21 results about "Hypertrophic scars" patented technology

The embodiment of the invention provides a self-powered microneedle patch for repairing hypertrophic scars as well as a preparation method and application of the self-powered microneedle patch. The self-powered microneedle patch comprises: a friction nano-generator for generating a current; the conductive drug-loaded microneedle patch is connected with the friction nano-generator, and the friction nano-generator is connected with the conductive drug-loaded microneedle patch; the conductive drug-loaded microneedle patch comprises a conductive microneedle patch body and a crosslinked gelatin-crosslinked hyaluronic acid microneedle bearing Sb4. The surface of the conductive micro-needle patch is provided with a metal coating, and the conductive micro-needle patch is used for mediating current generated by the friction nano-generator and applying percutaneous electrical stimulation; the cross-linked gelatin-cross-linked hyaluronic acid microneedle is coated at the tip of the conductive microneedle patch. According to the self-powered microneedle patch provided by the embodiment of the invention, myofibroblasts of hypertrophic scars are transdifferentiated into adipocytes by providing percutaneous electrochemical stimulation, inflammatory factor release is inhibited, and a tissue microenvironment is remodeled, so that the hypertrophic scars are reversed, and skin repair and tissue regeneration are realized.

Some embodiments are directed to a skin treatment system that contains a laser generating device. A hydrogel patch may include a region, at a first side of the hydrogel patch, to be in contact with a person's skin. The region may contain an adsorbing medium (e.g., carbon black or any other substance that would have a similar effect) that, when receiving a laser beam from the laser generating device, results in Extracorporeal Shock Wave Therapy (“ESWT”) being applied to the person's skin to treat a dermatologic condition such as an epidermal or dermal tissue structure irregularity, cellulite, a stretch mark, a scar, scar-tissue, a hypertrophic scar, an acne scar, etc.

The invention discloses an application of an activator combined by one or more genes / proteins in preparation of drugs for treating hypertrophic scars, and belongs to the technical field of biological medicines. In order to solve the problem that when retinoic acid cream is used for preparing hypertrophic scars, a specific mode and an action target of a retinoic acid signal channel for regulating and controlling fibroblasts are not disclosed yet, the action target and a regulation and control mechanism of ATRA for regulating and controlling fibroblast activation and glucose metabolism remodeling are explored through in-vivo and in-vitro experiments; and on the basis of a Cre-loxP system, the function of the target gene is verified. Researches in the invention show that ATRA promotes transcription of HIC1 and inhibits transcription and expression of TGF-beta1 by activating RAR alpha on one hand, and ATRA promotes transcription of HIC1 and inhibits transcription and expression of TGF-beta1 on the other hand; on the other hand, the transcription of PCK1 and PCK2 is promoted, so that the proliferation and abnormal activation of HSFs are reduced, and the occurrence and development processes of hypertrophic scars are finally inhibited. The conclusion provides a sufficient theoretical basis for inhibiting hypertrophic scar formation by ATRA.

The invention discloses a bionic hybrid carrier for actively targeting hypertrophic scars as well as a preparation method and application of the bionic hybrid carrier. According to the preparation method, materials such as scar fibroblast cell membrane protein, a cation carrier and siRNA are adopted, hybridization of a cell membrane and the cation carrier is achieved through an ultrasonic co-extrusion technology, and the carrier is endowed with immune escape and homologous targeting capacity; high-efficiency loading of TGF-beta1 siRNA is realized by utilizing electrostatic self-assembly, so that a bionic transdermal delivery system with an active targeting characteristic is constructed. The bionic hybrid carrier not only provides an innovative thought for root therapy of hypertrophic scars, but also opens up a new way for gene intervention of other skin fibrosis and inflammation related diseases, and has important clinical transformation value.

The application discloses a kind of active targeting hyperplastic scar's biomimetic hybrid delivery vehicle and its preparation method and application.The application uses scar fibroblast membrane protein, cationic delivery vehicle and siRNA and other materials, realizes the hybridization of cell membrane and cationic delivery vehicle by ultrasonic co-extrusion technology, and gives the immune escape and homologous targeting ability of carrier;Efficient loading of TGF-β1 siRNA is realized by using electrostatic self-assembly, so as to construct a biomimetic transdermal delivery system with active targeting characteristics.The biomimetic hybrid delivery vehicle not only provides an innovative approach for the root cause treatment of hyperplastic scar, but also opens up a new way for gene intervention of other skin fibrosis and inflammation-related diseases, and has important clinical translation value.

The application belongs to the field of new use of drugs, and more particularly relates to application of 3-Deazaadenosine in preparation of a therapeutic drug for treating hypertrophic scars. 3-Deazaadenosine is an S-adenosylhomocysteine hydrolase inhibitor, and has antiviral, anti-inflammatory and other activities. Experiments show that the compound can significantly reduce the modification level of m6A in fibroblasts in hypertrophic scar tissue, inhibit the proliferation and migration of fibroblasts, promote the apoptosis of fibroblasts, and also can reduce the expression levels of Collagen I, Collagen III and alpha-SMA in fibroblasts. Therefore, the compound can be used for preparing a drug for relieving or treating hypertrophic scars, and has important clinical application value.

The invention provides multi-effect composite scar repair gel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention develops a multi-effect composite scar repair gel with barrier protection, anti-inflammatory regeneration and long-acting permeation by integrating a silicone base material, traditional Chinese medicine active ingredients and an ionic liquid permeation promotion technology. Wherein the high-viscosity polydimethylsiloxane is used for reducing skin tension; the low-viscosity polydimethylsiloxane improves the skin comfort level; the traditional Chinese medicine extract inhibits fibroblast proliferation and promotes microcirculation; the Ectoin-allantoin microcapsule is capable of realizing 72-hour slow-release anti-inflammatory repair; the BPC157 polypeptide can promote angiogenesis and accelerate wound healing; the transdermal rate of the active ingredients is increased by more than 3 times by the arginine-malic acid ionic liquid; the zinc hyaluronate can synergistically moisturize and regulate the inflammation microenvironment. Through cooperation of multiple mechanisms, the effects of barrier protection, anti-inflammatory regeneration and long-acting permeation are achieved, and the anti-inflammatory and long-acting anti-inflammatory ointment is suitable for repairing hypertrophic scars, acne scars and postoperative incisions.

This invention discloses a combination of biomarkers, a kit, and their applications for detecting hypertrophic scars (HTS). The biomarker combination includes a core biomarker and / or auxiliary biomarker 1 and / or auxiliary biomarker 2; the core biomarker is ABCC9 and CSPG4, auxiliary biomarker 1 is RGS5 and ACTA2, and auxiliary biomarker 2 is PDGFRB and TRPC6. This invention also provides a kit containing the above biomarker combination detection reagents and a drug screening method. This invention reveals for the first time that pathological pericytes are the core fibrotic cells in HTS, breaking through the traditional understanding that fibroblasts are the dominant cells. By targeting and inhibiting the abnormal activation, proliferation, and transdifferentiation of pericytes into myofibroblasts, the generation of myofibroblasts and matrix deposition are curbed at the source, providing a new strategy for precision treatment of HTS. Compared with traditional therapies, this approach has higher specificity and can achieve early molecular warning and quantitative detection of trace tissues for HTS, effectively overcoming the lag and subjectivity of clinical morphological diagnosis.

The invention discloses a double-drug-loading soluble microneedle patch with a hypertrophic scar improving function as well as a preparation method and application of the double-drug-loading soluble microneedle patch, and belongs to the technical field of medical cosmetology. The microneedle patch comprises a substrate and a needle body arranged on the surface of the substrate, wherein the needle body is mainly prepared from a cyclodextrin inclusion compound, colchicine and a microneedle framework material; the cyclodextrin inclusion compound is prepared from an insoluble drug shikonin and beta-cyclodextrin, and the microneedle framework material is prepared from sodium hyaluronate and polyvinylpyrrolidone. The double-drug-loading soluble microneedle patch has good mechanical strength and can accurately penetrate through scar skin to form a drug delivery channel. Compared with a traditional transdermal patch, the soluble microneedle has the advantages that the transdermal permeation efficiency of the medicine is greatly improved, and compared with traditional injection administration, the soluble microneedle reduces long-term irritation to the skin, reduces the risk of adverse reactions such as infection and bleeding and has a very good application prospect.

This application relates to the field of diagnostic reagents, specifically to a scar diagnostic reagent and its application. This application is the first to discover CD3+ in the peripheral blood of keloid patients. + CD8 + The study revealed a significant decrease in cytotoxic T cells, highlighting for the first time the crucial role of the immune microenvironment in the pathogenesis of keloids. Furthermore, it was the first time that sHLA-E expression was significantly different in normal individuals compared to patients with hypertrophic scars and keloids. Using sHLA-E as a diagnostic marker can differentiate between hypertrophic scars and keloids, which are traditionally considered pathological scars, and can also be used to assess the effectiveness of keloid treatment.

The application discloses a kind of active delivery system of load ABPC-EVs and its application in the preparation of preventing or treating hyperplastic scar, belong to the field of biological medicine technology.The active delivery system of load ABPC-EVs described above is composed of ABPC-EVs and drug delivery system.The application utilizes ABPC-EVs as core biological active substance, by constructing active delivery system, is applied to the treatment and prevention of hyperplastic scar, can accurately intervene the abnormal metabolism of fibroblast, inhibits the pathological accumulation of collagen fiber, breaks through the dense tissue barrier caused by hyperplastic scar, realizes the accurate delivery of drug, and then realizes the physical flat of hyperplastic scar, color improvement and physiological reconstruction, solve the problems, such as lack of accurate physical-biological synergistic intervention, poor tissue remodeling quality and low bioavailability, in the prior art for treating hyperplastic scar, has great clinical application prospect.

The invention relates to the technical field of biological medicine manufacturing, in particular to a traditional Chinese medicine compound gel containing bioactive organic components and capable of synergistically repairing hypertrophic scars based on four-season qi and a preparation method of the traditional Chinese medicine compound gel. The compound gel is formed by mixing a bottle A base matrix and a bottle B four-season additive according to the ratio of 9: 1, the base substrate of the bottle A contains various bioactive organic components such as a salvia miltiorrhiza extract, asiatic acid, bioactive hirudin, perilla oil and the like; according to the four-season additive in the bottle B, corresponding traditional Chinese medicine extracts are selected according to seasons, the preparation method adopts a biotechnology process including supercritical COextraction, a biocompatibility nanometer co-grinding technology and other modern biotechnologies, the transdermal absorption rate of mineral components is remarkably increased, the anti-fibrosis effect is enhanced through a hirudin-perilla oil soluble synergistic system, and the anti-fibrosis effect is improved. The four-season differentiated formula realizes accurate repair of preventing wind evil in spring, clearing blood heat in summer, moistening dryness injury in autumn and dredging collaterals in winter.

The invention provides a pharmaceutical composition for treating hypertrophic scars and application, and belongs to the technical field of traditional Chinese medicine, the pharmaceutical composition is obtained by screening traditional Chinese medicine centella asiatica and rheum officinale through an immobilized Notch1 receptor chromatography model, and the pharmaceutical composition is added into optimized blank ointment to prepare an anti-hypertrophic scar external cream preparation. A hypertrophic scar animal model is copied to evaluate the drug effect of the traditional Chinese medicine composition, and it is found that the screened traditional Chinese medicine composition has a good hypertrophic scar resisting effect.

This invention discloses a hypoallergenic traumatic scar repair spray, belonging to the field of skin trauma repair technology. The spray, per 100mL volume, is formulated as follows: 35.0g medical-grade polydimethylsiloxane, 1.2g asiaticoside, 0.8g onion bulb extract, 0.5g allantoin, 0.6g D-panthenol, 0.3g compound sodium hyaluronate, 0.4g tocopheryl acetate, 0.2g tranexamic acid, 0.3g β-glucan, 4.0mL medical-grade glycerin, 3.0mL food-grade propanol, 0.15g carbomer 940, appropriate amount of arginine, and purified water to 100mL. This invention utilizes a multi-pathway synergistic effect, combining medical-grade silicone for hydration, centella asiatica extract for collagen remodeling, onion extract for inhibiting hyperplasia, and tranexamic acid for fading pigmentation. It effectively softens, smooths, lightens, and repairs various traumatic scars, including those from surgery, external injuries, and burns. It shows significant improvement in hypertrophic, pigmented, and old scars. This formula is free of hormones, alcohol, fragrances, preservatives, and heavy metals, avoiding common skin allergens such as peanuts, milk, seafood, and pollen. It is gentle and non-irritating, suitable for long-term use on all skin types. The spray formulation is convenient, has good penetration, and high stability, demonstrating promising prospects for industrialization and clinical application.

The application discloses a traditional Chinese medicine for treating scars, which comprises the following components in terms of weight: white chrysanthemum 10-15 parts, canty caterpillar fungus 8-12 parts, clove 20-30 parts, peach kernel 4-8 parts, soapberry 3-5 parts, dandelion 20-40 parts, schizonepeta 6-8 parts, salvia miltiorrhiza 8-12 parts, rhubarb 3-5 parts and licorice 6-10 parts. The application can obviously improve superficial scars and hypertrophic scars within one month, soften scar tissues, promote epithelialization of scar tissues and normalization of skin gland tissue secretion, disperse local melanocyte aggregation, and increase skin gloss and skin elasticity.

This invention provides a FAP-targeted engineered exosome for treating hypertrophic scars, its preparation method, and its application, belonging to the field of biopharmaceutical manufacturing technology. After co-incubation with an ferroptosis inducer, the FAP-targeting small molecule ligand SUC-Lys(Ac)-PEG3-UAMC1110 is covalently linked to the exosome membrane surface using an EDC / NH-mediated amide bond coupling strategy to obtain engineered exosomes. These engineered exosomes are then used to prepare microneedle patches. The microneedle patches allow the engineered exosomes to accumulate at the scar site and preferentially enter FAP-highly expressed scar fibroblasts, inhibiting their abnormal proliferation, migration, and pro-fibrotic phenotype, reducing collagen deposition, and promoting hypertrophic scar tissue remodeling. This invention combines the advantages of strong targeting, low off-target toxicity, minimally invasive drug delivery, sustained local retention, and stable efficacy, making it suitable for preparing drugs to treat or improve hypertrophic scars, and possessing good clinical translational potential.

The invention discloses a microneedle system for treating hypertrophic scars and a preparation method, application and medicine of the microneedle system, and belongs to the technical field of medical treatment. According to the technical scheme, the microneedle system for treating the hypertrophic scars comprises a needle body and a load; the load is a mixture of collagenase and 5-fluorouracil, and the mass ratio of the collagenase to the 5-fluorouracil is 1: (4-6); on one hand, the collagenase in the application can break a scar collagen barrier and increase the permeability of medicine tissues, and on the other hand, the collagenase can perform enzymolysis on excessively deposited collagenous fibers; 5-fluorouracil in the micro-needle system has a deep effect to inhibit abnormal proliferation of fibroblasts, so that the micro-needle system synergistically inhibits and clears scars from a plurality of channels, and synergistic interaction is realized.

This invention relates to the field of biomedical dressings, specifically disclosing an exosome-loaded tanshinone hypertrophic scar dressing and its preparation method. The dressing comprises an exosome-tanshinone complex, methacrylamide gelatin, oxidized dextran, and a photoinitiator. The key to its preparation lies in: first, using DSPE-PEG-Maleimide as a bridge, covalently coupling the RGD targeting peptide to the exosome membrane via a Michael addition reaction to construct an active targeting carrier; then, efficiently loading tanshinone IIA using electroporation to form a complex; finally, mixing the complex with a gel precursor and cross-linking it under ultraviolet light. This invention solves the problem of easy detachment of the targeting ligand through chemical coupling, and utilizes a dual-network hydrogel to achieve responsive drug release to the MMP-2 enzyme in the scar microenvironment, thereby improving the local anti-fibrotic efficacy while reducing the single-drug dosage and toxic side effects.

The application belongs to the technical field of medicines, and particularly relates to the use of methylbenzoquinone in the preparation of medicines for preventing and / or treating hyperplastic scars. The application first finds through experiments that methylbenzoquinone can promote the apoptosis of fibroblasts, reduce the expression of IL-8, IL-beta, Col I, Col III and other fibrosis-related genes, thereby effectively treating hyperplastic scars, which shows that methylbenzoquinone has the potential to be used as a medicine for treating hyperplastic scars, and provides more choices for clinical treatment.

In order to solve the problems that in the prior art, a hypertrophic scar model is complex in modeling method, short in scar duration time and prone to fading of hypertrophic scars, the manufacturing method of the hypertrophic scar model is provided, and by means of the action characteristic that tissue such as muscles and livers can be induced to generate fibrosis through abuse of absolute ethyl alcohol, the hypertrophic scar model is obtained. Considering the possibility of hypodermic injection induced hypertrophic scar, according to the embodiment, the method specifically comprises the following steps: anesthetizing an experimental animal, depilating the back of the experimental animal, disinfecting and wiping the experimental animal with 75% alcohol, and subcutaneously applying 99.5% absolute ethyl alcohol (0.2 mL / 100g) to construct a hypertrophic scar model. According to the method, the hypertrophic scar formed on the back of the experimental animal is not prone to fading, long-term observation is facilitated, and the animal model is beneficial to pathogenesis research of the hypertrophic scar and has wide application prospects.

The present invention provides a MPO inhibitor, a method of preparing the same and a new use in the manufacture of a medicament for preventing or treating hypertrophic scars and keloids.