389 results about "Veterinary Drugs" patented technology

The invention discloses an intelligent traceability system for veterinary drug safety information, which relates to the technical field of veterinary drug safety and information and comprises a data fusion module, a risk traceability module, an event reconstruction module, a chain integration module, a critical path module and a report generation module. The system dynamically constructs a risk association map by fusing multi-source heterogeneous data in production circulation, actively recognizes a potential risk veterinary drug batch cluster and realizes full-chain reverse tracing. Fine-grained event reconstruction is carried out on each link, a risk event chain is formed after integration, a core event sequence causing risks is extracted by calculating the contribution degree weight of each event, and finally a traceability report and a disposal suggestion are generated in combination with a safety knowledge base. According to the system, intelligent tracing from passive query to active early warning and from link enumeration to root cause accurate positioning is realized.

The invention belongs to the field of veterinary drugs, and relates to an avian infectious bronchitis virus antigen recombinant protein S-Trimer and a subunit vaccine thereof. The invention provides an avian infectious bronchitis virus antigen recombinant protein S-Trimer. The amino acid sequence of the antigen recombinant protein S-Trimer is as shown in SEQ ID No. 4. The invention provides an infectious bronchitis virus antigen. The infectious bronchitis virus antigen is of a trimer structure of the recombinant protein S-Trimer. The invention provides a chicken infectious bronchitis virus subunit vaccine. The subunit vaccine comprises a pharmaceutically acceptable carrier and an immune dose of the chicken infectious bronchitis virus antigen. The vaccine is high in safety, good in immunogenicity and stable in batches, and can provide complete protection for attacking the infectious bronchitis virus.

The invention relates to the technical field of agricultural product safety detection, in particular to an agricultural product veterinary drug residue high-throughput detection method and system based on spectrum peak analysis. The method comprises the following steps: acquiring multiple batches of spectral data, and performing cross-batch pre-alignment according to the multiple batches of spectral data to obtain cross-batch alignment data; performing background baseline estimation according to the cross-batch alignment data to obtain background baseline data; congestion detection area extraction is carried out according to the cross-batch alignment data to obtain congestion detection area data; performing common-peak decoupling according to the congestion detection area data to obtain common-peak decoupling data; performing residual image construction on the common peak decoupling data according to the background baseline data to obtain residual image data; performing image feature extraction according to the residual image data to obtain image feature data; and performing residual judgment according to the graph feature data to obtain residual judgment data. According to the method, the identification accuracy of spectrum peak pseudo-congestion and residual abnormity in a high-throughput mixed agricultural product detection scene is improved.

The invention relates to the technical field of livestock and poultry product safety detection, in particular to a temperature-controllable crushing device for livestock and poultry product detection, which is characterized in that sound wave signals generated in a homogenizing process are acquired through a sound sensor arranged outside a detection cup, and spectrum drift and energy attenuation characteristics of the sound wave signals are analyzed by adopting a sound spectrum temperature inversion algorithm; inverting the temperature and distribution of the sample in real time; and meanwhile, a cooling air curtain is formed through nitrogen injection, the gas flow rate and the injection angle are intelligently adjusted through a control unit according to a temperature inversion result, directional focusing cooling of a local overheating area is achieved, and a closed-loop temperature control system driven by acoustic signals is formed. According to the device and the method, cross contamination and sensor adsorption effect caused by contact type temperature measurement are thoroughly avoided, the problems that the sensor is easy to pollute and difficult to maintain in a high-humidity and fat-rich environment are solved, heat-sensitive veterinary drug decomposition caused by friction temperature rise in the homogenizing process is effectively inhibited, and the accuracy, reliability and repeatability of veterinary drug residue detection are remarkably improved.

The invention provides an intelligent veterinary drug residue detection system and method based on multi-dimensional spectral characteristics, and relates to the technical field of veterinary drug residue detection, spectral response data of a to-be-detected sample solution in a visible light band and a near-infrared band is collected, and the residue discrimination degree of veterinary drug residues under any wavelength when the concentration dependence change exists is determined; abnormal wave band combinations with quantitative response to veterinary drug residues are screened out from the visible light wave band and the near-infrared wave band respectively, the residual peak deviation of the veterinary drug residues in the region of interest of the spectrum is determined according to the abnormal wave band combinations, and trace residue marks in the multiple spectrum intensity distribution modes are determined; and performing in-situ nondestructive screening on veterinary drug residues in the to-be-detected animal-derived food sample according to the residue discrimination and the trace residue mark. According to the method, on the premise that the dual-band spectrum collaborative response is enhanced, the veterinary drug residue characteristics can be directionally distinguished and detected, so that the veterinary drug residue screening accuracy is improved.

The invention relates to the field of veterinary drug residue detection, in particular to a fluorescence sensor based on DNA molecular machine mediated split Cas12a and application of the fluorescence sensor to ofloxacin detection, the fluorescence sensor comprises a system A, a system B and a system C. According to the final concentration of each system, the system A comprises an AP / CP double-stranded compound and a 20 mM Tris-HCl buffer solution 1, the system B comprises a double-stranded compound, an sRNA probe and a 10 mM Tris-HCl buffer solution 2, and the system C comprises a DNA molecular machine mediated split Cas12a. The system C comprises a Cas12a / hRNA compound, a pDNA / psG43 signal probe, ThT and a 20 mM Tris-HCl buffer solution; aP in the AP / CP double-chain compound is an aptamer of ofloxacin, and AP and CP in the AP / CP double-chain compound are paired and connected through complementary base pairing; the sequences of AP, CP, PS, SS, sRNA, hRNA, pDNA and psG43 are respectively as shown in SEQ ID NO.1-SEQ ID NO.8. The invention also discloses a kit for detecting the content of the protein. According to the application, the nucleic acid aptamer of ofloxacin is utilized, based on a DNA molecular machine and SCas12a as a signal amplification technology and sulfo-modified G43 as a fluorescent signal probe, even if the content of ofloxacin in a sample is extremely low, detection can be accurately realized.

The invention discloses a compound fluralana external preparation for dogs, a preparation method and application, belongs to the technical field of veterinary drugs, and solves the problems that an existing preparation is poor in skin surface permeability, a solvent is easy to volatilize, and use experience and drug effect exertion are influenced. The preparation is prepared from the following raw materials: fluralana, moxidectin, ethyl butylacetamidopropionate and N, N-dimethylformamide. The preparation method comprises the following steps: adding N, N-dimethylacetamide, acetone, an auxiliary adjuvant, a transdermal penetration enhancer, an antioxidant and a surface film-forming agent; according to the invention, the combination of the fluralab and the moxidectin can play a synergistic effect and expand an anti-parasitic spectrum so as to achieve an internal and external driving effect; both the fluralab and the moxidectin belong to high-fat-soluble substances, parasites can be quickly repelled and killed by adding novel adjuvant natural parasite expelling ingredients, and meanwhile, the skin permeability can be improved by adding the efficient transdermal penetration enhancer, and the risk that medicine residues are licked by pets is reduced.

The present application belongs to the field of veterinary drugs, and provides a recombinant protein S-Trimer of an infectious bronchitis virus antigen and a subunit vaccine therefor. Provided in the present application is a recombinant protein S-Trimer of an infectious bronchitis virus antigen, wherein the recombinant protein S-Trimer of the antigen has an amino acid sequence as set forth in SEQ ID No. 4. Also provided in the present application is an infectious bronchitis virus antigen. The infectious bronchitis virus antigen is of a trimer structure of the recombinant protein S-Trimer described above. The present application provides a subunit vaccine for an infectious bronchitis virus, wherein the subunit vaccine comprises a pharmaceutically acceptable carrier and an immunogenic amount of the infectious bronchitis virus antigen.

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.

The grinding equipment comprises a grinding box, the upper surface of the grinding box is fixedly communicated with a feeding port, the outer surface of the grinding box is fixedly connected with two first driving motors, and the output end of each first driving motor is fixedly connected with a first rotating column; and two groups of first bearings are fixedly embedded in the inner wall of the grinding box. According to the device, a first rotating column is driven by a first driving motor, a first crushing roller is driven by the first rotating column, so that veterinary drugs are crushed for the first time by the first crushing roller, a second rotating column is driven by a second driving motor, a second crushing roller is driven by the rotating column, so that the veterinary drugs are crushed for the second time by the second crushing roller, and the grinding effect is improved; according to the veterinary drug grinding device, the problem of low grinding efficiency is solved, the use convenience is improved, the ground veterinary drugs can flow into the collecting box through the two guide plates in the grinding box, and the problem that resources are wasted due to the fact that the veterinary drugs are scattered is avoided.

The present invention relates to the technical field of veterinary medicinal products and specifically to a composition for the treatment of a skin disease in an animal. The main active ingredients of the composition are rapamycin, miconazole, and meloxicam in a mass ratio of (0.01–10):(0.1–20):(0.1–5) and a solvent mixture of water and polyethylene glycol in which the main active ingredients are soluble. The composition has considerable curative effects on fungal infections on the skin surfaces of animals, with low toxicity and minimal irritation.

The application discloses a sweet wormwood extract, a preparation method and application thereof and a sweet wormwood extract veterinary drug, and the method comprises the following steps: S1, heating and extracting sweet wormwood byproducts with an extraction solvent, filtering, discarding the filtrate, and obtaining an intermediate product filter cake; S2, concentrating the intermediate product filter cake to a constant weight; S3, heating and extracting the constant weight obtained in the step S2 with deionized water, filtering, and taking the filtrate; S4, concentrating the filtrate obtained in the step S3 to a constant weight, and obtaining the sweet wormwood extract. The application provides a sweet wormwood extract and a preparation method thereof, and provides a veterinary drug based on the sweet wormwood extract; the veterinary drug obtained by the application can clear heat, resolve summer-heat, and relieve deficiency heat, and can be used for treating various livestock and poultry diseases; the preparation method is simple, easy to operate, raw materials are easy to obtain, production cost is low, and the application has a good market application prospect.

The present disclosure relates to a method for preparing a veterinary medicament dosage using a 3D printer. The method comprises printing a plurality of layers comprising one or more active pharmaceutical ingredients (APIs) on the printing substrate, so that each layer comprising API is surrounded by layers comprising one or more taste masking agents, until a required dose of the one or more APIs is obtained. The disclosure also relates to a veterinary medicament dosage obtainable by the method.

The utility model relates to the technical field of veterinary drugs, in particular to a raw material mixing and stirring device for veterinary drug processing, which comprises a stirring barrel, auxiliary support frames and a support base, three groups of auxiliary support frames are fixedly mounted on the outer wall of the side edge of the stirring barrel close to the bottom end at equal intervals, and the three groups of auxiliary support frames are all fixedly mounted above the support base. A liquid outlet pipe is fixedly mounted on the outer wall of the side edge of the bottom end of the stirring barrel, and a control valve is arranged outside the liquid outlet pipe. According to the raw material mixing and stirring device for veterinary drug processing, the stirring liquid level of the stirring barrel is controlled in a manner of physically blocking turbulent flow through cooperative use of the baffle strip and the baffle block, so that the liquid level is ensured to fluctuate within a preset range, and the height of the liquid level is effectively controlled; the assembly and the barrel wall are directly designed to be of an integrated structure, the response speed is high, the structure is simple, and maintenance is easy.

The invention discloses a compound fluralab chewable tablet and a preparation method thereof, and relates to the technical field of veterinary drug preparations, the chewable tablet is composed of fluralab, pyrantel and moxidectin solid dispersion constructed by poloxamer 407 / lauryl sodium sulfate (or sodium dodecyl sulfate); preferably, the particle size D50 of the dispersion is 5-30 microns, and D90 is less than or equal to 80 microns. The preparation method comprises the following steps: firstly, dissolving moxidectin in the system to form a clear solution, drying under reduced pressure, and grinding and sieving at low temperature to obtain a dispersed material; premixing with microcrystalline cellulose, then mixing with lactose, adding a disintegrating agent and a lubricating agent, and carrying out prepressing-main pressing two-stage tabletting to obtain the tablet. The system can maintain amorphous distribution of moxidectin in the tablet, the content uniformity and dissolution and acceleration stability are remarkably improved, broad-spectrum synergy is formed by the moxidectin, the fluralasodium and the pyrantel, and the moxidectin tablet is suitable for killing fleas and ticks, treating roundworms and hookworms and preventing canine heart filariasis and tubuloidiasis.

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.

The invention discloses a lactobacillus brevis with broad-spectrum bacteriostatic activity and a separation method and application thereof, and belongs to the technical field of microorganisms, in particular to a lactobacillus brevis AW04 with broad-spectrum bacteriostatic activity, which is characterized in that the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection, the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection, the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection, and the lactobacillus brevis AW04 is preserved in the China Center for Type Culture Collection. The address is Wuhan University Campus, Wuchang District, Wuhan City, Hubei Province; the postcode is 430072; the preservation number of the strain is CCTCC M 20241970; the preservation date is September 13, 2024. The strain provides a novel, safe and efficient strain resource for developing microecological preparations, feed additives or veterinary drugs for preventing and treating bacterial diarrhea of animals such as calves and the like, and has important value for reducing the use of antibiotics in the breeding industry and coping with bacterial drug resistance crisis. The strain can be produced on a large scale by using the existing fermentation technology and is convenient to apply.

The utility model relates to the technical field of veterinary drug production, in particular to a waste collecting device for veterinary drug production, which comprises an outer shell, a storage shell, a waste water feeding pipe, a solid waste feeding port and an isolation plate, the outer shell is fixedly mounted above the storage shell, and the inner space of the outer shell is communicated with the inner space of the storage shell; an isolation plate is connected and mounted between the inner wall of the top end of the shell and the inner wall of the bottom end of the storage shell, a crushing mechanism is arranged in the shell, an alarm mechanism is arranged in the storage shell, and a filtering mechanism is arranged on the inner wall of the side edge of the isolation plate. When solid waste enters the shell from the solid waste feeding port, the interior of the shell and the interior of the storage shell are divided into two parts through the partition plate, so that waste water and the solid waste are collected separately, and the problem that the waste water and the solid waste are mixed together, and cross contamination is caused is solved.

The utility model discloses veterinary drug liquid preparation filling equipment easy to clean, relates to the technical field of veterinary drug filling equipment, and solves the problems that in the prior art, cleaning of a filling head is time-consuming and labor-consuming, and the utilization rate of the equipment is reduced. Comprising a filling mechanism, the filling mechanism comprises a machine body, filling heads and a piston pump, the piston pump is connected to the upper end of the machine body, the filling heads are connected with a liquid outlet pipe of the piston pump through liquid conveying pipes, a liquid inlet pipe of the piston pump is connected with a cleaning pipe through a three-way valve, and the cleaning pipe communicates with a cleaning agent storage box; the cleaning agent storage box is connected to the upper end of the machine body; a cleaning tank is arranged at the lower end of the filling head, a conveying mechanism is arranged at the lower end of the cleaning tank, and the conveying mechanism corresponds to the filling head. The cleaning device has the beneficial effects that the piston pump and a connecting pipeline of the piston pump can be cleaned, residual liquid medicine in the filling head can be thoroughly cleaned, and the residual liquid medicine is prevented from breeding bacteria.

The utility model belongs to the technical field of veterinary drug liquid preparation production devices, and particularly relates to a veterinary drug liquid preparation uniform mixing device which comprises a tank body, connecting blocks are fixedly connected to the upper surface of the tank body, a motor is fixedly connected between every two adjacent connecting blocks, and the output end of each motor is fixedly connected with a first rotating shaft. A connecting piece is fixedly connected to the outer surface of the first rotating shaft, an inner gear ring is fixedly connected to the end, away from the first rotating shaft, of the connecting piece, first stirring blades are fixedly connected to the outer surface of the first rotating shaft, a fixing strip is fixedly connected to the inner surface of the tank body, and a second rotating shaft is movably installed on the upper surface of the fixing strip. The liquid medicine mixing tank is reasonable in structure, liquid medicine in the tank body forms a complex flowing form through stirring in different directions, strong convection and shearing are formed in the middle of the tank body through interaction of two kinds of circulation, exchange between the upper portion and the lower portion of the liquid medicine is promoted, and the mixing effect is improved.

The application belongs to the field of veterinary injection production, in particular to a liquid preparation mixing device for veterinary injection production and a processing method thereof. The device comprises a base, one side of the base is fixedly connected with a support plate, the outer wall of the support plate is fixedly connected with a support, and one side of the support is fixedly connected with a liquid preparation tank. The device can make the medicine in the liquid preparation tank sink and float up by the stirring of the stirring blade and the arc surface of the flow guide piece, thereby avoiding the stratification of the medicine. When the U-shaped frame rotates, the piston plate moves back and forth, and the external gas is blown out along the exhaust pipe, thereby making the bottom of the medicine in the liquid preparation tank bubble up, and the precipitation and crystallization in the medicine are easily made to rise up by the upwelling of the gas. In combination with the stirring of the stirring blade, the dissolution of the crystalline raw medicine is improved, and the medicine is more uniform, thereby preventing stratification.

The utility model discloses a molding device for rapid molding of veterinary drug particles, relates to the technical field of veterinary drug production equipment, and solves the problems in the prior art that cut particles are easy to adhere to each other when falling off, so that not only is the loss of production raw materials caused, but also the production cost is increased. Comprising a mixing auger, a discharging port of the mixing auger is connected with a conveying auger, a discharging port of the conveying auger is connected with a pelletizer, the pelletizer comprises a rack, a first driving air cylinder and a charging barrel, the first driving air cylinder and the charging barrel are connected to the rack, a discharging box is arranged at the discharging end of the charging barrel, an atomization spray head is connected into the discharging box, and the first driving air cylinder and the charging barrel are connected to the rack. And the atomizing nozzle is connected with the anti-adhesion spraying pressure tank through a connecting pipe. The anti-adhesion cutting device has the beneficial effects that an anti-adhesion agent can be sprayed through the atomization spray head during cutting, adhesion caused by surface viscosity is avoided, raw material loss is reduced, and the rate of finished products is increased.

The invention relates to the technical field of veterinary drug processing, in particular to a drug treatment device and method for veterinary drug processing. The drug treatment device comprises a grinding main machine, a mounting base, a material receiving frame and a filtering and selecting module and further comprises a material control assembly; the material control assembly comprises separation inclined plates, half-shielding inner plates, a discharging guide frame, a material blocking rotating plate, a lap joint component and a material rotating component, the two separation inclined plates are fixedly installed in the material receiving frame up and down and are matched with the two sets of filtering and selecting modules correspondingly, and the two half-shielding inner plates are rotatably installed in the material receiving frame; the two discharging guide frames correspond to the mounting positions of the two sets of filtering and selecting modules correspondingly, the four material blocking rotating plates are rotationally mounted in the material receiving frame, the material rotating component is connected with the material receiving frame, the raw material transferring process and multi-stage discharging of raw materials between the multi-stage grinding equipment can be optimized through the arranged components, and the efficiency is improved. And the overall machining efficiency is higher during multi-stage grinding and screening machining.

The invention discloses an application of compounds N-(1-naphthyl)-2-phenoxy acetamide and N-(1-naphthyl)-2-(phenylamino) ethyl thioamide in preparation of cryptosporidium resisting medicines, and belongs to the technical field of medicines and veterinary medicines of anti-parasitic medicines. The compound is obtained through functional group modification by taking NSC158011 as a pilot structure and can efficiently inhibit the activity of cryptosporidium parvum lactic dehydrogenase, and the inhibition rates respectively reach 60-70% and gt; 90%. An in-vitro experiment shows that parasite load is obviously reduced in HCT-8 cells by the two; in vivo, in a gamma-interferon gene knockout mouse and calf infection model, the fecal oocyst load is reduced by 40-100 times, the intestinal barrier repair can be promoted, and the safety is good. The invention reveals that the compound has efficient insect-resistant activity, high safety and intestinal protection effect for the first time, and provides important material basis and technical support for developing a new generation of cryptosporidium-resistant drugs.

The embodiment of the invention relates to the technical field of traditional Chinese veterinary medicine processing, and provides a reciprocating type medicine cutting machine and method for concentrated type traditional Chinese veterinary medicine processing The reciprocating type medicine cutting machine for concentrated type traditional Chinese veterinary medicine processing comprises a cutting bottom frame and further comprises an I-shaped conveying frame, a medicine conveying frame, a material cutting frame and an intermittent power assembly. The I-shaped conveying frame is arranged on the cutting bottom frame, the two sides of the I-shaped conveying frame are each provided with a medicine conveying assembly capable of automatically adjusting the tension force, the medicine conveying frame is arranged on the cutting bottom frame, the two medicine clamping assemblies are symmetrically arranged on the medicine conveying frame, and the medicine conveying assembly is located between the two medicine clamping assemblies. The medicinal material conveying assembly and the two medicinal material clamping assemblies form two material conveying channels, and the material cutting frame is arranged on one side of the medicine conveying frame. By means of the technical scheme, the problem that high-precision and high-quality medicine feeding operation is difficult to conduct when a reciprocating type medicine slicing machine in the prior art is used for processing flexible columnar medicine is solved.

The invention belongs to the technical field of industrial automation control, and particularly relates to an intelligent management method and system for a liquid veterinary drug production workshop, and the method comprises the steps: synchronously collecting the instantaneous flow velocity data and visual image data of liquid medicine; performing image processing on the visual image data, and calculating a foam texture index representing a bubble richness degree based on gray level distribution characteristics of the region of interest; constructing a foam structure stability model according to the foam texture index, calculating a foam structure stability factor, screening out a foam layer with a stable structure by utilizing the foam structure stability factor, and inhibiting splashing interference; the instantaneous flow velocity data of the liquid medicine, the observation height and the foam structure stability factor are input into a real liquid level decoupling formula, and the real liquid level after the thickness of the foam layer is removed is calculated. By means of multi-source data fusion and physical mechanism modeling, all-time high-precision liquid level tracking and intelligent feedback control are achieved.

The centrifugal slicing machine comprises a machine box and a shell, the shell is fixedly installed on the side wall of the machine box, a centrifugal mechanism is rotationally connected to the interior of the shell, a turning plate is rotationally connected to the top of a discharging hopper, and an installation mechanism is embedded and inserted into the portion, located on one side of the turning plate, of the interior of a feeding hopper. And the mounting mechanism extends into the shell. The traditional Chinese veterinary medicine raw materials are pretreated in the shell, the medicinal materials are driven by centrifugal force to be sliced and shredded, the blades can be selected to be installed according to use, the slicing machine can be suitable for treatment and processing of different medicinal materials, the medicinal materials are discharged after being treated through the discharging hopper, and the processing efficiency is improved. By arranging the openable discharging hopper, the interior of the device can be conveniently cleaned, the blades can be assembled through the turning plate, use convenience is improved, different blades are fixed through the assembling mechanism and the mounting mechanism, follow-up replacement operation is facilitated, and use convenience is improved.

The application discloses a high-water-solubility florfenicol powder and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. The powder is prepared from florfenicol, a water-soluble polymer carrier, tetraethyl orthosilicate or a mixture of the tetraethyl orthosilicate and methyl triethoxysilane and a C2-C6 organic polyacid containing polyhydroxy and polycarboxyl groups as raw materials through in-situ sol-gel spray drying one-step method. In the preparation, the controllable hydrolysis and condensation of organosilane and the in-situ esterification cross-linking of the organic polyacid are used to synergistically assemble and build an organic-inorganic hybrid network skeleton, and the amorphous florfenicol is anchored in the network skeleton. The product has both instant and moisture-proof properties. The method is simple in process, and the raw and auxiliary materials are safe and easy to obtain, so the method is suitable for industrial production and solves the problem that traditional solid dispersions are easy to absorb moisture and form lumps.

The invention discloses a water-soluble diclazuril solution and a preparation method thereof, and belongs to the technical field of veterinary drug preparations, the water-soluble diclazuril solution comprises 10-30 g / L of diclazuril, 100-500 g / L of an organic solvent, 30-60 g / L of an amine organic base, 5-10 g / L of a surfactant, the balance of water for injection, 3-5 g / L of propyl gallate, and 10-15 g / L of a composite fermentation broth, the organic solvent comprises the following components in percentage by mass: 20-40% of N, N-dimethylformamide, 40-70% of propylene glycol and 10-20% of ethanol, and the compound fermentation liquor is a fermentation product obtained by fermenting a mixture of felwort and tamarind fruits with a compound microbial inoculant. The water-soluble diclazuril solution provided by the invention not only can effectively prevent and treat chicken coccidiosis, but also is beneficial to improving the weight gain rate of broiler chickens in the recovery process after infection, the preparation method is simple, the cost is low, the use mode is convenient and efficient, and the use value of the water-soluble diclazuril solution in the aspect of broiler chicken breeding is effectively improved.