13 results about "Neurodermatitis" patented technology

The present invention relates generally to maqui berry for use in the treatment or prevention of skin diseases, wherein maqui berry may be the primary natural active ingredient. Particular embodiments as disclosed herein find application in, inter alia, the prophylaxis and the treatment of skin diseases, in particular, dermatitis, atopic dermatitis (neurodermatitis), dermatitis solaris, eczema, hand eczema, lichen planus, lupus erythematosus, psoriasis, urticaria, itching, scabies, age spot, freckles and dry / atopic skin of humans. In particular, the present invention relates to the use of maqui berry extract in the manufacture of a medicament or dietary supplement for use in treating or preventing said skin diseases or defects.

The invention discloses an external compound preparation for treating skin diseases as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation is prepared from the following raw materials in specific parts by weight: borneol, dipterex tablets, cantharides, huechys sanguinea, ephedra, calculus bovis, dragon's blood, centipedes and garter snakes. The preparation method comprises raw material pretreatment, mixing and blending, and sub-packaging and storage, and is simple in process and easy to operate; the ointment is externally applied to skin lesions every morning and evening, and is suitable for diseases such as eczema, psoriasis, neurodermatitis and the like. Through the synergistic effect of multiple components, the comprehensive curative effects of clearing heat, detoxifying, dredging collaterals, relieving itching and promoting tissue regeneration are achieved, the traditional Chinese medicine composition has the advantages of being rapid in effect taking, convenient to externally use and small in side effect, the problems that an existing skin disease treatment medicine is large in side effect and slow in effect taking are solved, and a new effective scheme is provided for clinical treatment of skin diseases.

To provide a TYK2 inhibitor having better drug-like properties.SOLUTION: Provided are a nitrogen-containing heterocyclic protein inhibitor compound having the following structure, and a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. Also provided are a preparation method for the nitrogen-containing heterocyclic compound, and a use thereof. A drug prepared from such a compound is widely used for treating diseases, the diseases comprising multiple types of autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, lupus erythematosus, neurodermatitis, dermatitis, psoriasis, psoriatic arthritis, Crohn's disease, dry syndrome, and scleroderma.SELECTED DRAWING: None

The present invention relates to a collagen hydrolysate for use as an active substance in the treatment of neurodermatitis.

This invention discloses a long-acting antipruritic and antibacterial topical skin preparation, comprising N-ethyl-γ-L-glutamine, 1-1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphate-N-(L-γ-glutamyl-N-ethyl)-ethanolamine (POPE-N-Et-Gln-α), chlorhexidine acetate, and saffron extract as active ingredients, formulated into a hydrogel or cream with a pharmaceutically acceptable matrix. POPE-N-Et-Gln-α provides rapid transdermal action, while N-ethyl-γ-L-glutamine offers sustained-release and long-lasting effects; saffron extract provides anti-inflammatory and antioxidant effects, and chlorhexidine acetate provides antibacterial and antifungal effects. This invention is hormone-free and non-addictive, achieving both rapid and long-lasting antipruritic effects, and is suitable for eczema, urticaria, dry skin, neurodermatitis, psoriasis, microbial infections, and skin itching caused by insect bites.

The utility model discloses a disposable noninvasive skin roller pin, which relates to the technical field of skin roller pins and comprises a handheld handle component and a roller pin component. The grab handle part is composed of a U-shaped clamping part, an arch-shaped bearing part and a caudal vertebra holding part, stress in use is effectively dispersed, and the problem of structural fracture caused by too large force is avoided. The roller pin component comprises a roller, convex columnar roller pin heads are distributed on the outer edge of the roller at equal intervals, noninvasive stimulation on acupuncture points is achieved through superficial contact, the skin breaking bleeding and infection risks of an existing roller pin are avoided, and meanwhile the stimulation effects of the acupuncture points, meridians, reflection points, reflection areas and the like are kept. The roller needle head is fixed in the interval groove, so that stability and uniform stimulation in the rolling process are ensured. The use safety is improved, the treatment comfort of a patient is improved, and the traditional Chinese medicine composition is suitable for treating diseases such as alopecia, migraine and neurodermatitis. The disposable disposable syringe is made of low-cost materials, meets the requirement for clinical mass use, has the advantages of being high in durability and convenient and fast to operate, and is suitable for wide popularization.

The invention provides a traditional Chinese medicine composition as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following medicinal raw materials: radix angelicae sinensis, radix rehmanniae preparata, rhizoma atractylodis macrocephalae, radix saposhnikoviae, radix astragali seu hedysari, radix polygoni multiflori, rhizoma gastrodiae, cortex dictamni, herba schizonepetae and radix glycyrrhizae. The traditional Chinese medicine composition and the traditional Chinese medicine preparation provided by the invention can remarkably relieve neurodermatitis and symptoms such as pruritus or edema caused by neurodermatitis, adopt pure natural plant raw materials, have no obvious adverse reaction in the use process of a patient, and can be used as a candidate medicine for treating neurodermatitis.

The invention belongs to the field of skin disease treatment, and provides a patch for treating neurodermatitis and a preparation method and application of the patch. The medicinal components comprise a lithospermum extract, a menthol compound and wintergreen oil; the adhesive matrix comprises a framework material, a tackifier, a softener and a cohesive high polymer material; the mass of the framework material accounts for 8-55% of the total mass of the adhesive matrix; the mass of the tackifier is not higher than 60% of the total mass of the adhesive matrix; the mass of the softening agent is not higher than 65% of the total mass of the adhesive matrix; the cohesive high polymer material accounts for not more than 10% of the total mass of the adhesive matrix; the mass of the lithospermum extract is not higher than 60% of the total mass of the medicinal components; the mass of the menthol compound accounts for not more than 75% of the total mass of the medicinal components; the wintergreen oil accounts for not higher than 65% of the total mass of the medicinal components. The patch has a remarkable treatment effect on neurodermatitis diseases.

The invention provides a traditional Chinese medicine compound composition as well as a preparation method and application thereof, and relates to the field of traditional Chinese medicine compositions. The composition comprises lacquer tree bark, cortex dictamni, radix curcumae, semen cuscutae, asiatic toddalia root, fructus kochiae, asarum, perfoliote knotweed herb, radix clematidis, sargentgloryvine stem, fructus evodiae, pomegranate seeds, adenosma indianum, spina gleditsiae, glechoma longituba and radix stemonae. The composition integrates four effects of dispelling wind, relieving itching, dredging collaterals and detoxifying, overcomes the defects in the prior art, is mainly used for treating diseases such as rheumatic arthralgia, skin itch, neurodermatitis, eczema and the like, has the effects of dispelling wind, eliminating dampness, relieving itching, dredging collaterals, resisting inflammation, easing pain and the like, has potential effects of resisting bacteria, resisting oxidation, regulating immunity and the like, and has a wide application prospect. The device is suitable for auxiliary treatment of dermatology, rheumatism and neurological diseases.

The invention discloses a traditional Chinese medicine composition for treating skin inflammation as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5 to 30 parts of snake slough, 5 to 30 parts of cortex dictamni, 10 to 50 parts of fructus mume, 5 to 30 parts of cortex fraxini, 5 to 30 parts of radix arnebiae seu lithospermi, 10 to 40 parts of radix isatidis, 10 to 40 parts of rhizoma anemarrhenae, 10 to 40 parts of gypsum and 5 to 30 parts of folium isatidis. The traditional Chinese medicine composition can effectively inhibit pruritus and inflammatory response caused by various dermatitis including neurodermatitis, accelerate tissue repair and healing processes of burn and scald parts, promote fading of red and swollen parts caused by mosquito bites, relieve local edema and discomfort and promote body function recovery.

A kind of nitrogen-containing heterocyclic protein inhibitor compound, its stereoisomer, tautomer or pharmaceutically acceptable salt, also provides preparation of nitrogen-containing heterocyclic compound and its use, the drug prepared using the compound is widely used in the treatment of diseases, wherein the diseases include multiple types of autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, lupus erythematosus, neurodermatitis, dermatitis, psoriasis, psoriatic arthritis, Crohn's disease, Sjogren's syndrome and scleroderma.

The invention relates to oak leaf perfumed soap and a preparation method thereof. The oak leaf perfumed soap comprises the following components in percentage by weight: 86-90% of vegetable oil soap base, 1-3% of essential oil and 8-12% of oak leaf extract. Due to the addition of the oak leaf extract component, the oak leaf perfumed soap disclosed by the invention has corresponding functions (medicinal values) of enhancing skin antioxidant enzyme activity, neutralizing free radicals, reducing ultraviolet (UVA) damage, inhibiting excessive generation of melanin, improving chromatosis, reducing stains, calming sensitive skin, inhibiting fungi, relieving various tinea diseases and neurodermatitis and the like. According to the oak leaf perfumed soap, plant resources are scientifically utilized, the requirements of people for use functions of perfumed soap products are met, and the blank in the industry is filled.

The invention discloses a neurodermatitis model constructed by capsaicin stimulation and a construction method and application thereof, and belongs to the technical field of cosmetic raw material function testing. According to the application, the 3D skin model is stimulated by using capsaicin, and the culture solution of the 3D skin model is co-cultured with mast cells and vascular endothelial cells, so that the neurodermatitis model capable of simulating nerve-immunity-skin barrier-blood vessel complex interaction is successfully constructed in vitro. Based on the model, a multi-index joint detection and weighted comprehensive scoring system covering four dimensions of nerves, inflammations, skin barriers and vascular reactions is also established, and deep, systematic and quantitative evaluation of the in-vitro neurodermatitis relieving and repairing effects of cosmetic raw materials is realized.