High-throughput detection method for 99 residual veterinary drugs in animal-derived food

A technology for veterinary drug residues and detection methods, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of limited number of analytical compounds, time-consuming, low resolution, etc., to improve the efficiency of supervision work, high-sensitivity screening, and solve Wide variety of effects

Active Publication Date: 2017-04-26
INSPECTION & QUARANTINE TECH CENT OF NINGBO ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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Problems solved by technology

Traditional LC-MS/MS has certain advantages in quantitative analysis, but there are also shortcomings, such as: only the compounds covered by the mass spectrometry method can be detected, the number of analyzed compounds is limited, and parameters need to be optimized for each compound. It is time-consuming, sensitive to matrix interference, and related sample preparation methods are relatively complicated; the resolution is low, and compounds with similar molecular weights cannot be effectively

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  • High-throughput detection method for 99 residual veterinary drugs in animal-derived food
  • High-throughput detection method for 99 residual veterinary drugs in animal-derived food
  • High-throughput detection method for 99 residual veterinary drugs in animal-derived food

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Embodiment Construction

[0067] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0068] The present invention will be further described below with embodiment, but protection scope of the present invention is not limited thereto, protection scope is as the criterion with claims.

[0069] 1. Materials and equipment

[0070] 1.1 Main reagents and materials

[0071] Unless otherwise specified, the listed reagents are chromatographically pure, and the water is the first-grade water specified in GB / T 6682.

[0072] Acetonitrile; methanol; ultrapure water: 18.2 MΩ; ammonia water: analytically pure; formic acid; ammonium acetate; oxalic acid: analytically pure; oxalic acid and 3.7g disodium edetate, dissolved in 500ml of water, adjusted to pH 3.0 with ammonia water; oxalic acid buffer (100mmol / L): weigh 0.9g of oxalic acid, dissolved in 90ml of water, adjusted with ammonia water PH to 5.0, add water to 100ml; acetonitrile-water...

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Abstract

The invention discloses a high-throughput detection method for 99 residual veterinary drugs in animal-derived food. The detection method is characterized by comprising the following concrete steps: (1) carrying out extraction and purification on 99 residual veterinary drugs having substantially different physicochemical properties and belonging to eight kinds of common veterinary drugs through one-step pretreatment based on carrier-assisted liquid-liquid extraction technology; (2) preparation of a mixed standard solution and a matrix standard curve; and (3) determining the concentrations of 99 residual veterinary drugs in a to-be-detected solution by using ultrahigh performance liquid chromatography-triple quadrupole tandem mass spectrometry. According to the invention, the pretreatment and instrumental analysis process of the method is directed at compounds with different physicochemical properties, so the method has the advantages of good compatibility, high detection efficiency, good operability and low detection cost, and the detection limit of the method can meet requirements of all the test objects.

Description

technical field [0001] The invention relates to a detection method for veterinary drug residues, in particular to a high-throughput detection method for 99 kinds of veterinary drug residues in animal source food. Background technique [0002] There are many types of veterinary drugs, and veterinary drugs with greater residual toxicological significance can be classified according to their uses: antibiotics, synthetic antibiotics, antiparasitics, growth promoters, and insecticides. According to the definition of the Joint Legislative Committee on Veterinary Drug Residues of the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO), veterinary drug residues refer to the parent compound and its metabolites of veterinary drugs contained in any edible part of animal products, and Impurities related to veterinary drugs. [1] Because veterinary drug residues are extremely harmful to the human body, veterinary drug residues in animal-d...

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8813
Inventor 陈树兵陈先锋李双朱海强方科益劳华均
Owner INSPECTION & QUARANTINE TECH CENT OF NINGBO ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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