65 results about "Rheumatic disease" patented technology

The present invention is in the fields of medicinal chemistry, biotechnology and pharmaceuticals. The invention provides compositions comprising one or more collagen mimetic peptides, optionally attached to one or more therapeutic compounds or one or more imaging compounds, for use in methods of treating, preventing, ameliorating, curing and diagnosing certain diseases and physical disorders in humans and veterinary animals, as well as methods of manufacturing such composition. The invention also provides medical devices comprising one or more such compositions of the invention. The invention also provides methods of use of such compositions and devices in treating and diagnosing certain diseases and physical disorders in humans and veterinary animals, including ocular diseases or disorders, skin diseases or disorders, certain cancers, particularly intraluminal cancers, gastrointestinal diseases or disorders, genitourinary tract diseases or disorders, fibrotic diseases / disorders and rheumatic diseases / disorders.

The invention relates to a device and method for thermal therapy of a selected region of a human or animal body, particularly for treating tissue damage after surgery, injuries, inflammation, chronic rheumatic conditions, and for supporting chemotherapy. The system includes a temperature control device that circulates a temperature-controlled fluid through a heat transfer unit configured for uniform skin contact, and a pressure device to optimize thermal transfer. During chemotherapy, the device maintains the selected region, such as hands or feet, at a target temperature to prevent or reduce chemotherapy-induced polyneuropathy (CIPN). Sensors monitor temperature and pressure, enabling feedback control for consistent therapy. Methods include fitting the device to the patient, adjusting pressure, and maintaining even skin cooling throughout chemotherapy, thereby improving patient comfort, reducing adverse side effects, and supporting adherence to treatment. The invention provides improved outcomes in thermal therapy applications.

The invention belongs to the technical field of medical health, and discloses a detection system for evaluating rheumatism activity, which comprises a data acquisition module, a multi-modal data preprocessing module, a feature fusion extraction module, an intelligent evaluation model module and a result output module which are connected in sequence. Through synchronous acquisition of multi-modal data (clinical data, image data, symptom data and behavior data), the limitation of single data dimension is broken through, the rheumatism activity can be comprehensively reflected from multiple aspects such as physiological indexes, imaging performance, subjective feeling and objective behaviors, and a foundation is laid for accurate evaluation; through combined processing of adaptive threshold filtering, normalization and time sequence interpolation, the problems of noise, dimension difference and missing of multi-modal data are effectively solved, meanwhile, time sequence features are reserved, and the accuracy of subsequent feature extraction and model operation is ensured; through combination of the deep learning network and the attention mechanism, adaptive weighted fusion of cross-modal features is realized, the complementary value of each modal data can be fully mined, the richness and distinction degree of feature expression are improved, and actual application and operation are facilitated.

The invention provides a muscle-bone injury area identification method and system, and relates to the technical field of muscle-bone image injury identification. The method comprises the following steps: acquiring a two-dimensional gray-scale ultrasonic image of a target muscle-bone injury area, and positioning a synovial tissue area from the two-dimensional gray-scale ultrasonic image; extracting target feature information from the synovial tissue region; and determining the inflammation activity degree of the synovial tissue according to the target feature information. According to the method, Doppler blood flow signals are completely bypassed, the rheumatism inflammation activity degree is evaluated only through rich information contained in the two-dimensional gray-scale ultrasonic image, and therefore interference of probe pressure artifacts is thoroughly avoided.

The invention relates to a multi-mode-based self-adaption rheumatism glove control method and a multi-mode-based self-adaption rheumatism glove control system. The method comprises the following steps: acquiring a multi-source data set including impedance data, thermodynamic distribution data, joint movement data, pressure distribution data and the like; respectively performing inflammation activity quantification, joint function evaluation and infection risk evaluation processing according to the data set to obtain an inflammation score, a function index and a risk identifier, and generating a state vector; based on the state vector and a historical state vector sequence loaded from a historical database, carrying out illness state stage identification processing to obtain an identification result, and generating a control instruction according to the identification result; and performing thermal therapy-electrical stimulation cooperative processing based on the control instruction, generating a pressure target value according to the state vector, performing pressure regulation and control processing, and generating a treatment log. According to the method, multi-source data are comprehensively analyzed, personalized control instructions and pressure regulation and control strategies are generated, accurate and personalized treatment schemes can be provided, and the treatment experience and rehabilitation effect of rheumatism patients are improved.

The invention relates to the technical field of medical rehabilitation information, in particular to a rheumatism rehabilitation intelligent evaluation system based on an ICF concept and a classification system, and the system comprises a multi-source data module which is used for collecting and integrating multi-dimensional data; the dynamic evaluation module is used for constructing a dynamic weight distribution model based on an ICF theory and updating an evaluation result and a radar map according to the multi-dimensional data; the data feature module is used for performing high-dimensional feature dimension reduction processing according to the evaluation result and the radar map on the basis of a potential profile analysis algorithm, and identifying a hidden subtype; and the causal intervention module is used for nesting multi-dimensional dynamic coupling evaluation of an ICF theory, subtype identification of subtype analysis and causal modeling of a structural equation model to be applied to rheumatism rehabilitation decision making based on the hidden subtype when the rheumatism rehabilitation decision making system is used. The problems that traditional evaluation dimensions are single, data are statically isolated and are difficult to adapt to individual differences are solved, and the accuracy of an intervention strategy and the rehabilitation effect of a patient are improved.

The present invention provides the use of SE-DR (HLA-DR molecule containing a shared epitope) affinity peptide for the preparation of a medicament for treating rheumatic diseases in rheumatic patients who are tuberculosis positive and / or have hepatitis B. The present invention solves the problem that patients with rheumatic diseases have limited drug options. The present invention also provides a pharmaceutical composition comprising an SE-DR affinity peptide and a non-antigen specific antirheumatic drug, and its use for the preparation of a medicament for the treatment of various types of rheumatic diseases. The pharmaceutical composition can rapidly inhibit the progression of rheumatic diseases for complete control of rheumatic diseases, and can achieve sustained remission even after tapering or discontinuation of the drug.

The present invention describes a Hyaluronic acid-based homogenous composition with high molecular weight in combination with epigallocatechin-3-O-Gallate (EGCG) and / or xanthohumol (XAN) for use in treating rheumatic pathologies or for cosmetic use to prevent and treat skin aging.

Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof:wherein each symbol is as defined in the SPECIFICATION.

The application relates to the field of medical devices, in particular to a joint protection device suitable for children with rheumatic and immunological diseases, which comprises a joint protection sleeve, a plurality of first sliding grooves and a plurality of connecting rods are arranged on the two sides of the joint protection sleeve, the first sliding grooves and the connecting rods are in one-to-one correspondence, when the joint protection sleeve wraps the joint, the connecting rods are inserted into the first sliding grooves, and the connecting rods and the first sliding grooves are in sliding cooperation; the adjusting holes and the anti-occlusion mechanisms are communicated in the first sliding grooves, the opening and closing mechanisms are communicated on the communication paths of the adjusting holes and the first sliding grooves, and the opening and closing mechanisms are used for controlling the on-off of the adjusting holes and the first sliding grooves; the anti-occlusion mechanisms are used for connecting the first sliding grooves with the outside based on the negative pressure size in the first sliding grooves. The application can realize dynamic adaptation and intelligent protection, and reduce the occlusion risk caused by rigid fixation of the device.

The invention discloses an application of green tendon relaxing ketone in preparation of a medicine for treating rheumatoid diseases. The invention proposes and verifies that the green tendon relaxing ketone can effectively promote fibroblast-like synovial cell ferroptosis so as to inhibit synovial hyperplasia and inhibit the expression of proinflammatory cytokines so as to effectively relieve the progress of rheumatoid arthritis for the first time, and has an excellent application prospect in clinical treatment of rheumatoid diseases.

This invention relates to a protective device for rheumatism, belonging to the field of protective technology. It includes a locking block with a strap around it. The strap is fixedly connected to a first sleeve, which is fixedly connected to a connecting sleeve. The connecting sleeve is fixedly connected to a second sleeve. All three sleeves—the first, second, and connecting sleeves—are made of a resilient material. A plaster tray is fixedly connected to the connecting sleeve. The first sleeve is equipped with a massage component for massaging the leg at the knee joint. When the patient walks, the continuous bending and straightening movements of the knee drive the rollers to roll back and forth, thereby massaging the leg joint at the knee and relieving rheumatic pain.

The present invention relates to ultrasound devices and interchangeable ultrasound heads for said device that allow the ultrasound heads to be interchanged to apply therapeutic treatment in various areas. In particular, the present invention relates to an interchangeable head for an ultrasound apparatus comprising: a head holder configured to receive an ultrasonic transducer comprising a piezoelectric material arranged in a metal container; a coupling unit configured to balance the impedances of the ultrasonic transducer; and a contact connector arranged for interconnecting the coupling unit and an ultrasound apparatus. The ultrasonic transducer operates at a frequency selected between approximately 0.8 MHz and 3 MHz, and the head emits ultrasonic energy with an effective intensity from approximately 0.1 W / cm2 to 2.5 W / cm2 with the aim of improving the quality of life of people with rheumatism such as soft tissue rheumatism and osteoarthritis. The present invention further relates to an ultrasound device comprising: a housing; an interconnection unit; a power and control system; and a power unit, wherein the interconnection unit is configured to receive an interchangeable head.

The present invention provides a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and / or cancer including colorectal cancer.The present invention relates to a compound of formula [I-a], [I-b] or [I-c] or a pharmaceutically acceptable salt thereof:wherein each symbol is as defined in the specification.

The invention provides targeted precise immunotherapy by applying a biological protein nano-robot to carry a biological agent and a preparation method of the biological protein nano-robot, and relates to the field of immunotherapy, the preparation method comprises the following steps: S100, preparing a serum albumin aqueous solution with the serum albumin concentration of 5-10% w / v, and a phosphate buffer solution with the pH value of 7.4 as a solvent; and S200, preparing an organic solution of a hydrophobic anti-rheumatism drug, wherein the drug is one or more of adalimumab, jucuiliumab, ezetizumab, tetronigerb, tolzumab and rituximab. When the albumin nano-robot targeting drug is used for treating rheumatism, effective targeting can be realized by utilizing the chemotactic effect of the albumin nano-robot targeting drug for immunotherapy on high-expression iNOS and ROS in an immune microenvironment, and the released anti-rheumatism drug and nitric oxide play a synergistic effect for combined treatment; wherein the anti-rheumatism medicine and nitric oxide (NO) generated in the targeting process of the nano-robot can jointly start immune circulation in vivo, and the anti-rheumatism medicine and the nitric oxide (NO) cooperate with the chemotherapy medicine to achieve the killing effect, so that the combined treatment effect is achieved.

The present invention relates to the prophylactic and / or therapeutic treatment of a disease selected from the group consisting of long-term COVID disease, myalgic encephalomyelitis / chronic fatigue syndrome (ME / CFS) disease, fibromyalgia, dementia, neoplastic disease, autoimmune disease, schizophrenia, epileptic seizure disease, excessive inflammatory disease, chronic inflammatory bowel disease, rheumatic disease, obesity, and the like. Hyperuricemia, diabetes (IDDM / NIDDM), acute viral diseases, amyotrophic lateral sclerosis (ALS), bronchial asthma, atopic allergic disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, autoimmune diseases / antibody-related diseases, bipolar affective disorders, celiac disease (CD), chronic obstructive pulmonary disease (COPD), and the like. Chronic inflammatory bowel disease (CED) (i.e. Crohn's disease, ulcerative colitis), cystic fibrosis / cystic fibrosis, depression, endometriosis, polycystic ovarian syndrome, eating disorders, anxiety disorders, addiction disorders, frontotemporal dementia (Pickk's disease), Graves's disease (GD), generalized cardiovascular diseases, Alzheimer's disease, Parkinson's disease, meningitis, multiple sclerosis (MS), and the like. Muscular dystrophy, neurodermatitis, peripheral arterial occlusion disease (PAOD), pneumonia, generalized post-vaccination syndrome and vaccine damage, post-viral infection syndrome, psoriasis, pulmonary arterial hypertension, restless leg syndrome, restrictive pulmonary disease, rheumatoid arthritis (RA), division affective disorder, sepsis, sicca syndrome (SS), scleroderma, and the like. Systemic lupus erythematosus (SLE) and unsatisfactory fertility desires, using an active agent having a nicotinic acetylcholinergic agonist and / or an active agent having a muscarinic acetylcholinergic agonist and / or a muscarinic acetylcholinergic antagonist. This provides a very effective prophylactic and / or therapeutic treatment for these diseases. This prevention or treatment is also readily tolerable, cost effective and easy to apply.

This utility model discloses a production device for a gel used in rheumatism, relating to the field of gel production technology for rheumatism. It includes a base and a mixing tank. A fixing frame is provided on the upper outer surface of the base, and a shaking frame is provided in the middle of the fixing frame. A first drive motor is fixedly installed on one outer surface of the fixing frame, and a tank lid is provided on the upper outer surface of the mixing tank. In this rheumatism gel production device, the shaking frame is connected to the mixing tank via an internal vibration motor. A second drive motor drives a shaft to stir the material. During stirring, the vibration motor is activated, simultaneously vibrating the mixing tank and a movable block. This prevents material from adhering to the inner wall of the mixing tank. When the movable block is vibrated, it shakes via a limit spring, indirectly causing the mixing tank to shake, thus improving the mixing effect and efficiency of the material inside the mixing tank.

The invention relates to the technical field of rheumatism external application devices, in particular to a rheumatism external application device with an auxiliary heating function, which comprises an external application device, the external application device comprises two mounting plates arranged in parallel, and a stainless steel conveying belt is mounted between the two mounting plates; a plurality of supports are arranged in the middle of the upper portion of the mounting plate in a linear array mode, rolling wheels are rotationally mounted on the inner sides of the supports, and telescopic assemblies are arranged at the lower ends of the supports; a supporting plate is fixedly connected between the mounting plates, a first material box and a second material box are fixedly mounted at the upper end of the supporting plate, and a plurality of charged sprayers are mounted at the top end of the first material box and the top end of the second material box. According to the device, the neck is attached and comfortably supported through the headrest and the silica gel roller, and heating ionization water mist and cleaning wiping are matched, so that pain is effectively relieved, the skin is kept clean, and cross infection is prevented; then, the medicine liquid permeation is accelerated by utilizing electrostatic charge targeted aggregation and a permeation promoting part, the focus absorption rate is remarkably improved, and the whole-body medicine side effect is reduced.

The present invention provides novel hydroquinone derivatives of formula (I), processes of preparation, as well as pharmaceutical compositions and methods of treating and / or preventing e.g. autoimmune, immunological, rheumatology, vascular disorders, ophthalmologic disorders, fibrotic disorders, metabolic and gastrointestinal disorders, neuroinflammatory and neurodegenerative diseases, neoplasms and cancer associated disorders, hormone related diseases and immunological disorders resulting from viral and bacterial infectious diseases and complications thereof. wherein R 1 is COOR 4, (CH 2 ) n COOR 4, SO 3 H, (CH 2 ) n SO 3 H or CONH-R 10; one of R 2 and R 3 is H and the other is R 5.

The present invention provides a method for sample pretreatment and preservation for cytokine flow detection of rheumatism patients, and a diagnostic kit for determining the type of autoimmune disease and diagnosing autoimmune diseases (such as rheumatism). Specifically, the method and kit provided by the present invention have clinical significance for improving the stability and accuracy of cytokine detection results based on flow cytometry in rheumatism patients. In addition, the method established according to the particularity of cytokine expression in the bodies of rheumatism patients has accurate detection results, good repeatability, and is easy to be clinically popularized and applied.

The present invention relates to a carboxyalkyl chitosan, compositions comprising same, a process for manufacturing same, and various applications thereof, in particular in the field of therapy, rheumatology, ophthalmology, aesthetic medicine, plastic surgery, internal surgery, dermatology or cosmetics.

The present invention relates to an inhibitor of CD74 protein activity or expression, for therapeutic use in the prevention and / or treatment of a chronic inflammatory disease selected from: chronic inflammatory rheumatic diseases, chronic inflammatory dermatoses, chronic inflammatory bowel diseases, and chronic inflammatory neurological diseases. In another aspect, the invention relates to an isolated anti-CD74 antibody or fragment thereof, comprising at least one CD74 receptor (CDR) having a sequence selected from SEQ ID NO. 1 to 5.

This invention provides the use of SE-DR (HLA-DR molecule containing a co-epitope) affinity peptides for the preparation of drugs to treat rheumatic diseases in rheumatoid arthritis patients who are tuberculosis-positive and / or have hepatitis B. [Solution] The present invention provides a pharmaceutical composition comprising an SE-DR affinity peptide and a non-antigen-specific antirheumatic drug, and the use thereof for the preparation of drugs for the treatment of various types of rheumatic diseases. The pharmaceutical composition can rapidly inhibit the progression of rheumatic diseases and achieve sustained remission even after tapering or discontinuation of the drug, for complete control of rheumatic diseases.

The invention relates to a food composition capable of regulating immune cytokine balance, and belongs to the technical field of food capable of regulating cytokine balance. Comprising 20-230 parts of medicago sativa linn and 10-130 parts of robinia pseudoacacia flowers which are mixed to form a medicago sativa linn-robinia pseudoacacia flower mixture. The traditional Chinese medicine composition solves the problems that traditional anti-rheumatism medicines for rheumatism patients have great side effects and anti-rheumatism biological preparations are expensive, is safe and convenient to use and low in price, and can be eaten throughout the year. Inflammation channels and inflammation factors are blocked and inhibited through the complementary effect of the gypsophila oldhamiana and the robinia pseudoacacia flowers, and the anti-inflammatory effect is achieved.

The utility model provides a new energy passenger car air conditioner, which belongs to the technical field of vehicle-mounted air conditioners and comprises an air regulating shell. The sleeving machine groove is formed in the upper end of the air adjusting shell; the vehicle-mounted air conditioner is arranged in the machine sleeving groove; the vertical air adjusting assembly comprises a ventilation hole, a fixed rotating plate, a rotating groove, a vertical air opening, a staggered rotating plate, a supporting plate, a ventilation interlayer and a staggered groove, the number of the air blocking plates is two, the ventilation hole is formed in the lower inner wall of the machine sleeving groove, and the staggered groove is formed in the lower end of the air adjusting shell and communicates with the ventilation hole. Cold air transversely blown out of the air outlet flaring does not make direct contact with passengers, and the situation that the passengers suffering from arthralgia or rheumatism are stimulated due to direct blowing of the cold air is avoided while the whole compartment is cooled.

The invention relates to the technical field of rheumatism plasters, and discloses a rheumatism plaster which is characterized by being prepared from the following raw materials in parts by weight: 10-50 parts of coriander, 10-50 parts of gastrodia elata, 10-60 parts of notopterygium root, 10-70 parts of fresh ginger, 10-60 parts of medicinal xiangwang, 10-50 parts of rhizoma alismatis, 10-60 parts of ramulus mori, 10-40 parts of radix angelicae pubescentis, 10-50 parts of radix clematidis, 10-50 parts of zaocys dhumnade and 10-40 parts of garden balsam stem. According to the rheumatism plaster, the plaster patch and the preparation method of the plaster patch, the effective components of the traditional Chinese medicine materials are ground into the plaster, so that the plaster has the effects of clearing and activating the channels and collaterals, inducing diuresis, removing dampness, promoting blood circulation, dredging channels, relieving pain and resisting toxicity, sweating, promoting blood circulation to promote menstruation, dispelling wind, eliminating dampness, removing toxicity, diminishing swelling and relieving pain, and the interaction of the plaster in the skin and the vitality of the plaster can be displayed; the medicine is widely suitable for treating rheumatism.

The present disclosure provides a composition comprising primed extracellular vesicles and a biologically or pharmaceutically acceptable carrier, wherein the primed extracellular vesicles comprise an upregulated miRNA, and a fold change of the upregulated miRNA of the primed extracellular vesicles compared to miRNA of naturally occurring extracellular vesicles is greater than 1. The present disclosure further provides a method for preventing, treating, or ameliorating a gynecological or a rheumatological disorder comprising administering the composition of the present disclosure to a subject in need thereof. The present disclosure also provides a method for producing the composition. The method comprises cultivating a stem cell in a culture medium containing a Polygonum multiflorum Thunb extract and resveratrol to obtain a cell culture.

The present invention is in the fields of medicinal chemistry, biotechnology and pharmaceuticals. The invention provides compositions comprising one or more collagen mimetic peptides, optionally attached to one or more therapeutic compounds or one or more imaging compounds, for use in methods of treating, preventing, ameliorating, curing and diagnosing certain diseases and physical disorders in humans and veterinary animals, as well as methods of manufacturing such composition. The invention also provides medical devices comprising one or more such compositions of the invention. The invention also provides methods of use of such compositions and devices in treating and diagnosing certain diseases and physical disorders in humans and veterinary animals, including ocular diseases or disorders, skin diseases or disorders, certain cancers, particularly intraluminal cancers, gastrointestinal diseases or disorders, genitourinary tract diseases or disorders, fibrotic diseases / disorders and rheumatic diseases / disorders.

The invention relates to an anti-rheumatism medicine precise personalized intelligent aid decision making method and system, and relates to the field of intelligent medical treatment, and the method comprises the steps: obtaining patient diagnosis related data; performing language analysis on the patient diagnosis related data to obtain current keyword information; performing range screening on drugs stored in a preset recommendation database based on the current keyword information in sequence to obtain recommended drugs, wherein the recommendation database stores keyword information matched with the current keyword information, a mapping relationship among the drugs and drug curative effects; searching a corresponding recommended drug curative effect from a preset recommendation database based on the current keyword information and the recommended drug; and forming a recommendation scheme based on the recommended medicine and the curative effect of the recommended medicine, and displaying the recommendation scheme on a preset doctor end. The method has the effects of performing recommendation by automatically forming the recommended medicine combination, not needing a doctor to depend on personal experience for judgment, reducing selection deviation of the treatment scheme and improving the accuracy of medicine recommendation.

A composition comprising primed extracellular vesicles and a biologically or pharmaceutically acceptable carrier, wherein the primed extracellular vesicles comprise an upregulated miRNA, and a fold change of the upregulated miRNA of the primed extracellular vesicles compared to miRNA of naturally occurring extracellular vesicles is greater than 1. A method for preventing, treating, or ameliorating a gynecological or a rheumatological disorder comprising administering the composition to a subject in need thereof. A method for producing the composition, comprising: cultivating a stem cell in a culture medium containing a Polygonum multiflorum Thunb extract and resveratrol to obtain a cell culture.