43 results about "Rheumatic disease" patented technology

The present invention is in the fields of medicinal chemistry, biotechnology and pharmaceuticals. The invention provides compositions comprising one or more collagen mimetic peptides, optionally attached to one or more therapeutic compounds or one or more imaging compounds, for use in methods of treating, preventing, ameliorating, curing and diagnosing certain diseases and physical disorders in humans and veterinary animals, as well as methods of manufacturing such composition. The invention also provides medical devices comprising one or more such compositions of the invention. The invention also provides methods of use of such compositions and devices in treating and diagnosing certain diseases and physical disorders in humans and veterinary animals, including ocular diseases or disorders, skin diseases or disorders, certain cancers, particularly intraluminal cancers, gastrointestinal diseases or disorders, genitourinary tract diseases or disorders, fibrotic diseases / disorders and rheumatic diseases / disorders.

The invention relates to a device and method for thermal therapy of a selected region of a human or animal body, particularly for treating tissue damage after surgery, injuries, inflammation, chronic rheumatic conditions, and for supporting chemotherapy. The system includes a temperature control device that circulates a temperature-controlled fluid through a heat transfer unit configured for uniform skin contact, and a pressure device to optimize thermal transfer. During chemotherapy, the device maintains the selected region, such as hands or feet, at a target temperature to prevent or reduce chemotherapy-induced polyneuropathy (CIPN). Sensors monitor temperature and pressure, enabling feedback control for consistent therapy. Methods include fitting the device to the patient, adjusting pressure, and maintaining even skin cooling throughout chemotherapy, thereby improving patient comfort, reducing adverse side effects, and supporting adherence to treatment. The invention provides improved outcomes in thermal therapy applications.

The invention belongs to the technical field of medical health, and discloses a detection system for evaluating rheumatism activity, which comprises a data acquisition module, a multi-modal data preprocessing module, a feature fusion extraction module, an intelligent evaluation model module and a result output module which are connected in sequence. Through synchronous acquisition of multi-modal data (clinical data, image data, symptom data and behavior data), the limitation of single data dimension is broken through, the rheumatism activity can be comprehensively reflected from multiple aspects such as physiological indexes, imaging performance, subjective feeling and objective behaviors, and a foundation is laid for accurate evaluation; through combined processing of adaptive threshold filtering, normalization and time sequence interpolation, the problems of noise, dimension difference and missing of multi-modal data are effectively solved, meanwhile, time sequence features are reserved, and the accuracy of subsequent feature extraction and model operation is ensured; through combination of the deep learning network and the attention mechanism, adaptive weighted fusion of cross-modal features is realized, the complementary value of each modal data can be fully mined, the richness and distinction degree of feature expression are improved, and actual application and operation are facilitated.

The invention provides a muscle-bone injury area identification method and system, and relates to the technical field of muscle-bone image injury identification. The method comprises the following steps: acquiring a two-dimensional gray-scale ultrasonic image of a target muscle-bone injury area, and positioning a synovial tissue area from the two-dimensional gray-scale ultrasonic image; extracting target feature information from the synovial tissue region; and determining the inflammation activity degree of the synovial tissue according to the target feature information. According to the method, Doppler blood flow signals are completely bypassed, the rheumatism inflammation activity degree is evaluated only through rich information contained in the two-dimensional gray-scale ultrasonic image, and therefore interference of probe pressure artifacts is thoroughly avoided.

The invention relates to a multi-mode-based self-adaption rheumatism glove control method and a multi-mode-based self-adaption rheumatism glove control system. The method comprises the following steps: acquiring a multi-source data set including impedance data, thermodynamic distribution data, joint movement data, pressure distribution data and the like; respectively performing inflammation activity quantification, joint function evaluation and infection risk evaluation processing according to the data set to obtain an inflammation score, a function index and a risk identifier, and generating a state vector; based on the state vector and a historical state vector sequence loaded from a historical database, carrying out illness state stage identification processing to obtain an identification result, and generating a control instruction according to the identification result; and performing thermal therapy-electrical stimulation cooperative processing based on the control instruction, generating a pressure target value according to the state vector, performing pressure regulation and control processing, and generating a treatment log. According to the method, multi-source data are comprehensively analyzed, personalized control instructions and pressure regulation and control strategies are generated, accurate and personalized treatment schemes can be provided, and the treatment experience and rehabilitation effect of rheumatism patients are improved.

The present invention provides the use of SE-DR (HLA-DR molecule containing a shared epitope) affinity peptide for the preparation of a medicament for treating rheumatic diseases in rheumatic patients who are tuberculosis positive and / or have hepatitis B. The present invention solves the problem that patients with rheumatic diseases have limited drug options. The present invention also provides a pharmaceutical composition comprising an SE-DR affinity peptide and a non-antigen specific antirheumatic drug, and its use for the preparation of a medicament for the treatment of various types of rheumatic diseases. The pharmaceutical composition can rapidly inhibit the progression of rheumatic diseases for complete control of rheumatic diseases, and can achieve sustained remission even after tapering or discontinuation of the drug.

The present invention describes a Hyaluronic acid-based homogenous composition with high molecular weight in combination with epigallocatechin-3-O-Gallate (EGCG) and / or xanthohumol (XAN) for use in treating rheumatic pathologies or for cosmetic use to prevent and treat skin aging.

The application relates to the field of medical devices, in particular to a joint protection device suitable for children with rheumatic and immunological diseases, which comprises a joint protection sleeve, a plurality of first sliding grooves and a plurality of connecting rods are arranged on the two sides of the joint protection sleeve, the first sliding grooves and the connecting rods are in one-to-one correspondence, when the joint protection sleeve wraps the joint, the connecting rods are inserted into the first sliding grooves, and the connecting rods and the first sliding grooves are in sliding cooperation; the adjusting holes and the anti-occlusion mechanisms are communicated in the first sliding grooves, the opening and closing mechanisms are communicated on the communication paths of the adjusting holes and the first sliding grooves, and the opening and closing mechanisms are used for controlling the on-off of the adjusting holes and the first sliding grooves; the anti-occlusion mechanisms are used for connecting the first sliding grooves with the outside based on the negative pressure size in the first sliding grooves. The application can realize dynamic adaptation and intelligent protection, and reduce the occlusion risk caused by rigid fixation of the device.

The invention discloses an application of green tendon relaxing ketone in preparation of a medicine for treating rheumatoid diseases. The invention proposes and verifies that the green tendon relaxing ketone can effectively promote fibroblast-like synovial cell ferroptosis so as to inhibit synovial hyperplasia and inhibit the expression of proinflammatory cytokines so as to effectively relieve the progress of rheumatoid arthritis for the first time, and has an excellent application prospect in clinical treatment of rheumatoid diseases.

This invention relates to a protective device for rheumatism, belonging to the field of protective technology. It includes a locking block with a strap around it. The strap is fixedly connected to a first sleeve, which is fixedly connected to a connecting sleeve. The connecting sleeve is fixedly connected to a second sleeve. All three sleeves—the first, second, and connecting sleeves—are made of a resilient material. A plaster tray is fixedly connected to the connecting sleeve. The first sleeve is equipped with a massage component for massaging the leg at the knee joint. When the patient walks, the continuous bending and straightening movements of the knee drive the rollers to roll back and forth, thereby massaging the leg joint at the knee and relieving rheumatic pain.

The present invention provides a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and / or cancer including colorectal cancer.The present invention relates to a compound of formula [I-a], [I-b] or [I-c] or a pharmaceutically acceptable salt thereof:wherein each symbol is as defined in the specification.

The present invention relates to the prophylactic and / or therapeutic treatment of a disease selected from the group consisting of long-term COVID disease, myalgic encephalomyelitis / chronic fatigue syndrome (ME / CFS) disease, fibromyalgia, dementia, neoplastic disease, autoimmune disease, schizophrenia, epileptic seizure disease, excessive inflammatory disease, chronic inflammatory bowel disease, rheumatic disease, obesity, and the like. Hyperuricemia, diabetes (IDDM / NIDDM), acute viral diseases, amyotrophic lateral sclerosis (ALS), bronchial asthma, atopic allergic disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, autoimmune diseases / antibody-related diseases, bipolar affective disorders, celiac disease (CD), chronic obstructive pulmonary disease (COPD), and the like. Chronic inflammatory bowel disease (CED) (i.e. Crohn's disease, ulcerative colitis), cystic fibrosis / cystic fibrosis, depression, endometriosis, polycystic ovarian syndrome, eating disorders, anxiety disorders, addiction disorders, frontotemporal dementia (Pickk's disease), Graves's disease (GD), generalized cardiovascular diseases, Alzheimer's disease, Parkinson's disease, meningitis, multiple sclerosis (MS), and the like. Muscular dystrophy, neurodermatitis, peripheral arterial occlusion disease (PAOD), pneumonia, generalized post-vaccination syndrome and vaccine damage, post-viral infection syndrome, psoriasis, pulmonary arterial hypertension, restless leg syndrome, restrictive pulmonary disease, rheumatoid arthritis (RA), division affective disorder, sepsis, sicca syndrome (SS), scleroderma, and the like. Systemic lupus erythematosus (SLE) and unsatisfactory fertility desires, using an active agent having a nicotinic acetylcholinergic agonist and / or an active agent having a muscarinic acetylcholinergic agonist and / or a muscarinic acetylcholinergic antagonist. This provides a very effective prophylactic and / or therapeutic treatment for these diseases. This prevention or treatment is also readily tolerable, cost effective and easy to apply.

This utility model discloses a production device for a gel used in rheumatism, relating to the field of gel production technology for rheumatism. It includes a base and a mixing tank. A fixing frame is provided on the upper outer surface of the base, and a shaking frame is provided in the middle of the fixing frame. A first drive motor is fixedly installed on one outer surface of the fixing frame, and a tank lid is provided on the upper outer surface of the mixing tank. In this rheumatism gel production device, the shaking frame is connected to the mixing tank via an internal vibration motor. A second drive motor drives a shaft to stir the material. During stirring, the vibration motor is activated, simultaneously vibrating the mixing tank and a movable block. This prevents material from adhering to the inner wall of the mixing tank. When the movable block is vibrated, it shakes via a limit spring, indirectly causing the mixing tank to shake, thus improving the mixing effect and efficiency of the material inside the mixing tank.

The present invention provides novel hydroquinone derivatives of formula (I), processes of preparation, as well as pharmaceutical compositions and methods of treating and / or preventing e.g. autoimmune, immunological, rheumatology, vascular disorders, ophthalmologic disorders, fibrotic disorders, metabolic and gastrointestinal disorders, neuroinflammatory and neurodegenerative diseases, neoplasms and cancer associated disorders, hormone related diseases and immunological disorders resulting from viral and bacterial infectious diseases and complications thereof. wherein R 1 is COOR 4, (CH 2 ) n COOR 4, SO 3 H, (CH 2 ) n SO 3 H or CONH-R 10; one of R 2 and R 3 is H and the other is R 5.

The present invention relates to a carboxyalkyl chitosan, compositions comprising same, a process for manufacturing same, and various applications thereof, in particular in the field of therapy, rheumatology, ophthalmology, aesthetic medicine, plastic surgery, internal surgery, dermatology or cosmetics.

The present invention relates to an inhibitor of CD74 protein activity or expression, for therapeutic use in the prevention and / or treatment of a chronic inflammatory disease selected from: chronic inflammatory rheumatic diseases, chronic inflammatory dermatoses, chronic inflammatory bowel diseases, and chronic inflammatory neurological diseases. In another aspect, the invention relates to an isolated anti-CD74 antibody or fragment thereof, comprising at least one CD74 receptor (CDR) having a sequence selected from SEQ ID NO. 1 to 5.

This invention provides the use of SE-DR (HLA-DR molecule containing a co-epitope) affinity peptides for the preparation of drugs to treat rheumatic diseases in rheumatoid arthritis patients who are tuberculosis-positive and / or have hepatitis B. [Solution] The present invention provides a pharmaceutical composition comprising an SE-DR affinity peptide and a non-antigen-specific antirheumatic drug, and the use thereof for the preparation of drugs for the treatment of various types of rheumatic diseases. The pharmaceutical composition can rapidly inhibit the progression of rheumatic diseases and achieve sustained remission even after tapering or discontinuation of the drug, for complete control of rheumatic diseases.

The invention relates to a food composition capable of regulating immune cytokine balance, and belongs to the technical field of food capable of regulating cytokine balance. Comprising 20-230 parts of medicago sativa linn and 10-130 parts of robinia pseudoacacia flowers which are mixed to form a medicago sativa linn-robinia pseudoacacia flower mixture. The traditional Chinese medicine composition solves the problems that traditional anti-rheumatism medicines for rheumatism patients have great side effects and anti-rheumatism biological preparations are expensive, is safe and convenient to use and low in price, and can be eaten throughout the year. Inflammation channels and inflammation factors are blocked and inhibited through the complementary effect of the gypsophila oldhamiana and the robinia pseudoacacia flowers, and the anti-inflammatory effect is achieved.

The present disclosure provides a composition comprising primed extracellular vesicles and a biologically or pharmaceutically acceptable carrier, wherein the primed extracellular vesicles comprise an upregulated miRNA, and a fold change of the upregulated miRNA of the primed extracellular vesicles compared to miRNA of naturally occurring extracellular vesicles is greater than 1. The present disclosure further provides a method for preventing, treating, or ameliorating a gynecological or a rheumatological disorder comprising administering the composition of the present disclosure to a subject in need thereof. The present disclosure also provides a method for producing the composition. The method comprises cultivating a stem cell in a culture medium containing a Polygonum multiflorum Thunb extract and resveratrol to obtain a cell culture.

A composition comprising primed extracellular vesicles and a biologically or pharmaceutically acceptable carrier, wherein the primed extracellular vesicles comprise an upregulated miRNA, and a fold change of the upregulated miRNA of the primed extracellular vesicles compared to miRNA of naturally occurring extracellular vesicles is greater than 1. A method for preventing, treating, or ameliorating a gynecological or a rheumatological disorder comprising administering the composition to a subject in need thereof. A method for producing the composition, comprising: cultivating a stem cell in a culture medium containing a Polygonum multiflorum Thunb extract and resveratrol to obtain a cell culture.

The application relates to an engineered exosome and a preparation method and application thereof, wherein the engineered exosome comprises a natural exosome, a photosensitizer and miR451a loaded in the natural exosome, and an anti-FAP alpha antibody or an antibody fragment loaded on the surface of the natural exosome; the anti-FAP alpha antibody is used for guiding the target receptor cell of the engineered exosome to be combined; the photosensitizer and the miR451a participate in the occurrence of ferroptosis of the target receptor cell under the action of photodynamic effect; and the target receptor cell is an activated fibroblast-like synoviocyte in rheumatic lesions. The application has the beneficial effects of providing a synergistic scheme of "biological carrier + physical stimulation" for RA treatment and having the treatment characteristics of high efficiency, low toxicity and high targeting.

A compound of the formula (I) or a salt thereof (R represents methyl group or fluorine atom) having an mPGES-1 inhibitory activity and useful as an active ingredient of a medicament for prophylactic and / or therapeutic treatment of such diseases as inflammation, pain, or rheumatism.

The invention relates to the technical field of medical treatment equipment, and discloses a rheumatism electrotherapy device based on ultrasonic heat therapy, which comprises a shell, a medicine feeding component is fixedly connected in the shell, a supporting block is fixedly connected outside the shell, a connecting pipe is arranged in the shell, and a connecting rod is arranged in the connecting pipe. The bottom end of the treatment head is installed at a liquid outlet of the connecting pipe, an electrotherapy piece is fixedly connected to the outside of the treatment head, a first fixing column is fixedly connected to the inside of the treatment head, an ultrasonic heating head is fixedly connected to the inside of the first fixing column, and a medicine feeding pipe is fixedly connected between the treatment head and the first fixing column. The bottom end of the medicine feeding pipe is fixedly connected with a connecting shell, and a switch assembly is arranged in the connecting shell. Through mutual cooperation of the shell, the medicine feeding assembly, the treatment head, the ultrasonic heating head, the electrotherapy piece and the medicine feeding pipe, the synergistic effect of ultrasonic heating, electrotherapy and medicine treatment is achieved, the problem that a traditional single therapy is limited in effect on the rheumatism focus is solved, and the treatment efficiency is improved.

A playful and therapeutic device for the rehabilitation of fine manual motor skills; specifically for the rehabilitation of patients with rheumatic, traumatic and neurological pathologies who have fine motor sequelae in the wrist, palm and fingers of both hands; characterized by having a cultural theme related to the Guelaguetza of Oaxaca and by comprising a container with a lid and handle that will serve to store and transport other components such as a puzzle, cylindrical pieces with and without slots, cards and tweezers.The device facilitates playful and therapeutic activities for mental, sensory, and physical stimulation; such as placing and removing the lid of the container to perform pronation and supination movements and palmar grasp; assembling a puzzle to perform pronation and supination movements, palmar grasp, four-finger pinch, and visuo-manual coordination; fitting cylinders into holes to perform two-finger pinch, three-finger pinch, and visuo-manual coordination movements; inserting cards into slots to perform pronation and supination movements, two-finger pinch, and visuo-manual coordination; and hooking tweezers onto a surface to perform pronation and supination movements, two-finger pinch, and visuo-manual coordination.

A compound of the formula (I) or a salt thereof (R represents methyl group or fluorine atom) having an mPGES-1 inhibitory activity and useful as an active ingredient of a medicament for prophylactic and / or therapeutic treatment of such diseases as inflammation, pain, or rheumatism.

The invention relates to the field of medical artificial intelligence, in particular to a multi-modal deep learning fused early-stage intelligent screening system for rheumatic diseases, which comprises an intelligent question and answer module, a knowledge graph module, an auxiliary diagnosis module and a hierarchical diagnosis module, innovatively introduces an algebraic topology theory, and represents medical knowledge as a pure complex structure, so that the medical knowledge can be quickly and accurately screened; weak signals in the early stage of diseases are captured through the continuous homology feature extraction technology, clinical phenotypes, laboratory examination and iconography information are integrated through a spectrum topology fusion network, the system adopts a multi-head topology perception attention mechanism, contributions of different modes are dynamically balanced, early accurate screening and clinical verification display of rheumatism are achieved, and the system has a wide application prospect. The system can identify the early performance of rheumatism six months in advance, the diagnosis accuracy reaches 85%, reliable decision support is provided for early intervention, and the system is particularly suitable for primary medical screening, specialized auxiliary diagnosis and multi-center clinical research.

The present application relates to the field of medical rehabilitation information technology, in particular to a rheumatism rehabilitation intelligent evaluation system based on ICF concept and classification system, comprising: a multi-source data module for collecting and integrating multi-dimensional data; a dynamic evaluation module based on ICF theory, constructing a dynamic weight distribution model, updating the evaluation results and radar chart according to the multi-dimensional data; a data feature module based on latent profile analysis algorithm, performing high-dimensional feature dimension reduction processing according to the evaluation results and radar chart, and identifying hidden subtypes; a causal intervention module based on the hidden subtypes, wherein the present application, in use, applies the multi-dimensional dynamic coupling evaluation of ICF theory, the subtype identification of latent profile analysis and the causal modeling of structural equation model to the rheumatism rehabilitation decision-making in a nested manner, so as to solve the problems of single evaluation dimension, static and isolated data and difficulty in adapting to individual differences, and improve the accuracy of intervention strategy and the rehabilitation effect of patients.

The invention relates to the technical field of remote diagnosis and treatment of rheumatism, in particular to an early diagnosis and treatment system and method for rheumatism based on a remote monitoring function. And extracting characteristic indexes such as joint movement range variability, a stiffness diffusion mode, a local temperature abnormal region and a pressure asymmetry coefficient. And inputting the indexes into a risk assessment model to obtain individualized risk levels and pathological sign labels, and automatically generating a dynamic monitoring plan comprising monitoring items, frequency and early warning threshold adjustment schemes according to the individualized risk levels and pathological sign labels. And finally, based on plan execution feedback, generating a periodic risk assessment report and a diagnosis and treatment suggestion draft. According to the method, accurate identification of the early risk of rheumatism and dynamic personalized adjustment of the monitoring strategy are realized.

The invention relates to an anti-inflammatory and analgesic traditional Chinese medicine composition and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is mainly prepared from pagoda pagoda, cavalerie mosla herb, elsholtzia rugulosa, five-claw pseudo-ginseng, hibiscus mutabilis leaf, bock greenbrier rhizome and cassia twig, and the traditional Chinese medicine composition has a good treatment effect on rheumatism on the basis of the traditional Chinese medicine composition.