35results about How to "Safety profile" patented technology

Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.

The present disclosure describes methods for treating or preventing Type 1 diabetes mellitus in juveniles, particularly in juveniles newly diagnosed with Type 1 diabetes. This prevention or treatment of Type 1 diabetes is achieved by administering one or more therapeutic agents to a juvenile in need, wherein the therapeutic agent is, for example, a competitive inhibitor of mevalonate synthesis, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or an inducer of AMP protein kinase (AMPK) activity. In certain embodiments, juveniles with Type 1 diabetes are treated with an HMG-CoA reductase inhibitor such as a statin, thereby decreasing the destruction of islet cells, or maintaining endogenous insulin production, in the juvenile.

The invention belongs to a climbing prevention and antitheft device for a balcony and a window of a building and particularly relates to a window warning flower groove and a manufacture method of the window warning flower groove. The window warning flower groove mainly consists of a flower groove and a warning device and is characterized in that a plurality of baffle rods outwards extend from the front side of the long groove-shaped flower groove, and a hinge is arranged at the lower part of the flower groove. The window warning flower groove is arranged outside a window and is blocked on the only way of a thief, the antitheft protection functions of climbing prevention, hanging prevention and the like can be realized, the preventative measures are taken, the window warning flower groove can also be used for culturing flowers, drying objects and preventing unexpected falling of people and objects from high altitude, in addition, the life escape and the disaster cannot be influenced, and the window warning flower groove can be widely used for antitheft protection of various building floors.

The invention relates to the field of medicine, in particular to the field of veterinary medicine. The invention relates to glucocorticoids, especially ciclesonide or a pharmaceutically acceptable derivative or salt thereof, for the treatment of airway disease in horses, such as pulmonary disease, preferably recurrent airway obstruction (RAO), Summer Pasture Associated Obstructive Pulmonary disease (SPAOPD), and inflammatory airway disease (IAD).

Effective and safe pharmaceutical composition and method for treating atrial fibrillation are described. The combined use of dofetilide and mexiletine resulted in an enhanced efficacy in the prevention and treatment of atrial fibrillation with markedly reduced risk of the life-threatening ventricular arrhythmia TdP.

The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed to cyclic pentapeptide and hexapeptide analogs of endomorphin that have (i) a carboxy-terminal extension with an amidated amino acid and (ii) a D-amino acid substitution in position 2. These peptide analogs exhibit decreased tolerance relative to morphine, increased solubility compared to similar tetrapeptide analogs, while maintaining favorable or improved therapeutic ratios of analgesia to side effects.

It is provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of trans-thyretin-associated amyloidosis. It is also provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis in combination therapy with another COMT inhibitor, a benzoxazole derivative, iododiflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxocycline, or epigallocatechin-3-gallate.

The aim of the invention is to provide a rubber profiled safety strip or an elastic profiled safety strip which can carry out a signaling function. To this end a profiled safety strip (10) is provided for a door (15) of a transport means, wherein the profiled safety strip (10) contains an opaque elastic main part (11) in which at least one receiving region (17, 18) is formed, and in the at least one receiving region (17, 18) an insert strip (12, 31) is disposed, which contains at least one light source (13, 32) and is made of an elastic material that is at least partly transparent.

The invention belongs to an anti-creeping and anti-theft device for balconies and windows of buildings, and particularly relates to a manufacturing method for a window alarm planter. The window alarm planter mainly consists of a planter body and alarm equipment, and is characterized in that a plurality of stop levers extend upwards at the front side of the elongated slot-shaped planter body; the lower part of the planter body is provided with hinges; the window alarm planter is arranged on the outside of a window to block the only way that a thief necessarily passes; the window alarm planter has anti-theft protection functions of creeping prevention, hanging prevention and the like, can take preventive measures, and can also be used for growing flowers, drying objects, and preventing people and objects from falling by accident from high altitude, and moreover, escape or disaster relief is not influenced; the window alarm planter can be widely used for the anti-theft protection of floors of various buildings.

Disclosed is a fabricating method of a cobweb-shaped alarm net. The cobweb-shaped alarm net is mainly composed of warps, wefts and an alarm device and is characterized in that the wefts are distributed spirally around the central point of a plurality of the warps to form the net body and connected with the alarm device. The cobweb-shaped alarm net is a bionic design, is mounted outside a window, has the functions of shearing-resistance, anti-creeping, burglar prevention and protective alarming, avoids accidental high-altitude falling of people or objects, has no influence on escaping and disaster relief and can be widely applied to various building storeys.

The present disclosure describes methods for treating Type 1 diabetes mellitus in juveniles. This treatment of Type 1 diabetes is achieved by administering one or more therapeutic agents to a juvenile in need, wherein the therapeutic agent is, for example, a competitive inhibitor of mevalonate synthesis, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or an inducer of AMP protein kinase (AMPK) activity. In certain embodiments, juveniles with Type 1 diabetes are treated with an HMG-CoA reductase inhibitor such as a statin.

The present disclosure provides therapeutic methods for prevention and treatment of type-2 diabetes comprising administering to the subject an effective amount of FTY720 or an analog.

A method of treating inflammation includes administering an anti-inflammatory agent to a patient in need thereof. The anti-inflammatory agent is selected from Compound 1 ([(2-{[3-(4-methyl-1H-benzimidazol-2-yl)piperidin-1-yl]carbonyl}phenyl) amino] acetic acid) and Compound 2 (Ethyl-1-(5-cyano-2-hydroxyphenyl)-4-oxo-5-phenoxy-1,4-dihydropyridine-3-carboxylate). Compound 1 and Compound 2 selectively inhibit COX-2 enzyme, without substantially inhibiting COX-1 enzyme, in contrast to many other NSAIDs.