92 results about "Disodium Edetate" patented technology

The invention belongs to the field of pharmaceutical preparations, and particularly relates to nitrogen hydrochloride # imgabs0 # stine eye drops and a preparation process thereof, the nitrogen hydrochloride # imgabs0 # stine eye drops comprise 0.05% of nitrogen hydrochloride # imgabs1 # stine, 0.2-0.3% of hydroxypropyl methylcellulose, 0.1-0.2% of edetate disodium, 0.12-0.15% of an isoosmotic adjusting agent, 0.04-0.07% of a preservative and 0.005-0.0075% of choline aromatic folic acid; the nitrogen hydrochloride # imgabs2 # stine eye drops prepared by the preparation method disclosed by the invention have the advantages that the adsorption of nitrogen hydrochloride # imgabs3 # stine on a low-density polyethylene bottle is well inhibited under the condition of visible light, and the reduction of the concentration of nitrogen hydrochloride # imgabs4 # stine in the eye drops is remarkably prevented, so that the medication safety is improved. Besides, the added cholinofolic acid and hydroxypropyl methylcellulose have small irritation to eyes under a specific ratio, and can also have a large enough contact angle with the eyes of rabbits at high temperature, so that the retention property of the eye drops on the eyes can be improved, and the drug effect can be favorably exerted.

The invention discloses external emulsifiable paste for directionally delivering tranexamic acid to an epidermal layer, which is prepared from the following raw materials in percentage by weight: 1-15% of tranexamic acid, 0.5-7% of alpha-arbutin, 0.3-4% of edetate disodium, 1-5% of azone, 1-5% of sodium dodecyl benzene sulfonate and the balance of water. The skin care product is prepared from, by weight, 0.1%-2% of salicylic acid, 1%-10% of glycerin, 2%-15% of propylene glycol, 0.1%-4% of tween-80 or 0.4%-2% of sorbitan oleate, 0.5%-5% of alpha-tocopherol, 0.5%-5% of diisostearyl alcohol malate, 0.5%-6% of soybean phospholipid, 1%-10% of glycerin monostearate, 0.5%-10% of tetradecanol, 0.02%-0.1% of propyl hydroxybenzoate, 1%-10% of stearic acid, 0.5%-6% of stearyl alcohol and the balance water. Meanwhile, the invention also discloses a preparation method, experiments show that the external cream prepared by the invention has strong capacity of delivering tranexamic acid to the epidermal layer and can ensure that the tranexamic acid can be quickly absorbed by cells to take effect, and the defect that tranexamic acid is difficult to pass through skin cuticle obstacles due to strong hydrophilicity is overcome.

The invention discloses a composition and a preparation method of a single-dose vitamin B12 eye drop without a bacteriostatic agent, and the single-dose vitamin B12 eye drop without the bacteriostatic agent is prepared from vitamin B12, a buffering agent, sodium hyaluronate, edetate disodium and water for injection. According to the vitamin B12 eye drops and the preparation method thereof disclosed by the invention, the vitamin B12 eye drops are produced by adopting a totally-closed sterile filling process, and a disposable single-dose packaging container is arranged, so that the sterility of medicines is ensured, and meanwhile, the use safety, the operation convenience index and the safety performance are improved.

The invention relates to a dexamethasone sodium phosphate injection and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: 1, sequentially adding glycerol, edetate disodium and dexamethasone sodium phosphate into water for injection according to a weight ratio of (20-25): (0.08-0.12): (4-6), mixing and dissolving, and introducing nitrogen until the dissolved oxygen content is less than or equal to 1mg / L to obtain a liquid medicine 1; step 2, adding a pH regulator into the liquid medicine 1 to regulate the pH value to 7.0-8.5 to obtain liquid medicine 2; and step 3, filtering, filling and sealing the liquid medicine 2, and controlling the residual oxygen content to be less than or equal to 5% to obtain the dexamethasone sodium phosphate injection. Wherein the whole preparation process is protected by inert gas. According to the preparation method of the dexamethasone sodium phosphate injection provided by the invention, the prescription composition of an original drug does not need to be changed, and the prepared dexamethasone sodium phosphate injection can be stably stored at room temperature by adjusting a specific pH range, keeping filling of an inactive gas until the dissolved oxygen content is less than or equal to 1mg / L in the whole preparation process and controlling the residual oxygen content to be less than or equal to 5%.

The invention discloses a preparation for treating psoriasis and application. The preparation is prepared from the following raw materials: propylene glycol, halcinonide, fluocinonide acetate, salicylic acid, dimethyl sulfoxide, polyethylene glycol 400, glycerol, borneol, edetate disodium, ethylparaben and ethylparaben. The traditional Chinese medicine composition is reasonable in composition, the treatment effect on psoriasis can be remarkably improved, the problem of pigmentation after treatment can be effectively improved or avoided, and particularly, due to the use of salicylic acid and edetate disodium, it is verified that the traditional Chinese medicine composition has a remarkable curative effect on psoriasis. Salicylic acid and edetate disodium have a synergistic effect on psoriasis treatment effect and pigmentation improvement of the whole medicine system.

This invention discloses a carbetocin injection solution and its preparation process. The raw materials for the carbetocin injection solution include at least carbetocin, methionine, disodium edetate, an antibacterial agent, a pH adjuster, and a solvent. The pH of the carbetocin injection solution is 4.0-4.5. The concentration of carbetocin is 50 μg / ml-80 μg / ml, the concentration of methionine is 10 mg / ml-20 mg / ml, the concentration of disodium edetate is 5 mg / ml-10 mg / ml, and the concentration of the antibacterial agent is 2 mg / ml-3 mg / ml. By controlling the concentrations of carbetocin, methionine, disodium edetate, and the antibacterial agent, and simultaneously adjusting the pH of the injection solution to 4.0-4.5, this invention eliminates the need for nitrogen purging during the preparation process, thereby enabling the prepared carbetocin injection solution to exhibit high antioxidant properties and stability, allowing for long-term storage at room temperature.

The invention relates to the technical field of medical supplies, and particularly provides an NMN-containing circulation promoting and skin aging resisting repair patch which comprises a repair liquid and a non-woven fabric, the repairing liquid is prepared from the following raw materials in percentage by weight: 0.2 to 0.5 percent of sodium hyaluronate, 0.01 to 0.2 percent of beta-nicotinamide mononucleotide (NMN), 2 to 4 percent of glycerol, 0.5 to 1.5 percent of propylene glycol, 0.005 to 0.015 percent of ethylene diamine tetraacetic acid disodium salt, 0.015 to 0.03 percent of ethylparaben, 1 to 2 percent of sodium carboxymethyl cellulose, 0.05 to 2.0 percent of triethanolamine and the balance of purified water. The repair patch has good moisture retention, stability and oxygen permeability, and is small in irritation.

The invention belongs to the technical field of pharmacy, and particularly relates to amorolfine hydrochloride cream and a preparation method thereof. The amorolfine hydrochloride emulsifiable paste is prepared from the following raw materials: amorolfine hydrochloride, octadecanol, white vaseline, modified liquid paraffin, polyoxyl (40) stearate, phenoxyethanol, edetate disodium, carbomer homopolymer type B, sodium hydroxide and water. The modified liquid paraffin is added into the amorolfine hydrochloride emulsifiable paste, so that on one hand, the modified liquid paraffin and the active ingredients of the amorolfine hydrochloride emulsifiable paste have a synergistic effect, the structure and the function of fungi are destroyed, and the death of fungal cells is accelerated; on the other hand, the amorolfine hydrochloride emulsifiable paste can inhibit respiration of corresponding enzymes through water locking, energy synthesis is blocked, and fungus growth is inhibited. After the amorolfine hydrochloride emulsifiable paste is prepared by combining the preparation method provided by the invention, the stability of the amorolfine hydrochloride is good, the uniform release of effective components of the amorolfine hydrochloride is promoted, and a scientific basis is provided for preventing and treating fungi.

The invention relates to a lornoxicam freeze-dried preparation for injection and a preparation method of the lornoxicam freeze-dried preparation, and belongs to the technical field of pharmaceutical preparations. The preparation method of the freeze-dried preparation comprises the following steps: step 1, sequentially adding edetate disodium, mannitol and tromethamine into water at 53-65 DEG C, and mixing and dissolving to obtain a mixed solution A; 2, adding lornoxicam into the mixed solution A at 53-65 DEG C, and dissolving to obtain a mixed solution B; and step 3, filtering the mixed solution B to obtain the lornoxicam freeze-dried preparation. According to the preparation method of the lornoxicam freeze-dried preparation for injection, auxiliary materials do not need to be changed, and the lornoxicam freeze-dried preparation which is good in solubility, low in impurity content, good in redissolution clarity and stable can be obtained only through the specific liquid preparation temperature.

The invention belongs to the technical field of drug detection, and discloses a method for detecting edetate disodium in a levosalbutamol hydrochloride aerosol inhalation solution, which comprises the following steps: detecting a test solution of a to-be-detected sample by high performance liquid chromatography, with a mobile phase being a mixed solution of a borax solution and acetonitrile, the mass ratio of sodium tetraborate to water to acetonitrile in the mobile phase is (6-9): 100: (100-120). The content of edetate disodium in each batch of samples is detected, so that the safety and effectiveness of the levosalbutamol hydrochloride aerosol inhalation solution are guaranteed.

The invention discloses an adapalene gel preparation method, which comprises: 1) preparing a carbomer phase: mixing a first solution and a second solution to obtain a mixed solution, and adding carbomer into the mixed solution, the first solution being obtained by mixing edetate disodium and water, the second solution being obtained by mixing edetate disodium and water, and the first solution being obtained by mixing edetate disodium and water; the second solution is obtained by mixing phenoxyethanol, methylparaben and propylene glycol; 2) preparation of adapalene phase: adding water into poloxamer to obtain a solution, and then adding adapalene into the solution; and 3) total mixing: mixing the adapalene phase and the carbomer phase while stirring to obtain a gel precursor, and then degassing, filling and sealing the gel precursor.

The invention discloses a rifapentine isoniazide tablet and a preparation method thereof, the rifapentine isoniazide tablet is a core-coated tablet, and comprises an inner-layer tablet core containing rifapentine and an outer-layer tablet layer containing isoniazide; the inner-layer tablet core comprises rifapentine, edetate disodium, sodium ascorbate and lauryl sodium sulfate, the rifapentine accounts for 53-63% of the total mass of the inner-layer tablet core, and the rifapentine tablet further comprises a filler, a stabilizer, a disintegrating agent, an adhesive, a surfactant, a lubricant and a coating layer; the coating layer coats the inner-layer tablet core; the outer sheet layer comprises isoniazide, a filling agent, a disintegrating agent, an adhesive, a lubricant and an adhesive; and the mass of the isoniazide accounts for 75-95% of the total mass of the outer sheet layer. According to the rifapentine isoniazide tablet disclosed by the invention, the compliance of a patient is enhanced. And meanwhile, the potential safety hazard problem of impurity increase caused by incompatibility of rifapentine and isoniazide is solved.

The invention relates to the field of pharmaceutical analysis technology, and provides a method for determining disodium edetate in betamethasone sodium phosphate injection by liquid chromatography, wherein octadecylsilane bonded silica gel is used as a filler, the detection wavelength is 254nm, the flow rate is 0.8-1.2ml / min, the column temperature is 30-50℃, and the injection volume is 5-50µl. The method for detecting the content of disodium edetate by liquid chromatography of the invention makes up for the problem of inaccurate detection in the prior art, has strong specificity, good method precision, high accuracy, and the solution is stable within 48 hours, and can effectively control the content of disodium edetate in the injection.

The present invention relates to a method for alleviating asthenopia and a liquid composition for ophthalmic use. Specifically, on one hand, the invention relates to a liquid composition for eyes. The invention relates to a skin-care lotion, which is prepared from the following components: glycerol, p-hydroxyacetophenone, sodium hyaluronate, propylene glycol, menthol, borneol, methyl diisopropyl propionamide, menthol, SOLUBILISANT LRI, edetate disodium, water-locking magnetite, radix gentianae extract, totarol, sodium citrate, ectodoine, ergothioneine, hydrolyzed red algae extract and water. Furthermore, the invention also relates to an application of the liquid composition in preparation of a product for relieving eye asthenopia for eye use. The liquid composition of the present invention exhibits excellent properties, for example as described in the specification.

The present invention provides a lomefloxacin hydrochloride ear drop composition, its product, preparation method and application, relating to the technical field of pharmaceutical preparations. The lomefloxacin hydrochloride ear drop composition of the present invention is prepared from the following raw materials in parts by weight: 3.0 - 6.7 parts of lomefloxacin hydrochloride, 30 - 50 parts of polyethylene glycol 200 - 300, 20 - 40 parts of propylene glycol, 3 - 6 parts of hydroxypropyl cellulose, 1 - 3 parts of polyvinylpyrrolidone, 0.5 - 2 parts of sodium acetate and 0.5 - 2 parts of disodium edetate; the lomefloxacin hydrochloride ear drop composition is prepared into lomefloxacin hydrochloride ear drops by a method of stepwise heating and ultrasonic mixing. The lomefloxacin hydrochloride ear drop composition of the present invention has a fast transdermal absorption rate and can quickly exert the drug effect of lomefloxacin hydrochloride in a short time; it still has high stability under strong light conditions and has high drug safety.

The invention discloses a stable levocetirizine hydrochloride eye drop composition and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The composition is prepared from levocetirizine hydrochloride, glycerol, polyethylene glycol 400, polysorbate 80, edetate disodium, benzalkonium chloride, hydroxypropyl methylcellulose, sodium dihydrogen phosphate, sodium hydroxide, hydrochloric acid and water. The composition is simple in preparation method, the pH value and osmotic pressure molar concentration of the composition are similar to those of tears, and the composition is free of irritation, good in medication comfort and good in stability during storage.

The invention discloses an injection analgesic composition and a preparation method thereof, and belongs to the technical field of medicines. The pain relieving composition for injection is prepared from lornoxicam, tromethamine, edetate disodium, an alcohol excipient and amino acid. In the preparation process of the composition, the tert-butyl alcohol is added, so that the problem of long dissolving time of the lornoxicam is solved, after the tert-butyl alcohol is added, the dissolving time of the lornoxicam is shortened from about 100 minutes to 45 minutes or below, and the problem of solution turbidity does not occur after the lornoxicam is placed for 2 hours. In addition, the glycine is added, so that the problem of poor clarity of a solution after the composition is redissolved is solved, and the clarity of the solution after the composition is redissolved is equivalent to that of water.

This invention provides an birepiperazole oral solution, wherein the solution comprises birepiperazole 0.4-0.6 mg / ml, disodium edetate 0.1-0.5 mg / ml, methylparaben 1.5-2.0 mg / ml, propylparaben 0.15-0.25 mg / ml, an acidic pH adjuster 2.5-3.5 mg / ml, a flavoring agent 0.8-1.2 mg / ml, propylene glycol 40-60 mg / ml, glycerin 120-180 mg / ml, and a sodium hydroxide solution to adjust the pH to 2.9-3.3. The drug exhibits high stability during preparation, storage, and clinical formulation.

The invention discloses a medical gynecological gel dressing and a preparation method thereof, and relates to the technical field of medical dressings. The medical gel dressing is prepared from the following raw materials: a carbomer homopolymer, glycerol, edetate disodium, triethanolamine, a bacteriostatic agent and purified water, the preparation method of the medical gel dressing comprises a gel matrix preparation step, a mixing I step, a mixing II step, a mixing III step, a mixing IV step, a homogenizing step and a quality inspection step, the temperature is low in the material dissolving process, carbomer homopolymers are not prone to being decomposed and deteriorated, the stability of the gel structure is easily maintained, the preparation technology is simple, and the medical gel dressing is suitable for being used for preparing medical gel dressing materials. The probability of excessive swelling, degradation or local gel curing of the carbomer homopolymer can be reduced, and the biocompatibility of the gel dressing is improved.

The invention relates to a lornoxicam injection preparation and a preparation method thereof, comprising the following steps: adding edetate disodium and tromethamine to water for injection, adding lornoxicam raw material medicine after dissolving, adding mannitol after dissolving, cooling while dissolving, and adding water for injection to the prescribed amount; wherein, before cooling, the temperature of the water for injection is maintained at 45-70° C. The lornoxicam injection preparation prepared by the invention has a fast dissolution speed, reduces the generation of by-products, ensures the stability and solubility of the finished product, and the sample preparation process is simple and convenient, and is suitable for large-scale production.

The invention discloses a composition and a preparation method of an epinephrine hydrochloride injection, the formula comprises epinephrine, hydrochloric acid, sodium chloride (for injection), edetate disodium, L (+) tartaric acid, alpha-ketoglutaric acid, sodium hydroxide and water for injection, and the use amount of alpha-ketoglutaric acid is 0.35-0.75 mg / ml. The epinephrine hydrochloride injection disclosed by the invention is simple in composition and stable in quality, the preparation process is simple, convenient and efficient, special equipment and inert gas filling are not needed, and a filled sample is subjected to high-pressure steam sterilization under the condition of 121 DEG C / 12min.

The invention belongs to the technical field of medicine, and particularly relates to poloxamer hydrogel for treating haemorrhoids, the main component of the hydrogel is poloxamer, the content of the poloxamer is 2.5-3.5%, and the hydrogel can further contain carbomer, edetate disodium, glycerol, triethanolamine and methylparaben, and the haemorrhoids hydrogel is remarkable in curative effect, small in irritation and free of toxic and side effects. The traditional Chinese medicine composition can be used for treating symptoms such as anal falling swelling pain, mucosa hyperemia and hematochezia caused by internal hemorrhoids, external hemorrhoids and mixed hemorrhoids.

The present invention relates to the field of pharmaceutical chemicals, in particular to the synthetic method of acetylcysteine injection, comprising the steps of: 1) adding water for injection into a stainless steel preparation tank, continuing to pass through nitrogen to displace the air in the preparation tank, then adding disodium edetate at 50 55 DEG C, stirring, and obtaining a disodium edetate aqueous solution; 2) adding water for injection into another stainless steel preparation tank, continuing to pass through nitrogen to displace the air in the preparation tank, adding acetylcysteine, stirring and dissolving, using basic amino acid to adjust pH to 7.0 7.3, obtaining the acetylcysteine aqueous solution; 3) continuing to pass through nitrogen into the stainless steel preparation tank equipped with disodium edetate, the acetylcysteine aqueous solution obtained is added into the disodium edetate aqueous solution, stirring and dissolving, using basic amino acid to adjust pH to 7.0 7.3, filtering, sterilizing after canning, obtaining acetylcysteine injection. The present invention uses basic amino acid to adjust pH so that the impurities such as hydrogen sulfide in the system are significantly reduced.

The present application relates to the technical field of gynecological bacteriostatic gel, and particularly relates to a ulipristal bacteriostatic gel and a preparation method thereof; the ulipristal bacteriostatic gel comprises the following components in parts by weight: chlorhexidine acetate 1-3 parts, meihua grass extract 4-8 parts, carbomer 0.8-1.2 parts, triethanolamine 0.4-0.6 parts, penetration enhancer 0.5-1.5 parts, modified nano-silver 0.04-0.07 parts, glycerol 5-8 parts, hydrogenated polyisobutylene 0.03-0.07 parts, disodium edetate 0.1-0.3 parts and purified water in a remainder amount; the chlorhexidine acetate and the meihua grass ethanol extract are compounded at a ratio of 1:(2.5-4), the flavones and polyphenols in the meihua grass can destroy the cell membrane permeability of microorganisms, promote the chlorhexidine acetate to enter the inside of the microorganism, and significantly reduce the minimum bacteriostatic concentration.

The invention discloses a mecobalamin composition. The mecobalamin composition comprises mecobalamin, a stabilizer, a suspending aid and an adsorbent. The applicant can improve the stability of mecobalamin to a certain extent by adopting edetate disodium or citric acid as a stabilizer, and can uniformly disperse mecobalamin in the solid dispersion through spray drying to construct a physical barrier, thereby improving the light instability of mecobalamin.

A catgut implant for treating ascites and a preparation method thereof belong to the technical field of catgut preparation. Raw materials are as follows in percentage by mass: 27-31% of Gansui Banxia extract, 25-28% of humectant, 27-31% of water, 0.5-0.8% of glycyrrhizic acid, 5-9% of polyacrylic acid sodium, 1.5-4% of carboxymethyl cellulose sodium, 0.9-2.5% of polyvinylpyrrolidone, 0.03-0.06% of disodium edetate, 0.2-1.3% of organic acid, 0.5-0.9% of filling agent and 0.2-2% of transdermal penetration enhancer. The catgut implant improves the production process of catgut, reduces the production cost of catgut, has good formability and adhesion, and prepares Gansui Banxia decoction for treating ascites into catgut implant with controllable quality.

The invention relates to a revienacin inhalation solution and a preparation method thereof. The revienacin inhalation solution comprises revienacin, a stabilizing agent, a buffering agent and water for injection, wherein the stabilizer is disodium edetate and propylene glycol, and the mass volume ratio of the disodium edetate to the propylene glycol is (0.05-0.1) g: (50-300) ml. The revivin inhalation solution can effectively delay degradation of revivin under the high-temperature condition, the long-term stability of a preparation under the high-temperature condition is guaranteed, the preparation prescription and the preparation process are simple and easy to operate, and the revivin inhalation solution is suitable for large-scale industrial production.

The invention relates to a nadifloxacin emulsifiable paste and a preparation method thereof, the nadifloxacin emulsifiable paste comprises an active component nadifloxacin and pharmaceutic adjuvants, and is a water-in-oil or oil-in-water external emulsifiable paste preparation. The chemical and physical stability of the product is remarkably improved by adopting a buffer type alkaline hydrotropy system formed by sodium hydroxide and diethanol amine in a synergistic manner, an edetate disodium metal chelating agent and a specifically-formed composite oil phase matrix and combining a vacuum emulsification and double homogenization process; and the preparation process parameters are clear, the industrial amplification can be realized, and the technical problems of poor stability, large quality fluctuation, limited curative effect and the like of the existing nadifloxacin external preparation are solved.

The invention provides oral cavity debridement gel as well as a preparation method and application thereof. The preparation method of the oral cavity debridement gel comprises the following steps: (1) mixing edetate disodium, a pH regulator and water to prepare an edetate disodium solution; (2) mixing the edetate disodium solution with a dispersing agent to prepare a mixed solution; (3) mixing the mixed solution with a gel excipient to prepare a gel material; and (4) swelling the gel material to prepare the oral cavity debridement gel. According to the oral cavity debridement gel and the preparation method thereof, the preparation process is improved, and the gel excipient is added into the mixed solution containing edetate disodium, so that edetate disodium is relatively uniformly distributed in the process that the gel excipient forms a gel matrix, the distribution uniformity of edetate disodium in the prepared oral cavity debridement gel is improved, and the oral cavity debridement gel can be used for preparing oral cavity debridement gel. Furthermore, the removal effect of the oral cavity debridement gel on a contamination layer is improved, and the risk of damaging dentin is reduced.

The invention discloses a vitamin C injection and a preparation method thereof. The preparation method of the vitamin C injection comprises the following steps: taking water for injection, which accounts for 65-80% of the total volume of the prepared solution, and introducing carbon dioxide until the water is saturated, so as to obtain a saturated solution of carbon dioxide; the preparation method comprises the following steps: adding sodium pyrosulfite, edetate disodium and cysteine hydrochloride into a saturated solution of carbon dioxide, and stirring to fully dissolve the sodium pyrosulfite, the edetate disodium and the cysteine hydrochloride to obtain a first liquid medicine; uniformly mixing vitamin C and sodium bicarbonate to obtain mixed powder, and adding the mixed powder into the first liquid medicine in batches to obtain second liquid medicine; adding activated carbon into the second liquid medicine, stirring and then filtering, replenishing the residual 20-35% of water for injection, and then finely filtering; and packaging and warehousing the finely filtered liquid medicine after encapsulation, sterilization, leak detection and light inspection. The vitamin C injection prepared by the invention is colorless and clear, the content of effective components is as high as 99.6%, and the impurity content is extremely low.