Refined bear gall powder and application thereof in treating cholecystitis gall-stones and improving gall bladder functions
A technology for bear bile powder and cholecystitis, applied in the field of medicine, can solve the problems of limiting the application range of bear bile powder, many impurities, unstable properties and the like
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Embodiment 1
[0081] Embodiment 1: prepare refined bear bile powder
[0082] (1) the bear bile collected (without tube drainage method) (when it is dried under reduced pressure to obtain powder, measure the content of tauroursodeoxycholic acid and taurochenodeoxycholic acid in this powder, be respectively 22.63% And 16.31%, this data is the percentage content of two kinds of materials in bear bile solids) add water dilution (add 2.5 times of volume water dilutions), filter with 80 mesh screens, 80 mesh screens are filtered gained filtrate and use 1M hydrochloric acid Solution adjusts its pH=3.3, then adds 1.2% sodium chloride in the filtrate, obtains crude bear bile fluid (this crude bear bile fluid is dried under reduced pressure to obtain powder, measure tauroursodeoxycholic acid and taurine angiosperm in this powder The content of deoxycholic acid is 28.47% and 20.33% respectively, which shows that the ratio of the two is basically unchanged before filtration, but it is concentrated du...
Embodiment 2
[0102] Embodiment 2: prepare refined bear bile powder
[0103] Steps (1) to (4) are carried out according to Example 1; in step (5), the ethyl acetate-ether (5:1) mixture used is changed to ethyl acetate, and the precipitate is dried under reduced pressure to remove the solvent to obtain refined Bear bile powder. It was determined that the melting point of the refined bear bile powder was 162-163° C., and the difference in melting point indicated that it had a different crystal form from the refined bear bile powder in Example 1.
Embodiment 3
[0104] Embodiment 3: prepare refined bear bile powder
[0105] Steps (1) to (4) are carried out according to Example 1; in the step (5), the ethyl acetate-ether (5:1) mixed solution used is changed to ether, and the precipitate is dried under reduced pressure to remove the solvent to obtain refined bear bile pink. It is determined that the melting point of the refined bear bile powder is 173-175° C., and the difference in melting point shows that it has a different crystal form from the refined bear bile powder in Example 1.
[0106] The above results of Example 2 and Example 3 show that in step (5) the mixture of ethyl acetate-ether (5:1) can be used to obtain the T crystal form with a melting point of 187-189°C, instead of using this mixture The crystals obtained are different.
[0107]Place 3 months at 45 ℃ of temperature places to embodiment 1~3 gained three kinds of refined bear bile powders, then measure their fusing points, the fusing points of three batches of refi...
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