Gel preparation of Ciclopirox Olamine

The technology of ciclopirox olamine gel and ciclopirox olamine is applied in the direction of non-active ingredient medical preparations, antifungal agents, active ingredients of heterocyclic compounds, etc., and can solve the problems of less retention time, poor vaginal retention, Easy to layer and other problems, to achieve the effect of feeling comfortable and smooth, improving bioabsorption, and broad application prospects

Inactive Publication Date: 2007-10-10
山东省医疗器械研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Yet solution is because its residence time in affected part is few, and drug action time is short, and curative effect is poor; Milk/ointment adopts oily base, has greasy feeling, is difficult to clean, and patient is inconvenient to use, and milk/ointment adopts more generally. Dispersed system, easy to stratify during storage, which affects the use and efficacy; and suppositories are easy to deteriorate due to

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1. Prescription 1

[0037] Ciclopirox amine 10g, carbomer 940 10g, ethanol 100g, propylene glycol 300g, triethanolamine 28g, edetate 0.5g, polysorbate 80 to 20g, water to 1000g.

[0038] The preparation method is:

[0039] (1) Preparation of gel matrix

[0040]Weigh the disodium edetate and add it to an appropriate amount of water, heat it in a water bath and stir to dissolve it. Add the prescription amount of propylene glycol and the remaining part of the water, then add the prescription amount of Carbomer 940, and slowly add the above solution under stirring, fully stir to make the swelling and dispersion uniform; drop in the triethanolamine and stir evenly to form a gel matrix ;

[0041] (2) Preparation of liquid medicine

[0042] Take the prescription amount of the API, add the prescription amount of ethanol and polysorbate 80, and heat it in a warm water bath to dissolve;

[0043] (3) Preparation of gel

[0044] Add the medicinal solution dropwise to the gel ma...

Embodiment 2

[0045] Example 2. Prescription 2

[0046] Ciclopirox amine 10g, carbomer 940 10g, ethanol 100g, propylene glycol 300g, triethanolamine 13g, edetate 0.5g, polysorbate 80 to 20g, and water to 1000g.

[0047] The preparation method is the same as in Example 1

Embodiment 3

[0048] Example 3. Prescription 3

[0049] Ciclopirox amine 10g, carbomer 940 10g, ethanol 150g, propylene glycol 350g, triethanolamine 5g, edetate 0.5g, polysorbate 80-40g, and water to 1000g.

[0050] The preparation method is the same as in Example 1

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PUM

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Abstract

A gel medicine containing ciclopirox olamine for skin and vagina is proportionally prepared from ciclopirox olamine, carbomer, alcohol, propanediol, triethanolamine, bisodium versenate, polysorbide, and water. Its preparing process is also disclosed.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations, and more specifically, belongs to a gel preparation of ciclopirox amine. Background technique [0002] Dermatomycosis is a very common skin disease, which mainly occurs in southern China. According to domestic literature, its prevalence is as high as 58.59%. In northern my country, the prevalence of hand, foot, tinea corporis and tinea corporis is also relatively high. High, sometimes causing acute transmission in a small area. It can be seen that the incidence of dermatophytes is very widespread in my country. Therefore, research on new antifungal drugs is extremely important. [0003] In addition, candidal vaginitis, also known as candidal vaginosis, or fungal vaginitis, is one of the most common diseases in adult women. There are millions of women suffering from candidal vaginitis in the world. In the United States, candidal vaginitis is second only to bacterial vaginosis, and it is four ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/44A61K47/10A61K47/18A61P15/02A61P17/00A61P31/10
Inventor 杨清华刘富强王传栋刘裕
Owner 山东省医疗器械研究所
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