In-vitro liver perfusion device

Abstract

The invention discloses an in-vitro liver perfusion device which comprises a support, a clamping mechanism, a hepatic portal vein perfusion channel and a hepatic artery perfusion channel, wherein the clamping mechanism is arranged on the support and is used for clamping a ligament of the in-vitro liver so as to hang the in-vitro liver; the hepatic portal vein perfusion channel is slidably arranged on the support, and one end of the hepatic portal vein perfusion channel is communicated with a hepatic portal vein of the in-vitro liver; the hepatic artery perfusion channel is slidably arranged on the hepatic portal vein perfusion channel, and one end of the hepatic artery perfusion channel is communicated with the hepatic artery of the in-vitro liver. The ligament of the in-vitro liver is clamped through the clamping mechanism arranged on the support, so that the in-vitro liver is hung, the in-vitro liver is in a free sagging state, the whole in-vitro liver is not extruded, and the situation that the liver function is damaged due to stacking of the in-vitro liver when the in-vitro liver is directly contained in a container is prevented; and the hepatic portal vein perfusion channel and the hepatic artery perfusion channel are arranged, so that a perfusion tube can be conveniently inserted and is not easy to fall off, and perfusate can be prevented from leaking at the insertion part.

Description

technical field [0001] The invention relates to the field of isolated organ preservation equipment, in particular to an isolated liver perfusion device. Background technique [0002] Liver perfusion is to use cold electrolyte solution, such as lactated Ringer's solution, etc., to infuse through the portal vein or hepatic artery, and rapidly cool the liver so that its core temperature drops to 10-15°C. Since hypothermia can reduce the metabolic needs of the liver and increase the tolerance of the liver parenchyma to temporary hypoxia, it can better overcome the time limit of hypoxic damage caused by blocking the hepatic blood flow at normal temperature. Liver perfusion can be divided into isolated liver perfusion and in situ liver perfusion. The former is used for liver transplantation. After the donor liver is perfused, the liver is harvested and stored at low temperature. The latter is used for resection of liver tumors, and can be performed in an anemic or semi-anemic st...

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention proposes an isolated liver perfusion device to solve the problem that in the existing isolated liver perfusion process proposed in the above background technology, placing the isolated liver directly in the container will easily lead to isolated The accumulation of body liver will make the lower part of the accumulation be squeezed and oppressed, which will easily damage the liver function; it is very inconvenient to insert the perfusion tube directly into the portal vein or hepatic artery, and it is easy to fall off, and it is easy to cause leakage at the insertion point

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