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3 results about "Tauroursodeoxycholic acid" patented technology
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Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. It is the taurine conjugate form of ursodeoxycholic acid (UDCA). Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA in their bile; UDCA and conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears. TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. UDCA is produced in several countries for the treatment of gallstones and liver cirrhosis. It is not approved by the Food and Drug Administration, in the U.S. while UDCA is approved in the United States for the treatment of primary biliary cirrhosis Ongoing research is finding TUDCA has diminishing apoptotic effects, with potential application in heart disease, Huntington's disease, Parkinson's disease, and stroke. Recently, TUDCA has been found to have protective effects in the eye, especially concerning retinal degenerative disorders.
Marker combination for diagnosis or condition monitoring of intrahepatic cholestasis of pregnancy and application thereof
ActiveCN116338065Bimprove accuracygood conditionComponent separationIntrahepatic Biliary StasisMuricholic acid
The present application relates to the technical field of diagnostic markers and diagnostic methods for intrahepatic cholestasis of pregnancy (ICP), and in particular to a combination of diagnostic or condition monitoring markers for intrahepatic cholestasis of pregnancy and application thereof. The biomarkers include diagnostic markers for diagnosis and screening, and condition monitoring markers for follow-up; the diagnostic markers include a diagnostic combination marker composed of tauroursodeoxycholic acid and glycochenodeoxycholic acid, and taurohyocholic acid; and the condition monitoring markers include glycochenodeoxycholic acid, glycolcholic acid, and taurohyocholic acid. The technical solution solves the technical problem of the prior art that there is a lack of sensitive and specific diagnostic markers for intrahepatic cholestasis of pregnancy, and has important significance for early diagnosis, auxiliary clinical diagnosis and treatment, and improvement of population quality, and provides a new strategy for the difficult diagnosis and treatment of ICP.
Owner:重庆医科大学国际体外诊断研究院
A sperm protective agent for improving sperm preservation quality and embryo development potential and application thereof
The present application relates to the field of animal reproduction technology, and in particular to a sperm protection agent for improving sperm preservation quality and embryo development potential and application thereof, wherein the effective components of the sperm protection agent are selected from any one or several of acetyl carnitine, glycerophosphocholine, tauroursodeoxycholic acid, glutamic acid, sunflower acylcarnitine, pyridoxal phosphate and glyco ursodeoxycholic acid. Based on the regulation of the OR4C13-G13 / Golf signal axis related to sperm capacitation of the effective components, sperm viability can be maintained during preservation, premature capacitation can be inhibited, and the fertilization rate and embryo development potential can be improved. The present application is suitable for the normal temperature preservation of pig semen and can be extended to other mammalian or human assisted reproduction fields.
Owner:SICHUAN AGRI UNIV
A novel 7α-hydroxysteroid dehydrogenase gene R-α-1 and its application in the production of converted bear bile powder.
This invention relates to the field of artificial bear bile powder preparation technology, specifically to a novel 7α-hydroxysteroid dehydrogenase gene R-α-1 and its application in the production and conversion of bear bile powder. This method isolates a novel gene catalyzing asymmetric carbonyl reduction reactions from the feces of Sichuan brown bears. This gene encodes a 7α-hydroxysteroid dehydrogenase, which catalyzes the formation of the intermediate tauroursodeoxycholic acid from tauroursodeoxycholic acid, which is further catalyzed by a 7β-hydroxysteroid dehydrogenase to produce tauroursodeoxycholic acid, the main component of bear bile powder. The nucleotide sequence of this gene is shown in SEQ ID NO.1, and its encoded amino acid sequence is shown in SEQ ID NO.2. This technical solution can solve the technical problem that existing types of 7α-hydroxysteroid dehydrogenases cannot meet the needs of large-scale production due to unsatisfactory enzyme activity and thermostability, and has ideal prospects for widespread application.
Owner:CHONGQING KINBEAR BIOTECHNOLOGY CO LTD