15 results about "Oral application" patented technology

Provided is a glucuronidase activator containing, as an active ingredient, Levilactobacillus brevis (Levilactobacillusbrevis) strain I-3141 (accession number: CECT 7480).

The utility model belongs to the technical field of auxiliary devices, and particularly relates to an auxiliary device for visually impaired people to perceive colors in multiple dimensions, which comprises a book body, each page of the book body is respectively provided with a color marking card, a description card, an olfaction module and a touch module, different colors are marked on each page of the color marking card, and each page of the book body is provided with an olfaction module and a touch module. According to the braille learning book, visual impaired children can conveniently touch and read the braille learning book, the color marking cards and the touch module are fixedly connected with the book body through hook-and-loop fasteners, and shifting sense intercommunication is generated between various feelings and vision through the touch module and the olfaction module, so that things can be deeply known from multiple angles, and the visual impaired children can conveniently read the braille learning book. The visual impaired children can perceive colors in a more vivid and multi-dimensional mode, the feeling of the colors is deepened, description of the colors is more understood, and a certain foundation is laid for spoken language application and writing in the future.

The invention discloses bifidobacterium breve CCFM1505 capable of regulating skin ceramide de novo synthesis and improving skin health and a metagen thereof, and belongs to the technical field of microorganisms and medicines. The bifidobacterium breve CCFM1505 obtained through screening shows the effect of remarkably promoting skin ceramide synthesis in the aspects of external use and oral administration. The viable bacteria of the bifidobacterium breve CCFM1505 and the metabiotics thereof, especially the thallus lysate of the bifidobacterium breve, are orally taken, so that the content of ceramide in the skin tissue is remarkably increased, and meanwhile, the effects of increasing of transpedermis water loss, reducing of the water content of cuticle and inflammatory response caused by skin injury and reducing of the ceramide content can be effectively regulated and controlled, and the skin healing effect is improved. Therefore, the skin health is improved. Therefore, the bifidobacterium breve has a huge application prospect in preparation of external or oral medicines for promoting synthesis of skin ceramide and improving skin health, as well as in preparation of foods, health-care products or cosmetics.

A powdered composition for oral application of therapeutic agents includes a base material, at least one therapeutic agent, and a crosslinker. The composition is formed as a homogenous powder. An application device is also disclosed.

A glucuronidase activator including an active ingredient that is a Levilactobacillus brevis strain I-3141 deposited under accession number CECT 7480.

The invention provides an antibacterial peptide as well as application, a product and a preparation method thereof, and relates to the technical field of biology. The invention screens out a novel antibacterial peptide from kidney beans, which can specifically kill escherichia coli O157: H7 without damaging intestinal flora. By designing protective peptide chains at two ends of an effective sequence, an innovative strategy for keeping oral activity without embedding is established, and the stability and the utilization efficiency are remarkably improved. Meanwhile, a plant-based transgenic expression system is constructed, high-purity production of the antibacterial peptide is realized, and the antibacterial peptide can be directly applied to oral administration.

A powdered composition for oral application of therapeutic agents includes a base material, at least one therapeutic agent, and a crosslinker. The composition is formed as a homogenous powder. An application device is also disclosed.

The invention discloses an intelligent alginate-chitosan oligosaccharide microsphere which is prepared by the following method: (1) adding functional protein into a sodium alginate solution; (2) dropwise adding calcium salt or a solution thereof, and inducing ionic crosslinking to obtain alginate hydrogel; (3) adding 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide, and fully activating the carboxyl group on the chain of the alginate; and (4) dropwise adding a chitosan oligosaccharide solution, so that amino groups of chitosan oligosaccharide and the activated carboxyl groups are subjected to covalent coupling, and the intelligent alginate-chitosan oligosaccharide microspheres are obtained. The invention further discloses application of the intelligent alginate-chitosan oligosaccharide microspheres in serving as or preparing an intestinal tract positioning release preparation and application in delivering functional protein. The intelligent alginate-chitosan oligosaccharide microspheres can significantly prolong the residence time of encapsulated protein in intestinal tracts, show excellent cytocompatibility and in-vivo biological safety, and provide safety guarantee for oral application of the microspheres.

The invention discloses lactobacillus crispatus CCFM1462 and application of a metagen of the lactobacillus crispatus CCFM1462 in promoting skin ceramide synthesis by regulating a sphingomyelinase pathway, and belongs to the technical field of microorganisms and medicines. The lactobacillus crispatus CCFM1462 provided by the invention can effectively improve the content of ceramide in the aspects of external use and oral administration. According to the application disclosed by the invention, it is found that a metagen (fermented supernatant CCFM1462-S) prepared by oral administration of lactobacillus crispatus CCFM1462 can promote expression of sphingomyelinase, so that a sphingomyelinase pathway in a ceramide synthesis process is regulated and controlled, and rapid supplement of ceramide is realized. Therefore, the lactobacillus crispatus plays a crucial role in solving the problem that ceramide needs to be supplemented emergently after skin irritation, has a huge application prospect when being applied to oral or external medicines, and is used for transient stress repair of skin.

The invention provides an English situational dialogue simulation training device supporting multi-person cooperation, which relates to the field of language learning and is characterized by comprising a plurality of user terminals, a server and a situational database. The system has the advantages that an English dialogue environment in a real multi-person social scene is effectively simulated through cooperative operation of the multi-user terminal, the server and the scene database, so that learners can perform high-interactivity and high-simulation cooperative training in multi-role scenes such as business negotiation and airport inquiry; the practical application and the strain capacity of spoken language are obviously improved; meanwhile, by means of voice recognition, intelligent evaluation and dynamic difficulty adjustment modules, the system can analyze the performance of the learner in real time and provide personalized feedback, the limitation that a traditional teaching mode lacks real context and practice is overcome, the learning effect is deepened through recording playback and multi-view replay functions, and the learning efficiency is improved. Therefore, the language organization ability of the learner is comprehensively enhanced.

A nanoparticle composition for oral care includes at least one of a first set of spherical nanoparticles or a second set of coral shaped nanoparticles, and a stabilizing agent. The nanoparticle composition is added to a carrier suitable for application to an oral cavity, including to teeth and surrounding oral tissues. The nanoparticle composition can be a stable, 1-part composition. The nanoparticle composition is configured to control the pH of the microenvironment to which it is applied, thereby preventing and / or treating a variety of oral conditions. The nanoparticle composition can be provided as a concentrated nanoparticle additive addable to a mouthwash, mouth rinse, dentifrice, mouth spray, oral gel, denture cleaning solution, or other carrier suitable for oral application. The oral care composition is not a nasal spray.

Disclosed is a composition comprising an olive extract and a Scutellaria baicalensis extract for use as an HMG-CoA reductase inhibitor in the treatment of dyslipidemia.

The invention discloses insulin-loaded scutellaria baicalensis vesicle-like nanoparticles as well as a preparation method and application thereof, and the method comprises the following steps: mixing the scutellaria baicalensis vesicle-like nanoparticles and an insulin solution, and sequentially carrying out ultrasonic treatment, incubation and ultracentrifugation; and after the ultracentrifugation is finished, discarding the supernatant to remove free insulin, and retaining the precipitate, namely the insulin-loaded scutellaria baicalensis vesicle-like nanoparticles. The insulin-loaded scutellaria baicalensis vesicle-like nanoparticles prepared by the invention have a stable lipid bilayer structure in simulated gastrointestinal fluid, the biological activity of insulin is retained, the insulin-loaded scutellaria baicalensis vesicle-like nanoparticles can be orally taken for diabetes and diabetes complicated with colitis, a new strategy is provided for oral application of insulin, and the insulin-loaded scutellaria baicalensis vesicle-like nanoparticles have a better application prospect.

The present application relates to a berberine protein and its use as a nanocarrier for drug delivery. Specifically, the present application provides a berberine protein, which is prepared by the following method: (1) extracting berberine with water to obtain a water extract; (2) sequentially centrifuging and filtering the water extract, and then dialyzing the filtrate to obtain the berberine protein. The berberine protein of the present application used as a nanocarrier for drug delivery can significantly improve the solubility, dissolution rate and oral bioavailability of docetaxel, thereby improving the oral application value of docetaxel.

The invention provides an edible composition, which belongs to the technical field of food compositions and comprises the following components in parts by weight: 80-95 parts of collagen peptide; 0.5-3 parts of a rose hip seed extract; 0.01 to 1 part of non-denatured type II collagen and 1 to 3 parts of chitosan. According to the edible composition special for improving the degenerative joint disease, the rose hip seed extract and the collagen peptide are combined for use for the first time, the improvement effect is improved by utilizing the synergistic effect of active ingredients, and the non-denatured II-type collagen is especially added, so that the effect of improving the degenerative joint disease is achieved. And the onset speed and recovery speed of oral application of degenerative joint disease and cartilage wear are enhanced. The edible composition disclosed by the invention has the functions of improving arthralgia and degenerative arthropathy, is suitable for daily eating and has a good improvement effect.