Traditional Chinese medicine lotion for treating infantile eczema and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine lotion for treating infantile eczema and a preparation method thereof. The traditional Chinese medicine lotion is prepared from the following raw materials in parts by weight: 20-40 parts of honeysuckle, 20-40 parts of cortex dictamni, 25-35 parts of cicada slough, 10-20 parts of raw mint, 13-23 parts of scutellaria baicalensis, 85-95 parts of vine of multiflower knotweed, 25-35 parts of fructus forsythiae, 22-32 parts of fried fructus aurantii, 25-35 parts of dandelion and 13-23 parts of raw liquorice. The traditional Chinese medicine composition follows the medication principle of monarch, minister, assistant and guide of traditional Chinese medicines, and the honeysuckle and the cortex dictamni in the formula are compatible to serve as monarch drugs. The cicada slough, the mint and the scutellaria baicalensis are compatible and are used as ministerial drugs. And the four raw materials including the vine of multiflower knotweed, the fructus forsythiae, the fructus aurantii and the dandelion are compatible and are used as adjuvant drugs. And liquorice is used as a conductant drug for harmonizing the medicines. The medicinal materials are combined to achieve the effects of dispelling wind, clearing heat, removing dampness and relieving itching, and the traditional Chinese medicine composition is suitable for various skin diseases such as urticaria, eczema, insect bite inflammation and allergic dermatitis caused by wind-heat rheumatism of children and infants, does not relapse after being treated, and avoids the side effects that many complications occur after hormone medicines are used for a long time and the skin diseases are prone to relapse after medicine withdrawal.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicines, and in particular to a traditional Chinese medicine lotion for treating infantile eczema and a preparation method thereof. Background Art

[0002] Pediatric eczema is very common in clinical practice, and its occurrence is related to factors such as genetics, diet, environment, contact objects, and autoimmunity. The symptoms of eczema are polymorphic changes in skin lesions, diffuse distribution, prominent lesions in the central part, slowly developing to the periphery, blurred boundaries, severe exudation, and particularly prone to secondary skin infection. The course of the disease is long and easy to relapse. If it does not heal for a long time, pigmentation and skin desquamation can be seen, and the itching of the skin is often unbearable. The incidence of pediatric eczema is 12% to 25%, and it is increasing year by year. Most patients are children under 5 years old. Children often have a family history of allergies. Due to intolerance, spleen and stomach dysfunction, external rheumatism and heat evil, both of which block the skin. The main clinical manifestations of children are prone to occur on the head and face, and severe cases can extend to the trunk and limbs. The skin lesions are polymorphic, such as papules, blisters, and erosions. They are often symmetrically distributed, with unclear boundaries, severe itching, and a tendency to relapse. If the disease lasts for a long time and recurs repeatedly, the skin lesions may be dark or pigmented, or rough and thickened, and the itching may be unbearable.

[0003] At present, Western medicine mainly treats pediatric eczema with oral and topical drugs. Oral drugs are mainly antihistamines, such as chlorpheniramine, loratadine, cetirizine, etc., and antibiotics and glucocorticoids will also be considered according to clinical symptoms. For external use, glucocorticoids and immunosuppressants are usually selected clinically, among which glucocorticoids are the most commonly used first-choice drugs with significant anti-inflammatory effects, including mometasone furoate cream, triamcinolone acetonide econazole cream, etc.; immunosuppressants include pimecrolimus cream, etc., but their clinical safety remains to be verified. Although Western medicine has significant short-term effects, long-term use of hormone drugs will cause more complications, and it is easy to relapse after stopping the drug. Compared with Western medicine, because traditional Chinese medicine is better at regulating overall functions, for the different pathogenesis of pediatric eczema, the present invention provides a treatment method and medication that is more suitable for children's fragile skin barrier, less irritation, and a Chinese medicine lotion with fewer side effects. Summary of the invention

[0004] The purpose of the present invention is to obtain a Chinese medicine lotion for treating pediatric eczema with significant efficacy, wide application and modern new dosage form and a preparation method thereof in view of the treatment limitations of pediatric eczema.

[0005] The technical solution adopted by the present invention is a traditional Chinese medicine lotion for treating pediatric eczema, which is composed of the following raw materials in parts by weight: 20-40 parts of honeysuckle, 20-40 parts of white peony root, 25-35 parts of cicada shell, 10-20 parts of raw mint, 13-23 parts of scutellaria, 85-95 parts of Polygonum multiflorum, 25-35 parts of forsythia, 22-32 parts of stir-fried bitter orange, 25-35 parts of dandelion, and 13-23 parts of raw licorice.

[0006] Furthermore, the Chinese medicine lotion is composed of the following raw materials in parts by weight: 30 parts of honeysuckle, 30 parts of Dictamni cortex, 30 parts of cicada shells, 15 parts of raw mint, 18 parts of Scutellaria baicalensis, 90 parts of Polygonum multiflorum, 30 parts of Forsythia suspensa, 27 parts of stir-fried Citrus aurantium, 30 parts of Taraxacum mongolicum, and 18 parts of raw licorice.

[0007] Furthermore, the Chinese medicine lotion is composed of the following raw materials in parts by weight: 20 parts of honeysuckle, 20 parts of Dictamni cortex, 30 parts of cicada shells, 15 parts of raw mint, 18 parts of Scutellaria baicalensis, 90 parts of Polygonum multiflorum, 30 parts of Forsythia suspensa, 27 parts of stir-fried Citrus aurantium, 30 parts of Taraxacum mongolicum, and 18 parts of raw licorice.

[0008] Furthermore, the Chinese medicine lotion is composed of the following raw materials in parts by weight: 20 parts of honeysuckle, 20 parts of Dictamni cortex, 35 parts of cicada shells, 20 parts of raw mint, 23 parts of Scutellaria baicalensis, 95 parts of Polygonum multiflorum, 35 parts of Forsythia suspensa, 32 parts of stir-fried Citrus aurantium, 35 parts of Taraxacum mongolicum, and 23 parts of raw licorice.

[0009] Furthermore, the Chinese medicine lotion is composed of the following raw materials in parts by weight: 40 parts of honeysuckle, 40 parts of Dictamni cortex, 25 parts of cicada shells, 10 parts of raw mint, 13 parts of Scutellaria baicalensis, 85 parts of Polygonum multiflorum, 25 parts of Forsythia suspensa, 22 parts of stir-fried Citrus aurantium, 25 parts of Taraxacum mongolicum, and 13 parts of raw licorice.

[0010] The present invention also provides a method for preparing a Chinese medicine lotion for treating pediatric eczema, comprising the following steps:

[0011] (1) weigh honeysuckle, Dictamni cortex, cicada shell, raw mint, scutellaria baicalensis, Polygonum multiflorum, forsythia suspensa, stir-fried fructus aurantii, dandelion and raw liquorice according to the weight ratio and set aside;

[0012] (2) taking honeysuckle, white peony root, cicada shell, raw mint, scutellaria, Polygonum multiflorum, forsythia, stir-fried fructus aurantii and dandelion, adding 8-12 times the amount of water, soaking for 1-2 hours, and heating and decocting for the first time for 1.5 hours;

[0013] (3) adding raw mint to the mixture, filtering, and collecting the first extract and the medicinal residue;

[0014] (4) adding 6-10 times the amount of water to the medicinal residue, heating and boiling for a second time for 1 hour, filtering, and collecting a second extract;

[0015] (5) combining and mixing the first extract and the second extract, and heating and concentrating the mixture to obtain a concentrated solution;

[0016] (6) The concentrated liquid is sterilized in a water bath to obtain the finished product.

[0017] Wherein, in step (3), raw mint is added 5-10 minutes before the end of the first heating and boiling.

[0018] Wherein, in step (3), raw mint is added after the first heating and boiling is completed.

[0019] After step (5), the following operations may be performed: sampling the concentrated liquid, and after the sampled concentrated liquid is inspected and found to be qualified, the concentrated liquid is filled and sealed by an automatic filling machine.

[0020] Among them, the inspection passing standard is pH value of 4.0-6.0 and concentrated relative density of 1.00-1.05.

[0021] The pharmacological effects of the ten medicinal materials in the formula of the present invention are as follows:

[0022] (1) Honeysuckle, also known as "Lonicera japonica" in ancient times, was first recorded in "Ming Yi Bie Lu" and named "Jin Yin Hua" in "Compendium of Materia Medica". [Nature and flavor and meridians] It is cold in nature, sweet in taste, and enters the lung, heart, and stomach meridians. It has the effects of clearing away heat and detoxifying, and dispersing wind-heat. It is clinically used to treat bloating, fever due to febrile diseases, and carbuncle due to heat and toxicity. Honeysuckle contains chemical components such as flavonoids, iridoid glycosides, and organic acids, and has pharmacological effects such as anti-inflammatory and antipyretic, anti-tumor, and antibacterial and antiviral.

[0023] (2) Dictamni peel was first recorded in Shennong's Herbal Classic. [Nature and flavor] It tastes bitter and is cold in nature. It enters the spleen, stomach, and bladder meridians. [Functions and indications] The 2020 edition of the Pharmacopoeia of the People's Republic of China records that Dictamni peel has the functions of clearing away heat and dampness, dispelling wind and detoxifying. It can be used for damp-heat sores, yellow water dripping, eczema, urticaria, scabies, rheumatism, jaundice, and red urine. Modern studies have shown that Dictamni peel contains chemical components such as alkaloids, limonoids, and flavonoids, which have antibacterial, anti-inflammatory, and anti-tumor effects. Modern studies have shown that Dictamni peel extract has a significant inhibitory effect on the production of NO by macrophages, cellular immunity, and humoral immune responses, and has the effects of reducing inflammatory cytokines and cell numbers and anti-lymphocyte proliferation. Therefore, it can be used to treat skin diseases, psoriasis, rheumatoid arthritis, chronic bronchitis, skin peeling, urticaria, and other diseases.

[0024] (3) Cicada slough, first recorded in Shennong's Herbal Classic. [Nature and flavor] It tastes sweet and is cold in nature. It enters the lung and liver meridians. [Functions and indications] It can dispel wind-heat, relieve sore throat, clear rashes, improve eyesight, and relieve spasms. Modern pharmacological studies have shown that cicada slough has pharmacological effects such as expectorant, antitussive, antiasthmatic, antipyretic, anticonvulsant, antibacterial, and improving blood rheology.

[0025] (4) Raw mint, mint, first recorded in the New Compendium of Materia Medica. [Nature and flavor and meridians] Spicy, cool in nature, enters the lung and liver meridians. [Functions and indications] It has the effects of dispersing wind-heat, clearing the head, relieving sore throat, clearing rashes, and soothing the liver and promoting qi. It is a commonly used product for treating wind-heat colds, itchy rashes, migraines, sore throats, and chest and flank distension. It has multiple pharmacological effects such as anti-aging, anti-hypoxia, anti-inflammatory, immune regulation, anti-cancer, anti-virus, and increasing white blood cells and platelets.

[0026] (5) Scutellaria baicalensis, first recorded in Shennong's Herbal Classic. [Nature and flavor and meridians] Bitter, cold in nature, enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. [Functions and indications] It has the effects of clearing away heat and dampness, purging fire and detoxifying. It has the effects of clearing heat and dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. It is often used for damp-heat, chest tightness and nausea due to summer heat, damp-heat fullness, diarrhea, jaundice, lung heat cough, high fever and thirst, blood heat vomiting and bleeding, carbuncle, sore, and fetal movement disorder. Relevant studies in modern pharmacology have shown that Scutellaria baicalensis has antioxidant, antibacterial, antifungal, antiviral, anti-inflammatory, anti-allergic, antiplatelet aggregation and anticoagulant, and lipid-lowering effects.

[0027] (6) Polygonum multiflorum was first recorded in the Illustrated Classic of Materia Medica written by Su Song in the Song Dynasty. [Nature and flavor and meridians] It tastes sweet and is neutral in nature. It enters the heart and liver meridians. [Functions and indications] Polygonum multiflorum has the effects of nourishing blood and calming the mind, dispelling wind and unblocking meridians. It is often used for oral administration to treat insomnia, dreaminess, body pain due to blood deficiency, rheumatic pain, etc. It can be used externally to treat skin itching such as urticaria, scabies, etc. Polygonum multiflorum has antioxidant and antibacterial effects.

[0028] (7) Forsythia suspensa was first recorded in Shennong's Herbal Classic. [Nature and flavor] It is bitter, slightly cold, and enters the heart and gallbladder meridians. [Functions and indications] It has the effects of clearing away heat and detoxifying, dispersing heat and wind, and reducing swelling and dispersing nodules. Modern pharmacological studies have confirmed that Forsythia suspensa has anti-inflammatory, antioxidant, antibacterial, anticancer, antiviral, antiallergic, and neuroprotective effects.

[0029] (8) Stir-fried Citrus aurantium was first recorded in Shennong's Herbal Classic. [Nature and flavor] It tastes bitter, sour, slightly pungent, and slightly cold. It enters the lung and stomach meridians. [Functions and indications] It has the effects of regulating qi, relieving fullness, and relieving stagnation and distension. It is mainly used to treat chest and flank qi stagnation, distension and pain, and indigestion. After being stir-fried with bran, it can "remove dryness and soothe the stomach", alleviate its pungent and dry nature, and enhance its function of regulating qi and dissolving stagnation. It has antibacterial, antiviral, and capillary fragility inhibition effects.

[0030] (9) Dandelion was first recorded in Tang Materia Medica. [Nature and flavor] It has a slight smell and a slightly bitter taste. It enters the liver and stomach meridians. [Functions and indications] It has antibacterial, liver-protecting and choleretic, immune-promoting, anti-endotoxin and anti-gastric damage effects. Dandelion contains a variety of biologically active ingredients, mainly including flavonoids, terpenes, alkaloids, coumarins, stilbenes, esters, sterols, etc. These substances have strong antibacterial, anti-inflammatory and antioxidant biological activities. It is mainly used clinically to treat furunculosis, acne, acute conjunctivitis, acute tonsillitis, acute mastitis, acute bronchitis, acute and chronic appendicitis, rhinitis, pharyngitis, gastritis, peptic ulcer, cholecystitis, cholelithiasis, hepatitis, urinary tract infection, vaginitis, pelvic inflammatory disease, osteomyelitis, mumps and cancer. In recent years, it has been reported that it has significant anticancer activity against breast cancer.

[0031] (10) Raw licorice, which was first recorded in Shennong's Herbal Classic. [Nature and flavor] It is sweet, mild, non-toxic, and enters the heart, lung, spleen, and stomach meridians. [Functions and indications] It has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving acute pain, and harmonizing various medicines.

[0032] In the Chinese medicine lotion for treating pediatric eczema provided by the present invention, honeysuckle is cold in nature, sweet in taste, and enters the lung, heart, and stomach meridians, and has the effects of clearing away heat and detoxifying, cooling blood, and promoting blood circulation; Dictamni is bitter and cold in nature, enters the spleen, stomach, and bladder meridians, and has the effects of clearing heat and dampness, dispelling wind and detoxifying, and relieving itching, and the two medicines are the main medicine. Cicada shell is cool in nature, sweet and salty in taste, enters the lung and liver meridians, and has the effects of dispersing wind-heat, clearing the throat and relieving sore throat; peppermint is pungent in taste and cool in nature, enters the lung and liver meridians, and has the effects of dispersing wind-heat, clearing the head and eyes, relieving sore throat and rash, and soothing the liver and promoting qi; Scutellaria baicalensis is bitter in taste and cold in nature, enters the lung, gallbladder, spleen, large intestine, and small intestine meridians, and clears heat and dampness, purges fire, detoxifies and stops bleeding. The three medicines are used together and are the ministerial medicine; Polygonum multiflorum is sweet in taste and flat in nature, enters the heart and liver meridians, nourishes blood and calms the mind, dispels wind and relieves itching The Compendium of Materia Medica records that "Shouwu Teng: "Itching caused by wind sores, scabies and ringworms, decoction and bathing, very effective"; Forsythia suspensa is cold in nature, enters the lung, spleen and large intestine meridians, and has the effects of clearing away heat and detoxification, reducing swelling and dispersing knots, dispersing wind and heat, and promoting urination; Citrus aurantium is bitter, pungent and sour in taste, slightly cold in nature, enters the spleen and stomach meridians, and has the functions of removing stagnation and eliminating accumulation, regulating qi and widening the chest; Taraxacum mongolicum is bitter, sweet and cold in taste, enters the liver and stomach meridians, clears away heat and detoxification, reduces swelling and dispersing knots, and the above four medicines are adjuvants. Licorice is sweet and flat, enters the heart, lung, spleen and stomach meridians, clears away heat and detoxification, relieves urgency and relieves pain, and harmonizes the other medicines as the guiding medicine. The combination of the various medicines has the functions of dispersing wind and heat, removing dampness and relieving itching.

[0033] Compared with the prior art, the present invention has the following beneficial effects: the present invention provides a Chinese medicine lotion for treating pediatric eczema, which uses honeysuckle, Dictamni, cicada slough, raw mint, scutellaria, Polygonum multiflorum, forsythia, stir-fried fructus aurantii, dandelion and raw licorice as raw materials, and follows the principle of "monarch, minister, assistant and messenger" of Chinese medicine. In the formula, honeysuckle clears away heat and detoxifies, cools blood and promotes blood circulation; Dictamni clears heat and dries dampness, dispels wind and detoxifies, and relieves itching, and the two raw materials are used as monarch drugs. Cicada slough dispels wind-heat, clears the throat and relieves sore throat; mint dispels wind-heat, clears the head and relieves sore throat and rash, and relieves the liver and promotes qi; scutellaria clears heat and dries dampness, purges fire, detoxifies and stops bleeding, and the three raw materials are used as minister drugs. Polygonum multiflorum nourishes blood and calms the mind, dispels wind and relieves itching; Forsythia suspensa clears heat and detoxifies, reduces swelling and resolves knots, evacuates wind-heat, and promotes diuresis; Citrus aurantium removes stagnation and eliminates accumulation, regulates qi and relieves chest tightness; Taraxacum officinale clears heat and detoxifies, reduces swelling and resolves knots, and the four raw materials are combined as adjuvants. Licorice clears heat and detoxifies, relieves urgency and relieves pain, and harmonizes the various drugs as a guiding drug. The combination of the various drugs has the effects of dispelling wind and heat, removing dampness and relieving itching. It is suitable for urticaria, eczema, insect bite inflammation, allergic dermatitis and other skin diseases caused by wind-heat and rheumatism in children and infants. It does not recur after treatment, and avoids the side effects of long-term use of hormone drugs that may cause more complications and easy recurrence after stopping the drug. DETAILED DESCRIPTION

[0034] The technical scheme of the present invention is further described below in conjunction with specific embodiments. However, it should be understood by those skilled in the art that the following examples are only used to illustrate the present invention and should not be regarded as limiting the present invention. The specific conditions not specified in the examples are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used, unless otherwise specified, are conventional products obtained through commercial channels.

[0035] (1) Implementation Case 1

[0036] 30 parts of honeysuckle, 30 parts of Dictamni cortex, 30 parts of cicada shells, 15 parts of raw mint, 18 parts of scutellaria, 90 parts of Polygonum multiflorum, 30 parts of forsythia, 27 parts of stir-fried Citrus aurantium, 30 parts of dandelions, and 18 parts of raw liquorice.

[0037] Specifically, 30g of honeysuckle, 30g of Dictamni cortex, 30g of cicada shell, 15g of raw mint, 18g of Scutellaria baicalensis, 90g of Polygonum multiflorum, 30g of Forsythia suspensa, 27g of stir-fried Citrus aurantium, 30g of dandelion, and 18g of raw licorice.

[0038] Weigh the prescription Chinese medicine slices according to the preparation amount, and after checking, wrap them in non-woven bags to make medicine bags. Put the medicine bags except raw mint into the Chinese medicine extraction tank in turn and add 10 times the amount of water to soak for 2 hours. After the medicine bag is fully soaked, start the first heating and decoction for 1.5 hours. Add raw mint 5 minutes before the first heating and decoction is completed or after the first heating and decoction is completed, filter, and collect the first extract. Continue to add 8 times the amount of water, heat and decoct for the second time for 1 hour, filter, collect the second extract, and combine the two extracts. Heat and concentrate the combined extract to obtain a concentrated solution, and sample the concentrated solution for semi-finished product inspection. The inspection standard is that the pH value of the medicine solution is 4.0 and the concentrated relative density is 1.00; after the inspection is qualified, the concentrated solution is filled and filled by an automatic filling machine, and after being sterilized in a water bath at 100℃ for 30 minutes, it is labeled and checked for storage.

[0039] (2) Implementation Case 2

[0040] 20 parts of honeysuckle, 20 parts of Dictamni cortex, 30 parts of cicada shells, 15 parts of raw mint, 18 parts of scutellaria, 90 parts of Polygonum multiflorum, 30 parts of forsythia, 27 parts of stir-fried Citrus aurantium, 30 parts of dandelions, and 18 parts of raw liquorice.

[0041] Specifically, 20g of honeysuckle, 20g of Dictamni bark, 30g of cicada shell, 15g of raw mint, 18g of Scutellaria baicalensis, 90g of Polygonum multiflorum, 30g of Forsythia suspensa, 27g of stir-fried Citrus aurantium, 30g of dandelion, and 18g of raw licorice.

[0042] Weigh the prescription Chinese medicine slices according to the preparation amount, and after checking, wrap them in non-woven bags to make medicine bags. Put the medicine bags except raw mint into the Chinese medicine extraction tank in turn and add 8 times the amount of water to soak for 1.5 hours. After the medicine bag is completely soaked, start the first heating and decoction for 1.5 hours. Add raw mint 8 minutes before the first heating and decoction is completed or after the first heating and decoction is completed, filter, and collect the first extract. Continue to add 6 times the amount of water, heat and decoct for the second time for 1 hour, filter, collect the second extract, and combine the two extracts. Heat and concentrate the combined extract to obtain a concentrated solution, and sample the concentrated solution for semi-finished product inspection. The inspection standard is that the pH value of the medicine solution is 5.0 and the concentrated relative density is 1.02; after the inspection is qualified, the concentrated solution is filled and filled by an automatic filling machine, and after being sterilized in a water bath at 100℃ for 30 minutes, it is labeled and checked for storage.

[0043] (3) Implementation Case 3

[0044] 20 parts of honeysuckle, 20 parts of Dictamni cortex, 35 parts of cicada shells, 20 parts of raw mint, 23 parts of scutellaria, 95 parts of Polygonum multiflorum, 35 parts of forsythia, 32 parts of stir-fried Citrus aurantium, 35 parts of dandelions, and 23 parts of raw liquorice.

[0045] Specifically, 20g of honeysuckle, 20g of Dictamni bark, 35g of cicada shell, 20g of raw mint, 23g of Scutellaria baicalensis, 95g of Polygonum multiflorum, 35g of Forsythia suspensa, 32g of stir-fried Citrus aurantium, 35g of Taraxacum mongolicum, and 23g of raw licorice.

[0046] Weigh the prescription Chinese medicine slices according to the preparation amount, and after checking, wrap them in non-woven bags to make medicine bags. Put the medicine bags except raw mint into the Chinese medicine extraction tank in turn and add 12 times the amount of water to soak for 1 hour. After the medicine bag is completely soaked, start the first heating and decoction for 1.5 hours. Add raw mint 10 minutes before or after the first heating and decoction is completed, filter, and collect the first extract. Continue to add 10 times the amount of water, heat and decoct for the second time for 1 hour, filter, collect and merge the two extracts. Heat and concentrate the combined extract to obtain a concentrated solution, and sample the concentrated solution for semi-finished product inspection. The inspection standard is that the pH value of the medicine solution is 6.0 and the concentrated relative density is 1.05. After the inspection is qualified, the concentrated solution is filled and filled by an automatic filling machine, and after sterilization in a water bath at 100℃ for 30 minutes, it is labeled and checked for storage.

[0047] (4) Implementation Case 4

[0048] 40 parts of honeysuckle, 40 parts of Dictamni cortex, 25 parts of cicada shells, 10 parts of raw mint, 13 parts of scutellaria, 85 parts of Polygonum multiflorum, 25 parts of forsythia, 22 parts of stir-fried fructus aurantii, 25 parts of dandelions, and 13 parts of raw liquorice.

[0049] Specifically, take 40g of honeysuckle, 40g of Dictamni, 25g of cicada shell, 10g of raw mint, 13g of Scutellaria baicalensis, 85g of Polygonum multiflorum, 25g of Forsythia suspensa, 22g of stir-fried Citrus aurantium, 25g of dandelion, and 13g of raw licorice.

[0050] Weigh the prescription Chinese medicine slices according to the preparation amount, and after checking, wrap them in non-woven bags to make medicine bags. Put the medicine bags except raw mint into the Chinese medicine extraction tank in turn and add 12 times the amount of water to soak for 1 hour. After the medicine bag is completely soaked, start the first heating and decoction for 1.5 hours. Add raw mint 10 minutes before or after the first heating and decoction is completed, filter, and collect the first extract. Continue to add 10 times the amount of water, heat and decoct for the second time for 1 hour, filter, collect and merge the two extracts. Heat and concentrate the combined extract to obtain a concentrated solution, and sample the concentrated solution for semi-finished product inspection. The inspection standard is that the pH value of the medicine solution is 6.0 and the concentrated relative density is 1.05. After the inspection is qualified, the concentrated solution is filled and filled by an automatic filling machine, and after sterilization in a water bath at 100℃ for 30 minutes, it is labeled and checked for storage.

[0051] Clinical observation of the Chinese medicine for treating eczema in children according to the present invention:

[0052] 1. General information: The cases observed in this study were from outpatients of Zhongwei Traditional Chinese Medicine Hospital. This study included 100 patients with pediatric eczema.

[0053] 2. Usage and dosage of the present invention: For external use. For children, take 50 ml of the liquid, dilute with 3 times the amount of warm water, and then wash or apply it to the affected area, three times a day. For adults, take 50 ml of the liquid, and directly wash or apply it to the affected area, three times a day, or follow the doctor's advice.

[0054] 3. Precautions for the present invention: 1. Avoid smoking, drinking, spicy, cold, and greasy food, and eat a light diet. 2. Children, pregnant women, breastfeeding women, and the elderly and infirm should use this product under the guidance of a physician. 3. Use it strictly according to the usage and dosage, and this product should not be used for a long time. 4. If the symptoms do not improve after 3 days of medication, you should go to the hospital for treatment. 5. Those who are allergic to this product are prohibited from using it, and those with allergic constitutions should use it with caution. 6. It is prohibited to use this product when its properties change. 7. Children must use it under adult supervision. 8. Please keep this product out of reach of children. 9. If you are using other medicines, please consult a physician or pharmacist before using this product.

[0055] 4. TCM diagnostic criteria

[0056] Infantile eczema is also known as milk ringworm and wet sore. It is characterized by erythematous miliary papules, papules or blisters that appear after rupture, with pitting erosion, exudation, scabs and severe itching.

[0057] (1) Skin lesions often occur on the face, starting from the cheeks and then spreading to the scalp. They can also spread throughout the body, often with severe itching, accompanied by insomnia, irritability, and prolonged duration.

[0058] (2) Skin lesions can be divided into wet and dry types. The wet type is characterized by erythema, blisters, erosions, and fluid retention, and is more common in children aged 1 to 3 years. The dry type is characterized by dry skin, desquamation, and no fluid retention, and is more common in thin children over 1 year old.

[0059] (3) The skin lesions are sometimes mild and sometimes severe, sometimes healed and sometimes recurred. They often disappear suddenly during fever or diarrhea, and reappear after the fever subsides and the diarrhea stops.

[0060] (4) Some children and other family members have a history of asthma and other diseases.

[0061] 5. Western medicine diagnostic criteria

[0062] Common allergic rashes have diverse skin lesions and various shapes, accompanied by symptoms such as itching, erosion, and scabs. According to the symptoms, it can be divided into bleeding type, dry type, seborrheic type, and eczema.

[0063] (1) Exudative type of syndrome of excess dampness and heat: Clinical manifestations: Skin lesions on the head, face and neck are characterized by erythematous papules and blisters, with obvious sebum and water exudation followed by crusting, itching, dry and hard stools, short and yellow urine, and a slippery and rapid pulse.

[0064] (2) Seborrheic type of spleen deficiency and dampness excess syndrome: Skin lesions are large red spots and papules covered with greasy, flaky or scabby skin, which are rough and itchy. Some patients are accompanied by indigestion, galactorrhea, loose stools or undigested food.

[0065] (3) Blood deficiency and wind dryness syndrome, dry type: Clinical manifestations include recurrent rash with light-colored rashes and constant itching.

[0066] Table 1 Clinical use of eczema lotion in children

[0067] years 2019 2020 2021 2022 2023 Dosage / bottle 2732 4708 10049 12052 8486

[0068] Table 2 Observation of the efficacy of external use of eczema lotion in the treatment of 100 cases of eczema in children

[0069] Evaluation effect Evaluation Criteria Number of cases get well Skin lesions and clinical symptoms all disappeared 76 Significant effect More than 2 / 3 of the skin lesions disappeared and the clinical symptoms improved significantly. 18 efficient More than 1 / 3 of the skin lesions disappeared and the clinical symptoms were alleviated. 6 invalid No significant improvement in skin lesions or worsening of clinical symptoms 0

[0070] According to the results analysis in Table 2, the patients' clinical symptoms were significantly improved after taking the medicine. In the treatment group, 76 cases (76%) were cured, 18 cases (18%) were significantly effective, 6 cases (6%) were effective, and 0 cases (0%) were ineffective. The effective rate was 100%, indicating that the pediatric eczema wash has a significant therapeutic effect on infant eczema.

[0071] The beneficial effects of the drug of the present invention for treating pediatric eczema are further described by the specific experimental examples in the following table:

[0072] Experimental drugs:

[0073] In the prescription of the present invention, honeysuckle and Dictamni are the main medicines. The inventor has found through experiments that heavy use of honeysuckle and Dictamni is helpful for reducing swelling and relieving itching. When the dosage of the two is reduced and the dosage of other Chinese medicines remains unchanged, the effect is significantly reduced; when the dosage of the two is reduced and the dosage of other Chinese medicines (ministerial medicine, adjuvant medicine, guiding medicine) in the prescription is increased, the therapeutic effect is still significantly reduced than when honeysuckle and Dictamni are used as the main medicines.

[0074] The composition of each formula in Table 3 is as follows:

[0075] Group 1: 30g honeysuckle, 30g white peony root, 30g cicada shell, 15g raw mint, 18g scutellaria, 90g Polygonum multiflorum, 30g forsythia, 27g stir-fried Citrus aurantium, 30g dandelion, 18g raw licorice

[0076] Group 2: Take 20g of honeysuckle, 20g of Dictamni cortex, 30g of cicada shell, 15g of raw mint, 18g of Scutellaria baicalensis, 90g of Polygonum multiflorum, 30g of Forsythia suspensa, 27g of stir-fried Citrus aurantium, 30g of Taraxacum mongolicum, and 18g of raw licorice.

[0077] Group 3: Take 20g of honeysuckle, 20g of Dictamni cortex, 35g of cicada molt, 20g of raw mint, 23g of Scutellaria baicalensis, 95g of Polygonum multiflorum, 35g of Forsythia suspensa, 32g of stir-fried Citrus aurantium, 35g of Taraxacum mongolicum, and 23g of raw licorice.

[0078] Table 3: Experimental example of drug dosage screening (%)

[0079] Grouping get well Significant effect Improvement invalid Total effective 1 group 16(80％) 3(15％) 1(5％) 0(0％) 19(95％) 2 groups 12(60％) 2(10％) 6(30％) 0(0％) 14(70％) 3 groups 9(45％) 4(20％) 6(30％) 1(5％) 13(65％)

[0080] It can be found in Table 3 that the drugs in groups 1-3 of the implementation cases were respectively used for experiments. The experiments show that the best therapeutic effect can be achieved by using honeysuckle and Dictamni as the main drugs in the prescription of the present invention. When the dosage of the two drugs is reduced as in Group 2 or the dosage of the two drugs is reduced as in Group 3 while the dosage of other drugs is increased, the total effective rate of treatment is significantly reduced.

[0081] Typical treatment cases:

[0082] Case 1, Wang, male, 2 years old, came to our department for treatment with facial red maculopapular itching for 1 week. Examination: the child was mentally tired, had average nutrition, facial flushing, light red papules were evacuated, there were blisters, scratches, and obvious itching. He was diagnosed with eczema. Chinese medicine diagnosed it as wet sores, which belonged to the wind-heat external attack type. He was treated with 3 doses of the pediatric eczema lotion of the present invention. During the follow-up visit, according to the child's mother, the child's rash was alleviated on the day of medication, and the itching improved. Five days later, the child's rash subsided, the skin color returned to normal, and the itching was significantly relieved. After treatment, the child was clinically cured, and another dose was prescribed for consolidation treatment.

[0083] Case 2, patient Zhang, male, 3 years old, came to our department for treatment due to rash and itching on his limbs for half a year, which worsened for 2 weeks. Examination showed that there were papules, blisters, scratches on the upper and lower limbs, which were symmetrically distributed, and the itching was obvious. There were scabs and pigmentation on the skin of the calves. He was diagnosed with chronic eczema. The Chinese medicine diagnosis was wet sore, which was a damp-heat internal accumulation type. The child was treated with 5 doses of the pediatric eczema lotion of the present invention for external washing. According to the feedback from the parents of the child during the follow-up visit, the itching was relieved after taking the medicine on the same day, the rash subsided after 1 week, the blisters dried up, and pigmentation remained. After continuing the medication for one course of treatment, the child's rash completely subsided, the itching disappeared, and the skin of the calf was left with pigmentation, which was basically clinically cured.

[0084] Case 3, Li Moumou, female, 18 months old, came to our department for treatment with papules, erosion and itching on the head for 3 days. Examination showed that the child was tired in mental state, with average nutrition. She had red papules on the head, some of which merged into erythema, accompanied by erosion and exudation, and obvious itching. She was diagnosed with eczema. Chinese medicine diagnosed it as wet sore, which was a wind-heat external attack type. She was treated with 5 doses of the pediatric eczema lotion of the present invention for external washing. The parents of the child reported that after 2 days of medication, the exudation of the child's rash decreased and the itching was alleviated. After one week, the rash basically subsided, the erythema subsided, and there was no exudate. After continuing the medication for a course of 7 days, the child's rash completely subsided, the skin was smooth, and she was clinically cured.

[0085] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine lotion for treating pediatric eczema, characterized in that: The Chinese medicine lotion is composed of the following raw materials in parts by weight: 20-40 parts of honeysuckle, 20-40 parts of white peony root, 25-35 parts of cicada shell, 10-20 parts of raw mint, 13-23 parts of scutellaria, 85-95 parts of Polygonum multiflorum, 25-35 parts of forsythia, 22-32 parts of stir-fried fructus aurantii, 25-35 parts of dandelion, and 13-23 parts of raw licorice.

2. A Chinese medicinal lotion for treating pediatric eczema according to claim 1, characterized in that: The Chinese medicine lotion is composed of the following raw materials in parts by weight: 30 parts of honeysuckle, 30 parts of Dictamni cortex, 30 parts of cicada shells, 15 parts of raw mint, 18 parts of Scutellaria baicalensis, 90 parts of Polygonum multiflorum, 30 parts of Forsythia suspensa, 27 parts of stir-fried Citrus aurantium, 30 parts of Taraxacum mongolicum, and 18 parts of raw licorice.

3. A Chinese medicinal lotion for treating pediatric eczema according to claim 1, characterized in that: The Chinese medicine lotion is composed of the following raw materials in parts by weight: 20 parts of honeysuckle, 20 parts of Dictamni cortex, 30 parts of cicada slough, 15 parts of raw mint, 18 parts of Scutellaria baicalensis, 90 parts of Polygonum multiflorum, 30 parts of Forsythia suspensa, 27 parts of stir-fried Citrus aurantium, 30 parts of Taraxacum mongolicum, and 18 parts of raw licorice.

4. A Chinese medicinal lotion for treating pediatric eczema according to claim 1, characterized in that: The Chinese medicine lotion is composed of the following raw materials in parts by weight: 20 parts of honeysuckle, 20 parts of Dictamni cortex, 35 parts of cicada molt, 20 parts of raw mint, 23 parts of Scutellaria baicalensis, 95 parts of Polygonum multiflorum, 35 parts of Forsythia suspensa, 32 parts of stir-fried Citrus aurantium, 35 parts of Taraxacum mongolicum, and 23 parts of raw licorice.

5. A Chinese medicinal lotion for treating pediatric eczema according to claim 1, characterized in that: The Chinese medicine lotion is composed of the following raw materials in parts by weight: 40 parts of honeysuckle, 40 parts of Dictamni cortex, 25 parts of cicada molt, 10 parts of raw mint, 13 parts of Scutellaria baicalensis, 85 parts of Polygonum multiflorum, 25 parts of Forsythia suspensa, 22 parts of stir-fried Citrus aurantium, 25 parts of Taraxacum mongolicum, and 13 parts of raw licorice.

6. A method for preparing a Chinese medicinal lotion for treating pediatric eczema according to any one of claims 1 to 5, characterized in that: The following steps are involved: (1) weigh honeysuckle, Dictamni cortex, cicada shell, raw mint, scutellaria baicalensis, Polygonum multiflorum, forsythia suspensa, stir-fried fructus aurantii, dandelion and raw liquorice according to the weight ratio and set aside; (2) taking honeysuckle, white peony root, cicada shell, raw mint, scutellaria, Polygonum multiflorum, forsythia, stir-fried fructus aurantii and dandelion, adding 8-12 times the amount of water, soaking for 1-2 hours, and heating and decocting for the first time for 1.5 hours; (3) adding raw mint to the mixture, filtering, and collecting the first extract and the medicinal residue; (4) adding 6-10 times the amount of water to the medicinal residue, heating and boiling for a second time for 1 hour, filtering, and collecting a second extract; (5) combining and mixing the first extract and the second extract, and heating and concentrating the mixture to obtain a concentrated solution; (6) The concentrated liquid is sterilized in a water bath to obtain the finished product.

7. The method for preparing a Chinese medicinal lotion for treating pediatric eczema according to claim 6, wherein in step (3), raw mint is added 5-10 minutes before the end of the first heating and decoction.

8. The method for preparing a Chinese medicinal lotion for treating pediatric eczema according to claim 6, wherein in step (3), raw mint is added after the first heating and decoction is completed.

9. The method for preparing a Chinese medicine lotion for treating pediatric eczema according to claim 6, wherein the following operation can be performed after step (5): sampling the concentrated liquid, and after the sampled concentrated liquid is inspected and found to be qualified, the concentrated liquid is filled by an automatic filling machine and sealed and packaged.

10. The method for preparing a traditional Chinese medicine lotion for treating pediatric eczema according to claim 9, wherein the qualified inspection standard is a pH value of 4.0-6.0 and a concentrated relative density of 1.00-1.05.