fold cross validation mode. The outputs of the network are then post-processed to extract image features: normalize lesion risks, predict lesion diameters, and MPD diameters of the head, body, and tail of the pancreas. A logistic regression model is calibrated to predict the presence of a lesion based on the features.

The invention discloses a cleaning device for circulating liquid in an organ perfusion system, relates to the technical field of organ culture, and solves the problems that a traditional cleaning device interferes with main circulation, waste removal is not thorough, and perfusion is broken during maintenance. The perfusion system body comprises an aorta side / portal vein side liver inlet pipeline, a liver outlet liquid return pipeline, a liquid storage bag, an organ container and a four-pump body assembly, the double liver inlet pipelines are in butt joint with a liver aorta and a portal vein respectively, and the liver outlet pipeline is connected with the liquid storage bag through a third pump body; the cleaning device comprises a filter which is connected with the liquid storage bag in parallel and connected with a fourth pump body in series to form auxiliary circulation, the filter is divided into first-stage permeation filtration and second-stage dialysis membrane filtration, and a bypass pipeline with a valve / three-way switch is further arranged; the device ensures the stability of main circulation, efficiently removes waste in a grading manner, does not interrupt perfusion during maintenance, and assists in maintaining the in-vitro activity of organs.

The invention relates to a microcirculation resistance value obtaining method and device and an operation planning method. The method comprises the following steps: acquiring first medical image data and portal vein circulation models of one or more training objects; iterating the microcirculation resistance value in the portal vein circulation model until the similarity between the portal vein circulation model and the portal vein of the training object meets a preset condition, and obtaining a first microcirculation resistance value of the training object; according to the first microcirculation resistance value and the corresponding first medical image data, training to obtain a mapping relation between the microcirculation resistance value and the medical image data; and obtaining a second microcirculation resistance value of the target object based on the mapping relation and the second medical image data of the target object. By adopting the method, an accurate microcirculation resistance value can be obtained, so that the TIPS surgical planning precision is improved.

The invention discloses a navigation system, a storage medium and a method for portal vein and branch vein puncture, and belongs to the technical field of medical instruments. The system comprises a modeling module used for constructing a three-dimensional blood vessel model containing a target belonging branch; the image fusion and navigation display module is used for performing registration fusion on the model and the intraoperative real-time image to generate an augmented reality navigation interface; the surgical instrument tracking and positioning module is used for acquiring and displaying the spatial pose of the instrument in real time; and the intelligent distinguishing module is used for analyzing the physical sensing signal of the instrument and automatically generating a distinguishing signal of entering a blood vessel cavity. The technical problems that an existing navigation system cannot clearly recognize deep branch blood vessels, is not intuitive in guidance and lacks objective successful criteria are solved, accurate, intuitive and intelligent surgical navigation of portal vein specific branches is achieved, and the system is particularly suitable for clinical scenes needing high-quality portal vein blood samples, such as free nucleic acid detection.

The invention discloses an implantable portal vein and branch vein blood sampling system and blood sampling method thereof, and belongs to the technical field of medical instruments. The blood sampling system comprises an implant unit which can be completely implanted into a body, and the implant unit is provided with a blood flow path communicated with a target blood vessel, a driving unit used for generating negative pressure, a control unit and a wireless communication unit. The control unit receives an in-vitro instruction through the communication unit and accurately controls working parameters of the driving unit so as to extract a blood sample with a preset volume. In a preferable scheme, the system is integrated with a pressure sensor to realize closed-loop monitoring, and a sample can be output through a subcutaneous port or a built-in blood storage cavity. By means of an implantable wireless control scheme, long-term, accurate and repeatable collection of portal vein system blood is achieved, trauma, infection risks and operation errors caused by traditional repeated puncture are effectively avoided, and a safe and reliable solution is provided for dynamic blood flow monitoring and high-frequency inspection requirements.

The invention discloses a non-invasive portal vein hemodynamic parameter measuring method and device and a medium, and relates to the technical field of medical detection equipment and biomedical signal processing.The method comprises the steps that abdominal epidermal potential distribution data is collected, a conductivity change area is recognized, and a portal vein trunk three-dimensional thermodynamic diagram is generated; peak coordinates of the portal vein trunk three-dimensional thermodynamic diagram are extracted, a portal vein trunk space positioning coordinate set is obtained, a graphene quantum tunneling sensor is driven to be attached to the abdominal skin surface of the patient based on the portal vein trunk space positioning coordinate set, and an attachment ready signal is output; based on the attachment ready signal, an original current data flow is collected, temperature drift correction is performed on the original current data flow, the original current data flow is converted into an instantaneous flow velocity, and a time-flow velocity sequence is generated. The microcosmic dynamic of early portal extravasated blood is captured, the pathological low-speed event which cannot be detected by the traditional technology is identified, and a non-invasive early warning index is provided for the liver cirrhosis progress risk.

The present application relates to the technical field of medical devices, in particular to a puncture guiding method, device and equipment based on image processing and a storage medium, the method comprising: acquiring a two-dimensional perspective image including a target tissue region in real time, the target tissue region including a portal vein region and a diaphragm region; identifying the diaphragm region in the two-dimensional perspective image to obtain first edge position information of the top of the diaphragm region; acquiring three-dimensional image information of the portal vein region and second edge position information of the top of the diaphragm region, the three-dimensional image information and the second edge position information being determined based on a three-dimensional reconstruction image including the target tissue region; superimposing the three-dimensional image information and the second edge position information into the two-dimensional perspective image to obtain a superimposed image; and displaying the superimposed image to guide puncture. The method can provide intraoperative image guidance for TIPS to improve puncture accuracy and shorten puncture time.

The utility model belongs to the technical field of portal vein pressure detection, and discloses a minimally invasive portal vein pressure home detection kit which comprises a rubber plate, a sample pad, a colloidal gold combination pad, a chromatography membrane and a water absorption layer, wherein the sample pad, the colloidal gold combination pad, the chromatography membrane and the water absorption layer are arranged at the upper end of the colloidal plate, the sample pad, the colloidal gold combination pad, the chromatography membrane and the water absorption layer are sequentially connected, a detection line and a quality control line are arranged on the chromatography membrane, and a GP73 colloidal gold marker is arranged on the colloidal gold combination pad. The minimally invasive portal vein pressure home detection kit is simple to operate and low in use cost, and a patient can obtain a non-invasive and real-time portal vein pressure prediction value in a home environment.

The invention provides a liver and gall image segmentation method based on a 2.5 D model and drainage basin analysis, and the method comprises the steps: constructing a voxel-level liver segment label graph through Couinaud liver segment structure analysis based on a portal vein center line; secondly, a 2.5 D model guided by structure perception is adopted for liver and gall structure segmentation, three-dimensional context information and a structure attention mechanism are fused in the model, and the discrimination ability at a complex junction is enhanced; then, in the intraoperative navigation stage, a stable registration relation is established by utilizing the structure number diagram and a visual image obtained in real time, dynamic posture adjustment is achieved, and the navigation stability is improved; and finally, the postoperative focus quantitative analysis module performs attribution analysis, volume quantification and credibility calculation on the focus area in combination with the structure numbering diagram and the model thermodynamic diagram. The whole process integrates dissection consistency, cross-stage adaptability and interpretability, and the requirements of the hepatobiliary surgery department for precise operation planning, real-time navigation and postoperative follow-up visit are met.

A determination method, an apparatus, an electronic device, and a storage medium for a postoperative portal vein pressure are provided, wherein the determination includes obtaining preoperative imaging data and measurement data of a patient; and inputting the preoperative imaging data and the measurement data of the patient into a portal vein geometric multi-scale model to obtain a postoperative portal vein pressure of the patient output by the portal vein geometric multi-scale model, wherein the portal vein geometric multi-scale model is formed by coupling a three-dimensional model of a portal vein system and a zero-dimensional model of a liver blood circulation system of the patient.

The invention belongs to the technical field of pet supplies, and particularly discloses a composition and application thereof in preparation of a product for reducing pet tear stains, the composition can effectively reduce the tear stains, and the composition, the composition and the product all have certain anti-inflammatory effects and jointly reduce tear secretion and inflammation-related tear stains. Meanwhile, the althaea rosea extract can improve the availability of hydroxytyrosol and fucoidan polysaccharide sulfate, improve eye microcirculation and relieve eye fatigue and dryness, fucoidan polysaccharide sulfate reduces iron elements entering tears through portal vein circulation and blocks generation of porphyrin-iron compounds, hydroxytyrosol improves metabolism and accelerates ferriporphyrin metabolism, and the effect of improving eye quality is achieved. The althaea officinalis extract promotes biliary secretion and accelerates ferriporphyrin metabolism, the synergistic interaction of the althaea officinalis extract, the althaea officinalis extract, the ferriporphyrin and the althaea officinalis extract can effectively reduce formation of tear stains, the risk of eye inflammation and bacterial infection is reduced, immunity can be improved, blood circulation can be promoted, and finally the pet is helped to keep a clean and healthy eye environment.

The invention discloses a kit for detecting circulating tumor DNA (deoxyribonucleic acid) of portal vein and branch vein blood of portal vein. The kit comprises: a nucleic acid extraction assembly comprising an optimized lysate and selectively bound magnetic beads; the library construction component comprises a terminal repair / tailing fusion enzyme and a Y-shaped linker with a molecular identifier; the targeted enrichment assembly comprises a specific primer group and a probe group and is used for enriching related gene targets of the abdominal organ tumors; and necessary reaction components. Through an optimized nucleic acid extraction method, an efficient library construction system and a precise targeted enrichment technology, high-sensitivity detection of low-abundance ctDNA in portal venous blood is achieved, and the lower detection limit reaches 0.1% of mutation allele frequency. The kit is particularly suitable for early diagnosis, curative effect monitoring and prognosis evaluation of abdominal organ tumors such as intestinal cancer, liver cancer and pancreatic cancer.

The present invention discloses the use of a short-term embolic agent in reducing drug accumulation in the liver, hepatic clearance and / or liver toxicity. The present invention provides the use of a short-term embolic agent in the manufacture of a medical composition for: (a) temporarily embolizing blood vessels supplying the liver; and (b) reducing the accumulation of a drug subsequently or concurrently administered intravenously in the liver. The strategy aims to minimize the exposure of a drug (such as LNP) to the liver by temporarily blocking the blood supply to the liver via the portal vein and / or arteries. The present invention significantly reduces the non-specific accumulation of a drug in the liver by temporarily blocking the portal vein, arterial and / or their branch blood flow, thereby greatly reducing the opportunity for the drug to enter the liver from a hemodynamic root.

A method includes acquiring a series of images over time from a liver of a subject injected with a contrast bolus, wherein the series of images span multiple phases of the contrast-enhanced scan. The method includes inputting the series of images into a trained neural network framework and utilizing the trained neural network framework to separately segment an aorta and a portal vein from each image of the series of images. The method includes utilizing the trained neural network framework to select exact respective time points for at least an aortic phase and a portal-venous phase based on the aorta and the portal vein segmented in each image. The method includes outputting a first set of images associated with the aortic phase and a second set of images associated with the portal-venous phase based on the exact respective time points selected for the aortic phase and the portal-venous phase.

The application provides an AI treatment decision system for liver cirrhosis acute variceal hemorrhage, relates to the technical field of treatment decision, extracts a transient characteristic indicator of blood flow pressure from a pressure fluctuation signal, predicts a transient pressure peak of the portal vein blood flow during acute variceal hemorrhage through the transient characteristic indicator and a blood flow dynamic model, predicts a quasi-steady pressure field of the portal vein blood flow during acute variceal hemorrhage according to the gradient distribution of the portal vein blood flow pressure and an initial treatment strategy of acute variceal hemorrhage, performs multi-scale coupling on the transient pressure peak and the quasi-steady pressure field to obtain a coupling characteristic of the portal vein blood flow, and then uses the coupling characteristic of the blood flow pressure to perform hierarchical coupling adjustment on the treatment strategy of liver cirrhosis acute variceal hemorrhage. Based on the above scheme, hierarchical coupling of the treatment strategy of liver cirrhosis acute variceal hemorrhage can be realized, so that the prediction accuracy of the portal vein blood flow pressure during acute variceal hemorrhage can be improved.

To provide a technology capable of reducing a workload imposed on the user when, after generating an ultrasound image of an examination site of a subject, another ultrasound image of the same examination site is generated.SOLUTION: With reference to an annotation list including symbols representing annotations and meanings corresponding to the symbols, an apparatus identifies the meaning of an annotation PV (portal vein) added to an ultrasound image 22. The apparatus sets a region of interest 51 at a position corresponding to the portal vein in the ultrasound image 22, sets values of flow velocity parameters V1 and V2 to values suitable for the portal vein, displays a color Doppler image 71 within the region of interest 51 set in the ultrasound image 22, and further displays a PW wave 91.SELECTED DRAWING: Figure 13

The application discloses a kind of hepatic portal vein system thrombus identification method and device, it is related to medical image processing technical field, wherein the method comprises: the CTA image to be handled is input to rough segmentation model, and the output blood vessel cavity;Blood vessel cavity includes blood vessel and thrombus in blood vessel;Rough segmentation model is obtained by training nnunet network;The HU value distribution of pixel in the blood vessel cavity is counted, combined with human liver tissue standard HU value, determine the segmentation threshold for segmenting thrombus;Based on density clustering algorithm, determine the cluster center coordinates of thrombus in the blood vessel;With cluster center coordinates as seed point, according to the similarity of pixel HU value in blood vessel cavity and the segmentation threshold, region growth is carried out, until encountering blood vessel boundary or there is no pixel point to be grown, obtain fine segmentation result;The fine segmentation result includes each pixel where thrombus is located.The application can improve the accuracy of hepatic portal vein system thrombus identification.

The utility model provides a positioning device for portal vein high pressure interventional radiotherapy, which comprises a treatment bed, a lower support frame and a head and neck support assembly, and a bed plate is arranged at the upper end of the internal composition of the treatment bed. A head and neck supporting assembly is fixed through connection of an upper connecting plate and a lower connecting plate, the neck of a to-be-treated person is supported by a neck supporting seat, the material of the neck supporting seat can be selected according to the to-be-treated person, and an adjusting sliding block slides in an adjusting sliding groove to adjust two groups of head fixing seats to proper positions to be clamped on the two sides of the head; according to the adaptive posture, a medical worker enables an adjusting stud to rotate in an adjusting threaded hole, the head fixing base and the neck supporting base are adjusted to be at the proper height position, the positioning comfort can be improved, and the head refreshing degree of the to-be-treated person can be improved by additionally arranging the head and neck supporting assembly.

The present invention relates to a method for measuring glomerular filtration rate (GFR) ex vivo in a subject that has been administered a contrast agent and that has been subjected to computed tomography (CT) or magnetic resonance imaging (MRI) including an excretion phase, a plain scan phase, an arterial phase, and a renal parenchyma phase or a portal vein phase, the method includes the step of calculating contrast agent clearance from CT or MRI data using manual, automated or semi-automated segmentation software, thereby obtaining a measured GFR.

The invention relates to the technical field of transplantation medicine and pharmacology crossing, in particular to application of Xuebijing injection in preparation of a medicine for inhibiting instant blood-mediated inflammatory response after portal vein pancreas islet transplantation. According to the application, the application is innovatively applied to prevention and treatment of instant blood-mediated inflammatory response in pancreas islet transplantation, complement activation, blood coagulation cascade and inflammatory cell infiltration are synergistically inhibited through multiple targets, and the curative effect bottleneck of a traditional single anti-coagulation or anti-inflammatory strategy is broken through; the invention provides a Chinese and western medicine combined patent solution which has the advantages of efficient regulation and safety for overcoming early-stage key inflammatory injury after transplantation.

The present disclosure provides 3D bio-printed livers and methods of making or using the same. Aspects of the disclosure relate to compositons of 3D bio-printed livers. In some embodiments, the 3D bio-printed livers comprise a mesh casing, a plurlaity of microporous organoid-infused microgel matrices, and a hetaptic vasculature. Other aspects of the disclosure relate to methods of making the 3D bio-printed livers dislcosed herein. In some embodiments, the methods relate to creating a mesh casing in the shape of a liver, or portion thereof, loading a plurality of microporous organoid-infused microgel matrices into the mesh casing, and using embedded bioprinting to create a hepatic artery, a portal vein, and biliary duct within the mesh casing.

A system for measuring a pressure in a vein includes a needle sized and shaped to be inserted through a working channel of an endoscope. The needle is extending longitudinally and including a channel extending longitudinally therethrough. The system also includes a pressure sensing device including a longitudinally extending body sized and shaped to be slidably inserted through the channel of the needle and a sensor mounted on a distal portion of the body and connected to a proximal portion of the pressure sensing device via a connection cable. The sensor is configured to detect information corresponding to a pressure of a flow of blood through a vein.