This invention discloses a long-acting
antipruritic and antibacterial topical
skin preparation, comprising N-ethyl-γ-L-
glutamine, 1-1-palmitoyl-2-oleoyl-sn-
glycerol-3-
phosphate-N-(L-γ-glutamyl-N-ethyl)-
ethanolamine (POPE-N-Et-Gln-α),
chlorhexidine acetate, and
saffron extract as active ingredients, formulated into a hydrogel or cream with a pharmaceutically acceptable matrix. POPE-N-Et-Gln-α provides rapid transdermal action, while N-ethyl-γ-L-
glutamine offers sustained-release and long-lasting effects;
saffron extract provides anti-inflammatory and
antioxidant effects, and
chlorhexidine acetate provides antibacterial and
antifungal effects. This invention is
hormone-free and non-addictive, achieving both rapid and long-lasting
antipruritic effects, and is suitable for eczema, urticaria,
dry skin,
neurodermatitis,
psoriasis, microbial infections, and
skin itching caused by
insect bites.