32 results about "Hepatic portal vein" patented technology

A procedure for image segmentation on three-dimensional (3D) medical images, and a system, apparatus, and computer program that operate in accordance with the procedure. The procedure includes generating a projection including an anatomic structure, tracing a curve corresponding to the anatomic structure, extracting a curved volume of interest based on the curve and the projection, and extracting a segmentation of the anatomic structure. Also provided is a procedure for aligning anatomic structures in images, and a system, apparatus, and computer program that operate in accordance with the procedure. The procedure includes determining part of a biliary system in a first image, determining part of a hepatic portal vein or a hepatic artery in a second image, determining a gallbladder in the images, determining a cost function, and aligning the biliary system and the hepatic portal vein or hepatic artery by maximizing the cost function.

The invention provides a method for isolating and culturing liver primary cells. The method comprises the following steps: (1) inputting perfusate from hepatic portal vein of a liver; (2) inputting collagenase perfusate; (3) soaking the maturely digested liver in the collagenase perfusate; (4) adding a cleaning solution to stop digestion, filtering, and collecting hepatic cell suspension; and (5) centrifuging, discarding supernatant, resuspending with complete medium, and culturing. The operation of the method provided by the invention is simple, is low in cost and is stable and efficient, and the hepatic cells are high in yield, high in vitality and easy for adherence. The method can be generalized in laboratories, and is a conventional method for scientific research.

The invention discloses a small and medium diameter artificial blood vessel with adjustable pressure and flow. The artificial blood vessel comprises a blood vessel wall, a blood vessel cavity is in the blood vessel wall, and a pressure and flow controller capable of adjusting the diameter of the artificial blood vessel is arranged outside the artificial blood vessel. Concave and convex grains are arranged on the blood vessel wall. The pressure and flow controller comprises a fixed shell and a control spring, wherein the fixed shell takes the shape of a cylindrical structure, and the control spring is configured to be a cylindrical structure, the control spring is arranged in the fixed shell and sleeved outside of the blood vessel wall of the artificial blood vessel, the control spring is provided with a limit spring handle for adjusting the diameter of the blood vessel, and the spring handle passes through a control frame. The fixed shell is provided with position fixing holes, and the control spring is provided with position fixing holes. The fixed shell is provided with a fastener. The pressure and flow controller comprises a mechanical pressure and flow controller, an in-vitro remote control pressure and flow controller and an in-vivo induction pressure and flow controller. The blood vessel is applicable to controlling the size of fractional flow according to an induced pressure of a hepatic portal vein after a portosystemic blood vessel is anastomosed and shunted so as to ensure the hepatic portal vein perfusion pressure required by individuals.

The invention discloses a small and medium diameter artificial blood vessel with adjustable pressure and flow. The artificial blood vessel comprises a blood vessel wall, a blood vessel cavity is in the blood vessel wall, and a pressure and flow controller capable of adjusting the diameter of the artificial blood vessel is arranged outside the artificial blood vessel. Concave and convex grains are arranged on the blood vessel wall. The pressure and flow controller comprises a fixed shell and a control spring, wherein the fixed shell takes the shape of a cylindrical structure, and the control spring is configured to be a cylindrical structure, the control spring is arranged in the fixed shell and sleeved outside of the blood vessel wall of the artificial blood vessel, the control spring is provided with a limit spring handle for adjusting the diameter of the blood vessel, and the spring handle passes through a control frame. The fixed shell is provided with position fixing holes, and the control spring is provided with position fixing holes. The fixed shell is provided with a fastener. The pressure and flow controller comprises a mechanical pressure and flow controller, an in-vitro remote control pressure and flow controller and an in-vivo induction pressure and flow controller. The blood vessel is applicable to controlling the size of fractional flow according to an induced pressure of a hepatic portal vein after a portosystemic blood vessel is anastomosed and shunted so as to ensure the hepatic portal vein perfusion pressure required by individuals.

The invention relates to an oral suspension of a liposome-encapsulated insulin lyophilized preparation, named as O-SCULI. The O-SCULI contains lecithin, cholesterol, polyglycol aliphatic acid ester, vitamin E, insulin, water, sodium chloride and phosphate buffer. The invention also provides a two-step process of the O-SCULI, comprising (1) a dewatering / moistening control process: preparing a liposome-encapsulated insulin lyophilized preparation and SCLI so that the encapsulation rate of the insulin is increased to 80 percent by liposome amalgamation; and (2) a respective constant volume / stepped liquefaction process: preparing the SCLI into an O-SCULI oral suspension, preventing the SCLI liposome from leaking and keeping the constant encapsulation rate of the insulin. After a patient acutely takes the O-SCULI, the liposome insulin effectively enters the intestine-hepatic portal vein, the liver and the blood circulation to reduce blood sugar, blood fatty acids and blood ketone with highutilization degree. After a patient continuously orallly takes the oral suspension, the saccharification of hematoglobin, triglyceride and, aminotransferase and the oxidative stress are reduced, the structural damage of liver cells is recovered, and the comprehensive curative effects of diabetes treatment by using various liver functions are improved. The invention also opens up a new path for non-injection administration of active polypeptide protein, such as cytochrome C, albumin, interferon, and the like.

The present invention relates to a controlled-release composition for producing a sustained-release preparation containing udenafil. More particularly, the present invention relates to a controlled-release composition for producing a sustained-release preparation containing udenafil, said composition comprising (A) udenafil and a pharmaceutically acceptable salt, (B) a solubility modulator, (C) an adsorbent, and (D) a hydrophilic polymer. The controlled-release composition for producing a sustained-release preparation containing udenafil according to the present invention releases drugs constantly regardless of the pH level in the gastrointestinal tract, and thus freely controls the drug release time within the range of 3 to 24 hours, and reduces the variability in the effect of drugs among individuals. In addition, the composition of the present invention can be produced into a sustained-release preparation which has an optimum condition for expressing the effect of drugs in the treatment of diseases such as pulmonary arterial hypertension, hepatic portal vein hypertension, benign prostatic hyperplasia, and the like, which can be treated by udenafil and which requires the administration of drugs over a long period of time. Further, the composition of the present invention can control the release of drugs in accordance with the time taken for the absorption thereof when said drugs are applied to a living body, and thus can be valuably used in preventing and treating erectile dysfunction.

The invention provides a method for isolating and culturing liver primary cells. The method comprises the following steps: (1) inputting perfusate from hepatic portal vein of a liver; (2) inputting collagenase perfusate; (3) soaking the maturely digested liver in the collagenase perfusate; (4) adding a cleaning solution to stop digestion, filtering, and collecting hepatic cell suspension; and (5) centrifuging, discarding supernatant, resuspending with complete medium, and culturing. The operation of the method provided by the invention is simple, is low in cost and is stable and efficient, and the hepatic cells are high in yield, high in vitality and easy for adherence. The method can be generalized in laboratories, and is a conventional method for scientific research.

The invention belongs to the field of animal experimental models, and relates to application of ultrasonic detection equipment in semiquantitatively determining a sheep fatty liver. The application comprises the steps that a sheep fatty liver model is built by simulating negative balance of energy in the natural state; by means of characteristic analysis on liver ultrasonic images and corresponding data analysis on liver triglyceride content, a sheep fatty liver ultrasonic diagnosis method for semiquantitatively diagnosing that the liver triglyceride content is smaller than 4%, between 4% and 10% and larger than 10% is determined according to the liver echo brightness enhancing degree, the liver and kidney echo ratio increasing degree, the hepatic vessel visualization weakening degree and the acoustic shadow visualization fuzzy degree of hepatic portal veins, postcaval veins, rumen walls, intestines and diaphragms at the far field of the liver. The method is high in sensitivity, high in specificity and good in repeatability and has an ideal application prospect.

The invention discloses an in-vitro liver perfusion device which comprises a support, a clamping mechanism, a hepatic portal vein perfusion channel and a hepatic artery perfusion channel, wherein the clamping mechanism is arranged on the support and is used for clamping a ligament of the in-vitro liver so as to hang the in-vitro liver; the hepatic portal vein perfusion channel is slidably arranged on the support, and one end of the hepatic portal vein perfusion channel is communicated with a hepatic portal vein of the in-vitro liver; the hepatic artery perfusion channel is slidably arranged on the hepatic portal vein perfusion channel, and one end of the hepatic artery perfusion channel is communicated with the hepatic artery of the in-vitro liver. The ligament of the in-vitro liver is clamped through the clamping mechanism arranged on the support, so that the in-vitro liver is hung, the in-vitro liver is in a free sagging state, the whole in-vitro liver is not extruded, and the situation that the liver function is damaged due to stacking of the in-vitro liver when the in-vitro liver is directly contained in a container is prevented; and the hepatic portal vein perfusion channel and the hepatic artery perfusion channel are arranged, so that a perfusion tube can be conveniently inserted and is not easy to fall off, and perfusate can be prevented from leaking at the insertion part.

The invention discloses a liver division method based on a CT image, which comprises the following steps: firstly, an MSCTP artery sequence image and a hepatic portal vein sequence image of the abdomen are pretreated, and the outline of the liver is automatically divided to obtain the liver image; secondly, a multi-scale filtering method based on a Hessian matrix is used for strengthening blood vessels, a dividing method such as region enlargement, and the like is used for dividing the hepatic portal vein, and a three-dimensional topology thinning method is used for picking up the central line of the hepatic portal vein; the blood vessels are identified mutually in classification; distance change and Voronoi arithmetic are then used for calculation, and the outline of the liver is used for covering values to obtain division results; the three-dimensional liver division results are finally reconstructed. The system comprises a liver division module, a blood vessel strengthening dividing and a thinning module, a blood vessel classifying module, a liver dividing module and a three-dimensional reconstructing module. The invention can reduce noise as well as avoid the vagueness of the boundary of the liver, effectively and exactly divides the outline of the liver, improves the division quality of the hepatic portal vein tree, and realizes accurate and rapid division of the liver.

A procedure for image segmentation on three-dimensional (3D) medical images, and a system, apparatus, and computer program that operate in accordance with the procedure. The procedure includes generating a projection including an anatomic structure, tracing a curve corresponding to the anatomic structure, extracting a curved volume of interest based on the curve and the projection, and extracting a segmentation of the anatomic structure. Also provided is a procedure for aligning anatomic structures in images, and a system, apparatus, and computer program that operate in accordance with the procedure. The procedure includes determining part of a biliary system in a first image, determining part of a hepatic portal vein or a hepatic artery in a second image, determining a gallbladder in the images, determining a cost function, and aligning the biliary system and the hepatic portal vein or hepatic artery by maximizing the cost function.

The invention provides a deep learning segmentation system for hepatic veins and hepatic portal veins. The deep learning segmentation system comprises a coding module, a sequence attention association fusion module, an inter-slice-graph association module and a decoding module. An inter-slice-graph association module designed based on a graph neural network captures richer and higher-order relationships between adjacent CT sequences and improves the continuity of blood vessel segmentation; a sequence attention association fusion module designed based on an attention mechanism associates and fuses information of different dimensions, and the fine blood vessel segmentation accuracy is improved; in addition, the invention further provides a loss function combined with a blood vessel edge measurement constraint term, and the blood vessel edge is optimized and adjusted.

The invention discloses a hepatic portal blood flow blocking device, which relates to the field of clinical medicine, and comprises a catheter, a blocking bag and a positioning head. The base end of the catheter is provided with a protective plug to prevent external impurities from entering the catheter; At least one layer of flexible layer material, the inner surface of the flexible layer or in the flexible layer is provided with linear support frames arranged at intervals, and the support frames are made of shape memory alloy; the flexible layer surrounds the interior to form a cavity; the end of the cavity The positioning head is formed by a protrusion away from the catheter. The center of the positioning head is provided with a pinhole-shaped through hole connecting the outside to the cavity. The positioning head is also covered with an annular positioning ring. It realizes the ability to reduce the requirements for ultrasound-guided technology and puncture technology during use, and realizes simple and rapid blood flow occlusion in the hepatic portal vein, so as to implement precise resection. The technical effect of reducing the chance of portal vein metastasis and improving the survival rate of patients in the perioperative period after surgery.

A system and method for cooperatively regulating the pressure and flow of an afferent vessel, such as both the hepatic portal vein and the hepatic artery. The present invention solves the problem of less-than-therapeutic portal flow during perfusion preservation by implementing cooperative regulation of inputs, such as the portal vein and hepatic artery pumping systems, on the organ preservation device. The system includes an algorithm adapted to the situation where the portal vein has reached minimum flow and maximum pressure. A cooperative regulation algorithm detects a problem with the portal vein and resolves it by adjusting the flow state of the hepatic artery.