9 results about "Ciclopirox Olamine" patented technology

The invention discloses a rapid selective detection and monitoring culture medium for candida auricula as well as a preparation method and application of the rapid selective detection and monitoring culture medium, and belongs to the technical field of microbiological detection. The culture medium comprises the following components: peptone, yeast extract powder, glucose, agar, a selective inhibitor, a chromogenic substrate and auxiliary components, the chromogenic substrate comprises the following components: dulcitol and X-Gal, the culture medium disclosed by the invention is added with chloramphenicol and ciclopirox olamine to inhibit infectious microbes, and a chromogenic system of dulcitol and X-Gal realizes specific detection of candida auricula. The culture medium has the advantages of high selectivity, rapid identification and low cost, and is suitable for clinical sample and environment monitoring.

The invention provides an application of ciclopirox amine in preparation of an anti-poxvirus medicine, and belongs to the technical field of biological medicines. The invention relates to an application of ciclopirox olamine in preparation of anti-poxvirus drugs. It is proved for the first time that ciclopirox amine has efficient anti-poxvirus activity, can inhibit orthopoxvirus and goat poxvirus from infecting host cells, and meanwhile inhibits poxvirus replication. Therefore, the ciclopirox olamine can be applied to treatment of diseases related to poxvirus infection and drug development. The invention opens up a new way for the application of ciclopirox olamine, and provides a new means for treating poxvirus infection related diseases in the fields of breeding industry and biomedicine.

Compositions and methods for the treatment of onychomycosis. The compositions include a pharmaceutically effective amount of one or more anti-fungal agents in a petrolatum carrier. The one or more anti-fungal agents may include, for example, terbinafine HCl, ciclopirox, ciclopirox olamine, fluconazole, itraconazole, ketoconazole, amorolfine, efinaconazole, clotrimazole, miconazole (miconazole nitrate), and any combination thereof.

The invention particularly discloses ciclopirox olamine nanoemulsion capable of effectively inhibiting fungi and application of the ciclopirox olamine nanoemulsion, and relates to the technical field of biological medicine. According to the ciclopirox olamine nanoemulsion provided by the invention, quaternized chitosan and ciclopirox olamine are synergistically antibacterial, and MIC can be reduced to 1 / 16 of that of a single drug when the quaternized chitosan and the ciclopirox olamine are combined for use.

The invention provides a ciclopirox olamine composite medicine and application thereof in preparation of a medicine for inhibiting scars, and a preparation method of the ciclopirox olamine composite medicine comprises the following steps: S1, preparing a hyaluronic acid solution; and S2, adding the ciclopirox olamine into a hyaluronic acid solution, and carrying out ultrasonic dissolution to obtain the ciclopirox olamine composite medicine. The ciclopirox olamine composite medicine has the effect of inhibiting hypertrophic scars at lower concentration.

The application provides a cyclopirox olamine lotion formula and a preparation method, relates to the field of antibacterial lotions, and the raw materials of the cyclopirox olamine lotion include cyclopirox olamine, sodium laureth sulfate, cocamidopropyl betaine, cocamide DEA, hexylene glycol, oleyl alcohol, polysorbate, polyquaternium, disodium hydrogen phosphate dodecahydrate, citric acid, essence and water. The preparation method is simple, the prepared cyclopirox olamine lotion can solve the problems of instability, poor adhesive peeling strength and the like of traditional ointments, the foam is more abundant, the drug efficacy is facilitated to play, and the use feeling, such as combing property, cleaning effect, after-washing freshness and dandruff-removing and itching-relieving effect, is better.

The invention relates to a Ziconotide temperature-sensitive nasal spray, which comprises a solvent, and Ziconotide, a first matrix, a second matrix, an absorption enhancer, a pH buffer system and a polypeptide stabilizer dispersed in the solvent, the first matrix is poloxamer 407, and the second matrix is poloxamer 188; the temperature-sensitive nasal spray comprises the following components in percentage by mass: 5%-20% of the first substrate, 0-5% of the second substrate, 0.01%-10% of the absorption enhancer, and the balance of the temperature-sensitive nasal spray, the pH buffer system is an acetic acid-acetate system or a lactic acid-lactate system. The ziconotide temperature-sensitive nasal spray can form a good spray form through a nasal spray device, the viscosity has a temperature-sensitive characteristic, and the ziconotide temperature-sensitive nasal spray is not easy to lose and has good stability.

The invention relates to cosmetic or dermatological compositions for combating dandruff, which compositions comprise: water; at least 20% by weight of at least one polyol relative to the total weight of the composition; at least one anionic surfactant selected from among acyl glutamic acids and cosmetically acceptable salts thereof, sodium lauryl sarcosinate, and disodium 5-cocoglucoside citrate, and mixtures thereof; at least one non-ionic surfactant selected from among alkyl glucosides; and at least one anti-dandruff agent which is piroctone olamine, the composition being free of ciclopirox olamine and zinc pyrithione.

The present invention provides a derivative having a ciclopirox olamine tetravalent platinum structure, a preparation method, and uses thereof. The compound having a ciclopirox olamine tetravalent platinum tetravalent platinum structure is shown in general formula (I). In view of the synergistic effect of CPX and platinum drugs in damaging mitochondria, the present invention introduces CPX into the platinum (IV) system to construct a series of ciclopirox olamine platinum (IV) anti-tumor complexes. These drugs exert anti-tumor effects by inducing DNA damage, activating mitochondrial autophagy, and activating immunity. The ciclopirox olamine platinum (IV) anti-tumor compounds developed in this research belong to innovative structural systems in the field of pharmaceutical chemistry, aiming to develop new and effective platinum anti-tumor drugs. They are original innovative work and are of great significance.