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32 results about "Equivalent dose" patented technology

Equivalent dose is a dose quantity H representing the stochastic health effects of low levels of ionizing radiation on the human body which represents the probability of radiation-induced cancer and genetic damage. It is derived from the physical quantity absorbed dose, but also takes into account the biological effectiveness of the radiation, which is dependent on the radiation type and energy. In the SI system of units, the unit of measure is the sievert (Sv).

Nanodosimeter based on single ion detection

A nanodosimeter device (15) for detecting positive ions induced in a sensitive gas volume by a radiation field of primary particle, comprising an ionization chamber (10) for holding the sensitive gas volume to be irradiated by the radiation field of primary particles; an ion counter system connected to the ionization chamber (10) for detecting the positive ions which pass through the aperture opening and arrive at the ion counter (12) at an arrival time; a particle tracking system for position-sensitive detection of the primary particles passing through the sensitive gas volume; and a data acquisition system capable of coordinating the readout of all data signals and of performing data analysis correlating the arrival time of the positive ions detected by the ion counter system relative to the position sensitive data of primary particles detected by the particle tracking system. The invention further includes the use of the nanodosimeter for method of calibrating radiation exposure with damage to a nucleic acid within a sample. A volume of tissue-equivalent gas is radiated with a radiation field to induce positive ions. The resulting positive ions are measured and compared with a determination of presence or extent of damage resulting from irradiating a nucleic acid sample with an equivalent dose of radiation.
Owner:LOMA LINDA UNIVERSITY +1

17-Hydroxyprogesterone Ester-Containing Oral Compositions and Related Methods

ActiveUS20130029957A1Effectively delivered orallyHigh percent w/w loadingPowder deliveryOrganic active ingredientsEquivalent dose17α-Hydroxyprogesterone
The present invention provides for bioavailable oral dosage forms containing esters of 17-hydroxyprogesterone as well as related methods. The oral dosage forms can be formulated for pregnancy support and can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. In another embodiment, a pharmaceutically acceptable oral dosage form for pregnancy support is provided. The pharmaceutically acceptable oral dosage can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. The oral dosage form can, when measured using a USP Type-II dissolution apparatus in 900 mL of deionized water with 0.5 (w / v) of sodium lauryl sulfate at 50 RPM at 37° C., release at least 20 wt % of the dose of the ester of 17-hydroxyprogesterone after 60 minutes, or in the alternative release at least 20 wt % more after 60 minutes than an equivalently dosed oral dosage form without the carrier.
Owner:LIPOCINE

Ship reactor shielding design optimization method based on neural network and genetic algorithm

The invention discloses a ship reactor shielding design optimization method based on a neural network and a genetic algorithm. A Monte Carlo method is used for simulating and calculating the reactor neutron and photon transport process; an MCNP (Monte Carlo N Particle Transport Code) program is used for carrying out simulation and calculation on a ship reactor layered shielding model; a neutron and photon flux after the reactor shielding is obtained; the total equivalent dose is worked out; a topological structure of a BP (Back Propagation) neural network is determined according to the input parameter number n1 and the output parameter number n2 of a sample; an adaptation degree function of the genetic algorithm is determined according to a reactor shielding problem objective; the recommended adaptation degree function is selected; and the strong optimization capacity of the genetic algorithm is used and is mutually coupled with the neural network to find the optimum shielding parameter. The ship reactor shielding design optimization method has the advantages that the high fitting capability of the neural network is used; the time consumption of the MCNP program in the particle transport process is reduced; the good optimization capacity of the genetic algorithm is used; and the optimum shielding parameter can be found in few iteration steps.
Owner:NANHUA UNIV

Method and apparatus for control of exposure in radiological imaging systems

Method and apparatus for adjustment of the entrance dose of a radiology apparatus of the type containing a means of X-ray beam emission, a means of detection of the X-ray beam after it has crossed an object having to be visualized, and a means of visualization connected to the means of detection, in which the distance between the means of emission and the object is estimated and, when the distance between the means of emission and the object or the distance between the means of emission and the means of detection varies, the entrance dose is modified according to said distances in order to maintain an appreciably constant equivalent dose in the plane containing the object, the distance between the means of emission and the means of detection being known.
Owner:GE MEDICAL SYSTEMS INC

Nanodosimeter based on single ion detection

A nanodosimeter device (15) for detecting positive ions induced in a sensitive gas volume by a radiation field of primary particle, comprising an ionization chamber (10) for holding the sensitive gas volume to be irradiated by the radiation field of primary particles; an ion counter system connected to the ionization chamber (10) for detecting the positive ions which pass through the aperture opening and arrive at the ion counter (12) at an arrival time; a particle tracking system for position-sensitive detection of the primary particles passing through the sensitive gas volume; and a data acquisition system capable of coordinating the readout of all data signals and of performing data analysis correlating the arrival time of the positive ions detected by the ion counter system relative to the position sensitive data of primary particles detected by the particle tracking system. The invention further includes the use of the nanodosimeter for method of calibrating radiation exposure with damage to a nucleic acid within a sample. A volume of tissue-equivalent gas is radiated with a radiation field to induce positive ions. The resulting positive ions are measured and compared with a determination of presence or extent of damage resulting from irradiating a nucleic acid sample with an equivalent dose of radiation.
Owner:LOMA LINDA UNIVERSITY +1

System for determining UV dose in a reactor system

The is described a process for determining a validated Reduction Equivalent Dose for reducing the concentration of a target contaminant contained in a fluid in a radiation fluid treatment system. In one embodiment, the process comprises the steps of: (a) determining a short wavelength Reduction Equivalent Dose for the target contaminant or a challenge contaminant in a first region of the electromagnetic spectrum having a wavelength of less than or equal to about 240 nm; (b) determining a long wavelength Reduction Equivalent Dose for the target contaminant or a challenge contaminant in a second region of the electromagnetic spectrum having a wavelength of greater than about 240 nm; and (c) summing the short wavelength Reduction Equivalent Dose and the long wavelength Reduction Equivalent Dose to produce the validated Reduction Equivalent Dose for the target contaminant. In a preferred embodiment, the present invention provides a useful approach for determining the relevant Reduction Equivalent Dose (RED) for Cryptosporidium disinfection and accomplishes this by using the discovered relation between the short wavelength sensor signal and the short wavelength RED, and subtracting the short wavelength RED from the RED determined using a challenge microbe with synthetic lamp sleeves, to obtain the long wavelength RED applicable to Cryptosporidium disinfection. In a bioassay, one would only need the short wavelength sensor reading and the challenge microbe RED using synthetic lamp sleeves to determine the applicable RED, once the relationship between the short wavelength sensor reading and the short wavelength RED was established.
Owner:TROJAN TECH

Wide-range TEPC (tissue-equivalent proportional counter) and application thereof

The invention relates to a radiation detection device and provides a wide-range TEPC (tissue-equivalent proportional counter) and an application thereof in order to solve the problem that an existing TEPC is hard to give consideration to radiation field measurement with larger differences of fluence rate and equivalent dose rate levels. The wide-range TEPC comprises a casing, a voltage division circuit, a multichannel signal collection system as well as a conductive tissue equivalent material negative plate, a conductive tissue equivalent material plate, a GEM membrane and a positive plate which are located in the casing and overlaid in sequence from top to bottom. The application method of the wide-range TEPC comprises steps as follows: step one, the wide-range TEPC is placed in a to-be-detected radiation field; step two, signals are collected; step three, the signals are processed. The wide-range TEPC has a quite wide measuring range, can realize measurement of the radiation fields with low fluence rate and high fluence rate conveniently, is smaller in size, relatively simple in structure, easy to manufacture and quite wide in applicable range, and can be applicable to radiation monitoring of various occasions.
Owner:CHINA INSTITUTE OF ATOMIC ENERGY

Sensitivity correction method of optically stimulated luminescence dating experiment

ActiveCN109115732AThe equivalent dose value is reasonableSensitivity Variation CorrectionAnalysis by material excitationCorrection methodEquivalent dose
The invention provides a sensitivity correction method of an optically stimulated luminescence dating experiment. The sensitivity correction method comprises the following steps of, in each loop teststep, calculating a regenerative-dose luminescence signal value and a test-dose luminescence signal value which are obtained through measurement, and acquiring a current regenerative-dose sensitivitychange value, wherein the current regenerative-dose sensitivity change value is a change quantity of the luminescence signal value measured by an equivalent regenerative dose; correcting the current regenerative-dose sensitivity change value, and obtaining a corrected regenerative-dose sensitivity change value, wherein a current test-dose sensitivity change value is a difference value between thetest-dose luminescence signal value measured in a previous loop test step and a current test-dose luminescence signal value measured in a current loop test step; and correcting the current test-dose sensitivity change value, and obtaining a corrected test-dose sensitivity change value. The sensitivity correction method can be used for effectively optimizing a correction method of a sensitivity change, so as to improve the test accuracy and reliability of an equivalent dose of a sample.
Owner:GUANGZHOU COLLEGE OF SOUTH CHINA UNIV OF TECH

Liposomal corticosteroids for treatment of inflammatory disorders in humans

InactiveCN104144679AEfficient removalOvercome inherent problemsOrganic active ingredientsAntipyreticLipid formationCorticosteroid preparation
The invention relates to a pharmaceutical composition comprising liposomes composed of non-charged vesicle-forming lipids, optionally including not more than 10 mole percent of negatively charged vesicle- forming lipids and / or not more than 10 mole percent of PEGylated lipids, the liposomes having a selected mean particle diameter in the size range of 40-200 nm and comprising a first corticosteroid in water soluble form, for the site-specific treatment of inflammatory disorders in humans, providing in human patients a fast, strong, and durable anti-inflammatory effect for at least 2 weeks at a dose of at most 5 mg / kg body weight of prednisolone or an equipotent dose corticosteroid other than prednisolone at a treatment frequency of at most once per two weeks. Furthermore the present invention relates to the application of the above-mentioned pharmaceutical composition given as intervention therapy in inflammatory disorders such as rheumatic disease or a related inflammatory connective tissue disorder, inflammatory diseases of the kidney or inflammatory bowel disorders, in combination with chronic therapy with a second free corticosteroid formulation or in combination with chronic treatment with a disease- modifying agent such as methotrexate.
Owner:ENCELADUS PHARMA BV

Optimization method for shielding design of marine reactor based on neural network and genetic algorithm

The invention discloses a method for optimizing the shielding design of a marine reactor based on a neural network and a genetic algorithm. The Monte Carlo method is used to simulate and calculate the transport process of neutrons and photons in the reactor, and the MCNP program is used to simulate and calculate the layered shielding model of the marine reactor to obtain the reactor. Neutron and photon flux after shielding, and calculate the total equivalent dose; according to the number of input parameters n of samples 1 and the number of output parameters n 2 To determine the topology of the BP neural network; determine the fitness function of the genetic algorithm according to the objective of the reactor shielding problem, select the recommended fitness function, and use the strong optimization ability of the genetic algorithm to couple with the neural network to find the best shielding parameters. The invention has the advantages of reducing the time consumption of the MCNP program in the particle transport calculation process by using the strong fitting ability of the neural network and using the good optimization ability of the genetic algorithm, and can find the optimal shielding in few iteration steps parameter.
Owner:NANHUA UNIV

Exposure dose control method based on exposure dose control system

The invention provides an exposure dose control method based on an exposure dose control system. The method comprises the following steps: controlling a shutter to open; receiving an energy value collected by an energy sensor, and determining an accumulated exposure dose value based on the energy value; determining whether the accumulated exposure dose value is not less than a target dose value; if the accumulated exposure dose value is not less than the target dose value, controlling the shutter to start to close; taking the accumulated exposure dose value corresponding to the jitter delay ending moment after the shutter is completely closed as an actual accumulated exposure dose value; determining an exposure dose error value based on the actual accumulated exposure dose value; determining whether the exposure dose error value meets requirements or not; if the exposure dose error value does not meet the requirement, updating the equivalent dose value, and returning to execute the first step; and if the exposure dose error value meets the requirement, applying the equivalent dose value to the exposure system. Through the exposure dose control method based on the exposure dose control system, the problem of low exposure dose control precision is solved.
Owner:BEIJING SEMICON EQUIP INST THE 45TH RES INST OF CETC

A Space Telescope for Charged Particles Based on Cadmium Zinc Telluride

The invention discloses a space charged particle telescope based on cadmium zinc telluride. The top of the outer cover is provided with an opening, the outer cover is provided with a mounting seat, and the mounting seat is provided with a Si semiconductor detector, a first CZT detector and a second CZT The detector, the Si semiconductor detector and the first CZT detector form a first group of ΔE‑E detector systems, the first CZT detector and the second CZT detector form a second group of ΔE‑E detector systems, and the first group ΔE The ‑E detector system and the second group of ΔE‑E detector systems work together to measure charged particles of different energies. The invention can measure components such as charged particles, thermal neutrons and gamma rays in the space environment. It can effectively measure the linear energy transfer (LET), equivalent dose, charged particle energy spectrum, total dose, dose rate and other information of charged particles in space, which is of great significance for astronaut radiation risk assessment. Compared with traditional scintillation The crystal system can improve the resolution of particle energy spectrum and enhance the ability of particle identification.
Owner:SUZHOU UNIV

Space charged particle telescope based on cadmium zinc telluride

The invention discloses a space charged particle telescope based on cadmium zinc telluride. An opening is formed in the top end of an outer cover of the space charged particle telescope, a mounting base is arranged in the outer cover, a Si semiconductor detector, a first CZT detector and a second CZT detector are arranged on the mounting base, and the Si semiconductor detector and the first CZT detector form a first delta EE detector system; and the first CZT detector and the second CZT detector form a second group of delta EE detector systems, and the first delta EE detector system and the second delta EE detector system are matched to respectively measure charged particles with different energies. According to the invention, charged particles, thermal neutrons, gamma rays and other components in a space environment can be measured. The telescope can effectively measure information such as energy transfer linear density spectrum (LET), equivalent dose, charged particle energy spectrum, total dose, dose rate and the like of charged particles in space, has very important significance for astronaut radiation risk assessment, and can improve the resolution of the particle energy spectrum and enhance the particle identification capability compared with a traditional scintillation crystal system.
Owner:SUZHOU UNIV
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