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Virtual hepatic vein pressure gradient measurement method

A pressure gradient and measurement method technology, applied in the medical field, can solve the problems of large numerical variation, high operation difficulty, and many interference factors of non-invasive methods, and achieve the effect of high accuracy

Pending Publication Date: 2021-06-04
LANZHOU UNIVERSITY
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the above-mentioned invasive methods are risky and difficult to operate, while the non-invasive methods have many interference factors and large value variations

Method used

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  • Virtual hepatic vein pressure gradient measurement method
  • Virtual hepatic vein pressure gradient measurement method
  • Virtual hepatic vein pressure gradient measurement method

Examples

Experimental program
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Embodiment 1

[0106] This embodiment provides a method for measuring the virtual hepatic venous pressure gradient, specifically refer to the following steps:

[0107] 1. Inject contrast agent from the median cubital vein of the specimen, perform CT angiography (CTA), obtain the CTA layer sequence including the hepatic venous phase, and export the layer sequence, the format is dicom, the layer thickness is 1.25mm, and the image resolution is 512×512 pixels (such as figure 1 shown).

[0108] 2. Import the obtained CTA layer sequence into the medical image control software MIMICS, and select the hepatic venous phase layer sequence (such as figure 2 As shown, layer thickness 1.25mm), set the orientation of the image sequence (such as image 3 shown), the MIMICS software automatically recognizes the image sequence, and generates coronal, sagittal, and horizontal images of the hepatic venous phase CTA image sequence (such as Figure 4 shown).

[0109] 3. To find the hepatic vein-portal vein ...

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Abstract

The invention discloses a virtual hepatic vein pressure gradient measurement method, and belongs to the technical field of medicine. The method comprises the following steps: establishing a finite element calculation platform comprising a fluid mechanics calculation module, a solid mechanics calculation module and a fluid-solid coupling calculation module, importing an open geometric model for simulating liver vein free pressure, dividing grids of blood and a blood vessel wall, setting parameters, simulating fluid-solid coupling of the blood vessel wall and the blood, 0btaining pressure distribution and blood flow distribution of the simulated three-dimensional blood vessel model; obtaining a liver-portal vein model pressure distribution diagram and a virtual liver vein free pressure value; and obtaining the virtual hepatic vein wedging pressure, taking the difference value between the wedging pressure of the virtual hepatic vein and the free pressure of the virtual hepatic vein as the pressure gradient of the virtual hepatic vein. According to the method, a fluid-solid coupling model which better conforms to the real physiological condition of a human body is adopted, and the virtual hepatic vein pressure gradient measurement method with high accuracy is obtained.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a virtual hepatic vein pressure gradient measurement method. Background technique [0002] Portal hypertension is an important feature of decompensated liver cirrhosis, and its clinical diagnosis often lags behind the occurrence of severe complications in the late stage. [0003] At present, related technologies at home and abroad include invasive hepatic venous pressure gradient measurement method and non-invasive hepatic venous pressure gradient measurement method. The former is punctured through the internal jugular vein and then passed through the internal jugular vein, superior vena cava, right atrium, and inferior vena cava. Enter the hepatic vein, measure free hepatic venous pressure (FHVP) and hepatic venous wedge pressure (wedged hepatic venous pressure, WHVP), and calculate the difference between them to obtain the HVPG virtual hepatic venous pressure gradient measurem...

Claims

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Application Information

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IPC IPC(8): G06F30/28G06F30/23G06T17/20G16H50/50G16H30/20G06F119/14
CPCG06F30/28G06F30/23G06T17/20G16H50/50G16H30/20G06F2119/14
Inventor 祁小龙梁明凯李小果康宁刘川徐丹
Owner LANZHOU UNIVERSITY
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