106 results about "Vena porta" patented technology

The invention discloses a hepatic vein vascular tree modeling method and a system thereof. The method comprises the following steps: using a liver model to obtain a liver image, and utilizing the multi-scale filtration method to strengthen a blood vessel; cutting a hepatic vein; extracting a central line of the hepatic vein; detecting and removing a link in the central line; and utilizing OSG/VTK to rebuild the hepatic vein vascular tree after pruning. The system comprises an image acquisition module, a blood vessel strengthening module, a blood vessel cutting module, a vascular tree central line extracting module and a vascular tree rebuilding module. The invention improves similarity functions in the filtering process, analyzes the characteristics of the ring and adopts corresponding unlinking methods for different links; and utilizes the relation of radius of blood vessel and the branch length when pruning. The invention effectively enhances the hepatic vein, improves the contrast between the blood vessel and liver parenchyma, and can extract more than five class branches, effectively unlink and prune the central line of the hepatic vein, rebuild the hepatic vein vascular tree and directly display the branches of the heptatic vein.

According to the liver tumor automatic classification method and device based on multi-stage CT image analysis, full-automatic bile duct cell carcinoma and hepatocellular carcinoma can be recognized,and a high-precision bile duct cell carcinoma and hepatocellular carcinoma recognition model is obtained. The method comprises the following steps: (1) acquiring a contrast-enhanced abdominal CT scanning image, storing the contrast-enhanced abdominal CT scanning image as an arterial phase, a portal vein phase and a delay phase, and carrying out definite diagnosis on liver cancer categories to which all data belong to serve as a model training gold standard; (2) constructing a three-dimensional full convolutional neural network segmentation model, and segmenting the intrinsic characteristics ofthe liver tissue in each stage from the abdominal CT image through model training learning; (3) constructing a three-dimensional convolutional neural network classification model; and inputting the image data obtained by segmentation into a classification model for training, so as to enable the model to perform joint learning and training on the cancer features in multiple periods, thereby predicting the category to which the cancer belongs, comparing the prediction result with a gold standard, and supervising the training process of the model in a loss value feedback mode.

The invention provides a noninvasive portal vein hemodynamic parameter measuring method which includes the steps of firstly, using a thin-section CT image to build a three-dimensional geometric model of a liver portal vein; secondly, using the finite element analyzing method of hydromechanics calculating software ANSYS to perform meshing on the geometric model and build a three-dimensional mathematic model; thirdly, calculating the hemodynamic parameter of the portal vein in an analog manner to obtain a speed and pressure distribution effect picture. The method is safe, noninvasive, simple to operate, visualized, quantized and high in accuracy, and the effective model is built for scientific researches and clinic services.

The invention relates to the field of medical image processing and provides a method and system for segmenting the liver. The method comprises the following steps that firstly, an obtained medical human body nuclear magnetic resonance sequence image is segmented, the liver part, the hepatic vein part, the portal vein part and the hepatic artery part are segmented and extracted, wherein the hepatic vein part, the portal vein part and the hepatic artery part are located in the liver part; secondly, all the branch points of a vessel tree are extracted according to the segmented hepatic vein part, the portal vein part and the hepatic artery part; all the main branches of blood vessels are analyzed according to all the branch points of the vessel tree; the main branches of the hepatic vein part, the portal vein part and the hepatic artery part are marked, and the liver is segmented according to the occupied space proportion of all the main branches of the vessel tree in liver body data. The method and system for segmenting the liver provide visual reference and guarantee for clinical operations or medical experiments.

There is provided an image detecting system including an image detecting section that detects a moving image of an examination subject into which a radiopaque contrast medium flows through one of an artery and a portal vein, and a change image generating section that generates a change image representing a change in the moving image. Here, the change is caused by movement of the radiopaque contrast medium after a timing at which the radiopaque contrast medium that has flown into one of the artery and the portal vein flows into capillaries.

The invention relates to a multifunctional balloon catheter integrated with a puncture needle and a system. The balloon catheter adopting unique design and the system can be used for different types of tumor such as benign and malignant bile duct stenosis, esophagus cancer, colorectal cancer, bronchogenic carcinoma, gastric antrum cancer, portal vein and vena cava tumor thrombus of primary hepatic carcinoma and the like, a far-end part where an eccentric balloon and the puncture needle are located is precisely put in the part where tumor of a lumen is located, a swelling balloon pushes the far end of the puncture needle to attach to the tumor, a near end of a rotating system operates a nut of the system and pushes the puncture needle to extend out of the catheter, the far end of the puncture needle with shape memory is bent and punctures the tumor, the puncture needle can be used for injecting a tumor treatment drug into the tumor to treat tumor or sucking tissue for biopsy or is used as a radiofrequency ablation electrode to perform radiofrequency ablation/heating to treat the tumor; on the basis of the system, with the adoption of different designs, the multifunctional balloon catheter can be used for injection of the treatment drug into atherosclerosis plaques and treatment of aortic dissecting aneurysm.

The invention discloses a liver blood vessel segmentation method based on a CT image, and the method comprises the steps of: firstly obtaining an original 3D liver image, and carrying out the preprocessing, and obtaining a training set; then using the training set obtained through preprocessing for training a 3D convolutional neural network, wherein the adopted 3D convolutional neural network adopts a Unet network structure, an encoder is provided with a side output layer for deeply supervising the structure of the convolutional network system, an output end is provided with two parallel branches, the upper branch is used for extracting features, different from the background, of the hepatic vein and the portal vein, and the lower branch is used for extracting features for distinguishing the hepatic vein and the portal vein; and finally processing the 3D liver image by using the trained 3D convolutional neural network to obtain a liver blood vessel segmentation result. According to the method, a side output layer is added from an encoder part to help bottom layer features to extract more semantic information, and meanwhile, two parallel branches are arranged at the output end, so that the segmentation effect of the hepatic vein and the portal vein in the liver image is improved.

The invention discloses a hepatic portal vein catheter which comprises a catheter body, wherein a guide wire channel, a sensor groove and a lead groove are formed in the catheter body; a sensor whichis arranged in the sensor groove and used for measuring hepatic portal vein pressure; a lead which is arranged in the catheter body lead groove and is used for electrically connecting the sensor withexternal equipment of the catheter body; and coatings which are arranged on the outer surface of the wall surface of the catheter body and the sensing outer surface of the sensor and used for isolating direct contact between the catheter and external blood. The hepatic portal vein catheter integrates the pressure micro-sensor and the drug/electrical stimulation targeted treatment micro-channel atthe same time, hepatic portal vein pressure monitoring and targeted treatment can be carried out in a long-term implantation or short-term intervention mode, the sensor is directly integrated and packaged on the head of the catheter body, hepatic portal vein pressure can be directly measured, measurement feedback response is fast, accuracy is high, and popularization and application are easy. Meanwhile, the catheter is small in size, compact in structure and small in percutaneous puncture wound.

The invention provides a liver vein three-dimensional structural feature quantitative analysis method, and the method comprises the following steps: acquiring a to-be-analyzed liver three-dimensional image, and acquiring a segmentation region of a vein; calculating a center line; segmenting the blood vessel, and dividing the vein blood vessel into left, middle and right veins of the liver and left and right branches of the portal vein of the liver; according to the center line of each section and a vein model reconstructed by using a three-dimensional surface reconstruction algorithm, carrying out quantitative analysis on the three-dimensional structure characteristics of the vein, wherein the parameter indexes comprise one or more of a blood vessel form, a branch and a grid characterization index. The invention further provides a related device, computer equipment and a storage medium. Due to the fact that manual intervention is not needed, full-automatic analysis can be achieved, and the requirement for analyzing blood vessel parameters in batches can be met, the three-dimensional structure characteristic quantitative indexes of liver vein blood vessels can be rapidly and accurately analyzed in batches, and more comprehensive and detailed blood vessel three-dimensional structure characteristic quantitative analysis can be provided; and a more comprehensive reference can be provided for a doctor to evaluate blood vessels.

The invention relates to an indocyanine green fluorescence combined multimodal image-guided liver portal vein watershed developing method, and belongs to the technical field of medical images. According to the method, artificial intelligence technologies such as virtual reality, augmented reality and the like are integrated with traditional intraoperative ultrasound and indocyanine green fluorescent staining technologies, so that a surgeon can visualize three-dimensionally complex liver anatomical structures, accurately locate tumors in an operation, plan an operation scheme, accurately achieve developing of a target portal vein watershed, monitor and correct a liver parenchyma disconnection plane in real time, and perform accurate anatomical liver resection. In a liver operation, the method can display a portal vein branch blood flow supply area for supplying tumors in real time, accurately guide a liver resection range, can not only remove micrometastatic tumors that may exist in theportal vein, but also can ensure blood supply of the remaining liver, improve accuracy and safety of the operation, reduce operative complications, and improve efficacy of tumor operation.

The present disclosure relates to the field of early non-invasive diagnosis, and specifically, to a method of determining a virtual hepatic venous pressure gradient. The method includes: constructing a 3-dimensional (3D) hepatic vein-portal vein model; establishing a finite element division mathematical model; and applying fluid dynamics to compute and simulate a virtual hepatic venous pressure gradient (vHVPG). The method optimizes and improves a more complete 3D hepatic vein-portal vein model, finite element division, and fluid dynamic simulation computation, constructing and validating a new vHVPG determination technology providing better diagnosis, providing a safe, non-invasive, accurate, and quantitative method for early non-invasive diagnosis of a portal vein high pressure patient.

The invention discloses a TIPSS interventional therapy training device. The TIPSS interventional therapy training device comprises a vein blood vessel system, a cardiovascular system and a human body shell wrapping the vein blood vessel system and the cardiovascular system. Blood vessels of the vein blood vessel system are fixedly connected with a blood vessel fixing device and a circulating power device; the vein blood vessel system comprises a cerebral vein intervention module, a TIPSS intervention module, a heart intervention module and an inferior vena cava intervention module; two inlets are formed in the tail ends of the superior sagittal vein and the left and right iliac veins, and a total liquid outlet is formed in the right atrium to provide liquid for the whole device; two sheath entering tube openings are formed above the left iliac vein and the right iliac vein and are used for the entering of a catheter guide wire; the blood vessel fixing device comprises cerebral vein, heart, hepatic vein, portal vein and inferior vena cava blood vessel fixing bases; an operation display module comprises a movable high-definition camera and a high-definition display screen; the circulating power device comprises a circulating system box body, a controllable pressure adjusting motor and a pipeline. According to the device, the human body vein blood vessel system is highly restored, the device can be disassembled and assembled, blood vessels at the same part can be replaced, the flexibility of interventional operation simulation is improved, various types of operation simulation can be carried out, and the popularization and development of TIPSS interventional operations are promoted.

The invention relates to a liver acellular stent construction method based on an irreversible electroporation technology. The method comprises the following steps of 1.1) weighing a rat, carrying outgas inhalation anesthesia by using isoflurane, maintaining the gas inhalation anesthesia, after the anesthesia is effective, disinfecting abdominal skin of the SD rat in a supine position by using 75%alcohol, and opening the abdomen layer by layer to expose the liver; 1.2) clamping a left lateral lobe area of the rat liver by using a caliper type electrode, and performing high-voltage pulsed electric field treatment; 1.3) after the irreversible electroporation treatment is finished, performing transhepatic portal vein catheterization, perfusing with heparinized PBS (Phosphate Buffer Solution), cutting off the subhepatic inferior vena cava until the liver is full and the color is gradually lightened, gradually dissociating tissues and ligaments around the liver, taking down the liver, andimmersing the liver into the heparinized PBS; 1.4) putting the taken liver into a clean container, and performing one-way perfusion with deionized water, and 1.5) after the deionized water perfusion is finished, performing one-way perfusion with PBS for 30 minutes to complete the preparation of the stent. By the method disclosed by the invention, the construction efficiency of the in-vitro acellular stent can be effectively improved under the condition of not applying harmful chemical preparations.

The invention relates to application of protein C in treating hepatic portal hypertension, relates to the relevant research of the protein C and portal hypertension, and also relates to protein C inhibitors including miRNA. The protein C inhibitor (miRNA) can inhibit the proliferation of hepatocytes and promote the apoptosis of the hepatocytes, which can reduce hyperplasia tissue of hepatic sinusoids to make portal venous flow smooth and reduce the portal pressure, thereby opening up new research prospects for the treatment of the portal hypertension (especially portal vein cavernous transformation) and providing new ideas for the deep development of miRNA drugs and clinical treatment.

The invention relates to the technical field of image processing, in particular to a model training method, a model training device, a liver segment segmentation method, a liver segment segmentation device, a computer readable storage medium and electronic equipment, and solves the problem that an existing model is poor in liver segment segmentation effect. As the liver vein, portal vein and other veins of the liver have close position relation with the division of the liver segment, the model training method provided by the embodiment of the invention utilizes the training data set comprising the liver sample image data, the liver segment labeling data corresponding to the liver sample image data and the vein labeling data, so that the liver segment labeling data corresponding to the liver sample image data can be obtained. According to the method, the initial network model is trained, so that the initial network model can refer to the vein position in the liver segment segmentation learning process, the segmentation effect of the liver segment segmentation model obtained through training is improved, and the robustness and accuracy of liver segment segmentation are improved.

The invention relates to the field of medical instruments, and in particular relates to a transjugular vein intrahepatic portal vein puncture stent (TIPS stent) capable of automatically adjusting blood flow pressure. The stent is composed of a bare stent and a stent inner diameter adjusting structure, and two ends of the stent inner diameter adjusting structure are respectively provided with a development structure. The stent inner diameter adjusting structure can automatically adjust the inner diameter of the product according to the portal vein blood flow pressure. When the portal vein pressure rises, the stent inner diameter is increased, the blood flow in the stent is increased, and tissue bleeding of a patient caused by excessive rising of the portal vein pressure can be prevented; and when the portal vein pressure reduces, the inner diameter of the stent is reduced, the blood flow in the stent is reduced, and the occurrence rate of hepatic encephalopathy after a TIPS operation can be prevented. The product is simple and reliable in structure, the inner diameter change of the stent inner diameter adjusting structure is in smooth transition, and the occurrence rate of thrombusformed in the stent is reduced.

The invention discloses a balloon catheter applied to the portal vein.The balloon catheter applied to the portal vein comprises a first catheter cavity, a second catheter cavity, a third catheter cavity, a source applying box and a catheter core.The far end of the first catheter cavity is connected with the balloon, and the near end of the first catheter cavity is connected with a filling valve.The second catheter cavity is formed in the length direction of the first catheter cavity, the far end of the second catheter cavity is a blunt end with an opening, and the near end of the second catheter cavity is connected with a catheter cap.The third catheter cavity is formed in the length direction of the first catheter cavity, the far end of the third catheter cavity is sealed, and an opening is formed in the near end of the third catheter cavity.The source applying box is arranged at the far end in the third catheter cavity and is fixedly provided with a pull wire, and a radioactive source is arranged in the source applying box.The catheter core is arranged in the third catheter cavity and is in butt joint with the source applying box.When the balloon catheter applied to the portal vein in the embodiment is used for treating a patient, pharmaceutical treatment can be achieved through the second catheter cavity, and internal radiotherapy on tumor cells can be achieved through the third catheter cavity.Compared with the prior art, injuries to the skin of the patient can be reduced, the treatment effect can be improved, and the efficiency and operability of treatment can be improved.

The invention relates to the technical field of medicine diagnosis and in particular relates to an in-vitro liver function detection method and system. The method comprises the following steps: a) respectively accessing arteries, veins and biliary tracts of a liver into related pipelines of an in-vitro liver mechanical perfusion apparatus, wherein the pipelines are filled with whole blood in advance; b) injecting a contrast medium into a hepatic portal vein to implement circulation, and testing T1 relaxation time of discharged bile by using a low-field magnetic resonance imaging analyzer; andc) comparing variation situations of the T1 relaxation time of the discharged bile with a reference value, and judging that if the T1 relaxation time of a same time point is longer than the referencevalue, it means that the metabolic function of the liver is lower that a liver corresponding to the reference value, and otherwise, it means the metabolic function of the liver is better than that ofthe liver corresponding to the reference value. The method makes up the limitation that liver functions cannot be directly reflected by conventional detection indexes.

The invention provides a semi-supervised learning-based portal vein detection positioning method and system, and the method comprises the steps: carrying out model training through employing a semi-supervised learning model, carrying out feature extraction of unlabeled data, and taking the probability that whether a feature is a portal vein or not as a soft label; carrying out model training through a small number of label samples and a large number of label-free sample data, so that the manual labeling cost is greatly reduced; in addition, focus attention is formed through series connection of channel attention and space attention according to the position feature of the portal vein structure, so that priori knowledge is input into the convolutional neural network to guide model training, and the defects of existing portal vein detection are overcome; a loss function is replaced, a local loss function is selected as the loss function of the classifier, and normal training can still be carried out under the condition that positive and negative samples are unbalanced.

According to the hepatic vein portal vein separation method and device based on the local features, the stability of a separation algorithm can be improved, the influence of an incorrect segmentationresult is avoided, and the separation effect can be improved. The hepatic vein portal vein separation method based on the local features comprises the steps that (1) a blood vessel center line is obtained for a given liver blood vessel segmentation result, a communication path between portal veins and hepatic veins is extracted, and all intersection points and bifurcation points are obtained through analysis; (2) a weight is calculated by using local features to obtain a disconnection point, thereby achieving a separation purpose; and (3) branch completion is carried out on the intersection point of the hepatic vein and the portal vein according to the blood flow direction, and a hepatic vein and portal vein segmentation result is reconstructed based on the separated center line, so that subsequent effect evaluation is facilitated.

The liver segmentation system based on drainage basin analysis comprises a data receiving module, an image reading module, an image extraction module, an image processing module and an image analysis module; the image processing module comprises an image selection sub-module, an image editing sub-module and an image rendering sub-module, the image selection sub-module and the image editing sub-module carry out segmented processing on hepatic portal vein blood vessels, and the image rendering sub-module renders livers corresponding to the segmented hepatic portal vein blood vessels into different colors, thereby forming segments of the liver; and the image analysis module is used for carrying out segmented drainage basin analysis on the segmented liver. Compared with the prior art, accurate and personalized liver segmentation can be carried out according to portal vein space distribution condition characteristics of different patients, the segmentation result is accurate and objective, drainage basin analysis is carried out on the segmented liver, the liver segments with abnormal drainage basins are obtained, and determination and accurate implementation of a liver operation scheme are facilitated. Therefore, the operation time and cost can be saved, and pain of a patient is relieved.

The invention provides an ultrasonic contrast imaging method and device. The method comprises the steps that a first ultrasonic probe is controlled to emit first ultrasonic waves to a liver area of a target object; a first ultrasonic image is generated based on a first ultrasonic echo signal, and an area of interest on the first ultrasonic image is acquired to determine a position area to be subjected to contrast imaging in the liver area; under the condition that a contrast agent is injected into the target object, the first ultrasonic probe is controlled to emit second ultrasonic waves to the position area; after the contrast agent is injected and when preset conditions are met, a second ultrasonic probe is controlled to emit third ultrasonic waves to a portal vein area of the liver area, wherein the third ultrasonic waves are used for bursting microbubbles generated by the contrast agent in the portal vein, and emission of the second ultrasonic waves and emission of the third ultrasonic waves are conducted alternately or conducted independently; and a contrast image is generated based on a second ultrasonic echo signal. According to the method and device, pure hepatic artery ultrasonic contrast imaging can be achieved.

The invention discloses a teaching model for human body hepatic portal vein system anatomy and a demonstrating method of the human body hepatic portal vein system based on the model. The structure comprises a model box, an organ model and a vein system model are arranged in the model box, the organ model is composed of models of part of human organs, the vein system model is composed of vein models with the constitution being the same as that of the human body hepatic portal vein system, the vein models are hollow tubes made of a transparent material, LED lamp strips are arranged in the vein models in a penetrating manner, the LED lamp strips are connected to a power supply controller, and switch buttons used for controlling power supplies of the LED lamp strips are arranged on the power supply controller. According to the technical scheme, through the combination of sound, light and shape, the human body hepatic portal vein anatomy and blood circulation during the hepatic portal veinhypertension can be completely, accurately and intuitively displayed, so that a student can more easily understand the complicated anatomy structure, through practical teaching verification, the learning progress and understanding of the student for the relevant knowledge of the human body hepatic portal vein can be accelerated and deepened, in addition, the model device is integrally arranged inthe box, and thus teaching transfer is facilitated.