42 results about "Disodium Edetate" patented technology

The invention relates to a dexamethasone sodium phosphate injection and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: 1, sequentially adding glycerol, edetate disodium and dexamethasone sodium phosphate into water for injection according to a weight ratio of (20-25): (0.08-0.12): (4-6), mixing and dissolving, and introducing nitrogen until the dissolved oxygen content is less than or equal to 1mg / L to obtain a liquid medicine 1; step 2, adding a pH regulator into the liquid medicine 1 to regulate the pH value to 7.0-8.5 to obtain liquid medicine 2; and step 3, filtering, filling and sealing the liquid medicine 2, and controlling the residual oxygen content to be less than or equal to 5% to obtain the dexamethasone sodium phosphate injection. Wherein the whole preparation process is protected by inert gas. According to the preparation method of the dexamethasone sodium phosphate injection provided by the invention, the prescription composition of an original drug does not need to be changed, and the prepared dexamethasone sodium phosphate injection can be stably stored at room temperature by adjusting a specific pH range, keeping filling of an inactive gas until the dissolved oxygen content is less than or equal to 1mg / L in the whole preparation process and controlling the residual oxygen content to be less than or equal to 5%.

This invention discloses a carbetocin injection solution and its preparation process. The raw materials for the carbetocin injection solution include at least carbetocin, methionine, disodium edetate, an antibacterial agent, a pH adjuster, and a solvent. The pH of the carbetocin injection solution is 4.0-4.5. The concentration of carbetocin is 50 μg / ml-80 μg / ml, the concentration of methionine is 10 mg / ml-20 mg / ml, the concentration of disodium edetate is 5 mg / ml-10 mg / ml, and the concentration of the antibacterial agent is 2 mg / ml-3 mg / ml. By controlling the concentrations of carbetocin, methionine, disodium edetate, and the antibacterial agent, and simultaneously adjusting the pH of the injection solution to 4.0-4.5, this invention eliminates the need for nitrogen purging during the preparation process, thereby enabling the prepared carbetocin injection solution to exhibit high antioxidant properties and stability, allowing for long-term storage at room temperature.

The invention discloses an adapalene gel preparation method, which comprises: 1) preparing a carbomer phase: mixing a first solution and a second solution to obtain a mixed solution, and adding carbomer into the mixed solution, the first solution being obtained by mixing edetate disodium and water, the second solution being obtained by mixing edetate disodium and water, and the first solution being obtained by mixing edetate disodium and water; the second solution is obtained by mixing phenoxyethanol, methylparaben and propylene glycol; 2) preparation of adapalene phase: adding water into poloxamer to obtain a solution, and then adding adapalene into the solution; and 3) total mixing: mixing the adapalene phase and the carbomer phase while stirring to obtain a gel precursor, and then degassing, filling and sealing the gel precursor.

The invention discloses a rifapentine isoniazide tablet and a preparation method thereof, the rifapentine isoniazide tablet is a core-coated tablet, and comprises an inner-layer tablet core containing rifapentine and an outer-layer tablet layer containing isoniazide; the inner-layer tablet core comprises rifapentine, edetate disodium, sodium ascorbate and lauryl sodium sulfate, the rifapentine accounts for 53-63% of the total mass of the inner-layer tablet core, and the rifapentine tablet further comprises a filler, a stabilizer, a disintegrating agent, an adhesive, a surfactant, a lubricant and a coating layer; the coating layer coats the inner-layer tablet core; the outer sheet layer comprises isoniazide, a filling agent, a disintegrating agent, an adhesive, a lubricant and an adhesive; and the mass of the isoniazide accounts for 75-95% of the total mass of the outer sheet layer. According to the rifapentine isoniazide tablet disclosed by the invention, the compliance of a patient is enhanced. And meanwhile, the potential safety hazard problem of impurity increase caused by incompatibility of rifapentine and isoniazide is solved.

The present invention relates to a method for alleviating asthenopia and a liquid composition for ophthalmic use. Specifically, on one hand, the invention relates to a liquid composition for eyes. The invention relates to a skin-care lotion, which is prepared from the following components: glycerol, p-hydroxyacetophenone, sodium hyaluronate, propylene glycol, menthol, borneol, methyl diisopropyl propionamide, menthol, SOLUBILISANT LRI, edetate disodium, water-locking magnetite, radix gentianae extract, totarol, sodium citrate, ectodoine, ergothioneine, hydrolyzed red algae extract and water. Furthermore, the invention also relates to an application of the liquid composition in preparation of a product for relieving eye asthenopia for eye use. The liquid composition of the present invention exhibits excellent properties, for example as described in the specification.

This invention provides an birepiperazole oral solution, wherein the solution comprises birepiperazole 0.4-0.6 mg / ml, disodium edetate 0.1-0.5 mg / ml, methylparaben 1.5-2.0 mg / ml, propylparaben 0.15-0.25 mg / ml, an acidic pH adjuster 2.5-3.5 mg / ml, a flavoring agent 0.8-1.2 mg / ml, propylene glycol 40-60 mg / ml, glycerin 120-180 mg / ml, and a sodium hydroxide solution to adjust the pH to 2.9-3.3. The drug exhibits high stability during preparation, storage, and clinical formulation.

The invention discloses a medical gynecological gel dressing and a preparation method thereof, and relates to the technical field of medical dressings. The medical gel dressing is prepared from the following raw materials: a carbomer homopolymer, glycerol, edetate disodium, triethanolamine, a bacteriostatic agent and purified water, the preparation method of the medical gel dressing comprises a gel matrix preparation step, a mixing I step, a mixing II step, a mixing III step, a mixing IV step, a homogenizing step and a quality inspection step, the temperature is low in the material dissolving process, carbomer homopolymers are not prone to being decomposed and deteriorated, the stability of the gel structure is easily maintained, the preparation technology is simple, and the medical gel dressing is suitable for being used for preparing medical gel dressing materials. The probability of excessive swelling, degradation or local gel curing of the carbomer homopolymer can be reduced, and the biocompatibility of the gel dressing is improved.

The invention discloses a composition and a preparation method of an epinephrine hydrochloride injection, the formula comprises epinephrine, hydrochloric acid, sodium chloride (for injection), edetate disodium, L (+) tartaric acid, alpha-ketoglutaric acid, sodium hydroxide and water for injection, and the use amount of alpha-ketoglutaric acid is 0.35-0.75 mg / ml. The epinephrine hydrochloride injection disclosed by the invention is simple in composition and stable in quality, the preparation process is simple, convenient and efficient, special equipment and inert gas filling are not needed, and a filled sample is subjected to high-pressure steam sterilization under the condition of 121 DEG C / 12min.

The present application relates to the technical field of gynecological bacteriostatic gel, and particularly relates to a ulipristal bacteriostatic gel and a preparation method thereof; the ulipristal bacteriostatic gel comprises the following components in parts by weight: chlorhexidine acetate 1-3 parts, meihua grass extract 4-8 parts, carbomer 0.8-1.2 parts, triethanolamine 0.4-0.6 parts, penetration enhancer 0.5-1.5 parts, modified nano-silver 0.04-0.07 parts, glycerol 5-8 parts, hydrogenated polyisobutylene 0.03-0.07 parts, disodium edetate 0.1-0.3 parts and purified water in a remainder amount; the chlorhexidine acetate and the meihua grass ethanol extract are compounded at a ratio of 1:(2.5-4), the flavones and polyphenols in the meihua grass can destroy the cell membrane permeability of microorganisms, promote the chlorhexidine acetate to enter the inside of the microorganism, and significantly reduce the minimum bacteriostatic concentration.

The invention discloses a mecobalamin composition. The mecobalamin composition comprises mecobalamin, a stabilizer, a suspending aid and an adsorbent. The applicant can improve the stability of mecobalamin to a certain extent by adopting edetate disodium or citric acid as a stabilizer, and can uniformly disperse mecobalamin in the solid dispersion through spray drying to construct a physical barrier, thereby improving the light instability of mecobalamin.

A catgut implant for treating ascites and a preparation method thereof belong to the technical field of catgut preparation. Raw materials are as follows in percentage by mass: 27-31% of Gansui Banxia extract, 25-28% of humectant, 27-31% of water, 0.5-0.8% of glycyrrhizic acid, 5-9% of polyacrylic acid sodium, 1.5-4% of carboxymethyl cellulose sodium, 0.9-2.5% of polyvinylpyrrolidone, 0.03-0.06% of disodium edetate, 0.2-1.3% of organic acid, 0.5-0.9% of filling agent and 0.2-2% of transdermal penetration enhancer. The catgut implant improves the production process of catgut, reduces the production cost of catgut, has good formability and adhesion, and prepares Gansui Banxia decoction for treating ascites into catgut implant with controllable quality.

The invention relates to a revienacin inhalation solution and a preparation method thereof. The revienacin inhalation solution comprises revienacin, a stabilizing agent, a buffering agent and water for injection, wherein the stabilizer is disodium edetate and propylene glycol, and the mass volume ratio of the disodium edetate to the propylene glycol is (0.05-0.1) g: (50-300) ml. The revivin inhalation solution can effectively delay degradation of revivin under the high-temperature condition, the long-term stability of a preparation under the high-temperature condition is guaranteed, the preparation prescription and the preparation process are simple and easy to operate, and the revivin inhalation solution is suitable for large-scale industrial production.

The invention relates to a nadifloxacin emulsifiable paste and a preparation method thereof, the nadifloxacin emulsifiable paste comprises an active component nadifloxacin and pharmaceutic adjuvants, and is a water-in-oil or oil-in-water external emulsifiable paste preparation. The chemical and physical stability of the product is remarkably improved by adopting a buffer type alkaline hydrotropy system formed by sodium hydroxide and diethanol amine in a synergistic manner, an edetate disodium metal chelating agent and a specifically-formed composite oil phase matrix and combining a vacuum emulsification and double homogenization process; and the preparation process parameters are clear, the industrial amplification can be realized, and the technical problems of poor stability, large quality fluctuation, limited curative effect and the like of the existing nadifloxacin external preparation are solved.

The invention relates to sodium hyaluronate eye drops and a preparation method thereof. Every 1000 ml of the eye drops contain 1 g of sodium hyaluronate, sorbitol and nicotinamide, preferably, 2.8 g of sorbitol, 1.2 g of nicotinamide, 2 g of aminocaproic acid, 0.1 g of edetate disodium, 1.6 g of potassium chloride and 6.8 g of sodium chloride, the sodium hyaluronate eye drops prepared according to the prescription process have extremely high quality stability, the effectiveness of medication is improved, and the sodium hyaluronate eye drops are suitable for clinical application. The method is obviously superior to the prior art.

The invention belongs to the technical field of nursing products, and particularly discloses a spray for outdoor protection of infants and children and a preparation method thereof.The spray is prepared from, by mass, 1%-5% of glycerin, 0.5%-1.5% of trehalose, 0.01%-0.1% of edetate disodium, 2%-10% of a traditional Chinese medicine composition, 1%-10% of 1, 2-hexanediol, 1%-10% of 1, 2-pentanediol and the balance purified water; the preparation method of the spray comprises the following steps: S21, adding the purified water into an emulsifying pot, sequentially adding the glycerol, the trehalose, the edetate disodium and the traditional Chinese medicine composition, and then carrying out vacuum stirring and homogenizing treatment; s22, cooling, then adding 1, 2-hexanediol and 1, 2-pentanediol, and uniformly stirring; and S23, continuously cooling, keeping vacuum stirring, sieving, and discharging. According to the spray provided by the invention, the effects of preventing mosquitoes, relieving itching, repairing and relieving are provided by virtue of the traditional Chinese medicine composition, a spray type product which is easy to use is prepared by virtue of simple and common auxiliary materials, and the spray is simple in component, high in safety and good in effect.

The invention discloses pranoprofen eye drops and a production process thereof. Comprising the following raw material components in parts by weight: 0.1 to 0.5 part of pranoprofen, 1 to 5 parts of vitamin E polyethylene glycol 1000 succinate, 2 to 6 parts of soybean phospholipid, 3 to 8 parts of polyoxyethylated castor oil EL-40, 0.1 to 0.3 part of histidine, 0.2 to 0.6 part of sodium dihydrogen phosphate, 0.3 to 0.7 part of disodium hydrogen phosphate, 2 to 5 parts of glycerol, 1 to 4 parts of polyethylene glycol 400, 0.05 to 0.2 part of sodium hyaluronate, 0.1 to 0.4 part of D-panthenol and 0.01 to 0.03 part of benzalkonium chloride. The injection comprises the following components in parts by weight: 0.05-0.15 part of potassium sorbate, 0.005-0.02 part of epsilon-polylysine, 0.01-0.05 part of edetate disodium, 0.02-0.08 part of vitamin E acetate, 0.005-0.015 part of L-cysteine and the balance of water for injection, and the total weight part of the water for injection is 100 parts. According to the invention, pranoprofen is taken as a core, and vitamin E polyethylene glycol 1000 succinate, soybean phospholipid and polyoxyethylated castor oil EL-40 are adopted for synergistic solubilization, so that the problem of poor water solubility of the medicine is solved; histidine and phosphate are compounded for buffering and are matched with multiple stabilizers, so that the stability of the preparation is improved.

The invention discloses a preparation method of clindamycin phosphate injection, and belongs to the field of pharmacy. The preparation method of the clindamycin phosphate injection comprises the following steps: sequentially and respectively dissolving the auxiliary materials edetate disodium and sodium hydroxide, then dissolving the raw material clindamycin phosphate to completely dissolve the raw material in a stable solution state, then complementing the water for injection, and carrying out multiple filter element filtration, filling, full plug pressing and capping to obtain the clindamycin phosphate injection. The clindamycin phosphate injection is obtained. The clindamycin phosphate injection obtained by the preparation method disclosed by the invention is good in quality.

The invention discloses a method for analyzing edetate disodium in heparin sodium, and belongs to the technical field of medicine analys.The method comprises the steps that a 0.3% tetrabutylammonium hydroxide buffer solution (the pH value is adjusted to 4.0 through phosphoric acid)-water-acetonitrile (20: 45: 35) is used as a mobile phase; the flow rate is 1.0 ml per minute; the detection wavelength is 254 nm; the column temperature is 40 DEG C; the sample injection volume is 20 microliters. According to the method disclosed by the invention, the edetate disodium in the heparin sodium can be effectively separated, so that separation and determination of the heparin sodium and the edetate disodium are realized, and quality control of raw materials and preparations of the heparin sodium and the edetate disodium is realized.

The invention discloses a carbetocin injection and a preparation process thereof, the carbetocin injection at least comprises the following raw materials: carbetocin, methionine, edetate disodium, a bacteriostatic agent, a pH regulator and a solvent, and the pH of the carbetocin injection is 4.0-4.5; wherein the concentration of the carbetocin is 50 [mu] g / ml to 80 [mu] g / ml, the concentration of the methionine is 10 mg / ml to 20 mg / ml, the concentration of the edetate disodium is 5 mg / ml to 10 mg / ml, and the concentration of the bacteriostatic agent is 2 mg / ml to 3 mg / ml. By controlling the concentrations of carbetocin, methionine, edetate disodium and the bacteriostatic agent and adjusting the pH value of the injection to 4.0-4.5, the prepared carbetocin injection can have higher oxidation resistance and stability without introducing nitrogen in the preparation process, and can be stored for a long time at room temperature.

The invention belongs to the technical field of dressings, and particularly relates to a gel dressing containing recombinant collagen as well as a preparation method and application of the gel dressing. The gel dressing containing the recombinant collagen is prepared from the following raw materials in percentage by weight: 0.1 to 1 percent of the recombinant collagen, 0.5 to 1 percent of sodium hyaluronate, 0.08 to 0.15 percent of radices stellariae dichotomae cyclopeptide, 0.5 to 1 percent of carbomer, 0.03 to 0.06 percent of cryptomeria fortunei bud extract, 15 to 20 percent of poloxamer, 0.1 to 0.5 percent of xanthan gum, 3 to 8 percent of glycerol, 0.04 to 0.08 percent of edetate disodium, 0.1 to 0.3 percent of triethanolamine, 0.08 to 0.12 percent of preservative and the balance of deionized water. The gel dressing has excellent biocompatibility, good hemostasis, cell growth promotion and tissue repair performance, and can be used for repairing vaginal mucous membrane chap and hemostasis of diffuse superficial bleeding, and improving the symptoms of elasticity reduction and the like caused by vaginal atrophy.

The invention provides a lactulose oral solution and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the oral solution comprises an active component lactulose, a solvent, a humectant, a stabilizer, a bacteriostatic agent and purified water; the stabilizing agent is prepared from hydroxypropyl chitosan and edetate disodium. The lactulose oral solution can overcome the defect of instability of lactulose through the cooperation of the stabilizer hydroxypropyl chitosan and edetate disodium, so that the lactulose oral solution has good stability.

The invention relates to an eye care solution capable of relieving eyeball aging, and belongs to the technical field of care solutions. The eye care solution capable of relieving eyeball aging is prepared from the following raw materials in percentage by mass: 1.5 to 2.5 percent of glycerol, 0.78 to 0.82 percent of sodium chloride, 0.01 to 0.02 percent of water-soluble lutein, 0.1 to 0.15 percent of taurine, 0.03 to 0.05 percent of hydrolyzed pearl, 0.2 to 0.28 percent of boric acid, 0.05 to 0.07 percent of borax, 0.02 to 0.04 percent of edetate disodium, 0.0035 to 0.0045 percent of benzalkonium chloride, 0.002 to 0.005 percent of borneol, 0.005 to 0.01 percent of menthol and the balance of purified water. The eye care solution disclosed by the invention aims at office workers who use eyes for a long time, middle-aged and elderly people who are susceptible to eyeball aging, asthenopia and dry eye surfaces, realizes mild moisturizing and relieving of the eye surfaces, supplements nutrients required by eye tissue metabolism, resists eyeball aging caused by light damage, and has the effects of relieving eye fatigue and relieving eye fatigue. Meanwhile, eyeball senescence related eye discomfort such as eye dryness, eye acerbity and blurred vision is relieved, bacteriostatic protection of the ocular surface microenvironment is considered, the physiological state of eye tissue can be improved after long-term use, and the eyeball senescence process is delayed.

The invention relates to the technical field of medicine, in particular to a metal ion complexing agent, a metronidazole gel preparation thereof and a preparation method of the metronidazole gel preparation. The first component is selected from at least one of disodium edetate, sodium calcium edetate and tetrasodium edetate; the second component is selected from at least one of sodium tartrate and sodium citrate; wherein the mass ratio of the first component to the second component is (8: 1)-(1: 6). The metronidazole gel preparation has the advantages that the preparation process is simple, the stability is better, and the safety and the effectiveness can be guaranteed.

The invention discloses an optimized adapalene gel preparation method, which comprises: 1) preparing an edetate disodium solution: adding edetate disodium powder into purified water, and stirring to form a uniform edetate disodium solution; the method comprises the following steps: 1) preparing an edetate disodium solution, 2) preparing a carbomer phase: scattering carbomer into the edetate disodium solution in a small amount and multiple times under a stirring condition, 3) preparing an adapalene solution: mixing adapalene, propylene glycol and glycerol, and stirring until adapalene is completely dissolved in propylene glycol and glycerol to form a uniform adapalene solution; and 4) preparation of adapalene gel: under a stirring condition, fully mixing the adapalene solution with a carbomer phase, and adjusting the pH value of the gel with sodium hydroxide to obtain the adapalene gel.

The application relates to a shrinking and lubricating gel, which comprises the following raw materials in percentage by weight: xanthan gum 0.1-2%, trehalose 0.1-2%, carbomer 0.1-3%, glycerol 1-20%, gelatin alginate complex 1-10%, humectant 0.2-4%, disodium edetate 0.01-0.1%, polyethylene glycol 0.1-2%, pH regulator 0.1-3%, royal jelly extract 0-2%, schisandra extract 0-2%, and the balance is water. The application forms a protective biological gel layer on the vaginal wall through the lubricating gel, so as to prevent pathogenic microorganisms from planting, and is suitable for improving itching, erosion, burning, vaginal atrophy, sexual intercourse pain, senile vaginitis, abnormal leucorrhea, urinary urgency, dysuria and other menopausal reproductive urological syndromes.

The application discloses a benzalkonium chloride contraceptive gel for killing AIDS pathogens and a preparation method thereof, and belongs to the technical field of biological medicine manufacturing. The benzalkonium chloride contraceptive gel is prepared from water, hydroxypropyl methyl cellulose, polyquaternium-10, modified cyclodextrin, disodium edetate, benzalkonium chloride and glycerol in a specific proportion. In the preparation, the hydroxypropyl methyl cellulose and the polyquaternium-10 are first dispersed by heating, and then the water solution of the modified cyclodextrin, the disodium edetate and the benzalkonium chloride is sucked into the mixture after cooling, and the glycerol is added, and the finished product is obtained through cooling homogenization and vacuum degassing. Compared with the prior art, the amino acid grafted modified cyclodextrin enhances the inclusion and mucosal adhesion performance, the obtained gel has a fast inactivation rate for the AIDS pathogens, a long vaginal retention time, and has the high-efficiency antiviral and long-acting barrier effects, and has low irritation and is safe and reliable.

The invention discloses ketoconazole emulsifiable paste and a preparation method thereof, and the ketoconazole emulsifiable paste is prepared from the following components in parts by weight: 1 to 25 parts of ketoconazole, 1 to 80 parts of stearic acid, 1 to 55 parts of glyceryl monostearate and glyceryl distearate, 1 to 130 parts of light liquid paraffin, 0.1 to 1 part of ethylparaben, 100 to 350 parts of glycerol, 0.1 to 2 parts of edetate disodium, 1 to 6 parts of triethanolamine and 1 to 5 parts of anhydrous sodium sulfite. 0.1 to 2 parts of butylated hydroxytoluene, and 100 to 450 parts of purified water. The stability, the drug effect and the safety are comprehensively improved, the bacteriostasis effect on candida albicans is obvious, the treatment efficiency is improved, and the better fungal infection resisting effect is achieved.

The preparation method specifically comprises the following steps: 1) preparing a solution A: dissolving 4-6 parts by weight of edetate disodium in water, adding 50-70 parts by weight of pectin, and stirring; 2) preparation of a solution B: stirring 70-90 parts by weight of methylparaben and 15-25 parts by weight of propyl hydroxybenzoate in 280-320 parts by weight of propylene glycol, adding water, and adding 70-80 parts by weight of nitrohydroxyethyl into the solution; 3) mixing: mixing the solution A and the solution B to obtain a mixed solution C; and 4) adding a sodium hydroxide solution into the mixed solution C, and adjusting the pH value to 4.0-6.5. The freeze-thaw resistance and light stability of the prepared nitro-hydroxyethyl gel are remarkably improved, and the stability of medicine components is favorably improved.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a non-final sterilization production process for improving the stability of calcium folinate injection and application. The non-final sterilization production process for improving the stability of calcium folinate injection comprises the following steps: (1) dissolving calcium folinate in water for injection, adding sodium dihydrogen phosphate and disodium edetate, and adjusting the pH of the drug solution by using hydrochloric acid or sodium hydroxide solution; (2) filtering the drug solution through a 0.45-micron pre-filter filter core and a 0.22-micron terminal sterilization filter core in sequence; and (3) filling the drug solution into a container and sealing the container in an environment with a cleanliness of grade A. The process does not comprise a final sterilization step. The application reduces the risk of drug efficacy reduction and safety caused by drug degradation. Although the whole process does not comprise a final sterilization step, the sterility of the injection can be effectively guaranteed, and the risk of microbial contamination can be reduced. The production process is optimized, the production cost is reduced, and the application scenarios of the injection in clinical treatment are widened.

The invention relates to an HCT detection kit, an HCT detection method and application, and belongs to the technical field of biological detection. The kit comprises anti-mouse IgG (immunoglobulin G), bovine serum albumin, polyethylene glycol 8000, ethylenediamine tetraacetic acid disodium salt, lauryl sodium sulfate and polyethylene glycol octyl phenyl ether. The light transmission effect of the to-be-detected sample is remarkably improved through multiple reagent anti-interference measures, and the detection accuracy and stability are improved. In the detection method, 540nm is selected as a detection wavelength, and an optimized light source, a sensor and a dynamic feedback calibration mechanism are combined, so that high precision of a detection result is ensured, a modified layer on the surface of a reaction vessel has a low adsorption effect, sample residues can be reduced, and the repeatability and accuracy of detection are further improved.