729 results about "Veterinary Drugs" patented technology

The invention provides a traditional Chinese medicine composition and an application thereof in preparing a product for preventing, alleviating or treating acute hepatopancreatic necrosis of shrimp, belonging to the field of veterinary medicine. The active ingredients of the traditional Chinese medicine composition include isatis root, artificial bezoar, liquorice, borneol, pig gall powder and xuanming powder. The traditional Chinese medicine composition has a good therapeutic effect on preventing, alleviating or treating acute hepatopancreatic necrosis of shrimp, with a cure rate of more than 70%, has antibacterial and liver-protecting effects, can effectively improve the degree of liver damage, improve the survival rate of shrimp and reduce losses.

The invention discloses an intelligent traceability system for veterinary drug safety information, which relates to the technical field of veterinary drug safety and information and comprises a data fusion module, a risk traceability module, an event reconstruction module, a chain integration module, a critical path module and a report generation module. The system dynamically constructs a risk association map by fusing multi-source heterogeneous data in production circulation, actively recognizes a potential risk veterinary drug batch cluster and realizes full-chain reverse tracing. Fine-grained event reconstruction is carried out on each link, a risk event chain is formed after integration, a core event sequence causing risks is extracted by calculating the contribution degree weight of each event, and finally a traceability report and a disposal suggestion are generated in combination with a safety knowledge base. According to the system, intelligent tracing from passive query to active early warning and from link enumeration to root cause accurate positioning is realized.

The invention discloses a fluralamide moxidectin drop and a preparation method thereof, and relates to the technical field of veterinary drugs. The drop is prepared from the following components in parts by weight: 26 to 26.5 parts of fluralan, 1.32 parts of moxidectin, 0.10 part of butylated hydroxytoluene, 29.5 to 30.5 parts of dimethylacetamide, 19.5 to 20 parts of tetrahydrofuran polyethylene glycol ether, 13 to 13.5 parts of diethyl toluamide, 8.5 to 9.3 parts of acetone and 1.0 to 1.5 parts of ethanol. The invention has the effects of improving the stability, permeability and lasting effect of the medicine.

The invention relates to the field of veterinary drugs, in particular to a furalan chewable tablet and a preparation method thereof.According to the furalan chewable tablet, a coating agent with xanthan gum, gelatin and other components as main bodies is utilized, the coating performance of the furalan chewable tablet on furalan is improved, and good palatability can be provided on the basis that the whole furalan chewable tablet has good hardness, tablet preparation performance and disintegration performance; the feed is more suitable for animals to eat.

The invention belongs to the technical field of liquid chromatography-mass spectrometry detection pretreatment, and particularly relates to a pretreatment method for liquid chromatography-tandem mass spectrometry analysis of pesticide and veterinary drug residues in serum, which comprises the following steps: (S1) carrying out heating reaction on Sc (III) salt, Cu (II) salt and 1H-pyrazole-4-formic acid (H2PyC) in a polar aprotic solvent, and cooling to obtain a green crystal, namely MOF-919; the chemical formula of the MOF-919 is [Sc < 3 > (mu3-O) (OH) < 3 >] [Cu3 (mu3-O) (mu-PyC) < 3 > (H2O) < 6 >] < 2 >; (S2) mixing the serum sample with an acetonitrile solution containing formic acid, carrying out ultrasonic treatment, vortex oscillation and centrifugation, taking supernate, and diluting the supernate with an aqueous solution containing formic acid to obtain a to-be-purified solution; and (S3) adding MOF-919 into the to-be-purified liquid, mixing, performing ultrasonic treatment, performing vortex oscillation, centrifuging, and taking supernate, thereby completing the pretreatment of the to-be-purified liquid. According to the method, the MOF-919 is used for adsorbing chemical pollutant residues in serum, especially phospholipids, so that the purpose of removing the chemical pollutant residues in blood is achieved. The method is simple and convenient to operate, small in organic solvent consumption and good in purification effect, and can be widely applied to residue analysis of chemical pollutants in serum.

The invention relates to a serum liquid chromatography-tandem mass spectrometry pretreatment method, which comprises: (S1) mixing a serum sample and a formic acid-containing acetonitrile solution, carrying out ultrasonic treatment, vortex oscillation and centrifugation, taking the supernatant, and diluting with a formic acid-containing aqueous solution to obtain a liquid to be purified; (S2) mixing the to-be-purified liquid with PCN-777, performing ultrasonic treatment, vortex oscillation and centrifugation, and taking supernate to obtain to-be-detected liquid; the PCN-777 is a C24H23N3O16Zr3 phospholipid removal material, and the PCN-777 is a C24H23N3O16Zr3 phospholipid removal material, and the PCN-777 is a C24H23N3O16Zr3 phospholipid removal material. According to the present invention, the serum ultra-high performance liquid chromatography-tandem mass spectrometry pretreatment method is developed by using the known MOFs material PCN-777, such that different types of phospholipids in the serum can be specifically, rapidly and effectively removed, the efficient recovery and detection of pesticide and veterinary drugs can be achieved, and the interference of phospholipids can be avoided.

The invention belongs to the field of veterinary drugs, and relates to an avian infectious bronchitis virus antigen recombinant protein S-Trimer and a subunit vaccine thereof. The invention provides an avian infectious bronchitis virus antigen recombinant protein S-Trimer. The amino acid sequence of the antigen recombinant protein S-Trimer is as shown in SEQ ID No. 4. The invention provides an infectious bronchitis virus antigen. The infectious bronchitis virus antigen is of a trimer structure of the recombinant protein S-Trimer. The invention provides a chicken infectious bronchitis virus subunit vaccine. The subunit vaccine comprises a pharmaceutically acceptable carrier and an immune dose of the chicken infectious bronchitis virus antigen. The vaccine is high in safety, good in immunogenicity and stable in batches, and can provide complete protection for attacking the infectious bronchitis virus.

The invention relates to the technical field of agricultural product safety detection, in particular to an agricultural product veterinary drug residue high-throughput detection method and system based on spectrum peak analysis. The method comprises the following steps: acquiring multiple batches of spectral data, and performing cross-batch pre-alignment according to the multiple batches of spectral data to obtain cross-batch alignment data; performing background baseline estimation according to the cross-batch alignment data to obtain background baseline data; congestion detection area extraction is carried out according to the cross-batch alignment data to obtain congestion detection area data; performing common-peak decoupling according to the congestion detection area data to obtain common-peak decoupling data; performing residual image construction on the common peak decoupling data according to the background baseline data to obtain residual image data; performing image feature extraction according to the residual image data to obtain image feature data; and performing residual judgment according to the graph feature data to obtain residual judgment data. According to the method, the identification accuracy of spectrum peak pseudo-congestion and residual abnormity in a high-throughput mixed agricultural product detection scene is improved.

The invention belongs to the technical field of veterinary drug preparations, and particularly relates to a compound external ointment for treating parasites of dogs and cats and skin tinea and a preparation method, the compound external ointment comprises the following components by mass percent: 2%-12% of selamectin, 3%-20% of imidacloprid, 0.5%-2% of terbinafine hydrochloride, 2%-12% of dipropylene glycol monomethyl ether, 10%-50% of isopropanol, 9%-45% of polyethylene glycol 400 and the balance of water. The adhesive is prepared from, by weight, 9%-45% of polyethylene glycol 3350, 5%-15% of caprylic / capric polyethylene glycol glyceride, 1%-8% of oleyl alcohol, 0.5%-5% of dimeticone, 0.01%-0.1% of butylated hydroxytoluene and 1%-5% of cassava starch polymethylsesquioxane. The preparation method comprises the following steps: uniformly stirring the selamectin, the imidacloprid, the terbinafine hydrochloride and the mixed solvent, then mixing with the matrix (the polyethylene glycol 400 and the polyethylene glycol 3350 are heated and uniformly mixed in advance), the emulsifier and other components, and homogenizing. The compound selamectin ointment prepared by the invention can realize accurate administration at the edge of the auricle of an animal, and not only can ensure that the medicine is fully absorbed, but also can improve the compliance of animal administration; the composition not only can expel parasites in a broad spectrum, but also has broad-spectrum antifungal activity, and can prevent and treat a plurality of skin diseases of pets.

The invention relates to the technical field of intelligent production of veterinary oral liquid, discloses an intelligent temperature control mixing method of a veterinary oral liquid preparation tank and a system thereof, and mainly solves the problems that a traditional liquid preparation tank depends on manpower, the temperature control precision is low, mixing is uneven, thermosensitive components are prone to inactivation and the like. The method comprises the steps of parameter presetting, medium temperature pre-adjustment, component dynamic adding and temperature control mixing, uniformity verification and output cleaning. The system is composed of a central control module, a multi-parameter monitoring module, a high-precision temperature control module, an intelligent stirring drive module, a material management module and a data communication module. According to the invention, the incremental PID algorithm is adopted to accurately control the temperature, and the stirring speed is adaptively adjusted based on the temperature change rate and the real-time viscosity, so that the full-automatic intelligent control of the mixing process is realized. According to the invention, the uniformity of the product and the retention rate of active ingredients can be obviously improved, the energy consumption and the labor cost are reduced, the complete tracing of production data is realized, and the method is suitable for veterinary oral liquid production with strict temperature control requirements.

The invention discloses a fermented traditional Chinese medicine feed additive as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese veterinary medicines. The additive is prepared by solid state fermentation and extraction of a traditional Chinese medicine composition and a complex microbial inoculant, the traditional Chinese medicine composition comprises poria cocos, astragalus membranaceus, codonopsis pilosula, pericarpium citri reticulatae and radix puerariae, and the complex microbial inoculant comprises bacillus subtilis, lactobacillus plantarum and aspergillus niger. Through a fermentation and extraction combined process, the effective components in the traditional Chinese medicines are higher in extraction rate and easier to absorb, the animal intestinal flora balance can be remarkably regulated, the immunity is enhanced, the growth performance is promoted, and the prospect is wide.

This invention belongs to the field of veterinary drug technology, specifically relating to a 2,3-disubstituted naphthoquinone compound, its uses, and a preparation method. The 2,3-disubstituted naphthoquinone compound has the general formula: where X is selected from C, NH, O, and S; where X is selected from C, the X-R1 substituent represents an aryl substituent; when X is selected from NH, R1 is selected from hydrogen atom, C1-6 alkyl, C3-6 cycloalkyl, substituted aryl, substituted benzyl, or substituted acyl; when X is selected from O, R1 is selected from hydrogen atom, C1-6 alkyl, C3-6 cycloalkyl, C4-6 cycloalkyl, C5-6 cycloalkyl, C6-6 cyclo ... 3-6 cycloalkyl, substituted benzyl, substituted acyl; when X is selected from S, R1 is selected from C1-6 alkyl, substituted aryl, substituted benzyl; R2 is selected from C1-16 alkyl, substituted aryl, Ra-(CH2)n-, Ra-CO-(CH2)n-; This series of compounds has novel structures, excellent antiparasitic activity, and has been successfully applied in the field of veterinary drugs, solving long-standing safety and toxicity problems; its synthesis process is simple, the conditions are mild, and it can efficiently prepare a variety of 2,3-disubstituted naphthoquinone compounds.

The invention discloses a livestock feed continuous feeding device of veterinary drug mixed feed, and relates to the technical field of poultry breeding and drug mixing, the livestock feed continuous feeding device comprises a movable feeding trolley, the movable feeding trolley is used for feeding materials into a three-dimensional chicken house, the three-dimensional chicken house is fixedly connected with a plurality of feeding trough frames in a linear array, the movable feeding trolley is symmetrically and fixedly connected with two vertical plates, and the two vertical plates are fixedly connected with the movable feeding trolley. A plurality of medicine mixing feeding assemblies are symmetrically arranged on the vertical plate, each medicine mixing feeding assembly comprises a storage barrel, and the storage barrels are fixedly connected to the vertical plate through bolts; through operation of the medicine mixing and feeding assembly, feed and veterinary medicine are vibrated in the feeding process, dynamic mixing of the feed and the veterinary medicine is promoted, lumps can be beaten, the veterinary medicine is more evenly attached to the surface of the feed, it is ensured that the feed falling into the feeding trough frame and the veterinary medicine are kept in a loose and evenly-mixed state, chicken pecking is facilitated, and the feeding efficiency is improved. The design is particularly more friendly to sick chickens or chickens with weak ingestion ability, and is beneficial to improving the ingestion effect of medicines and nutrients.

The present invention relates to a pretreatment method for serum liquid chromatography-tandem mass spectrometry analysis, comprising the following steps: (S1) mixing a serum sample with an acetonitrile solution containing formic acid, ultrasonicating, vortexing, and centrifuging, taking the supernatant and diluting it with an aqueous solution containing formic acid to obtain a liquid to be purified; (S2) mixing the liquid to be purified with PCN-777, ultrasonicating, vortexing, and centrifuging, taking the supernatant and obtaining a liquid to be tested; the PCN-777 is C 24 H 23 N3O 16 Zr3 phospholipid removal material, the PCN-777 is C 24 H 23 N3O 16 Zr3. The present invention uses a known MOFs material PCN-777 to develop a pretreatment method for serum ultra-high performance liquid chromatography-tandem mass spectrometry analysis, which can specifically, quickly and effectively remove different types of phospholipids in serum, and achieve efficient recovery and detection of pesticides and veterinary drugs, avoiding interference from phospholipids.

The invention relates to the technical field of livestock and poultry product safety detection, in particular to a temperature-controllable crushing device for livestock and poultry product detection, which is characterized in that sound wave signals generated in a homogenizing process are acquired through a sound sensor arranged outside a detection cup, and spectrum drift and energy attenuation characteristics of the sound wave signals are analyzed by adopting a sound spectrum temperature inversion algorithm; inverting the temperature and distribution of the sample in real time; and meanwhile, a cooling air curtain is formed through nitrogen injection, the gas flow rate and the injection angle are intelligently adjusted through a control unit according to a temperature inversion result, directional focusing cooling of a local overheating area is achieved, and a closed-loop temperature control system driven by acoustic signals is formed. According to the device and the method, cross contamination and sensor adsorption effect caused by contact type temperature measurement are thoroughly avoided, the problems that the sensor is easy to pollute and difficult to maintain in a high-humidity and fat-rich environment are solved, heat-sensitive veterinary drug decomposition caused by friction temperature rise in the homogenizing process is effectively inhibited, and the accuracy, reliability and repeatability of veterinary drug residue detection are remarkably improved.

The invention provides an intelligent veterinary drug residue detection system and method based on multi-dimensional spectral characteristics, and relates to the technical field of veterinary drug residue detection, spectral response data of a to-be-detected sample solution in a visible light band and a near-infrared band is collected, and the residue discrimination degree of veterinary drug residues under any wavelength when the concentration dependence change exists is determined; abnormal wave band combinations with quantitative response to veterinary drug residues are screened out from the visible light wave band and the near-infrared wave band respectively, the residual peak deviation of the veterinary drug residues in the region of interest of the spectrum is determined according to the abnormal wave band combinations, and trace residue marks in the multiple spectrum intensity distribution modes are determined; and performing in-situ nondestructive screening on veterinary drug residues in the to-be-detected animal-derived food sample according to the residue discrimination and the trace residue mark. According to the method, on the premise that the dual-band spectrum collaborative response is enhanced, the veterinary drug residue characteristics can be directionally distinguished and detected, so that the veterinary drug residue screening accuracy is improved.

The invention relates to plant-based pet ear drops with effects of diminishing inflammation and relieving itching and a preparation method of the plant-based pet ear drops, and belongs to the technical field of veterinary drugs. The invention discloses plant-based pet ear drops. The plant-based pet ear drops are prepared from, by mass, comprising 6%-8% of a tea tree extract, 6%-8% of a witch hazel extract, 6%-8% of a chamomile extract, 6%-8% of a soybean extract, 2%-6% of a lithospermum extract, 2%-6% of a centella asiatica extract, 2%-6% of a mint extract, 2%-6% of a licorice extract, 4%-6% of a humectant, 0.1%-0.5% of a preservative, 0.1%-0.5% of a conditioning agent and the balance of water. Through reasonable matching of various plant extracts, the ear drops have broad-spectrum antibacterial, anti-inflammatory, soothing and repairing effects, and can effectively deal with various common problems of pet ears, such as bacterial infection, fungal infection, allergic dermatitis, ear mite expelling and the like. The pet ear canal cleaner can also be used for cleaning and nursing pet ear canals, is mild in performance, and can effectively remove dirt, dust and wax in the ear canals.

The invention relates to the field of veterinary drugs, in particular to a veterinary GS-441524 tablet and a preparation method thereof. In the application, the GS-441524 raw material medicine, the filling agent, the disintegrating agent, the lubricating agent and the stabilizing agent are used as raw materials, the combination of mannitol and microcrystalline cellulose is selected as the filling agent, and coating is performed, so that the novel veterinary GS-441524 tablet is prepared, the medicine loss caused by thermal decomposition of API in the tabletting process is reduced, and the uniformity and the stability of the medicine in the tablet are improved.

The invention relates to the field of veterinary drug residue detection, in particular to a fluorescence sensor based on DNA molecular machine mediated split Cas12a and application of the fluorescence sensor to ofloxacin detection, the fluorescence sensor comprises a system A, a system B and a system C. According to the final concentration of each system, the system A comprises an AP / CP double-stranded compound and a 20 mM Tris-HCl buffer solution 1, the system B comprises a double-stranded compound, an sRNA probe and a 10 mM Tris-HCl buffer solution 2, and the system C comprises a DNA molecular machine mediated split Cas12a. The system C comprises a Cas12a / hRNA compound, a pDNA / psG43 signal probe, ThT and a 20 mM Tris-HCl buffer solution; aP in the AP / CP double-chain compound is an aptamer of ofloxacin, and AP and CP in the AP / CP double-chain compound are paired and connected through complementary base pairing; the sequences of AP, CP, PS, SS, sRNA, hRNA, pDNA and psG43 are respectively as shown in SEQ ID NO.1-SEQ ID NO.8. The invention also discloses a kit for detecting the content of the protein. According to the application, the nucleic acid aptamer of ofloxacin is utilized, based on a DNA molecular machine and SCas12a as a signal amplification technology and sulfo-modified G43 as a fluorescent signal probe, even if the content of ofloxacin in a sample is extremely low, detection can be accurately realized.

The invention discloses a compound fluralana external preparation for dogs, a preparation method and application, belongs to the technical field of veterinary drugs, and solves the problems that an existing preparation is poor in skin surface permeability, a solvent is easy to volatilize, and use experience and drug effect exertion are influenced. The preparation is prepared from the following raw materials: fluralana, moxidectin, ethyl butylacetamidopropionate and N, N-dimethylformamide. The preparation method comprises the following steps: adding N, N-dimethylacetamide, acetone, an auxiliary adjuvant, a transdermal penetration enhancer, an antioxidant and a surface film-forming agent; according to the invention, the combination of the fluralab and the moxidectin can play a synergistic effect and expand an anti-parasitic spectrum so as to achieve an internal and external driving effect; both the fluralab and the moxidectin belong to high-fat-soluble substances, parasites can be quickly repelled and killed by adding novel adjuvant natural parasite expelling ingredients, and meanwhile, the skin permeability can be improved by adding the efficient transdermal penetration enhancer, and the risk that medicine residues are licked by pets is reduced.

The utility model discloses a raw material preparation device for veterinary drug production, which comprises a base, a preparation barrel is fixedly embedded on the base, a mixing mechanism for mixing raw materials is arranged in the preparation barrel, a cover plate covers the top of the preparation barrel, and a feed hopper for feeding the preparation barrel is embedded on the top of the cover plate. A batching mechanism for quantitatively adding raw materials is mounted in the middle of the top of the cover plate; through cooperation of four groups of quantitative cylinders in the batching mechanism and scale marks on the outer walls of the quantitative cylinders, the adding amount of veterinary drug raw materials can be accurately controlled, then the proportion of the raw materials and auxiliary materials needing to be added in veterinary drug blending is accurately mastered, a rotating motor drives a rotating disc to rotate in a stepping mode, and the raw materials and the auxiliary materials in the four groups of quantitative cylinders can be sequentially rotated to the position above a feeding hopper; the feeding pipe at the bottom of the quantitative barrel is matched with the first electromagnetic valve, raw materials in the quantitative barrel are added into the preparation barrel, the adding proportion of the raw materials during veterinary drug preparation is accurately mastered, and the phenomenon that the drug effect of oral liquid is affected due to inaccurate proportion is reduced.

The invention belongs to the field of veterinary drugs, and particularly relates to water-soluble amoxicillin powder which comprises the following components: 50-60 parts of amoxicillin, 5-10 parts of polyvinyl alcohol modified beta-cyclodextrin, 1-3 parts of tryptophan, 20-30 parts of a filler and 0.5-1 part of a flavoring agent. The water-soluble amoxicillin powder disclosed by the invention has an excellent slow-release effect and storage stability.

The present application belongs to the field of veterinary drugs, and provides a recombinant protein S-Trimer of an infectious bronchitis virus antigen and a subunit vaccine therefor. Provided in the present application is a recombinant protein S-Trimer of an infectious bronchitis virus antigen, wherein the recombinant protein S-Trimer of the antigen has an amino acid sequence as set forth in SEQ ID No. 4. Also provided in the present application is an infectious bronchitis virus antigen. The infectious bronchitis virus antigen is of a trimer structure of the recombinant protein S-Trimer described above. The present application provides a subunit vaccine for an infectious bronchitis virus, wherein the subunit vaccine comprises a pharmaceutically acceptable carrier and an immunogenic amount of the infectious bronchitis virus antigen.

A semi-automated veterinary medicine delivery device may sense whether and how much air may have been incorporated into a dose delivered to an animal. The device may also sense an incomplete injection in some cases and may cause a second dose to be administered to make up for the incomplete dose. The device may compare a position sensor on a syringe in combination with a current sensor on a motor attached to the syringe to detect any abnormalities. In the case of an improper dose, the device may alert the user and administer a second dose.

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.

The invention discloses a livestock veterinary drug smashing, screening and discharging device, and relates to the field of veterinary drug processing, the livestock veterinary drug smashing, screening and discharging device comprises a screening box and a treatment mechanism which is arranged in the screening box and used for controlling the discharging amount and screening, the treatment mechanism is composed of a discharging assembly, a scraping assembly and a vibration assembly, the discharging assembly is arranged on a square discharging pipe, and the scraping assembly is arranged above an inclined screen; the scraping assembly is in transmission connection with the discharging assembly, the discharging assembly is used for controlling opening and closing of the square discharging pipe to limit the discharging amount, the scraping assembly is used for evenly spreading the falling veterinary medicine powder, and the vibration assembly is used for providing vibration to promote the powder to pass through the inclined screen. According to the veterinary drug powder feeding device, the discharging amount of smashed veterinary drugs can be controlled, the situation that veterinary drug powder is accumulated due to the excessive discharging amount can be effectively avoided through cooperation with the linked scraping plate, the load of the inclined screen is reduced, the falling veterinary drug powder is evenly spread on the inclined screen, local accumulation of the veterinary drug powder is prevented, and it is ensured that all areas of the screen can be effectively screened.

The present invention relates to a method and a dual-color detection kit for the rapid and simultaneous detection of MS-222 and malachite green, and a technology for the rapid detection of veterinary drug residues in aquatic products. The invention utilizes red and blue colloidal gold with different particle sizes, combined with specific antibodies to construct different red and blue probes, respectively. The invention utilizes the principle that MG-BSA complete antigen and 3-aminobenzoic acid-BSA antigen coated on the T1 line and the T2 line, respectively, can compete with MG and MS-222 in the sample for binding to the blue probe and the red probe, thereby constructing a dual-color rapid detection test strip for MS-222 and malachite green that is clearly distinguishable to the naked eye and simple to operate.

The invention provides a thymol derivative as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The preparation method comprises the following steps: carrying out esterification reaction on thymol and indole-3-carboxylic acid to prepare a thymol derivative, namely 2-isopropyl-5-methyl phenyl 1H-indole-3-carboxylic ester. Under the process conditions provided by the invention, the yield of the thymol derivative can reach 93-94%. The anti-coccidiosis index of the thymol derivative is as high as 196.51, and the thymol derivative can obviously reduce the influence of chicken coccidiosis on the weight of chicken, has a remarkable effect of promoting the growth and development of the body, and can obviously improve the clinical symptoms of chicken infected with coccidiosis, recover the mental condition and appetite of sick chicken, obviously reduce the occurrence of bloody stool and improve the intestinal tract lesion condition; the anti-coccidiosis effect of the thymol derivative provided by the invention is obvious and is obviously better than that of thymol, and the thymol derivative is expected to become a new veterinary drug for treating chicken coccidiosis infection.

The grinding equipment comprises a grinding box, the upper surface of the grinding box is fixedly communicated with a feeding port, the outer surface of the grinding box is fixedly connected with two first driving motors, and the output end of each first driving motor is fixedly connected with a first rotating column; and two groups of first bearings are fixedly embedded in the inner wall of the grinding box. According to the device, a first rotating column is driven by a first driving motor, a first crushing roller is driven by the first rotating column, so that veterinary drugs are crushed for the first time by the first crushing roller, a second rotating column is driven by a second driving motor, a second crushing roller is driven by the rotating column, so that the veterinary drugs are crushed for the second time by the second crushing roller, and the grinding effect is improved; according to the veterinary drug grinding device, the problem of low grinding efficiency is solved, the use convenience is improved, the ground veterinary drugs can flow into the collecting box through the two guide plates in the grinding box, and the problem that resources are wasted due to the fact that the veterinary drugs are scattered is avoided.