2205 results about "Veterinary Drugs" patented technology

Compositions are provided comprising a lipophilic active compound, e.g., a human or veterinary drug or a nutraceutical, interwoven with a polymeric matrix formed by two or more polymers, wherein one of the polymers is an amphiphilic polymer and the other polymer is either an amphiphilic polymer with a different hydrophobic-hydrophilic balance or a hydrophilic polymer, and the active lipophilic compound has modified physicochemical properties. The composition forms colloidal nanodispersion upon contact with aqueous media.

The invention relates to an eubacterium ventriosum and two-shape eubacterium preparation and application thereof, in particular to microbial ecological preparation prepared by using eubacterium ventriosum or/and two-shape eubacterium as main active ingredients, and application of the microbial ecological preparation for treating relative diseases. The microbial ecological preparation comprises medicine composition, health products, drinks, veterinary drug and feed additive.

The invention discloses a special physiological regulator for maternal animals, and a preparation method thereof, and belongs to the field of feed additive. A technical scheme of the physiological regulator comprises: carrying out crushing and screening for dandelion, leonurus, licorice root and angelica; adding soybean meal and/or wheat bran; adding water to carry out immersing; adjusting pH value of the resulting mixture; carrying out a sterilization; inoculating probiotics to carry out a fermentation after cooling, followed by stoving after completing the fermentation to obtain the physiological regulator. With the prepared physiological regulator for the maternal animals, immunity and disease resistance of the maternal animals are raised, incidence rate of genital system infection is effectively reduced, feed inversion rate is increased, mammogenesis is improved, milk yield is raised, incidence rate of mammitis is reduced, and milk quality is improved. The physiological regulator has characteristics of quick onset, stable and reliable effect, no toxic and side-effect, no pollution, no residue, and no drug resistance generating, and meets requirements of safe feed additive and assurance of foods of animal origin. In addition, the physiological regulator for the maternal animals can be adopted as a veterinary drug through raising using dosage of the physiological regulator, and provides a substantial curative effect for prevention and cure of the mammitis.

The present invention relates to veterinary or pharmaceutical formulations which may comprise ceftiofur, ketoprofen, benzyl alcohol, or effective combinations thereof. The formulations of the present invention may include a wetting or dispersing agent, a preservative, a flocculating agent or resuspendability enhancer, and/or a biocompatible oil vehicle. This invention also provides for, inter alia, formulations for the treating, controlling and preventing of respiratory disorders, particularly bovine respiratory disease (BRD), in warm-blooded animals, such as livestock,. This invention further provides for methods of increasing the resuspendability of an oily formulation which may comprise the addition.

The present invention provides one kind of reagent for simultaneously detecting several kinds of small molecular compounds and its preparation process and usage. The preparation process includes the following steps: preparing coded microsphere reagent, and preparing one of the small molecular compound detecting antibody probes, including fluorescent quantum dot antibody probes, fluorescent quantum dot secondary antibody probes, fluorescent dye antibody probes and fluorescent dye secondary antibody probes. The method of detecting small molecular compounds with the antibody probe may be a direct antibody probe method or a indirect antibody probe method. The present invention may be used in detecting residual veterinary medicine, pesticide, banned drug, misused medicine and other small molecular compounds in food, agricultural product, living animal body and human body, and has the advantages of high sensitivity, high repeatability, etc.

The invention provides bacillus subtilis LFB112 with the collection number of CGMCC No.2996. The bacterial strain has relatively high antibacterial activity and has antibacterial effect on various animal pathogenic bacteria and food pathogenic bacteria. The invention also provides bacteriocin produced by the bacterial strain, wherein the bacteriocin is relatively stable against heat and acid and has a broad-spectrum antibacterial effect without inhibiting beneficial bacteria. Experiments indicate that the bacterial strain LFB112 provided by the invention and the bacteriocin produced by the same can be used for improving the clinical symptoms of chicken and increasing the growth speed and feed price, and can be used in biological veterinary medicaments or feed additives.

The invention discloses a high-throughput detection method for 99 residual veterinary drugs in animal-derived food. The detection method is characterized by comprising the following concrete steps: (1) carrying out extraction and purification on 99 residual veterinary drugs having substantially different physicochemical properties and belonging to eight kinds of common veterinary drugs through one-step pretreatment based on carrier-assisted liquid-liquid extraction technology; (2) preparation of a mixed standard solution and a matrix standard curve; and (3) determining the concentrations of 99 residual veterinary drugs in a to-be-detected solution by using ultrahigh performance liquid chromatography-triple quadrupole tandem mass spectrometry. According to the invention, the pretreatment and instrumental analysis process of the method is directed at compounds with different physicochemical properties, so the method has the advantages of good compatibility, high detection efficiency, good operability and low detection cost, and the detection limit of the method can meet requirements of all the test objects.

The invention discloses a disease-resistant growth promoter for aquatic animals and a preparation method thereof. The disease-resistant growth promoter is characterized in that a novel environmentally-friendly feed additive is prepared by combining the traditional Chinese medicine with a modern microbial transformation technology. The preparation method comprises the following steps: mixing dandelion, licorice root, lightyellow sophora root, barberry root and the like after crushing and screening; adding bran, soybean meal, corn flour and water as a fermentation culture medium, regulating thepH value, sterilizing, cooling, adding a strain, and fermenting; and drying after the fermentation is finished. The disease-resistant growth promoter for the aquatic animals is formed by virtue of beneficial combination of the traditional Chinese medicine and probiotics, can be used for replacing antibiotics and has the effects of resisting bacteria, preventing verminosis, resisting virus, improving the immunity, promoting the growth of the aquatic animals and the like; no toxicity, no side effects, no pollution, no residue and no drug resistance are produced during the long-term use of the disease-resistant growth promoter; and the effects are stable and reliable, and the requirements of people on safe production of aquatic products can be met. The disease-resistant growth promoter for the aquatic animals can also be applied as a veterinary drug by improving the using dose.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising an anti-IgE antibody for the treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease.

A disclosed method for simultaneously analyzing and detecting residual veterinary drug compositions in animal tissue comprises: performing homogenate on an animal tissue sample by 50% acetonitrile and ethanol, performing ultrasonic extraction and hexane purifying, and performing further precipitation by acetonitrile and ethanol, concentrating, utilizing UPLC-MS/MS to perform multi-reaction monitoring (MRM) determination under the negative ion mode, and quantifying according to a standard curve and an external standard method, detecting and calculating to obtain the content of 46 residual veterinary drug compositions in animal tissue. The method is applicable to present commonly-used veterinary drugs such as 18 kinds of quinolone drugs, 22 kinds of sulfanilamide drugs, dapsone, phenylethanolamine A, amoxicillin, adamantanamine, rimantadine, ethoxyquin and the like, and is capable of performing one-step simultaneous rapid accurate detection, and the application scope of the method is enlarged.

The invention provides a new Lactobacillus plantarum bacterial strain YJG which was preserved in the China General Microbiological Culture Collection Center (CGNCC) with the collection number of CGMCC No. 2994 on march, 30th, 2009. The Lactobacillus plantarum bacterial strain YJG can produce broad-spectrum bacteriostatic activity bacteriocin with high yield, and can express bacteriostasis for staphylococcus aureus, salmonella and E.coli of gram-negative bacterium, L. plantarum, L.brevis, Streptococcus and Bacillus of gram-positive bacterium, and the like. A virus attacking tests with high dosage proves that the Lactobacillus plantarum bacterial strain YJG is safe to animal bodies. The Lactobacillus plantarum bacterial strain YJG and a zymophyte liquid thereof can be used for preparing additives of green animal feeds, and the bacteriocin of the Lactobacillus plantarum bacterial strain YJG can be used for preparing green biological veterinary drugs, environmental-friendly biopreservatives, biocontrol drugs and the like.

The invention discloses application of an inclusion technology in preparing animal medicines, and an animal medicine inclusion compound. The animal medicine inclusion compound can increase the dissolution velocity and the solubility of indissolvable medicines, improve the stability of the medicines which are changeable in the presence of lights or moistures and the like, and facilitate the storage of medicines. The invention also provides a method for preparing the animal medicine inclusion compound, and the method is simple in operation, can reduce the use of organic solvent, lower the cost, reduce the poisonous side effects of the medicines, and can be applied to the preparation of animal medicines.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for the treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases.

The invention relates to the fields of analytical chemistry and food safety, particular to a method for detecting the residual quantity of multiple polypeptide veterinary drugs in animal-derived foods. The method comprises the following steps of: processing a sample with a TCA(trichloroacetic acid) and acetonitrile system for depositing proteins; extracting with a carbinol and 0.1% formic acid aqueous solution system; purifying with a Oasis HLB solid phase extraction column; performing gradient elution with an Eclipse XDB-C18 analytical column in the presence of an acetonitrile and 0.1% formic acid aqueous solution used as a mobile phase; and then performing electrospray and positive ion scanning mode separation for finally detecting four polypeptides. The limits of the four polypeptides, namely colistin, bacitracin A, polymyxin B and virginiamycin M, are 25 micrograms/kilogram, 100 micrograms/kilogram, 250 micrograms/kilogram and 120 micrograms/kilogram respectively; the recovery rates of colistin, bacitracin A, polymyxin B and virginiamycin M are 74.9-88.1%, 76.2-89.0%, 76.6-81.2% and 77.3-86.9% respectively; and the coefficients of variation (CV%) of colistin, bacitracin A, polymyxin B and virginiamycin M are 5.7-15.1%, 7.2-15.7%, 6.0-8.0% and 9.5-18.6% respectively. The detection limit, the recovery rate, the accuracy and other technical indexes all meet related detection requirements at home and aboard.

The invention provides an UPLC-MS/MS method for analyzing four categories and 29 types of restricted veterinary drug residues in animal foodstuff. The method is characterized in that an advanced QuEChERS method is adopted for conducting sample preprocessing, a sample is subjected to McIlvaine buffering liquid-acetonitrile extraction, an extracting solution is subjected to acidification and salting out, a small amount of acetonitrile phase is taken, a C18 and NH2 adsorbing agent is utilized for conducting dispersive solid-phase extraction and purification, after purification liquid is subjected to concentration and volume setting, an ultra-high performance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS) is adopted to conduct detection. The problem that it is difficult for tetracycline class veterinary drug to be extracted and purified along with other types of veterinary drugs is solved, meanwhile the sample processing steps are simplified, the UPLC-MS/MS method has the advantages of being efficient, rapid, low in cost, simple and convenient to operate, good in purification effect and high in sensitivity, and the accuracy and precision both meet the requirement of a multi-residue analysis method.

The invention relates to a finished cattle quality safety feeding and management method and a system which are based on radio frequency identification devices (RFID) technology. Cattle ear tags are knocked in ears of finished cattle, a feeding process of the finished cattle is tracked, using conditions of feed, health cleaning, epidemic prevention and immunization, feeding environment, inspection and quarantine and veterinary drug used in the feeding process are recorded through an RFID data reading and writing technology. The whole process of feeding of the finished cattle is comprehensively and truly recorded, and therefore adequate feeding information is provided for future quality and safety tracing.

The invention relates to the field of analysis and testing and particularly relates to a method for analyzing residual veterinary drugs in mutton. The method at least comprises sample pretreatment, enzymatic hydrolysis, extraction, purification and on-machine testing. Compared with the existing detection method, the method provided by the invention has higher accuracy, extracts, purifies and testsa variety of veterinary drugs, and is fast and efficient. The method utilizes a multi-extraction method using three different solvents, fully extracts the veterinary drugs in mutton as many as possible, improves the detection accuracy and reduces the influence caused by the base on the veterinary drugs. In gradient elution, three mobile phases are used so that it is solved that the original two mobile phases with solubility under action of an adsorbent in a chromatographic column are layered so that the target drugs are respectively dissolved in two solvents, the characteristic peak detectedby the detector splits into a primary characteristic peak and a secondary characteristic peak, the drug content capable of being detected is reduced and the determination of other drugs is influenced.

The invention is directed to the use of a formulation containing meloxicam or a pharmacologically acceptable meloxicam salt of an organic or inorganic base, one or more vehicles and one or more suitable additives for preparing a veterinary medical composition for intramammary treatment of inflammatory diseases in mammals, particularly mastitis. The intramammary administration leads to an effective concentration in the target tissue, which is achieved very quickly.

A method for the treatment of bacterial infections in humans and non-human mammals, which comprises administering to a subject suffering such infection an antibacterially effective dose of a compound of formula (I) or a pharmaceutically or veterinarily acceptable salt thereof:wherein:R1 represents hydrogen, or C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms; R2 represents a group R10-(X)n-(ALK)m- wherein R10 represents hydrogen, or a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, any of which may be unsubstituted or substituted by (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, mercapto, (C1-C6)alkylthio, amino, halo (including fluoro, chloro, bromo and iodo), trifluoromethyl, cyano, nitro, -COOH, -CONH2, -COORA, -NHCORA, -CONHRA, NHRA, -NRARB, or -CONRARB wherein RA and RB are independently a (C1-C6)alkyl group, and ALK represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent -NH-, -O- or -S-linkages, X represents -NH-, -O- or -S-, and m and n are independently 0 or 1; and A represents a group as defined in the specification.

The invention relates to a method for detecting antibiotic residues in milk, and an application thereof, and belongs to the field of food safety. The invention discloses an online solid phase extraction-high performance liquid chromatography-mass spectrometry detection method in order to solve the detection problem of antibiotic residues in milk. The method allows five types of 33 veterinary drug residues comprising sulfanilamides, quinolones, beta-lactams, tetracyclines and chloramphenicols in the milk to be simultaneously detected. Influences of various factors on the reservation and selectivity of various antibiotics are optimized, so the method has the characteristics of high sensitivity, high recovery rate, high stability and high precision. The detected antibiotics can be qualitatively and quantitatively determined according to the reservation time and accurate mass numbers. The amounts of samples and reagents required and used in the method are small, the detection speed is fast, all operation processes are completed within 15.5min, and cost reduction and operating risk mitigation of dairy product processing enterprises are guaranteed.

The present invention is a chemical synthesis process of quinolone, which relates to the field of veterinary drug feed additives. The existing synthesis technology is to select from various quinoxaline compound substituted derivatives, but these compounds have relatively large toxic and side effects, and simply change The side chain can no longer meet the needs. The present invention uses heavy ion beams to modify the structure of quinoxaline to produce new compound molecules. Through pharmacodynamic research, the standard sample is separated for chemical synthesis. The present invention designs three synthetic routes. Corresponding to the three chemical synthesis processes, the new compound was identified by spectrum, and it was determined to be quinolone. After further growth-promoting and toxicity tests, it showed obvious improvement and improvement compared with the lead compound quinolone. The invention has the beneficial effects of greatly shortening the development cycle and greatly saving the development cost, and shows that quinolone is a very vital veterinary drug feed additive.

Disclosed is a veterinary medicine for treating virus diseases of domestic birds comprising the following constituents: honeysuckle flower 25-40 parts, capsule of weeping forsythia 25-40 parts, ledebouriella root 25-35 parts, herba schizonepetae 25-40 parts, epimedium 35-45 parts, baikal skullcap root 25-40 parts, radix isatidis 25-40 parts, dandehon herb 35-45 parts, dyers woad leaf 25-40 parts, bupleurum root 20-35 parts, cinnamon twig 25-40 parts, licorice root 25-40 parts, psoralea fruit 20-35 parts, astragalus root 35-45 parts, and cordate houttuynia 25-40 parts.