39 results about "Ciclopirox Olamine" patented technology

The invention relates to a ciclopirox olamine gel preparation used to cure vagina candida albicans and mycotic infection, wherein the gel preparation takes ciclopirox olamine as active material and macromolecule polymer carbomer as hydrophilic gel ground substance; meanwhile, the gel preparation is made through adding appropriate amount of cosolvent, pH regulator, percutaneous absorption enhancer, stabilizer and purified water according to the physiologic characteristics of vaginal administration and physical and chemical characters of ciclopirox olamine. The gel preparation is characterized by exquisite and smooth texture, no greasy feeling and easy cleaning and also has the advantages of no stimulus, strong adhesion and good adhering effect on skin; meanwhile, the gel preparation can prolong stay time of ciclopirox olamine in vagina and promote percutaneous absorption of medicine to improve antibacterial efficacy, thereby possessing high safety and clinic practicability.

The invention relates to a ciclopirox olamine pessary capable of reducing toxic and side effects of a medicament caused by systemic delivery, increasing local concentration of the medicament, fully playing the therapeutic effectiveness of the medicament and improving the adaptability of patients. The pessary can realize zero order release and is prepared by the following materials by weight portion: 1 portion of ciclopirox olamine, 65 to 90 portions of substrate, 0.2 to 3 portions of stearic acid, 0.1 to 5 portions of hydrogenated castor oil and 0.05 to 2 portions of sodium benzoate.

A gel medicine containing ciclopirox olamine for skin and vagina is proportionally prepared from ciclopirox olamine, carbomer, alcohol, propanediol, triethanolamine, bisodium versenate, polysorbide, and water. Its preparing process is also disclosed.

The invention discloses a cycloronesketamine crystal and preparing method, which comprises the following steps: 1) dissolving cyclorones and ethanolamine in the solvent or dissolving cycloronesketamine in the solvent with organic solvent and or water; 2) crystallizing the solvent in the step 1) to obtain the product.

The invention discloses a ciclopirox olamine vaginal suppository composition. The composition contains a spectrum antifungal drug ciclopirox olamine, a water-soluble matrix, a dissolution-assisting agent and a suitable acid, can be dissolved in vagina to be released, and also has a significant increase in stability. The composition contains the pharmaceutically effective amount of ciclopirox olamine dispersed in a suppository matrix, and the suppository matrix contains the water soluble matrix and the dissolution-assisting agent. The suppository matrix also contains purified water and the acid, and the dissolution-assisting agent is a combination of poloxamer 188 and polysorbate 80.

The invention especially relates to a ciclopirox olamine film-spraying agent and a preparation method thereof, belonging to the field of medicinal preparations. Ciclopirox olamine is a wide-spectrum pyridone antifungal agent and has strong antifungal and fungicidal effect. The ciclopirox olamine film-spraying agent prepared in the invention is clear and transparent in appearance and uniform in color; medicinal liquid can be sprayed in the form of mist and then form a film, so dual physical and biochemical protection and treatment effects are exerted on an affected part and discomfort produced during external application is avoided; and the preparation method is simple in process, low in cost and convenient to use.

The invention belongs to the field of medical technology and specifically relates to an application of ciclopirox olamine in the preparation of a medicine for treating or preventing epilepsy. A compound is screened through a pentylenetetrazol (PTZ) induced zebra fish epilepsy model. Ciclopirox olamine can significantly reduce rapid movement distance (V is greater than 20 mm / sec) of epilepsy zebra fish but doesn't affect total movement distance. It explains that at atoxic concentration, ciclopirox olamine shows good efficacy in curing or preventing epilepsy.

The invention discloses a synthesis method of ciclopirox olamine. The synthesis method includes following steps: (1), preparing dimethyl methacrylate; (2), preparing cyclohexane formyl chloride; (3), preparing 5-oxo-3-methyl-5-cyclohexyl-3-methyl pentenoate; (4), preparing 1-hydroxy-4-methyl-6-cyclohexyl-2(1H)-pyridone; (5), preparing 1-hydroxy-4-methyl-6-cyclohexyl-2(1H)-pyridone-2-amino-ethylate ciclopirox olamine. The synthesis method has the advantages of high yield, high product quality, low running cost, automatic running of equipment, high stability and easiness in meeting industrial needs.

The invention relates to a ciclopirox olamine pessary capable of reducing toxic and side effects of a medicament caused by systemic delivery, increasing local concentration of the medicament, fully playing the therapeutic effectiveness of the medicament and improving the adaptability of patients. The pessary can realize zero order release and is prepared by the following materials by weight portion: 1 portion of ciclopirox olamine, 65 to 90 portions of substrate, 0.2 to 3 portions of stearic acid, 0.1 to 5 portions of hydrogenated castor oil and 0.05 to 2 portions of sodium benzoate.

An antifungal liquid composition for topical administration is provided that contains turpentine and at least one of peppermint oil, mineral oil, and essential oil alcohols, and one or more antifungal medications selected from ciclopirox olamine, terbinafine, tolnaftate, microconazole, itraconazole, ketoconazole, econazole, and fluconazole, and optionally one or more antifungal essential oils, and its use in the topical treatment of fungal infection, particularly of the nail.

The invention discloses application of ciclopirox olamine in preparing a medicine for preventing or treating influenza virus infection. According to the application, firstly, the toxicity of ciclopirox olamine to MDCK (madin-darby canine kidney) cells is detected, and results indicate that maximum non-cytotoxic concentration of the ciclopirox olamine is 50.0 mu M; secondly, the anti-virus activity of the ciclopirox olamine is detected in a complete non-cytotoxic concentration range, and results indicate that the small molecular compound has a remarkable anti-virus activity, and the anti-virus effect shows a dose dependent effect; finally, the anti-virus activity of the ciclopirox olamine to different types and sub-type influenza viruses is detected, and results indicate that ciclopirox olamine can be used for inhibiting replication of all detected influenza virus strains in a dose dependent manner, and the anti-influenza virus activity of the ciclopirox olamine has broad spectrum. Therefore, the ciclopirox olamine is a novel broad-spectrum anti-influenza virus medicine, and can be used for preparing the medicine for preventing or treating influenza virus infection.

A gel medicine containing ciclopirox olamine for skin and vagina is proportionally prepared from ciclopirox olamine, carbomer, alcohol, propanediol, triethanolamine, bisodium versenate, polysorbide, and water. Its preparing process is also disclosed.

The invention provides a ciclopirox olamine ointment and a preparation method thereof, and belongs to the technical field of chemical agents. Each 1000 g of the ciclopirox olamine ointment comprises the following raw materials by weight: 8-12 g of ciclopirox olamine, 50-70 g of stearic acid, 50-70 g of glycerin monostearate, 50-70 g of albolene, 80-120 g of propylene glycol, 10-20 g of sodium dodecyl sulfate, 0.5-1.2 g of ethylparaben, 50-70 g of octadecanol, 80-100 g of liquid paraffin and the balance of purified water. The ciclopirox olamine ointment has the advantages of good bactericidal effect, better softness and better viscosity.

The invention relates to a ciclopirox olamine vaginal dilation suppository as well as a preparation method and a detection method thereof. The dilation suppository comprises a medicine-containing matrix formed by ciclopirox olamine and a matrix, and a dilation carrier. An organic acid and the ciclopirox olamine in the medicine-containing matrix are prepared into a solid dispersion and form a complex salt, so that the absorption of the ciclopirox olamine can be promoted, the bioavailability of the dilation suppository can be improved, and an acidic environment in the vagina can be kept; according to the hollow effervescent vaginal dilation suppository, the peak valley phenomenon generated during medicine release can be overcome, the stability of the dilation suppository is further improved and the curative effect can reach the depth and wrinkles of the vagina. As few types of excipients exist in the dilation suppository, the release of the ciclopirox olamine and the formation of the suppository are facilitated; in addition, the ciclopirox olamine vaginal dilation suppository provided by the invention adopts six unique leading technologies and has the beneficial effects of preventing outflow of medicine liquor and preventing secondary infection, and is high in stability, durable in curative effect and the like.

A method of treating bladder cancer is provided. The method of treating bladder cancer can include: providing a pharmaceutical composition having ciclopirox or ciclopirox olamine or a ciclopirox-POM prodrug having a structure of one of the formulae provided herein or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof; and administering the pharmaceutical composition to a subject having the bladder cancer. The ciclopirox or ciclopirox olamine or a ciclopirox-POM prodrug can be administered in a therapeutically effective amount.

The invention discloses a liniment for treating dermatophytosis and a preparation method thereof. The liniment contains chinar leaf extract and ciclopirox olamine, the weight ratio of which is (5 to 10):1; the chinar leaf extract is the alcohol extract of chinar leaves, and is prepared by the following steps: chinar leaves are soaked in ethanol solution for 5 to 10 days, and is then filtered, filtrate is concentrated into extract, and thereby the alcohol extract of chinar leaves is obtained. Since the chinar leaf extract and the ciclopirox olamine are compatibly used, the anti-dermatophyte spectrum of the liniment is broadened, the antibacterial effect of the liniment is enhanced, and moreover, cured dermatophytosis cannot easily recur. The liniment does not have peculiar smell, and the smell is fragrant and pleasant; the action of the liniment is mild, and the liniment does not have any irritation on skin.

The invention discloses a ciclopirox olamine vaginal suppository composition. It contains a broad-spectrum antifungal drug ciclopirox olamine, a water-soluble matrix, a cosolvent and a suitable acid, which can be dissolved in the vagina and released, and has significantly improved stability. It contains: a pharmaceutically effective amount of ciclopirox amine dispersed in a suppository base, and the suppository base includes a water-soluble base and a cosolvent. The suppository base also contains purified water and acid, and the co-solvent is a combination of both poloxamer 188 and polysorbate 80.

The invention provides anti-aging ethylene propylene diene monomer and a preparation method thereof. The anti-aging ethylene propylene diene monomer is prepared from the following components in partsby weight: 160-200 parts of ethylene propylene diene monomer, 8-15 parts of insoluble sulfur, 20-30 parts of light calcium carbonate, 5-8 parts of methyl methacrylate, 6-9 parts of azodicarbonamide, 0.8-3.5 parts of gallium oxide, 1-3 parts of phthalimide and 4-8 parts of ciclopirox olamine. The preparation method comprises the steps of milling, standing allowing, remilling, vulcanization, ultraviolet light prevention treatment and hot press molding. The ethylene propylene diene monomer obtained by the method provided by the invention has excellent aging resistance, tear resistance and wear resistance, and also has extremely strong ultraviolet light resistance to further prevent aging; the obtained ethylene propylene diene monomer is more suitable for severe environments of high temperature, insolation and the like.

The invention discloses a method for measuring ciclopirox olamine. A chromatographic column with C18 hydrophilic filler is selected, the clathration of beta-cyclodextrin on ciclopirox olamine is utilized, blended solution of aqueous solution of beta-cyclodextrin and acetonitrile is used as a mobile phase, an ultraviolet detector is adopted, and the method can be used for quantitatively measuring active ingredient ciclopirox olamine in a ciclopirox olamine emulsifiable paste. The method has low detection limit and wide linear range; and the linear range well covers the medicament concentrationrange of the ciclopirox olamine, so that the method can be well used for fast detection of the ciclopirox olamine in the medicament production process and clinical medicament monitoring.

The invention discloses a blood lipid and blood sugar lowering pharmaceutical composition and application thereof in preparation of drugs treating type 2 diabetes. The pharmaceutical composition is prepared from active ingredients and pharmaceutically available auxiliary materials. The active ingredients include: (1) rosuvastatin or other pharmaceutically acceptable salt; and (2) ciclopirox or ciclopirox olamine. Combined application of rosuvastatin calcium and ciclopirox has the effect of collaborative reduction of blood lipid and blood sugar, and the two can be prepared into a pharmaceutical composition to treat type 2 diabetes.

The invention relates to a ciclopirox olamine gel preparation used to cure vagina candida albicans and mycotic infection, wherein the gel preparation takes ciclopirox olamine as active material and macromolecule polymer carbomer as hydrophilic gel ground substance; meanwhile, the gel preparation is made through adding appropriate amount of cosolvent, pH regulator, percutaneous absorption enhancer, stabilizer and purified water according to the physiologic characteristics of vaginal administration and physical and chemical characters of ciclopirox olamine. The gel preparation is characterized by exquisite and smooth texture, no greasy feeling and easy cleaning and also has the advantages of no stimulus, strong adhesion and good adhering effect on skin; meanwhile, the gel preparation can prolong stay time of ciclopirox olamine in vagina and promote percutaneous absorption of medicine to improve antibacterial efficacy, thereby possessing high safety and clinic practicability.

The invention relates to a drug for treating itchy scalp and dandruff increase. The drug consists of the following components in parts by weight: 20-50 parts of Ciclopirox olamine, 70-90 parts of lauryl sodium sulfate, 5-20 parts of glycerol, 20-40 parts of sodium chloride, 0.5-2 parts of essence, 0.1-1 part of sodium benzoate, proper amount of citric acid and proper amount of deionized water. The invention further provides a preparation method of ciclopirox olamine hair lotion.

The invention discloses a new application of a pyridone antifungal medicine as a bactericide in prevention and treatment of crop diseases, wherein the pyridone antifungal medicine is ciclopirox olamine and piroctone olamine, and can be used for preventing and treating crop diseases caused by rhizoctonia solani, sclerotinia sclerotiorum, botrytis cinerea, fusarium graminearum, magnaporthe grisea, cotton fusarium oxysporum and citrus canker. According to the invention, ciclopirox olamine and piroctone olamine have excellent antibacterial effects on sclerotinia sclerotiorum, rhizoctonia solani, botrytis cinerea, fusarium graminearum, magnaporthe grisea, cotton fusarium wilt and citrus canker, the bactericidal effect is significantly higher than commercial bactericides azoxystrobin and bismerthiazol, and the pyridone antifungal medicine has potential application prospects in crop disease control.

The invention discloses a preparation method of a medicine for treating chronic eczema, comprising the following steps: 1) adding 20 g of calamine powder and 10 g of paeonol to 250 g of ethanol, stirring and dissolving to obtain a mixed solution for use; Sprinkle 4g ​​of polyvinyl alcohol evenly to make it swell naturally; 3) Add 1.0g of ciclopirox amine, stir continuously, and add ethanol to 1000mL; 4) Adjust pH to 6.0~7.0, stir well, and then it can be used for treatment Chronic eczema medication. In the present invention, calamine powder and paeonol have obvious effects on inhibiting bacteria. Calamine powder and paeonol are prepared into medicines. Due to the transdermal technology of laurofen, the penetration force of the skin and limbs of the medicine is increased, showing The superior efficacy of film coating agent on chronic eczema; the drug for the treatment of chronic eczema made of polyvinyl alcohol, non-greasy, easy to spread, strong adhesion, has a certain tear strength, easy to use, no irritation to the skin sex.

The invention relates to a pharmaceutical composition for treating gynecologic inflammations. The pharmaceutical composition comprises ciclopirox olamine, palmatine and clindamycin or secnidazole serving as active pharmaceutical ingredients, wherein a synergistic effect is achieved among the three active pharmaceutical ingredients. The preferable preparation form of the pharmaceutical composition is gel. The product is uniform, fine and smooth in texture and appropriate in thickness. The pharmaceutical composition can be used for effectively treating mixed infectious diseases, particularly mixed infective vaginitis.

The invention discloses a film-coating agent for treating chronic eczema, expressed by weight, consisting of 15-42g of calamine powder, 7-23g of paeonol, 83-125g of ethylene glycol, 2-8g of polyvinyl alcohol, Composition of ciclopirox olamine 0.5~2.1g, ethanol 500~900g. In the present invention, calamine powder and paeonol have obvious effects on inhibiting bacteria, and calamine powder and paeonol are prepared into medicine, and due to the ciclopirox amine transdermal technology, the penetrating power of medicine skin limbs has been increased, It shows the superior curative effect of the coating agent on chronic eczema; the chronic eczema medicine made of polyvinyl alcohol has no greasy feeling, is easy to spread, has strong adhesion, has a certain tear resistance strength, is easy to use, and is non-toxic to the skin. irritating.

An antifungal liquid composition for topical administration is provided that contains turpentine and at least one of peppermint oil, mineral oil, and essential oil alcohols, and one or more antifungal medications selected from ciclopirox olamine, terbinafine, tolnaftate, microconazole, itraconazole, ketoconazole, econazole, and fluconazole, and optionally one or more antifungal essential oils, and its use in the topical treatment of fungal infection, particularly of the nail.

The invention discloses a blood lipid / blood sugar reducing pharmaceutical composition containing simvastatin and an application of the pharmaceutical composition. The pharmaceutical composition is prepared from active ingredients and pharmaceutically available accessories; and the active ingredients include simvastatin and ciclopirox or ciclopirox olamine. The simvastatin and the ciclopirox or the ciclopirox olamine are combined to achieve a synergistic effect in reducing blood lipid and blood sugar, and the two ingredients are prepared into the pharmaceutical composition for treating the type 2 diabetes; the pharmaceutical composition is capable of correcting the dyslipidemia of a diabetic patient while reducing the blood sugar, and advantageous for preventing and treating the occurrence and development of macrovascular complications.

The invention relates to a pharmaceutical composition for treating gynecologic inflammations. The pharmaceutical composition comprises ciclopirox olamine, palmatine and clindamycin or secnidazole serving as active pharmaceutical ingredients, wherein a synergistic effect is achieved among the three active pharmaceutical ingredients. The preferable preparation form of the pharmaceutical composition is gel. The product is uniform, fine and smooth in texture and appropriate in thickness. The pharmaceutical composition can be used for effectively treating mixed infectious diseases, particularly mixed infective vaginitis.

The invention relates to a drug for treating itchy scalp and dandruff increase. The drug consists of the following components in parts by weight: 20-50 parts of Ciclopirox olamine, 70-90 parts of lauryl sodium sulfate, 5-20 parts of glycerol, 20-40 parts of sodium chloride, 0.5-2 parts of essence, 0.1-1 part of sodium benzoate, proper amount of citric acid and proper amount of deionized water. The invention further provides a preparation method of ciclopirox olamine hair lotion.