9 results about "Hepatic function" patented technology

The present invention relates to a composition comprising an estetrol component for use in alleviating estrogen deficiency symptoms, including menopause-related symptoms, in subjects characterized by a certain degree of liver dysfunction.Compared with existing estrogen-based compositions intended to alleviate estrogen deficiency symptoms, the composition described herein exhibits favorable pharmacokinetic properties.Also described herein are the uses for the above and corresponding treatment methods.

The present invention relates to a compound selected from nitazoxanide, tizoxanide, tizoxanide glucuronide and pharmaceutically acceptable salts thereof, for use in a method for the treatment of hepatic impairment.

The invention discloses application of curcumenone in preparation of a medicine for preventing and treating ischemia-reperfusion injury. The invention proposes and verifies that the caramel curcumenone can be used for preventing and treating the hepatic ischemia reperfusion injury for the first time, and the compound can effectively protect hepatic tissues and avoid liver function damage by inhibiting the oxidative stress level of the hepatic tissues after ischemia reperfusion, avoiding cell ferroptosis and improving bone marrow-derived macrophages, so that the caramel curcumenone can be used for preventing and treating the hepatic ischemia reperfusion injury. The invention provides a novel medicine with great application potential for preventing and treating ischemia reperfusion injury.

The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present disclosure provides methods for the acute treatment of migraine in patients having hepatic impairment; in patients with renal impairment; and in patients concurrently taking CYP3A4 modulators or BCRP and / or P-gp only inhibitors.

The invention discloses a comprehensive medicine bag for treating traumatic injuries, rheumatism bone diseases and postpartum sequelae and a preparation method thereof, and belongs to the technical field of comprehensive medicine bags, the medicine bag is prepared from the following raw materials in parts by weight: 1 part of white flower, 1 part of red bud flower, 1 part of sambucus williamsii, 1 part of cinnamomum camphora, 1 part of hematoxylon, 1 part of Chinese sausage leaves, 1 part of ruellia tenuifolia and 1 part of folium artemisiae argyi. The preparation method comprises the following steps: grinding fresh leaf branches or dry leaf branches of flos lonicerae, red bud flowers, sambucus williamsii, cinnamomum camphora, hematoxylon, folium saussureae leaves, ruellia tenuifolia and folium artemisiae argyi into coarse powder, and then fumigating the medicinal materials at 105 DEG C for 10-20 minutes to obtain the product. The formula can be used for treating traumatic injuries, rheumatism bone diseases and postpartum sequelae. The traditional Chinese medicine composition has the effects of removing wind, promoting blood circulation, relieving pain, tonifying fire, strengthening the body, diminishing swelling, promoting reunion of fractured tendons and bones, treating wind-cold-dampness arthralgia, waist and knee icy pain, cold impotence, various headache symptoms, limb joint spasm and dramatic pain, menstrual disorder, dysmenorrhea, amenorrhea, puerperal fever, clearing away heat and toxic materials, rheumatism limb joint swelling and pain, traumatic injury, rheumatism arthralgia and myalgia, edema, postpartum anemic fainting, hernia pain, stomachache, rheumatism leg pain and kidney deficiency nephritis. The traditional Chinese medicine composition has the effects of treating postpartum lumbago and thoracoabdominal stabbing pain, promoting blood circulation to treat wounds, clearing and activating the channels and collaterals, regulating blood vessels, improving liver functions, resisting oxidation, promoting digestion, relieving constipation, reducing blood pressure, controlling blood sugar, protecting the liver, beautifying the skin, resisting bacteria and diminishing inflammation, and well improving acnes, comedos and oily skin.

This composition for preventing or improving hepatic dysfunction contains glutathione trisulfide or a pharmacologically acceptable salt thereof.

The invention relates to the field of biomedical engineering and disease model construction, in particular to a construction method and application of a full-spectrum liver organoid. The construction method comprises the following steps: respectively differentiating induced pluripotent stem cells from human umbilical cord to obtain transitional hepatic endoderm cells, endothelial progenitor cells, red myeloid progenitor cells, hepatic stellate cells and diaphragm mesenchymal stem cells; transition hepatic endoderm cells, endothelial progenitor cells, red myeloid progenitor cells, hepatic stellate cells and diaphragm mesenchymal stem cells are inoculated into a 3D culture system according to the cell number ratio of (9-11): (6-8): (1-2): (1-2): (1-2); and performing self-assembly co-culture on the seed cells in a 3D culture system until the liver function is mature, thereby obtaining the full-spectrum liver organoid. The technical problem that physiological authenticity, functional integrity and application universality of an existing liver model need to be improved is solved.

Provided are methods for treating brain tumors, characterized by an IDH1 and / or IDH2 mutation, with vorasidenib, in patients with hepatic impairment.