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32results about How to "Effective penetration" patented technology

A gene therapy system for improving ocular neovascularization and a preparation method and application thereof

PendingCN122499325Aeffective penetrationInhibition formationOcular neovascularizationCapsid
This invention involves co-transfecting cells with an AAV vector plasmid carrying the target gene, a packaging plasmid providing Rep / Cap proteins, and a helper plasmid providing adenovirus assistance. The transfected cells are cultured under suitable conditions to produce viral particles containing recombinant AAV. Cells and culture supernatant are collected, cells are lysed to release the virus, and the viral particles are purified by centrifugation. A membrane-penetrating peptides or their derivatives are then modified onto the AAV capsid protein. Results show that the gene editing system combined with membrane-penetrating peptides or their derivatives enhances editing efficiency, effectively penetrates ocular surface tissues, and inhibits ocular neovascularization.
Owner:THE FIRST AFFILIATED HOSPITAL HENGYANG MEDICAL SCHOOL UNIV OF SOUTH CHINA

Use of tyk2 inhibitors for the treatment of ischemic stroke

PendingCN122582161AInhibition of abnormal activationprevent infiltration
The application relates to the use of a TYK2 inhibitor, in particular a heterocyclic compound represented by the formula (I) or a pharmaceutically acceptable salt, solvate or isomer thereof in the preparation of a drug for treating or preventing ischemic stroke.
Owner:PRIMEGENE (BEIJING) CO LTD

Annular double-T ventilation structure and device based on pore anisotropy

The invention provides an annular double-T ventilation structure and device based on pore anisotropy, and belongs to the technical field of grain storage. The annular double-T ventilation structure comprises an annular main air duct, two symmetrically-arranged air inlets and two T-shaped air ducts which are located in the annular main air duct and are in central symmetry; ventilation holes are formed in the walls of the annular main air duct and the T-shaped air duct, the T-shaped air duct comprises a longitudinal branch pipe and a transverse branch pipe, one end of the longitudinal branch pipe is connected with the air inlet, and the other end of the longitudinal branch pipe extends towards the center and is connected with the transverse branch pipe; a composite ventilation network with the outer ring and the inner T is formed, and the problem of ventilation blind areas in the center area of the bottom of the silo caused by pore anisotropy when wet grains containing impurities are stacked is effectively solved; the invention further provides a wet grain ventilation and cooling device comprising the ventilation structure, the ventilation uniformity of a grain pile can be remarkably improved, the grain temperature can be remarkably reduced, the wet grain ventilation and cooling device is suitable for rapid warehousing ventilation of high-impurity-content wet grains, strict cleaning is not needed, and time and cost are saved.
Owner:NANJING AGRI MECHANIZATION INST MIN OF AGRI

Method for rapidly determining activity of biological membrane cells in immobilized fermentation

PendingCN121954878AEfficient quantitative analysis of proportions Efficientefficient analysisMicrobiological testing/measurementMicroorganism based processesMethyl blueSpectrophotometric measurement
The invention relates to the field of biotechnology and dead / living cell detection, in particular to a method for rapidly determining the activity of biological membrane cells in immobilized fermentation. According to the method, a methylene blue and trisodium citrate synergistic chromosome system is optimized, a biofilm EPS matrix is synergistically penetrated by virtue of the dispersion effect of trisodium citrate and the reduction characteristic of methylene blue, and a spectrophotometric method is combined to detect the OD value of a staining solution instead of stained cells, so that the efficient quantitative analysis of the ratio of dead cells to living cells of the immobilized biofilm is realized. The method can complete detection within 200 s, is simple and convenient to operate and low in cost, does not need complex equipment, and is remarkably superior to a traditional fluorescent staining method.
Owner:NANJING TECH UNIV

A new type of corn quick freezer

ActiveCN224650088Uavoid stackingavoid squeezing each other
The utility model discloses a novel corn quick freezer, including main part, bulk material mechanism, transport mechanism and freezing mechanism, bulk material mechanism includes the distribution board and vibrator, transport mechanism includes first motor and conveyer belt, freezing mechanism includes fan and freezer, under the mutual cooperation of above -mentioned mechanism, the device prevents corn kernel stacking and can avoid mutual extrusion between corn kernels, reduces the damage, keeps the integrity and appearance quality of corn kernel, in addition, the device is evenly distributed and is helpful to cold air more effectively penetrate corn kernel layer, reduces the freezing time.
Owner:TANGSHAN SHENGJING FOOD CO LTD

Bubble eliminating device and electrophoresis tank for automobile front end drainage structure

ActiveCN224350794Uimprove product qualityImprove elimination effectElectrophoretic coatings
The application discloses a bubble eliminating device for a car front end drainage structure and an electrophoresis tank, which comprises a plurality of first connecting pipes, the liquid inlet of each of the first connecting pipes is connected with a liquid outlet on an electrophoretic liquid conveying pipe located at the front end of the electrophoresis tank; a plurality of first spray pipes, which are parallel to each other and in the same plane, the first spray pipes are arranged in an inclined upward manner, the top end of each of the first spray pipes is directed to the opening direction of the drainage structure when a car is immersed in the electrophoretic liquid, the bottom end of each of the first spray pipes is connected with the liquid outlet of each of the first connecting pipes; a plurality of first nozzles, which are of a nozzle type with a diameter gradually decreasing from the bottom end to the top end, and the bottom end of each of the first nozzles is connected with the top end of each of the first spray pipes; a connecting rod, which is connected with each of the first spray pipes; two supporting rods, which are located at the two ends of the connecting rod, the top end of each of the supporting rods is connected with the end of the connecting rod, and the bottom end of each of the supporting rods is connected with a fixing frame of the electrophoretic liquid conveying pipe. The application is helpful to improve the bubble eliminating effect in the car drainage structure in the electrophoresis process.
Owner:FAW VOLKSWAGEN AUTOMOTIVE CO LTD

Comb assisting in blow-drying hair

The utility model discloses a comb assisting in drying hair, which comprises a fixed comb body and a housing structure, a plurality of main comb teeth are arranged at one end of the fixed comb body, and the housing structure is fixedly connected to one side of the fixed comb body. The movable comb tooth mechanism is arranged on one side of the fixed comb body, the top of the movable comb tooth mechanism is connected with a gap between the cover shell structure and the top of the fixed comb body in a sliding and penetrating mode, and the movable comb tooth mechanism is matched with the main comb teeth to clamp bent hair through limitation of the cover shell structure. According to the comb, the fixed comb body and the movable comb tooth mechanism are combined through the housing structure, so that when the comb is used for blowing hair, hair can be combed while blowing, meanwhile, the movable comb tooth mechanism can be pushed to be staggered with the fixed comb body, the hair can be clamped and bent, and the hair can be separated; and wind enters the hair, so that the wind effectively permeates, and the hair drying efficiency is improved.
Owner:SHENZHEN HUAXI ACRYLIC PROD CO LTD

Positioning support for convenient fixing and safe removal in human blood vessels

This invention discloses a positioning stent for convenient fixation and safe removal within human blood vessels, relating to the field of surgical medical device technology. The positioning stent comprises: a metal wire stent with multiple pointed positioning spikes, each spike including an inner metal wire and a covering layer; the inner metal wire is connected to the metal wire of the metal wire stent, the diameter of the inner metal wire being smaller than the diameter of the metal wire of the metal wire stent; the covering layer is conical and made of a biodegradable material; the tips of the inner metal wires and the tips of the covering layer are spaced a predetermined distance apart, and the middle portion of the inner metal wire forms a spiral portion; after the covering layer degrades, the spiral portion changes from a compressed state to an extended state, allowing the inner metal wire to pierce the blood vessel wall, with a predetermined gap between the blood vessel wall surface and the surface of the metal wire stent. This invention achieves reliable stent fixation and safe removal.
Owner:BEIJING HONGHAI MICROTECH CO LTD

A mill positioning pin

ActiveCN224657684Ueffective penetrationimprove performance
The utility model relates to rolling mill technical field discloses a kind of rolling mill positioning pin, including, positioning pin main body, the positioning pin main body is cylindrical structure, one end of the positioning pin main body is machined with two mutually parallel grooves to form three parallel positioning teeth, at least two oil holes are vertically provided in the other end of the positioning pin main body and respectively penetrate two The groove;Pin cover, the pin cover includes cylindrical main part, one side of the main part is provided with the circular groove matching with the diameter of the positioning pin main body, and the main part is sleeved on the positioning pin main body away from the groove one end by the circular groove. The utility model increases the contact area of positioning pin and copper nut, improves the body strength of positioning pin. In addition, the design of oil eye makes the lubricating grease more effectively penetrate to rolling mill bearing seat and pressure ball pad bottom, significantly reduces the wear of bearing seat and pressure ball pad, improves the overall performance and service life of rolling mill.
Owner:SHANXI TONGCAI IND & TRADE CO LTD

Method for targeted activation of endogenous enzymes in flax seed for maintaining particle morphology and debittering and flavoring

PendingCN122503167ASolve the problem of adhesion and reunionInhibit swelling rate
This invention discloses a method for targeted activation of endogenous enzymes and debittering / fragrance enhancement in flaxseed while maintaining its granular shape. The method includes the following steps: microcrack treatment of flaxseed; spraying an ethanol-water solution onto the surface of the flaxseed to create a slightly moist state; heating and conditioning in a heat-preserving conditioning device to activate the endogenous cyanogenic glycoside hydrolytic enzyme system; short-term heat treatment under closed or semi-closed negative pressure conditions and introducing cyanide-containing exhaust gas into an exhaust gas treatment system; and cooling and tempering to obtain debittered and fragrance-enhanced flaxseed. This invention, through the synergistic effect of microcrack treatment and ethanol-water wetting, effectively activates endogenous enzymes to promote cyanogenic glycoside hydrolysis and removal of volatile cyanide-containing components under extremely low wetting solution addition conditions, while simultaneously inhibiting the hydration and swelling of seed coat mucilage. This results in treated flaxseed maintaining a dispersed granular state and good flowability, suitable for subsequent continuous pressing processing.
Owner:KANGBAO COUNTY YAMI FLAXSEED BIOTECHNOLOGY CO LTD

Flame-retardant moisture-proof melamine impregnated paper

The utility model relates to the technical field of melamine impregnated paper, in particular to flame-retardant moisture-proof melamine impregnated paper which comprises a melamine impregnated paper body, the melamine impregnated paper body comprises base material gummed paper, and original impregnated paper is glued to the top face and the bottom face of the base material gummed paper respectively. Modified impregnated paper is glued on one side, far away from the base material gummed paper, of the original impregnated paper, a carbon foam layer is glued and filled between the original impregnated paper and the modified impregnated paper, a hydrophobic layer is uniformly coated on one side, far away from the original impregnated paper, of the modified impregnated paper, and a flame-retardant layer is uniformly coated on one side, far away from the modified impregnated paper, of the hydrophobic layer. According to the flame-retardant moisture-proof melamine impregnated paper, the flame-retardant moisture-proof capability of the melamine impregnated paper is improved through the whole structure, and the service life is prolonged.
Owner:FOSHAN DAJIA NEW MATERIAL TECH CO LTD

A sugar-based carbon quantum dot oil displacement agent for unconventional reservoirs, a preparation method and application thereof

PendingCN122278461AHigh interface activityParticle size controllableUnconventional oilCarboxylic group
This invention discloses a glycosyl carbon quantum dot oil displacement agent for unconventional oil reservoirs, its preparation method, and its application, belonging to the field of oilfield chemical technology. The preparation of the glycosyl carbon quantum dot oil displacement agent for unconventional oil reservoirs of this invention includes: adding a carbon source and a modifier to an alcohol solution, stirring to dissolve, and then carrying out a hydrothermal reaction to obtain the product; wherein the modifier is a ketoxime modifier; this method is simple, low-cost, has controllable particle size, and high yield, making it suitable for industrial application; the obtained carbon quantum dots have a high specific surface area and functional groups such as carboxyl and hydroxyl groups, which can penetrate nanopores and synergistically reduce the oil-water interfacial tension to below 5.0 mN / m; this product has outstanding high-temperature resistance and penetration ability, and can effectively penetrate into the nanopore throat structure of tight reservoirs, significantly improving oil displacement efficiency through interfacial modification, and is particularly suitable for the exploitation of unconventional nano-oil and gas resources.
Owner:JIANGNAN UNIV

A hydrophilic epoxy resin waterproof coating, a preparation method and application thereof

ActiveCN118027787Blow viscosityEffective penetrationMethacrylatePolymer science
The application discloses a kind of hydrophilic epoxy resin waterproof coating and its preparation method and application, the coating includes by epoxy resin, modified epoxy resin, diluent and coupling agent component A, by curing agent, modified curing agent, accelerator component B, wherein modified epoxy resin is by octadecyl methacrylate with bisphenol A type epoxy resin after being mixed to obtain.Compared with conventional epoxy resin waterproof coating, the hydrophilic epoxy resin waterproof coating of the application has the following advantages: high permeability, more excellent waterproof performance is obtained, and construction is more simple;Wetting performance is good, can promote to improve the adhesion between coating and concrete, can obtain better and more long-lasting waterproof effect;It can be cured under low temperature and humid conditions;Easy to flow, it can realize the deep penetration of concrete under reasonable time conditions, no adhesive failure, strong waterproof ability, and reasonable operation time, easy to construction;Non-volatile, more green and environmental protection.
Owner:SHANGHAI ZHONGYAN BIOTECHNOLOGY CO LTD

Vaccine separator and its working method for achieving self-sterilization and cleaning function using vapor phase

This invention discloses a vaccine separator and its working method that utilizes vapor phase to achieve self-sterilization and cleaning functions. It relates to the field of vaccine separator technology and employs steam cleaning during the cleaning process of the vaccine separator. The principle behind this method is that vapor media have better permeability and diffusion than liquid media, and also possess superior heat dissipation and evaporation effects, resulting in better inactivation of residual bacteria during the separation process. Based on these aspects, a dual-path vapor-liquid structure is proposed, which, in essence, performs targeted and localized cleaning actions based on the injection method of the bacterial mixture during the separation process. This requires real-time interaction between the temperature and pressure environments inside the vessel according to the high-temperature steam injection process, ultimately aiming to improve the overall cleaning effect.
Owner:JIANGSU JUNENG MASCH CO LTD

Non-denatured type Ⅰ and Ⅲ collagen ultrafine powder with deep skin growth and three-dimensional repair effect, its molecular protection preparation method and multi-path application

PendingCN122272405AAchieve full layer repair effectEasy to synthesizeSkin repairBiomedical technology
This invention belongs to the field of biomedical technology and discloses a non-denatured type I and III collagen ultrafine powder with deep skin growth and three-dimensional repair effects, its molecular protection preparation method, and multiple application pathways. The ultrafine powder contains 50%-70% non-denatured type I collagen, 15%-30% non-denatured type III collagen, 5%-15% molecular protectant, 3%-10% transdermal penetration enhancer, and 2%-8% bioactive stabilizer. The mass ratio of type I to type III collagen is 7:3 to 8:2, the triple helix retention rate is not less than 85%, and the average particle size is 0.5-3 μm. The preparation method employs low-temperature enzymatic extraction and molecular protection complexation technology to achieve complete preservation of the collagen triple helix structure. The product can be applied through surface application, microneedle delivery, and injection to meet the needs of skin repair at different depths.
Owner:GUANGZHOU QUANNENG FRESH BONE POWDERS BIOLOGICAL FOOD CO LTD

Power plant specific area personnel behavior identification and early warning system

ActiveCN120632785BImprove violation identification accuracyRealize full-process closed-loop managementClosed circuit television systemsAlarmsOriginal dataData acquisition
This invention discloses a personnel behavior recognition and early warning system for specific areas of a power plant, relating to the field of intelligent industrial safety monitoring technology. It includes a data acquisition module, an edge computing module, and a central processing platform. The data acquisition module is responsible for collecting and initially processing multi-source heterogeneous data, including personnel identity, behavior, location, and environmental parameters. The edge computing module performs lightweight processing and localized decision-making on the raw data, reducing the load on the central processing platform. The central processing platform achieves full-process safety control of high-risk areas through multimodal data fusion, dynamic access control, and trajectory analysis. In this invention, lightweight AI models are embedded in various cameras of the employee badge authentication terminal and visual perception unit, enabling preliminary inference to be performed directly on the employee badge authentication terminal and camera, thus equipping the employee badge authentication terminal and camera with edge computing capabilities. Independent edge servers or industrial control computers are deployed near the data sources in various areas of the power plant as regional edge computing nodes.
Owner:ANHUI WOXU INTELLIGENT TECHNOLOGY CO LTD

A broad-spectrum antibacterial and low-toxicity antimicrobial peptide WP-4, WP-6, and their combinations and applications

This invention discloses broad-spectrum antibacterial peptides WP-4 and WP-6, their compositions, and applications, belonging to the fields of antimicrobial peptide technology and biomedicine. This invention obtains a series of antimicrobial peptides by truncating and rationally modifying template peptides to balance the relationship between charge number, hydrophobicity, and amphiphilicity. By measuring antibacterial activity, stability, hemolytic activity, and cytotoxicity, two novel antimicrobial peptides, WP-4 and WP-6, with high activity and low toxicity were obtained, and their amino acid sequences are shown in SEQ ID NO. 5 and SEQ ID NO. 7. The novel antimicrobial peptides obtained by this invention possess broad-spectrum antibacterial activity, good stability under temperature, pH, salt ion, pepsin, and serum conditions, and exhibit no significant hemolytic activity and low cytotoxicity. They are characterized by rapid bactericidal action and low likelihood of inducing drug resistance. Furthermore, the antimicrobial peptides of this invention can enter cells and have a strong inhibitory effect on intracellular bacteria, showing broad application prospects.
Owner:HUAZHONG AGRI UNIV

Amplification culture medium, amplification method and application of iPSC-derived hematopoietic progenitor cell population

The invention discloses an amplification culture medium, an amplification method and application of an iPSC (induced pluripotent stem cell) derived hematopoietic progenitor cell population, and relates to the technical field of cell culture. According to the amplification culture medium provided by the invention, animal-derived components are replaced by chemical small molecule combinations, so that the safety of cell products is remarkably improved; the yield of NK cells cultured by the culture medium is greatly increased, the HPC amplification multiple is increased to 2.5 times or more of that of a traditional process by adding tranexamic acid, and the bottleneck of industrial production is broken through. The method provided by the invention improves the process stability. The cells amplified according to the method provided by the invention strengthen the pertinence of lung cancer treatment.
Owner:SHENZHEN LEWEI HONGYUAN MEDICAL TECHNOLOGY CO LTD

Process for the preparation of a medium temperature curing epoxy resin material for carbon fibre prepregs

PendingCN122587413Aevenly distributedSimple process route
The application relates to the field of high polymer composite materials, in particular to a method for preparing a medium-temperature curing epoxy resin material for carbon fiber pre-impregnation, which comprises the steps of raw material preparation, resin dispersion premixing system and medium-temperature curing resin material preparation; the process carries out constant-temperature high-shear dispersion of an epoxy resin matrix and core-shell structure toughening particles at 50-60 DEG C; the core is that through physical shearing and thermodynamic swelling cooperation, the resin penetrates into the shell layer of the toughening particles, the toughening phase is introduced in a semi-stable state, and the core-shell active groups are utilized to realize co-curing reaction during curing; the application does not need high-temperature pre-reaction, breaks through the technical obstacles of high viscosity and particle filtration caused by traditional toughening and impregnation failure, and significantly improves the interlayer fracture toughness and shear strength of the composite material under the premise of maintaining the heat resistance and modulus of the system.
Owner:XIAN YUECHUAN NEW MATERIALS CO LTD

Clothes airing machine capable of generating high-speed drying airflow

The utility model discloses a clothes airing machine capable of generating high-speed drying airflow. The clothes airing machine comprises a main machine provided with a drying module and an airing rod for airing clothes. Hot air generated by the drying module is blown to clothes on the airing rod; the drying module comprises a fan, an airflow pressurizing device, a heating body and an air deflector; the airflow pressurizing device is an airflow cavity with an air inlet and an air outlet, and the airflow cavity is defined by a front plate, a rear plate, a left plate and a right plate; a pressurizing component is arranged in the air flow cavity, and a narrowed pressurizing air duct is formed in the air flow cavity by the pressurizing component; air flow generated by the fan forms high-speed air flow after passing through the pressurizing air duct, and the high-speed air flow is blown out after passing through the heating body and the air deflector. The efficient, uniform and energy-saving clothes drying effect is achieved.
Owner:ZHEJIANG HOOEASY SMART TECH

Polypeptide with anti-malassezia activity and application thereof in improvement of seborrheic dermatitis

PendingCN121779512AGrowth inhibitioninhibit settingCosmetic preparationsAntimycoticsMalasseziaSeborrheic dermatitis
The invention belongs to the technical field of biological medicines, and particularly discloses a polypeptide with malassezia resisting activity and application of the polypeptide in improvement of seborrheic dermatitis. The polypeptide provided by the invention comprises an amino acid sequence as shown in SEQ ID NO: 1. The polypeptide has a remarkable inhibiting effect on the key pathogenic bacterium-malassezia causing seborrheic dermatitis, experimental data shows that the polypeptide can remarkably inhibit the growth and constant value of the malassezia at a low concentration, and the effect of the polypeptide can be close to that of a positive control ketoconazole. The polypeptide shows an excellent dermatophyte removing effect in a malassezia induced mouse seborrheic dermatitis model, experimental data proves that the fungal load of the skin tissue of the affected part of a mouse is remarkably reduced after administration, and the polypeptide still can keep high biological activity and stability in a complex skin physiological microenvironment, and has a good application prospect. The malassezia can effectively penetrate through a sebum layer to act on thalli, so that the decomposition effect of the malassezia on sebum is effectively restrained.
Owner:HUNAN NORMAL UNIVERSITY

Coating, drying and softening integrated device for uvioresistant home fabric

PendingCN121945364ARegulated contact pressureevenly distributedFabric breaking/softeningPretreated surfacesFiberInterior space
The coating, drying and softening integrated device comprises a machine body, machine doors are arranged on the left side and the right side of the front end of the machine body correspondingly, and a cloth inlet and a cloth outlet are formed in the left end and the right end of the machine body correspondingly; the three partition plates sequentially divide the inner space of the machine body into a coating area, a pre-drying area, a main drying area and a softening area in the fabric conveying direction, and the problem that fabric coating is not uniform is solved. According to the technical scheme, the anti-ultraviolet home fabric coating, drying and softening integrated device is provided. The coating openings are axially arrayed on the peripheral surface of the coating compression roller, so that an anti-ultraviolet finishing agent not only can be uniformly distributed on the surface of a fabric, but also can effectively permeate into fibers, and the problem that the finishing agent only stays on the surface or is accumulated and leaked due to traditional fixed scraper or simple roller coating is fundamentally solved; therefore, the high uniformity and durability of the uvioresistant performance (UPF value) of the finished fabric are ensured.
Owner:ZHEJIANG YIZHEN INTELLIGENT MANUFACTURING CO LTD

Fishtail skirt abutted seam structure

The utility model discloses a fishtail skirt seam splicing structure which comprises a first fishtail skirt edge cloth strip and a thread hole, a folding cloth strip is arranged at the right end of the first fishtail skirt edge cloth strip, a second fishtail skirt edge cloth strip is arranged on the front side of the folding cloth strip, a first sewing thread groove is formed in the surface of the second fishtail skirt edge cloth strip, and a second sewing thread groove is formed in the surface of the second sewing thread groove. The suture hole is formed in the first suture line groove, and a first suture line penetrates through the interior of the suture hole. According to the fishtail skirt abutted seam structure, the attaching adhesive tape and the positioning adhesive tape are both soluble glue, when the attaching adhesive tape and the positioning adhesive tape are used for adhering clothes, the adhering effect can be provided, it is ensured that all parts of the first fishtail skirt edge cloth strip and all parts of the second fishtail skirt edge cloth strip are firmly combined, and the clothes are not prone to falling off. The first fishtail skirt cloth strip and the second fishtail skirt cloth strip are not prone to thread loosening or thread opening in the using process, the service life of the first fishtail skirt cloth strip and the service life of the second fishtail skirt cloth strip are prolonged, it can be ensured that different materials are tightly bonded through the high-quality attaching adhesive tape and the positioning adhesive tape, and the tear resistance and the wear resistance of the fabric are improved.
Owner:HANGZHOU YIFENGGE CLOTHING CO LTD

A shuttle peptide targeting YY1 S247 phosphorylation and its application

ActiveCN119708158Bgood treatment effecteffective penetrationPeptide/protein ingredientsDigestive systemDrosophila ornatifronsPhosphorylation
This invention discloses a shuttle peptide targeting YY1S247 phosphorylation and its application. The sequence of the shuttle peptide is shown in SEQ ID NO: 1. RQIKIWFQNRRMKWKK is a part of the Drosophila melanogaster tentacles peptide, used to provide cell penetration; PKKKRKV is the nuclear localization sequence of the SV40 large T antigen, used to guide the peptide into the cell nucleus; QIIGENSPPDYSE is the surrounding sequence of the YY1S247 site. The results show that the shuttle peptide (CPP) of this invention can competitively and specifically inhibit phosphorylation at the YY1S247 site, thereby inhibiting CD24 expression and enhancing the therapeutic effect of EGFR-TKIs.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV

Enterprise compliance inspection tour method based on rule and generative AI collaborative judgment

PendingCN122087075Aeffective penetrationAccurately identify hidden violation risksDigital data information retrievalSemantic analysisBusiness enterpriseNear neighbor
The invention provides an enterprise compliance inspection tour method based on rule and generative AI collaborative judgment, and relates to the technical field of artificial intelligence and enterprise crossing, and the method comprises the steps: S1, obtaining multi-source data which comprises a text data source, a table data source, a bill image data source, a voice data source and an external risk control library; s2, preprocessing the multi-source data to generate a preprocessed data set; the preprocessed data set comprises multi-modal data and a unified numbering result attached with entity associated information; s3, mapping the multi-modal data to the same vector space according to the preprocessed data set to obtain a multi-modal unified vector set; and establishing an approximate nearest neighbor retrieval index according to the multi-modal unified vector set, inputting a retrieval request, returning candidate evidence, and generating an RAG retrieval enhancement interface. Dynamic business semantics can be understood, logic explanation is generated, and safe collaborative evolution end-to-end intelligent patrol can be realized.
Owner:SHANGHAI INVESTIGATION DESIGN & RES INST CO LTD

A precast hollow composite shear wall installation wire penetrating guide device

ActiveCN118187477Beffective penetrationImprove stabilityBuilding material handling
This invention provides a rebar-threading guide device for installing prefabricated hollow composite shear walls, comprising a guide device body, which is rotatably connected to a first guide part and a second guide part. The device body has a first state and a second state. In the first state, the first and second guide parts are engaged to form a rebar-threading channel, and the upper parts of the first and second guide parts are respectively engaged with the channels of a corrugated pipe. The lower inner diameter of the rebar-threading channel increases from top to bottom, making the device body more adaptable. It can effectively guide the rebar to be threaded regardless of changes in the diameter of the rebar or fine adjustments to the threading angle. The positioning accuracy requirement for threading is low, reducing the construction difficulty and improving the stability and efficiency of the rebar-threading operation. In the second state, the first and second guide parts are separated from the corrugated pipe, and can be easily removed after construction.
Owner:BEIJING JIANGONG NEW BUILDING MATERIALS CO LTD

Improved fire fighting tow hook structure for electric vehicles

ActiveCN224404230UHook pull characteristics retainedavoid spreadingInsulation layerMarine engineering
The utility model belongs to the technical field of fire fighting apparatus, especially is involved in an improved fire fighting hook structure for electric vehicle. The combined hook lance is composed of hollow metal conical seat, sliding rail, tow hook, injection hole seat and penetrating cone. The sliding rail is welded to the outer surface of the hollow metal conical seat, the tow hook is connected to the sliding rail through bolts, the hollow metal conical seat is provided with the injection hole seat which is in communication with the hollow, and the penetrating cone is screwed to the upper end of the injection hole seat. The fire fighting hook is designed with hollow pipeline, which can quickly inject special fire extinguishing agent after piercing the battery pack shell, accurately extinguish the fire source and prevent the fire from rekindling. The hollow structure is integrated with an insulation layer, effectively preventing electric shock risk and significantly improving rescue safety and efficiency.
Owner:SHENZHEN ZHIDESHENG TECH CO LTD

Underwater ray external detection device

PendingCN121955040AStrong penetrating powereffective penetrationMaterial analysis by transmitting radiationThick wallReal time health monitoring
The invention discloses an underwater out-of-ray detection device which comprises an equipment rack suitable for underwater use, the equipment rack is provided with a two-half mechanism capable of being opened and closed through a shaft, the two-half mechanism is divided into a fixed part and a rotatable part, one half of the rotatable part is provided with an accelerator pressure-resistant cabin, the other half of the rotatable part is provided with an accelerator pressure-resistant cabin, and the accelerator pressure-resistant cabin is provided with an accelerator pressure-resistant cabin. An accelerator of which the X-ray energy is not lower than 4MeV is arranged in the pressure-resistant cabin; a detector pressure-resistant cabin is arranged on the other half opposite to the accelerator pressure-resistant cabin, and an array detector is arranged in the detector pressure-resistant cabin and is used for receiving X-rays. The underwater ray external detection device adopts the high-energy X-ray accelerator as a ray source, and compared with traditional radioactive isotopes, the underwater ray external detection device has higher penetrating power and can effectively penetrate through a seabed oil pipeline with a large pipe diameter, a thick wall or a composite structure, and the detection application range is remarkably widened. The device can perform external clamping type scanning on the premise of not disassembling the pipeline, is suitable for real-time health monitoring of the in-service pipeline, and reduces production halt loss.
Owner:OFFSHORE OIL ENG CO LTD

Green silane anticorrosive waterproof material and preparation method thereof

PendingCN122503016Aavoid wastingImprove thixotropyGlycosidePolymer science
The application discloses a kind of green silane anticorrosive waterproof materials and preparation method thereof, it is related to building material and coating technical field, the material is paste, it is prepared from the following mass fraction components: silane monomer 80-90 parts, water 10-20 parts, composite emulsifier 1-5 parts, nano-grade attapulgite 0.5-2 parts, alkyl glycoside APG 0810 0.5-3 parts.Composite emulsifier is compounded by imidazoline amphoteric surfactant, alkyl trimethyl betaine and cocamide propyl dimethylamine ethylene ketal according to 20:30:40.Realize that storage stability is excellent, VOC content is extremely low, facade construction does not flow and the like effect.The material of the application is green and environment-friendly, is suitable for industrial, civil building of concrete structure, seaport, concrete bridge component and different grade concrete base material protection.
Owner:BEIJING AOK REAL DETECTION TECH DEVCO +1