24 results about "Allergic dermatitis" patented technology

The invention relates to a traditional Chinese medicine composition for treating allergic dermatitis. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-35 parts of fried coix seeds, 5-35 parts of concha margaritifera, 1-30 parts of honeysuckle stems, 1-30 parts of smoked plums, 1-30 parts of fructus liquidambaris, 1-25 parts of fructus forsythiae, 1-25 parts of radix paeoniae rubra, 1-25 parts of raw sanguisorba officinalis, 1-25 parts of radix glehniae, 1-25 parts of radix ophiopogonis and 1-25 parts of raw radix polygonati officinalis. 1-25 parts by weight of talc and 1-25 parts by weight of lophatherum gracile. The traditional Chinese medicine composition has the effects of clearing heat, cooling blood without bitter cold, dispelling wind, eliminating dampness without hurting stomach, detoxifying, relieving itching and nourishing yin, is safe in clinical use, and has no adverse effect on liver and kidney.

The invention relates to plant-based pet ear drops with effects of diminishing inflammation and relieving itching and a preparation method of the plant-based pet ear drops, and belongs to the technical field of veterinary drugs. The invention discloses plant-based pet ear drops. The plant-based pet ear drops are prepared from, by mass, comprising 6%-8% of a tea tree extract, 6%-8% of a witch hazel extract, 6%-8% of a chamomile extract, 6%-8% of a soybean extract, 2%-6% of a lithospermum extract, 2%-6% of a centella asiatica extract, 2%-6% of a mint extract, 2%-6% of a licorice extract, 4%-6% of a humectant, 0.1%-0.5% of a preservative, 0.1%-0.5% of a conditioning agent and the balance of water. Through reasonable matching of various plant extracts, the ear drops have broad-spectrum antibacterial, anti-inflammatory, soothing and repairing effects, and can effectively deal with various common problems of pet ears, such as bacterial infection, fungal infection, allergic dermatitis, ear mite expelling and the like. The pet ear canal cleaner can also be used for cleaning and nursing pet ear canals, is mild in performance, and can effectively remove dirt, dust and wax in the ear canals.

Provided is a method for treating allergic dermatitis (excluding practices on humans), the method including one or more cycles of an irradiation step in which a plasma generation gas is supplied to a plasma generation unit provided with electrodes to generate plasma and a biological tissue is irradiated with an irradiation gas containing at least one of the plasma and an active gas generated by means of the plasma, wherein the irradiation step includes irradiating the biological tissue with the irradiation gas for 1-300 seconds per cm2.

The invention relates to the field of medicines, in particular to a stem cell factor composite medicine composition for treating allergic dermatitis and a preparation method thereof. The composite pharmaceutical composition is prepared from the following raw materials in parts by weight: 5 to 10 parts of stem cell factors, 2 to 6 parts of agilawood extract, 1 to 3 parts of forskolin and 0.1 to 0.3 part of stabilizer. The pharmaceutical composition can effectively inhibit bacteria, relieve pain and relieve itching, and can remarkably relieve itching and inflammation caused by allergic dermatitis by inhibiting release of inflammatory factors.

The invention belongs to the technical field of biological medicines, and relates to an efficient affinity anti-human IL-33 monoclonal antibody and a preparation method thereof. The monoclonal antibody provided by the invention has good specificity and affinity, accurately targets a key cell factor IL-33, and effectively blocks a binding path between the key cell factor IL-33 and a receptor ST2. As a core factor mediating various inflammatory diseases, such as asthma, allergic dermatitis, chronic sinusitis, chronic obstructive pulmonary disease (COPD) and the like, IL-33 is crucial in intervention of a regulation mechanism for disease treatment. The monoclonal antibody disclosed by the invention is novel in sequence, and provides a new thought for preparation of the medicine by inhibiting IL-33 mediated inflammatory reaction.

The invention belongs to the technical field of pharmacy, and particularly relates to minoxidil liniment and a preparation method thereof. According to the minoxidil liniment disclosed by the invention, the nano-liposome prepared from the lichen extract-phospholipid complex is used for wrapping minoxidil, the common allergic dermatitis phenomenon in the using process of the minoxidil liniment is avoided by utilizing a synergistic drug loading mechanism of the lichen extract and the phospholipid complex and through anti-inflammatory and anti-oxidation effects, and meanwhile, the drug structure is protected; the action time of the minoxidil liniment is prolonged; the gel substance formed by the polyvinyl alcohol-sodium carboxymethyl cellulose composite coating liquid reduces the surface exposure of minoxidil, avoids the precipitation of minoxidil crystals, and ensures the delivery and absorption efficiency of minoxidil drugs.

The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of a condition or disorder selected from a pruritic condition or an allergic condition, of equine mammals, preferably of horses. Furthermore, the invention provides methods for preventing or treating pruritus, preferably pruritus associated with a pruritic condition or an allergic condition such as allergic dermatitis, of equine mammals, preferably of horses.

The invention discloses a preparation method of a traditional Chinese medicine composition for treating skin tinea, allergic dermatitis and acne, and relates to the field of pharmaceutical preparations, the extraction rate of gallic acid and ethyl gallate contained in total tannin in fructus chebulae flesh, fructus terminaliae billericae flesh and fructus chebulae immaturus is improved through an enzymolysis method, and the transfer rate of effective components of quercetin is improved through a boiling granulation technology; therefore, the effect of treating psoriasis of the composition is improved. By adopting a boiling granulation technology, the technical problems of long preparation period and high cost in the prior art are solved. The release speed of aloe in intestinal tracts is controlled by adopting a slow release technology, and the upper and lower limit content range of barbaloin is controlled to reduce the occurrence rate of adverse reactions of the composition. Meanwhile, butyl hydroxy anisd (BHA), butylated hydroxytoluene (BHT) and a citric acid system are adopted, so that the problems of PEO skeleton degradation, out-of-control drug release behavior and insufficient main drug stability of the barbaloin-PEO sustained release preparation are solved.

The invention discloses a traditional Chinese medicine preparation for treating intractable skin diseases and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 10-50 parts of paper mulberry leaves, 10-50 parts of rhizoma smilacis glabrae, 10-30 parts of euphorbia cordifolia, 10-30 parts of trichosanthes kirilowii roots, 10-30 parts of spina gleditsiae and 3-5 parts of liquorice. The traditional Chinese medicine preparation is specially used for treating (conditioning) intractable skin diseases such as eczema, psoriasis (psoriasis), allergic dermatitis, lupus erythematosus and the like, is high in cure rate and small in side effect, and solves the problem that no medicine can treat the intractable skin diseases in the world.

Provided is a method for treating allergic dermatitis (excluding practices on humans), the method including one or more cycles of an irradiation step in which a plasma generation gas is supplied to a plasma generation unit provided with electrodes to generate plasma and a biological tissue is irradiated with an irradiation gas containing at least one of the plasma and an active gas generated by means of the plasma, wherein the irradiation step includes irradiating the biological tissue with the irradiation gas for 1-300 seconds per cm2.

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating allergic rhinitis and allergic dermatitis, a traditional Chinese medicine preparation and a preparation method. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: Shouwuteng 1000-2000 parts, Digupi 1000-2000 parts, Baijianpi 800-1600 parts, Baizhi 600-1800 parts, Kuanfenghua 300-1100 parts, Jinyinhua 300-700 parts, Yekuhua 200-800 parts, Huaihua 400-600 parts and Gancao 400-1000 parts. The nine traditional Chinese medicine raw materials of the traditional Chinese medicine composition are used as monarch, minister, assistant and envoy, and the nine medicines are used together to achieve the effects of cooling blood and detoxifying, nourishing blood and dispelling evil, dispelling wind and relieving itching, and promoting lung and descending qi. Pharmacological experiments show that the formula can significantly reduce inflammatory factors in blood of allergic dermatitis mice, and the effect is good. In addition, the optimal extraction process of the nine medicines is selected, the preparation process is researched, the types and the optimal ratio of the excipients are investigated, and the experimental basis can be provided for hospital preparation registration, so that the traditional Chinese medicine composition can serve allergic disease patients such as AD and AR as early as possible.

The application belongs to the technical field of pharmacy, and particularly relates to a minoxidil liniment and a preparation method thereof. The application wraps minoxidil by using a lichen extract-phospholipid complex to prepare nano-liposomes, utilizes the synergistic drug loading mechanism of the lichen extract and the phospholipid complex, avoids the common allergic dermatitis phenomenon in the use process of the minoxidil liniment through anti-inflammatory and antioxidant effects, protects the drug structure, and prolongs the action time of the minoxidil liniment; the gel-like substance formed by using a polyvinyl alcohol-carboxymethylcellulose sodium complex coating solution reduces the surface exposure of minoxidil, avoids the precipitation of minoxidil crystals, and guarantees the delivery and absorption efficiency of minoxidil drugs.

The present application relates to the use of substituted indazoles for treatment and / or prophylaxis of allergic and / or inflammatory diseases in animals, especially for treatment and / or prophylaxis of atopic dermatitis, Flea Allergy Dermatitis, inflammatory bowel disease, osteoarthritis and inflammatory pain, non-infectious recurrent airway disease, insect hypersensitivity, asthma, respiratory disease, mastitis and endometritis in animals.

The present application relates to the use of substituted indazoles for treatment and / or prophylaxis of allergic and / or inflammatory diseases in animals, especially for treatment and / or prophylaxis of atopic dermatitis, Flea Allergy Dermatitis, inflammatory bowel disease, osteoarthritis and inflammatory pain, non-infectious recurrent airway disease, insect hypersensitivity, asthma, respiratory disease, mastitis and endometritis in animals.

The invention belongs to the technical field of biological medicines, and relates to a monoclonal antibody capable of being specifically combined with IL-33 as well as a preparation method and application thereof. The monoclonal antibody capable of being specifically bound with the IL-33 can be specifically bound with the IL-33 in a high-affinity mode, and therefore binding of the IL-33 and a receptor ST2 of the IL-33 is effectively blocked. IL-33 is an important cell factor, and plays a key role in the occurrence and development of various diseases, such as asthma, specific reactive / allergic dermatitis, chronic sinusitis, chronic obstructive pulmonary disease (COPD) and the like. By blocking the combination of IL-33 and ST2, the antibody can inhibit inflammatory reactions mediated by IL-33, and a new strategy is provided for the treatment of these diseases.

The present invention relates to topical pharmaceutical compositions comprising a corticosteroid and an insecticide selected from pyrethrin or a synthetic pyrethroid insecticide. Methods for their use in the treatment of allergic dermatitis, particularly hypersensitivity to insect bites, in animals using the compositions of the invention are also described.

The invention discloses a compound double-flower external preparation for treating allergic dermatitis, and relates to the technical field of medicine preparation, and the compound double-flower external preparation comprises the steps of raw material pretreatment, stepped extraction, filtration, purification, concentration, matrix and additive preparation and compound forming sterilization. The preparation method comprises the following steps: firstly extracting andrographis paniculata and isatis root with ethanol to obtain fat-soluble effective components, then decocting residues with water, honeysuckle and fructus forsythiae to obtain water-soluble components, thereby avoiding the problem of component loss caused by a single extraction mode, carrying out targeted purification in combination with a macroporous resin column, effectively removing impurities and improving the purity of target components, and meanwhile, preparing the water-soluble components. Carboxymethyl chitosan and poloxamer 407 are prepared into a compound matrix, and the compound matrix is matched with a functional additive formed by a penetration enhancer solution and a liposome dispersion liquid, so that the transdermal efficiency of the medicine is improved, the skin irritation is reduced, and finally, the effects of better curative effect and better safety of the preparation are achieved.

The present invention relates to a collar for non-human animals, preferably for companion animals, comprising a polymeric matrix and a lipid extract comprising sphingomyelins. It also refers to the collar for use as a medicine, particularly for use as an adjuvant and for use in the treatment or prevention of atopic dermatitis or allergic dermatitis, as well as in restoring the integrity of the skin during or after an atopic dermatitis or an allergic dermatitis, increasing the hydration and flexibility of the skin, facilitating skin regeneration or reducing itching of the skin.

The present invention describes a topical veterinary solution composition comprising a JAK inhibitor, preferably olatinib or a pharmaceutically acceptable salt thereof, for use in an animal, preferably a canine, for the treatment of skin conditions such as allergic dermatitis, atopic dermatitis, pruritus and / or hot spots.

The present invention relates to the use of substituted indazoles for the treatment and / or prevention of allergic and / or inflammatory diseases in animals, in particular for the treatment and / or prevention of atopic dermatitis, flea allergic dermatitis, inflammatory bowel diseases, osteoarthritis pain and inflammatory pain, non-infectious recurrent airway diseases, and the use of substituted indazoles for the treatment and / or prevention of allergic and / or inflammatory diseases in animals. Insect allergy, asthma, respiratory system diseases, mastitis and endometritis.

The application belongs to the technical field of medicine, and discloses skin health antipruritic liquid, which comprises raw material components: angelica, cortex moutan, white alum, forsythia, schizonepeta, baizhi, humulus, zanthoxylum, lotus house, artemisia leaf, duckweed, alkanna, aloe, honeycomb, polygonatum, stemona, sophora, fly Yang grass, cortex periplocae, melaleuca, ophiorrhiza, white milkweed, gallic, spilanthes, kochia, taraxacum, clematis, xuchangqing, biota, radix falcaliae, radix pterostupiae, red plate, snake skin, wind-preventing plant, hollyhock, oak flower, oak, radix scrophulariae, radix paeoniae, radix bupleuri, radix scrophulariae, radix paeoniae, radix scrophulariae, radix paeoniae, radix scrophulariae, borage, borax, the application has multiple effects of clearing heat and cooling blood, sterilizing and resisting inflammation, removing dampness and relieving itching, removing toxicity and resolving mass, etc., can improve or treat various skin problems such as eczema, herpes, allergic dermatitis, tinea pedis, hemorrhoids, acne, psoriasis and skin itching, and is suitable for a wide range of scenes; the process combination of crushing, screening, specific proportion mixing, fermentation, multiple filtration and accurate concentration ensures that the active ingredients in the raw materials are fully extracted and purified, avoids the loss of effective components, improves the curative effect intensity of unit volume of liquid medicine, and has quick effect after spraying, which is beneficial to actual application and operation.

The invention discloses an intelligent evaluation and decision-making system for the relapse degree of allergic dermatitis based on a skin image, and relates to the technical field of image processing, and the system comprises the steps: carrying out the intelligent collection of a skin image of an atopic dermatitis part of a patient; segmenting the skin image into at least one human body secondary region; converting the read skin image into a hue saturation brightness color space image; generating a gray level co-occurrence matrix, and extracting texture features from the gray level co-occurrence matrix; edge information in the image is extracted, and the extracted edge is refined; fitting a regression equation, constructing a linear regression evaluation model, and carrying out cross validation on the linear regression evaluation model; and displaying the evaluation result to a doctor and a patient in a visual form. By arranging the color feature extraction module, the texture feature extraction module and the shape feature extraction module, the features such as the color, the texture and the shape of the skin lesion are extracted, the actual state of the skin can be reflected more accurately, and therefore the accuracy of recurrence degree evaluation is improved.

The present invention relates to the use of substituted indazoles for the treatment and / or prevention of allergic and / or inflammatory diseases in animals, in particular for the treatment and / or prevention of the following diseases in animals: atopic dermatitis, flea allergic dermatitis, inflammatory bowel disease, osteoarthritis pain and inflammatory pain, non-infectious recurrent airway disease, insect hypersensitivity, asthma, respiratory diseases, mastitis and endometritis.

The invention specifically discloses a novel chalcone compound as well as a preparation method, a pharmaceutical composition and application thereof, and belongs to the technical field of medicines. The chalcone compounds (+)-lupulusone C and (-)-lupulusone C have not been publically reported at present. Experimental results show that the compound shows remarkable anti-inflammatory activity in a lipopolysaccharide stimulated RAW 264.7 cell model, the action intensity of the compound is obviously superior to that of positive drugs dexamethasone and aspirin, and the compound can be used for developing drugs for treating inflammation-related diseases and has broad application prospects. Comprise but not limited to ulcerative colitis, rheumatic fever, allergic dermatitis, inflammatory bowel diseases, encephalitis, myocarditis and the like.